1. A compound of structural formula I:
or an enantiomer or a pharmaceutically acceptable salt thereof; wherein
a-b represents CH\u2550CH or CH2CH2;
d is 0 or 1;
R1 is selected from hydrogen, C1-4 alkyl, wherein said C1-4 alkyl is optionally substituted with one or more substituents independently selected from halogen, hydroxy, C1-4 alkoxy, and C1-4 alkylamino, and
R2 is chosen from
hydrogen,
hydroxy C0-10alkyl,
perfluoroC1-6alkyl,
perfluoroC1-6alkoxy,
C1-10 alkyl,
C2-10 alkenyl,
C2-10 alkynyl,
aryl C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl,
(C0-10 alkyl)1-2aminocarbonyloxy C0-10 alkyl,
(aryl C0-10 alkyl)1-2aminocarbonyloxy C0-10 alkyl,
(C3-8 cycloalkyl C0-10 alkyl)1-2aminocarbonyloxy C0-10 alkyl,
(C3-8 heterocyclyl C0-10 alkyl)1-2aminocarbonyloxy C0-10 alkyl,
(C0-10 alkyl)1-2aminocarbonylaminoC1-10 alkyl,
(aryl C0-10 alkyl)1-2aminocarbonylamino C1-10 alkyl,
(C3-8 cycloalkyl C0-10 alkyl)1-2aminocarbonylamino C1-10 alkyl,
(C3-8 heterocyclyl C0-10 alkyl)1-2aminocarbonylamino C1-10 alkyl,
(C0-10 alkyl)1-2aminocarbonyl C0-10 alkyl,
(aryl C0-10 alkyl)1-2aminocarbonyl C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl aminocarbonyl C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl aminocarbonyl C0-10 alkyl,
C0-10 alkyl carbonylamino C1-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl carbonylamino C1-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl carbonylamino C1-10 alkyl,
aryl C0-10 alkyl carbonylamino C1-10 alkyl,
C0-10 alkyloxy carbonylamino C1-10 alkyl,
C3-8 cycloalkyl C0-10 alkyloxy carbonylamino C1-10 alkyl,
C3-8 heterocyclyl C0-10 alkyloxy carbonylamino C1-10 alkyl,
aryl C0-10 alkyloxy carbonylamino C1-10 alkyl,
C0-10 alkyloxy carbonyloxy C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyloxy carbonyloxy C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyloxy carbonyloxy C0-10 alkyl,
aryl C0-10 alkyloxy carbonyloxy C0-10 alkyl,
C1-10 alkoxy (carbonyl)0-1C0-10 alkyl,
C1-10alkyloxy C0-10alkyl,
aryloxy C0-10 alkyl,
C3-8 cycloalkyloxy C0-10 alkyl,
C3-8 heterocyclyloxy C0-10 alkyl,
C3-8 heterocyclylC0-10alkyloxy C0-10 alkyl, and
C1-10 alkylcarbonyloxy C0-10 alkyl;
wherein in R2, said aryl is selected from phenyl, naphthyl, indanyl, and tetrahydronapthyl, and said heterocyclyl is selected from azabenzimidazolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, benzodihydrofuranyl, 1,3-benzodioxolyl, 2,3-dihydro-1,4-benzodioxinyl, imidazolyl, indanyl, indolyl, indazoyl, isoquinolyl, isothiazolyl, isoxazolyl, quinolyl, furanyl, thienyl, oxazolyl, thiazolyl, pyrazolyl, pyrrolyl, pyridyl, pyrimidyl, pyrazinyl, thiadiazolyl, oxadiazolyl, triazolyl, imidizopyridinyl, and tetrazolyl; and
further wherein in R2 is optionally substituted with one or more groups, R3, chosen from halogen, aryl, C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloheteroalkyl, aryl-C1-6 alkyl, amino-C0-6 alkyl, C1-6 alkylamino-C0-6 alkyl, (C1-6 alkyl)2amino-C0-6 alkyl, aryl-C0-6 alkylamino-C0-6 alkyl, (aryl-C0-6 alkyl)2amino-C0-6 alkyl, C1-6 alkylthio, aryl-C0-6 alkylthio, C1-6 alkylsulfinyl, aryl-C0-6 alkylsulfinyl, C1-6 alkylsulfonyl, aryl-C0-6 alkylsulfonyl, C1-6 alkoxy-C0-6 alkyl, aryl-C0-6 alkoxy-C0-6 alkyl, hydroxycarbonyl-C0-6 alkyl, C1-6 alkoxycarbonyl-C0-6 alkyl, aryl-C0-6 alkoxycarbonyl-C0-6 alkyl, hydroxycarbonyl-C1-6 alkyloxy, hydroxy-C0-6 alkyl, cyano, nitro, perfluoro-C1-4 alkyl, perfluoro-C1-4 alkoxy, C1-6 alkylcarbonyloxy, aryl-C0-6 alkylcarbonyloxy, C1-6alkylcarbonylamino, aryl-C0-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aryl-C0-6 alkylsulfonylamino, C1-6 alkoxycarbonylamino, aryl-C0-6 alkoxycarbonylamino, C1-6 alkylaminocarbonylamino, aryl-C0-6 alkylamino-carbonylamino, (C1-6 alkyl)2 aminocarbonylamino, (aryl-C0-6 alkyl)2 aminocarbonylamino, (C1-6 alkyl)2 aminocarbonyloxy, and (aryl-C0-6 alkyl)2 aminocarbonyloxy; and
wherein R3 is optionally substituted with one or more groups chosen from: OH, C1-6 alkoxy, halogen, CO2H, CN, O(C\u2550O) C1-6 alkyl, NO2, trifluoromethoxy, trifluoroethoxy, \u2014O(d)(C1-10)perfluoroalkyl, and NH2.
2. A compound of claim 1, chosen from:
N-(2,6-dichloropyridin-3-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-cyano-3-fluorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-cyano-3-chlorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-cyano-4-chlorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-cyano-3-methylphenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,1 1,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-chlorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-cyano-5-methylphenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-chlorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2,6-dichlorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-fluorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-fluorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-Benzyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b, 11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1-phenylethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1-(2-chlorophenyl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1-(3-chlorophenyl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1-(2,6-dichlorophenyl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b, 6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-1-(1,3-benzodioxol-5-yl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b, 6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1H-imidazol-2-yl)methyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-methyl-1H-imidazol-2-yl)methyl-((5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b, 6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1H-benzimidazol-2-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b, 6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(5-methoxy-1H-benzimidazol-2-ylmethyl)-((5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b, 6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-fluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-fluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-fluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2,6-difluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(pyridin-2-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(pyridin-3-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(pyridin-4-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-methylbenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-methylbenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-methylbenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1R,1-phenylpropyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1S, 1-phenylpropyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1H-imidazo4,5-bpyridin-2-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-methylthio-1H-imidazol-2-yl)methyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-chloro-4-cyanophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3,5-dichloropyridin-2-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-chloropyridin-3-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-chloropyridin-3-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-chloropyridin-5-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-1-(pyridin-2-yl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-1-(pyridin-3-yl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-1-(pyridin-4-yl)ethyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(primidin-4-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(5-cyanoprimidin-4-yl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
Methyl 2-{(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b,6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-\u03b1indeno5,4-fquinolin-8-ylcarbonylamino}butanoate;
N-(1S)-1-(aminocarbonyl)propyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1S)-1-(methylaminocarbonyl)propyl(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1S)-1-(dimethylaminocarbonyl)propyl(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2,2,2-trifluoroethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3,3,3-trifluoropropyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-4-(cyanomethyl)phenyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
Methyl 4-{(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-\u03b1indeno5,4-fquinolin-8-ylcarbonylamino}benzoate;
N-4-(aminocarbonyl)phenyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-\u03b1indeno5,4-fquinoline-8-carboxamide;
(5aR,5bS, 7aS, 8R, 10aS, 10bS)-N-4-(1,2,3-thiadiazol4-yl)phenyl-5b,6,7,7a,8,9,10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-\u03b1indeno5,4-fquinoline-8-carboxamide;
(5aR,5bS, 7aS, 8R, 10aS, 10bS)-N-(1H-indazol-6-yl)-5b,6,7,7a,8,9, 10,10a,10b,11,12,12a-dodecahydro-5aH-imidazo1,2-\u03b1indeno5,4-fquinoline-8-carboxamide;
N-(2,6-dichlorophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-cyanophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-methyl-4-cyanophenyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-benzyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-chlorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2,6-dichlorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-fluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-fluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2,6-difluorobenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(pyridin-2-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(2-methylbenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(3-methylbenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-methylbenzyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1R)-1-phenylethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1H-benzimidazol-2-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(1H-imidazo4,5-bpyridin-2-ylmethyl)-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(4-phenyl-1H-imidazol-2-yl)methyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(5-chloro-1H-benzoimidazol-2-yl)methyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
N-(5-methoxy-1H-benzoimidazol-2-yl)methyl-(5aR,5bS, 7aS, 8R, 10aS, 10bS)-5,5a,5b6,7,7a,8,9,10,10a,10b,11,12,12a-tetradecahydro4H-imidazo1,2-aindeno5,4-fquinoline-8-carboxamide;
pharmaceutically acceptable salts or stereoisomers thereof.
3. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt or stereoisomer thereof and a pharmaceutically acceptable carrier.
4. A process for making a pharmaceutical composition comprising combining a compound according claim 1 or a pharmaceutically acceptable salt or stereoisomer thereof and a pharmaceutically acceptable carrier.
5. A compound according to claim 1, wherein
R2 is chosen from:
hydrogen,
hydroxyC0-10alkyl,
C1-10alkyl,
aryl C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl,
(C0-10 alkyl)1-2aminocarbonyl-C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl aminocarbonyl C0-10 alkyl,
C0-10 alkyl carbonylamino C1-10 alkyl,
C0-10 alkyloxy carbonyloxy C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyloxy carbonyloxy-C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyloxy-carbonyloxy C0-10 alkyl,
aryl C0-10 alkyloxy carbonyloxy C0-10 alkyl,
C1-10 alkoxy-(carbonyl)0-1C0-10 alkyl,
C1-10alkyloxy-C0-10alkyl,
aryloxy C0-10 alkyl,
C3-8 cycloalkyloxy C0-10-alkyl,
C3-8 heterocyclyloxy C0-10 alkyl,
C3-8 heterocyclylC0-10alkyloxy C0-10 alkyl, and
C1-10 alkylcarbonyloxy C0-10 alkyl;
wherein in R2, said aryl is selected from phenyl, naphthyl, indanyl, and tetrahydronapthyl, and said heterocyclyl is selected from azabenzimidazolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, benzodihydrofuranyl, 1,3-benzodioxolyl, 2,3-dihydro-1,4-benzodioxinyl, imidazolyl, indanyl, indolyl, indazoyl, isoquinolyl, isothiazolyl, isoxazolyl, quinolyl, furanyl, thienyl, oxazolyl, thiazolyl, pyrazolyl, pyrrolyl, pyridyl, pyrimidyl, pyrazinyl, thiadiazolyl, oxadiazolyl, triazolyl, imidizopyridinyl, and tetrazolyl; and
further wherein in R2 is optionally substituted with one or more groups, R3, chosen from halogen, aryl, C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloheteroalkyl, aryl-C1-6 alkyl, amino-C0-6 alkyl, C1-6 alkylamino-C0-6 alkyl, (C1-6 alkyl)2amino-C0-6 alkyl, aryl-C0-6 alkylamino-C0-6 alkyl, (aryl-C0-6 alkyl)2amino-C0-6 alkyl, C1-6 alkylthio, aryl-C0-6 alkylthio, C1-6 alkylsulfinyl, aryl-C0-6 alkylsulfinyl, C1-6 alkylsulfonyl, aryl-C0-6 alkylsulfonyl, C1-6 alkoxy-C0-6 alkyl, aryl-C0-6 alkoxy-C0-6 alkyl, hydroxycarbonyl-C0-6 alkyl, C1-6 alkoxycarbonyl-C0-6 alkyl, aryl-C0-6 alkoxycarbonyl-C0-6 alkyl, hydroxycarbonyl-C1-6 alkyloxy, hydroxy-C0-6 alkyl, cyano, nitro, perfluoro-C1-4 alkyl, perfluoro-C1-4 alkoxy, C1-6 alkylcarbonyloxy, aryl-C0-6 alkylcarbonyloxy, C1-6alkylcarbonylamino, aryl-C0-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aryl-C0-6 alkylsulfonylamino, C1-6 alkoxycarbonylamino, aryl-C0-6 alkoxycarbonylamino, C1-6 alkylaminocarbonylamino, aryl-C0-6 alkylamino- carbonylamino, (C1-6 alkyl)2 aminocarbonylamino, (aryl-C0-6 alkyl)2 aminocarbonylamino, (C1-6 alkyl)2 aminocarbonyloxy, and (aryl-C0-6 alkyl)2 aminocarbonyloxy; and
wherein R3 is optionally substituted with one or more groups chosen from: OH, C1-6 alkoxy, halogen, CO2H, CN, O(C\u2550O) C1-6 alkyl, NO2, trifluoromethoxy, trifluoroethoxy, \u2014O(d)(C1-10)perfluoroalkyl, and NH2.
6. A compound according to claim 5, wherein
R2 is chosen from:
hydroxyC0-10alkyl,
C1-10 alkyl, aryl C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl,
C3-8 heterocyclyl C0-10 alkyl- aminocarbonyl C0-10 alkyl,
C0-10 alkyl carbonylamino C1-10 alkyl,
C1-10 alkoxy(carbonyl)0-1C0-10 alkyl,
C1-10alkyloxyC0-10alkyl,
aryloxy C0-10 alkyl,
C3-8 heterocyclyloxy C0-10 alkyl,
C3-8 heterocyclylC0-10alkyloxy C0-10 alkyl, and
C1-10 alkylcarbonyloxy C0-10 alkyl;
wherein in R2, said aryl is selected from phenyl, naphthyl, indanyl, and tetrahydronapthyl, and said heterocyclyl is selected from azabenzimidazolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, benzodihydrofuranyl, 1,3-benzodioxolyl, 2,3-dihydro-1,4-benzodioxinyl, imidazolyl, indanyl, indolyl, indazoyl, isoquinolyl, isothiazolyl, isoxazolyl, quinolyl, furanyl, thienyl, oxazolyl, thiazolyl, pyrazolyl, pyrrolyl, pyridyl, pyrimidyl, pyrazinyl, thiadiazolyl, oxadiazolyl, triazolyl, imidizopyridinyl, and tetrazolyl.
7. A compound according to claim 1, wherein a-b represents CH\u2550CH.
8. A compound according to claim 1, wherein a-b represents CH2CH2.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A herbicidal composition which comprises i) an isoxazoline derivative represented by the following formula (I) or a salt thereof
wherein R1 and R2 are independently a hydrogen atom, a C1 to C10 alkyl group, a C3 to C8 cycloalkyl group or a C3 to C8 cycloalkyl C1 to C3 alkyl group; or R1 and R2 may be bonded to each other to form a C3 to C7 spiro ring together with the carbon atoms to which they bond;
R3 and R4 are independently a hydrogen atom, a C1 to C10 alkyl group or a C3 to C8 cycloalkyl group; or R3 and R4 may be bonded to each other to form a C3 to C7 spiro ring together with the carbon atoms to which they bond; or R1, R2, R3 and R4 may form a 5- to 8-membered ring together with the carbon atoms to which they bond;
R5 and R6 are respectively independently a hydrogen atom or a C1 to C10 alkyl group;
Y is a 5- to 6-membered aromatic heterocyclic group or condensed aromatic heterocyclic group having one or more hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom; the heterocyclic group may be substituted with 0 to 6 same or different groups selected from the following substituent group \u03b1; when the heterocyclic group is substituted at the two adjacent positions with two alkyl groups, two alkoxy groups, an alkyl group and an alkoxy group, an alkyl group and an alkylthio group, an alkyl group and an alkylsulfonyl group, an alkyl group and a monoalkylamino group, or an alkyl group and a dialkylamino group, all selected from the substituent group \u03b1, the two groups may form, together with the atoms to which they bond, a 5- to 8-membered ring which may be substituted with 1 to 4 halogen atoms; the hetero atom of the heterocyclic group, when it is a nitrogen atom, may be oxidized to become N-oxide;
n is an integer of 0 to 2;
wherein said substituent group \u03b1 is selected from the group consisting of
hydroxyl group; thiol group; halogen atoms; C1 to C10 alkyl groups; C1 to C10 alkyl groups each mono-substituted with a group selected from the following substituent group \u03b2, C1 to C4 haloalkyl groups; C3 to C8 cycloalkyl groups; C1 to C10 alkoxy groups; C1 to C10 alkoxy groups each mono-substituted with a group selected from the following substituent group \u03b3; C1 to C4 haloalkoxy groups; C3 to C8 cycloalkyloxy groups; C3 to C8 cycloalkyl C1 to C3 alkyloxy groups; C1 to C10 alkylthio groups; C1 to C10 alkylthio groups each mono-substituted with a group selected from the substituent group \u03b3; C1 to C4 haloalkylthio groups; C2 to C6 alkenyl groups; C2 to C6 alkenyloxy groups; C2 to C6 alkynyl groups; C2 to C6 alkynyloxy groups; C1 to C10 alkylsulfinyl groups; C1 to C10 alkylsulfinyl groups each mono-substituted with a group selected from the substituent group \u03b3; C1 to C10 alkylsulfonyl groups; C1 to C10 alkylsulfonyl groups each mono-substituted with a group selected from the substituent group \u03b3; C1 to C4 haloalkylsulfinyl groups; C1 to C10 alkylsulfonyloxy groups each mono-substituted with a group selected from the substituent group \u03b3; C1 to C4 haloalkylsulfonyl groups; C1 to C10 alkylsulfonyloxy groups; C1 to C4 haloalkylsulfonyloxy groups; optionally substituted phenyl group; optionally substituted phenoxy group; optionally substituted phenylthio group; optionally substituted aromatic heterocyclic groups; optionally substituted aromatic heterocyclic oxy groups; optionally substituted aromatic heterocyclic thio groups; optionally substituted phenylsulfinyl groups; optionally substituted phenylsulfonyl groups; optionally substituted aromatic heterocyclic sulfonyl groups; optionally substituted phenylsulfonyloxy groups; acyl groups; C1 to C4 haloalkylcarbonyl groups; optionally substituted benzylcarbonyl group; optionally substituted benzoyl group; carboxyl group; C1 to C10 alkoxycarbonyl groups; optionally substituted benzyloxycarbonyl group; optionally substituted phenoxycarbonyl group; cyano group; carbamoyl group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups and optionally substituted phenyl group); C1 to C6 acyloxy groups; C1 to C4 haloalkylcarbonyloxy groups; optionally substituted benzylcarbonyloxy group; optionally substituted benzoyloxy group; nitro group; and amino group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups, optionally substituted phenyl group, C1 to C6 acyl groups, C1 to C4 haloalkylcarbonyl groups, optionally substituted benzylcarbonyl group, optionally substituted benzoyl group, C1 to C10 alkylsulfonyl group, C1 to C4 haloalkylsulfonyl groups, optionally substituted benzylsulfonyl group, and optionally substituted phenylsulfonyl group);
wherein said substituent group \u03b2 is selected from the group consisting of
hydroxyl group; C3 to C8 cycloalkyl groups (which may be substituted with halogen atom or alkyl group); C1 to C10 alkoxy groups; C1 to C10 alkylthio groups; C1 to C10 alkylsulfonyl groups; C1 to C10 alkoxycarbonyl groups; C2 to C6 haloalkenyl groups; amino group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups, C1 to C6 acyl groups; C1 to C4 haloalkylcarbonyl groups, C1 to C10 alkylsulfonyl groups and C1 to C4 haloalkylsulfonyl groups); carbamoyl group (its nitrogen atom may be substituted with same or different C1 to C10 alkyl groups); C1 to C6 acyl groups; C1 to C4 haloalkylcarbonyl groups; C1 to C10 alkoxyimino groups; cyano group; optionally substituted phenyl group; and optionally substituted phenoxy group;
wherein said substituent group \u03b3 is selected from the group consisting of
C1 to C10 alkoxycarbonyl groups; optionally substituted phenyl group; optionally substituted aromatic heterocyclic groups; cyano group; and carbamoyl group (its nitrogen atom may be substituted with same or different C1 to C10 alkyl groups); and
ii) at least one compound selected from the group consisting of
atrazine, simazine, cyanazine, isoxaflutole, mesotrione, flumetsulam, imazethapyr, imazapyr, dicamba, clopyralid, prosulfuron, halosulfuron-methyl, rimsulfuron, bentazone, carfentrazone-ethyl, metribuzin, thifensulfuron-methyl, nicosulfuron, primisulfuron, cloransulam-methyl, glufosinate, glyphosate, glyphosate-trimesium, pendimethalin, linuron, prometryn, diflufenican, flumioxazin, and metolachlor.
2. The herbicidal composition according to claim 1, wherein the isoxazoline derivative of the formula (I) or a salt thereof has a substituent selected from the substituent group \u03b1 on the heterocycle which may be substituted with 0 to 6 same or different groups, including hydroxyl group; halogen atoms; C1 to C10 alkyl groups; C1 to C10 alkyl groups each mono-substituted with a group selected from the substituent group \u03b2, C1 to C4 haloalkyl groups; C3 to C8 cycloalkyl groups; C1 to C10 alkoxy groups; C1 to C10 alkoxy groups each mono-substituted with a group selected from the substituent group \u03b3; C1 to C4 haloalkoxy groups; C3 to C8 cycloalkyloxy groups; C3 to C8 cycloalkyl C1 to C3 alkyloxy groups; C1 to C10 alkylthio groups; C1 to C10 alkylthio groups each mono-substituted with a group selected from the substituent group \u03b3; C1 to C4 haloalkylthio groups; C2 to C6 alkenyl groups; C2 to C6 alkenyloxy groups; C2 to C6 alkynyl groups; C2 to C6 alkynyloxy groups; C1 to C10 alkylsulfonyl groups; C1 to C4 haloalkylsulfonyl groups; optionally substituted phenyl group; optionally substituted phenoxy group; optionally substituted phenylthio group; optionally substituted aromatic heterocyclic groups; optionally substituted aromatic heterocyclic oxy groups; optionally substituted aromatic heterocyclic thio groups; optionally substituted phenylsulfonyl groups; optionally substituted aromatic heterocyclic sulfonyl groups; C1 to C6 acyl groups; C1 to C4 haloalkylcarbonyl groups; optionally substituted benzylcarbonyl group; optionally substituted benzoyl group; carboxyl group; C1 to C10 alkoxycarbonyl groups; cyano group; carbamoyl group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups and optionally substituted phenyl group); nitro group; and amino group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups, optionally substituted phenyl group, C1 to C6 acyl groups, C1 to C4 haloalkylcarbonyl groups, optionally substituted benzylcarbonyl group, optionally substituted benzoyl group, C1 to C10 alkylsulfonyl groups, C1 to C4 haloalkylsulfonyl groups, optionally substituted benzylsulfonyl group, and optionally substituted phenylsulfonyl group); when the heterocyclic group is substituted at the two adjacent positions with two alkyl groups, two alkoxy groups, an alkyl group and an alkoxy group, an alkyl group and an alkylthio group, an alkyl group and an alkylsulfonyl group, an alkyl group and a monoalkylamino group, or an alkyl group and a dialkylamino group, the two groups may form, together with the atoms to which they bond, a 5- to 8-membered ring which may be substituted with 1 to 4 halogen atoms.
3. The herbicidal composition according to claim 2, wherein the isoxazoline derivative of the formula (I) or its a salt thereof has a substituent selected from the substituent group \u03b10 on the heterocycle which may be substituted with 0 to 6 same or different groups, including halogen atoms; C1 to C10 alkyl groups; C1 to C4 haloalkyl groups; C1 to C10 alkoxy C1 to C3 alkyl groups; C3 to C8 cycloalkyl groups (which may be substituted with halogen atom or alkyl group); C1 to C10 alkoxy groups; C1 to C4 haloalkoxy groups; C3 to C8 cycloalkyl C1 to C3 alkyloxy groups; optionally substituted phenoxy group; C1 to C10 alkylthio groups; C1 to C10 alkylsulfonyl groups; acyl groups; C1 to C4 haloalkylcarbonyl groups; C1 to C10 alkoxycarbonyl groups; cyano group and carbamoyl group (its nitrogen atom may be substituted with same or different C1 to C10 alkyl groups).
4. The herbicidal composition according to claim 1, wherein R1 and R2 may be the same or different and are each a methyl group or an ethyl group; and R3, R4, R5 and R6 are each a hydrogen atom.
5. The herbicidal composition according to claim 1, wherein Y is a 5- or 6-membered aromatic heterocyclic group having a hetero atom selected from a nitrogen atom, an oxygen atom and a sulfur atom.
6. The herbicidal composition according to claim 5, wherein Y is a thienyl group, a pyrazolyl group, an isoxazolyl group, an isothiazolyl group, a pyridyl group or a pyrimidinyl group.
7. The herbicidal composition according to claim 6, wherein Y is a thiophen-3-yl group, a pyrazol-4-yl group, a pyrazol-5-yl group, an isoxazol-4-yl group, an isothiazol-4-yl group, a pyridyn-3-yl group or a pyrimidin-5-yl group.
8. The herbicidal composition according to claim 7, wherein Y is a thiophen-3-yl group and the thiophene ring is substituted with the substituent group \u03b1 at the 2- and 4-positions.
9. The herbicidal composition according to claim 7, wherein Y is a pyrazol-4-yl group and the pyrazole ring is substituted at the 3- and 5-positions with the substituent group \u03b1 and at the 1-position with a hydrogen atom, a C1 to C10 alkyl group, a C1 to C10 alkyl group mono-substituted with a group selected from the substituent group \u03b2, a C1 to C4 haloalkyl group, a C3 to C8 cycloalkyl group, a C2 to C6 alkenyl group, a C2 to C6 alkynyl group, a C1 to C10 alkylsulfinyl group, a C1 to C10 alkylsulfonyl group, a C1 to C10 alkylsulfonyl group mono-substituted with a group selected from the substituent group \u03b3, a C1 to C4 haloalkylsulfonyl group, an optionally substituted phenyl group, an optionally substituted aromatic heterocyclic group, an optionally substituted phenylsulfonyl group, an optionally substituted aromatic heterocyclic sulfonyl group, an acyl group, a C1 to C4 haloalkylcarbonyl group, an optionally substituted benzylcarbonyl group, an optionally substituted benzoyl group, a C1 to C10 alkoxycarbonyl group, an optionally substituted benzyloxycarbonyl group, an optionally substituted phenoxycarbonyl group, a carbamoyl group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups and optionally substituted phenyl group), or an amino group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups, an optionally substituted phenyl group, acyl groups, C1 to C4 haloalkylcarbonyl groups, an optionally substituted benzylcarbonyl group, an optionally substituted benzoyl group, C1 to C10 alkylsulfonyl groups, C1 to C4 haloalkylsulfonyl groups, an optionally substituted benzylsulfonyl group and an optionally substituted phenylsulfonyl group).
10. The herbicidal composition according to claim 7, wherein Y is a pyrazol-5-yl group and the pyrazole ring is substituted at the 4-position with the substituent group \u03b1 and at the 1-position with a hydrogen atom, a C1 to C10 alkyl group, a C1 to C10 alkyl group mono-substituted with a group selected from the substituent group \u03b2, a C1 to C4 haloalkyl group, a C3 to C8 cycloalkyl group, a C2 to C6 alkenyl group, a C2 to C6 alkynyl group, a C1 to C10 alkylsulfinyl group, a C1 to C10 alkylsulfonyl group, a C1 to C10 alkylsulfonyl group mono-substituted with a group selected from the substituent group \u03b3, a C1 to C4 haloalkylsulfonyl group, an optionally substituted phenyl group, an optionally substituted aromatic heterocyclic group, an optionally substituted phenylsulfonyl group, an optionally substituted aromatic heterocyclic sulfonyl group, an acyl group, a C1 to C4 haloalkylcarbonyl group, an optionally substituted benzylcarbonyl group, an optionally substituted benzoyl group, a C1 to C10 alkoxycarbonyl group, an optionally substituted benzyloxycarbonyl group, an optionally substituted phenoxycarbonyl group, a carbamoyl group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups and an optionally substituted phenyl group), or an amino group (its nitrogen atom may be substituted with same or different groups selected from C1 to C10 alkyl groups, an optionally substituted phenyl group, acyl groups, C1 to C4 haloalkylcarbonyl groups, an optionally substituted benzylcarbonyl group, an optionally substituted benzoyl group, C1 to C10 alkylsulfonyl groups, C1 to C4 haloalkylsulfonyl groups, an optionally substituted benzylsulfonyl group and an optionally substituted phenylsulfonyl group).
11. The herbicidal composition according to claim 7, wherein Y is an isoxazol-4-yl group and the isoxazole ring is substituted with the substituent group \u03b1 at the 3- and 5-positions.
12. The herbicidal composition according to claim 7, wherein Y is an isothiazol-4-yl group and the isothiazole ring is substituted with the substituent group \u03b1 at the 3- and 5-positions.
13. The herbicidal composition according to claim 7, wherein Y is a pyridin-3-yl group and the pyridine ring is substituted with the substituent group \u03b1 at the 2- and 4-positions.
14. The herbicidal composition according to claim 7, wherein Y is a pyrimidin-5-yl group and the pyrimidine ring is substituted with the substituent group \u03b1 at the 4- and 6-positions.
15. The herbicidal composition according to claim 1, wherein n is an integer of 2.
16. The herbicidal composition according to claim 1, wherein the compound of Group A is at least one compound selected from the group consisting of atrazine, cyanazine, simazine and prometryn.
17. The herbicidal composition according to claim 1, wherein the compound of Group A is at least one compound selected from the group consisting of glyphosate, glufosinate, linuron and flumetsulam.
18. A herbicidal composition which comprises i) the isoxazoline derivative or a salt thereof is a compound as defined in claim 9 and ii) the compound of Group A is at least one compound selected from the group consisting of atrazine, cyanazine, simazine, prometryn, glyphosate, glufosinate, linuron, flumetsulam, metribuzin, isoxaflutole, mesotrione, diflufenican, pendimethalin and flumioxazin.
19. A herbicidal composition which comprises i) the isoxazoline derivative or a salt thereof is a compound as defined in claim 9 and ii) the compound of Group A is at least one compound selected from the group consisting of atrazine, cyanazine, simazine and prometryn.
20. A herbicidal composition which comprises i) the isoxazoline derivative or a salt thereof is a compound as defined in claim 9 and ii) the compound of Group A is at least one compound selected from the group consisting of glyphosate, glufosinate, linuron and flumetsulam.
21. The herbicidal composition according to claim 1, wherein ii) at least one compound of Group A is comprised in an amount of from 0.001 to 100 parts by weight to 1 part by weight of i) an isoxazoline derivative represented by the Formula (I) or a salt thereof.
22. The herbicidal composition according to claim 1, which is used as an agrochemical product comprising i) an isoxazoline derivative of the Formula (I) or a salt thereof and ii) at least one compound of Group A in a total amount of from 0.5 to 90 wt %.