1. A compound of formula V:
wherein G is selected from the group consisting of:
\u2014CHO;
\u2014CH(ORm)2, where Rm is C1-6 alkyl, or both Rm groups are joined to form C2-6 alkylene;
\u2014COOH;
\u2014CH\u2550CH2; and
\u2014CH2-L, where L is a leaving group;
each Ra and Rb is independently selected from the group consisting of C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, cyano, halo, \u2014ORf, \u2014SRf, \u2014S(O)Rf, \u2014S(O)2Rf and \u2014NRgRh; or two adjacent Ra groups or two adjacent Rb groups are joined to form C3-6 alkylene, \u2014(C2-4 alkylene)\u2014O \u2014 or \u2014O\u2014(C1-4 alkylene)\u2014O\u2014; wherein each alkyl, alkylene, alkenyl, alkynyl and cycloalkyl group is optionally substituted with 1 to 5 fluoro substituents;
each Rc is independently selected from the group consisting of C1-4 alkyl and fluoro; wherein each alkyl group is optionally substituted with 1 to 5 fluoro substituents;
each Re is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-10 aryl, C2-9 heteroaryl, C3-6 heterocyclic, \u2014CH2\u2014Ri and \u2014CH2CH2\u2014Rj; or both Re groups are joined together with the nitrogen atom to which they are attached to form C3-6 heterocyclic; wherein each alkyl, alkenyl, alkynyl and cycloalkyl group is optionally substituted with 1 to 5 fluoro substituents; and each aryl, heteroaryl and heterocyclic group is optionally substituted with 1 to 3 substituents independently selected from Rk;
each Rf is independently selected from the group consisting hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl and C3-6 cycloalkyl; wherein each alkyl, alkenyl, alkynyl and cycloalkyl group is optionally substituted with 1 to 5 fluoro substituents;
each Rg and Rh is independently selected from the group consisting of hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl and C3-6 cycloalkyl; or Rg and Rh are joined together with the nitrogen atom to which they are attached to form C3-6 heterocyclic; wherein each alkyl, alkenyl, alkynyl and cycloalkyl group is optionally substituted with 1 to 5 fluoro substituents, and the heterocyclic group is optionally substituted with 1 to 3 substituents independently selected from C1-4 alkyl and fluoro;
each Ri is independently selected from the group consisting of C3-6 cycloalkyl, C6-10 aryl, C2-9 heteroaryl and C3-6 heterocyclic; wherein aryl, cycloalkyl, heteroaryl and heterocyclic group is optionally substituted with 1 to 3 substituents independently selected from Rk;
each Rj is independently selected from the group consisting of C3-6 cycloalkyl, C6-10 aryl, C2-9 heteroaryl, C3-6 heterocyclic, \u2014OH, \u2014O(C1-6 alkyl), \u2014O (C3-6 cycloalkyl), \u2014O(C6-10 aryl), \u2014O(C2-9 heteroaryl), \u2014S(C1-6 alkyl), \u2014S(O)(C1-6 alkyl), \u2014S(O)2(C1-6 alkyl), \u2014S(C3-6 cycloalkyl), \u2014S(O)(C3-6 cycloalkyl), \u2014S(O)2(C3-6 cycloalkyl), \u2014S(C6-10 aryl), \u2014S(O)(C6-10 aryl), \u2014S(O)2(C6-10 aryl), \u2014S(C2-9 heteroaryl), \u2014S(O)(C2-9 heteroaryl) and \u2014S(O)2(C2-9 heteroaryl); wherein each alkyl group is optionally substituted with 1 to 5 fluoro substituents; and each aryl, cycloalkyl, heteroaryl and heterocyclic group is optionally substituted with 1 to 3 substituents independently selected from Rk;
each Rk is independently selected from the group consisting of C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, cyano, halo, \u2014ORf, \u2014SRf, \u2014S(O)Rf, \u2014S(O)2Rf and \u2014NRgRh; or two adjacent Rk groups are joined to form C3-6 alkylene, \u2014(C2-4 alkylene)\u2014O\u2014 or \u2014O\u2014(C1-4 alkylene)\u2014O\u2014; wherein each alkyl, alkylene, alkenyl and alkynyl group is optionally substituted with 1 to 5 fluoro substituents;
a is an integer from 2 to 7;
b is 0 or 1;
c is an integer from 2 to 7; provided that a +b +c equals 7, 8 or 9;
m is an integer from 0 to 3;
n is an integer from 0 to 3;
p is 1;
q is an integer from 0 to 4;
or a salt or stereoisomer thereof.
2. The compound of claim 1, wherein b is 0.
3. The compound of claim 1, wherein b is 1.
4. The compound of claim 1, wherein a +b +c equals 7.
5. The compound of claim 1, wherein G is \u2014CHO.
6. The compound of claim 1, wherein G is \u2014CH(ORm)2.
7. The compound of claim 1, wherein G is \u2014COOH.
8. The compound of claim 1, wherein G is \u2014CH\u2550CH2.
9. The compound of claim 1, wherein G is \u2014CH2-L.
10. A compound of the formula:
wherein
G is selected from \u2014CHO; \u2014CH(ORm)2, where Rm is C1-6 alkyl, or both Rm groups are joined to form C2-6 alkylene; \u2014COOH; \u2014CH\u2550CH2; and \u2014CH2-L, where L is a leaving group;
a is an integer from 2 to 7;
b is 0 or 1;
c is an integer from 2 to 7; provided that a +b +c equals 7, 8 or 9;
or a salt or stereoisomer thereof.
11. The compound of claim 10, wherein b is 0.
12. The compound of claim 10, wherein b is 1.
13. The compound of claim 10, wherein G is \u2014CHO.
14. The compound of claim 10, wherein G is \u2014CH(ORm)2.
15. The compound of claim 10, wherein G is \u2014COOH.
16. The compound of claim 10, wherein G is \u2014CH\u2550CH2.
17. The compound of claim 10, wherein G is \u2014CH2-L.
18. The compound of claim 10, wherein G is \u2014CH2\u2014Cl.
19. The compound of claim 10, wherein G is \u2014CH2\u2014Br.
20. The compound of claim 10, wherein G is \u2014CH2\u2014I.
21. The compound of claim 10, wherein G is \u2014CH2\u2014O\u2014S(O)2CH3.
22. The compound of claim 10, wherein G is \u2014CH2\u2014O\u2014S(O)2(4-methylphenyl).
23. A compound of the formula:
or a salt thereof.
24. A compound of the formula:
or a salt thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A single piece hydrofoil comprising:
a yoke having a center body;
a longitudinal channel defined by said center body, said longitudinal channel having oppositely positioned walls defining oppositely positioned slots therein;
a pair of wings having a wing tip, a root, and a trailing edge, each said wing having a cross-sectional configuration of at least one true hydrofoil from said wing tip to said root, wherein said pair of wings are joined to said yoke at said root;
at least one non-invasive securing device suitable for retaining said hydrofoil on a cavitation plate;
an integrated yoke-bridge spanning said longitudinal channel.
2. The hydrofoil of claim 1, wherein said integrated yoke-bridge substantially precludes expansion of said longitudinal channel when said hydrofoil is secured to a cavitation plate.
3. The hydrofoil of claim 1, further comprising at least one threaded hole on each side of said center body, said threaded hole passing from the exterior of said center body and opening into said longitudinal channel.
4. The hydrofoil of claim 3, further comprising securing devices passing through said threaded holes passing from the exterior of said center body and opening into said longitudinal channel, said securing devices passing through said holes in said yoke-bridge legs thereby retaining said yoke-bridge on said hydrofoil.
5. The hydrofoil of claim 4, wherein when said hydrofoil is installed on a cavitation plate said securing devices compressively engage an edge of said cavitation plate thereby noninvasively retaining said hydrofoil to said cavitation plate.
6. The hydrofoil of claim 1, wherein the drop from top of the hydrofoil at about the center line to the wing tip is between zero and two inches.
7. The hydrofoil of claim 1, further comprising at least one threaded hole passing from the exterior of said center body and opening into said longitudinal channel, securing devices positioned within said threaded holes and wherein when said hydrofoil is installed on a cavitation plate said securing devices compressively engage an edge of said cavitation plate thereby non-invasively retaining said hydrofoil on a cavitation plate.
8. The hydrofoil of claim 1, further comprising no more than three drill bit centering recesses.
9. The hydrofoil of claim 1, further comprising no more than two drill bit centering recesses.
10. The hydrofoil of claim 1, further comprising no more than one drill bit centering recess.
11. A single piece hydrofoil comprising:
a yoke including:
a center body defining a longitudinal channel therein, wherein said longitudinal channel has a first and second side and is open to a front of said center body;
a yoke-bridge spanning said longitudinal channel;
a pair of open-ended slots oppositely disposed in each of said channel sides and extending along a substantial length of said sides, wherein said open-ended slots are capable of receiving a cavitation plate of a boat motor;
a pair of wings integrally joined with said yoke and projecting outwardly therefrom, said pair of wings having a leading edge and a trailing edge;
at least one non-invasive securing device suitable for retaining said hydrofoil on a cavitation plate;
an integrated yoke-bridge spanning said longitudinal channel;
at least one threaded hole passing from the exterior of said center body and opening into said longitudinal channel, non-invasive securing devices positioned within said threaded holes and wherein when said hydrofoil is installed on a cavitation plate said non-invasive securing devices compressively engage an edge of said cavitation plate thereby retaining said hydrofoil on a cavitation plate.
12. The hydrofoil of claim 11, wherein said integrated yoke-bridge substantially precludes expansion of said longitudinal channel when said hydrofoil is secured to a cavitation plate.
13. The hydrofoil of claim 11, wherein said integrated yoke-bridge substantially precludes expansion of said longitudinal channel when said hydrofoil is secured to a cavitation plate.
14. The hydrofoil of claim 11, wherein the drop from top of the hydrofoil at about the center line to the wing tip is between zero and two inches.
15. The hydrofoil of claim 11, wherein the drop from top of the hydrofoil at about the center line to the wing tip is between zero and two inches.
16. A single piece hydrofoil comprising:
a yoke including:
a center body defining a longitudinal channel therein, wherein said longitudinal channel has a first and second side and is open to a front of said center body;
a yoke-bridge spanning said longitudinal channel;
a pair of open-ended slots oppositely disposed in each of said channel sides and extending along a substantial length of said sides, wherein said open-ended slots are capable of receiving a cavitation plate of a boat motor;
a tail section integrally formed with said center body and covering a portion of said longitudinal channel;
a contoured trailing edge defined by said tail section, said contoured trailing edge angles upwardly into a trailing edge peak;
a pair of wings integrally joined with said yoke and projecting outwardly therefrom, said pair of wings having a leading edge and a trailing edge, wherein said trailing edge is seamlessly integrated with said contoured trailing edge of said tail section;
at least one non-invasive securing device suitable for retaining said hydrofoil on a cavitation plate;
an integrated yoke-bridge spanning said longitudinal channel;
at least one threaded hole passing from the exterior of said center body and opening into said longitudinal channel, securing devices positioned within said threaded holes and wherein when said hydrofoil is installed on a cavitation plate said securing devices compressively engage an edge of said cavitation plate thereby retaining said hydrofoil on a cavitation plate; and,
no more than three drill bit centering recesses positioned on the bottom of said single piece hydrofoil.
17. The hydrofoil of claim 16, wherein said integrated yoke-bridge substantially precludes expansion of said longitudinal channel when said hydrofoil is secured to a cavitation plate.
18. The hydrofoil of claim 16, wherein said integrated yoke-bridge substantially precludes expansion of said longitudinal channel when said hydrofoil is secured to a cavitation plate.
19. The hydrofoil of claim 16, wherein the drop from top of the hydrofoil at about the center line to the wing tip is between zero and two inches.
20. A single piece hydrofoil comprising:
a yoke having a center body;
a longitudinal channel defined by said center body, said longitudinal channel having oppositely positioned walls defining oppositely positioned slots therein;
a pair of wings having a wing tip, a root, and a trailing edge, each said wing having a cross-sectional configuration of at least one true hydrofoil from said wing tip to said root, wherein said pair of wings are joined to said yoke at said root;
an integrated yoke-bridge spanning said longitudinal channel.
21. The hydrofoil of claim 20, wherein said integrated yoke-bridge substantially precludes expansion of said longitudinal channel when said hydrofoil is secured to a cavitation plate.
22. The hydrofoil of claim 20, further comprising at least one threaded hole on each side of said center body, said threaded hole passing from the exterior of said center body and opening into said longitudinal channel.
23. The hydrofoil of claim 22, further comprising securing devices passing through said threaded holes passing from the exterior of said center body and opening into said longitudinal channel, said securing devices passing through said holes in said yoke-bridge legs thereby retaining said yoke-bridge on said hydrofoil.
24. The hydrofoil of claim 23, wherein when said hydrofoil is installed on a cavitation plate said securing devices compressively engage an edge of said cavitation plate thereby noninvasively retaining said hydrofoil to said cavitation plate.
25. The hydrofoil of claim 20, further comprising at least one threaded hole passing from the exterior of said center body and opening into said longitudinal channel, securing devices positioned within said threaded holes and wherein when said hydrofoil is installed on a cavitation plate said securing devices compressively engage an edge of said cavitation plate thereby non-invasively retaining said hydrofoil on a cavitation plate.
26. The hydrofoil of claim 20, wherein the drop from top of the hydrofoil at about the center line to the wing tip is between zero and two inches.