What is claimed is:
1. A method for modifying or regulating at least one of glucose or lipid metabolism disorders which comprises administering to a human or vertebrate animal subject in need of such modification or regulation a D1 dopamine agonist in conjunction with a dopamine D2 agonist wherein the conjoined administration is effective to improve at least one of the following lipid and glucose metabolic indices: body weight, body fat, plasma insulin, plasma glucose and plasma lipid, and plasma lipoprotein.
2. The method of claim 1 wherein the D2 agonist is an ergot alkaloid is selected from the group consisting of 2-bromo-alpha-ergocriptive, 6-methyl 8 beta-carbobenzyloxyaminoethyl-10-alpha-ergoline, 8-acylaminoergoline, pergolide, lisuride, 6-methyl-8-alpha-(N-acyl) amino-9-ergoline, 6-methyl-8-alpha-(N-phenyl-acetyl)amino-9-ergoline, ergocomine, 9,10-dihydroergocomine, and D-2-halo-4-alkyl-8-substituted ergolines, D-2-bromo-6-methyl-8-cyanomethylergoline.
3. The method of claim 1 wherein the D1 agonist comprises SKF38393.
4. The method of claim 2 wherein the ergot alkaloid comprises bromocriptine.
5. The method of claim 1 wherein the D2 agonist is administered at a predetermined time of day.
6. The method of claim 5 wherein the D1 agonist is administered at about the same time as the D2 agonist.
7. A method for modifying or regulating at least one of glucose or lipid metabolism disorders which comprises administering to a human or vertebrate animal subject in need of such modification or regulation a D1 agonist in conjunction with at least one member selected from the group consisting of an adrenergic 1 antagonist, an adrenergic 2 agonist and a serotonergic inhibitor wherein the amount of the combination is sufficient to effect at least one of the following lipid and glucose metabolic indices: body weight, body fat, circulating insulin, plasma or blood glucose, plasma lipid and plasma lipoprotein.
8. The method of claim 7 wherein the D1 agonist and the member of said group is administered at a predetermined time of day.
9. The method of claim 8 wherein the D1 agonist is administered at about the same time as member of said group.
10. A method for modifying or regulating at least one of glucose or lipid metabolism disorders which comprises administering to a human or vertebrate animal subject in need of said modification or regulation a D1 agonist in conjunction with at least one of a 2 agonist, a 1 antagonist and a serotonergic inhibitor, and further in conjunction with a D2 agonist sufficient to improve at least one of the following lipid and glucose metabolic indices: body weight, body fat, plasma insulin, plasma glucose and plasma lipid.
11. A therapeutic agent combination for modifying or regulating at least one of glucose and lipid metabolism disorders comprising:
a first amount of a dopamine D1 agonist; and
a second amount of at least one member selected from the group consisting of:
(i) a dopamine D2 agonist; and
(ii) at least one of an adrenergic 1 antagonist, an adrenergic 2 agonist and a serotonergic inhibitor.
12. A method for modifying or regulating at least one of glucose or lipid metabolism disorders comprising:
administering to a subject in need of said modification or regulation:
(i) a D2 agonist in a first amount; and
(ii) at least one of an adrenergic 1 antagonist, an adrenergic 2 agonist and a serotonergic inhibitor in a second amount;
said first and second amounts being sufficient to improve at least one of the following indices of glucose or lipid metabolism: body weight, body fat, plasma insulin, plasma glucose and plasma lipid.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method, comprising:
receiving information, including a user-desired destination as an end location, from a user-operated computing device;
electronically determining a current location of a user as a beginning location based on positional information received from the user-operated computing device;
based on the information, electronically generating potential routes from the beginning location to the end location;
electronically selecting one of the potential routes as a selected route;
outputting, to the user-operated computing device, (1) the electronically selected route, wherein the electronically selected route includes at least one of a mass transit portion, a motor vehicle route portion, and a pedestrian walking route portion, and (2) navigation instructions based on a then-current location of the user between the beginning location and the end location.
2. The method according to claim 1, further comprising:
dynamically regenerating the selected route based on the then-current location of the user, wherein the regenerating comprises electronically re-determining the current location based on least one of intermittent automated positioning and user input.
3. A method according to claim 2, further comprising:
receiving information, including a request for a livery vehicle, from the user-operated computing device; and
dispatching the livery vehicle to the then-current location of the user.
4. A method according to claim 1, wherein the mass transit portion includes at least one of a public and commercial bus portion, a public and commercial train portion, a public and commercial subway portion, a public and commercial air travel portion, a public and commercial ferry portion, and a public and commercial taxi portion.
5. A method according to claim 1, further comprising:
receiving, as user input, an air travel itinerary from the user-operated computing device, wherein the outputting further comprises outputting, to the user-operated computing device, navigation instructions based on the received air travel itinerary.
6. A method according to claim 5, further comprising:
receiving, as user input from the user-operated computing device, identification data corresponding to luggage belonging to the user.
7. A method according to claim 1, wherein the user-operated computing device is a network-enabled cell phone.
8. A method according to claim 1, further comprising:
accessing a network server adapted lo generate navigation and tracking data lo the user-operated computing device.
9. A method according lo claim 1, wherein the outputting of the navigation instructions includes determining a completion of a route portion based on a comparison between an elapsed time and an average historical time for the route portion.
10. A method according to claim 1, wherein the outputting of the navigation instructions includes at least one of outputting, to the user-operated computing device, a waiting location, a confirmation that the then-current location of the user is the correct waiting location, an estimated arrival time of a mass transit portion vehicle, an indication to exit the mass transit portion vehicle based on the then-current location of the user, and a fare associated with travel on the mass transit portion vehicle.
11. A method according to claim 10, wherein the outputting of the navigation instructions includes outputting, to the user-operated computing device, an image identifying the mass transit portion vehicle.
12. A navigation system, comprising:
a network server adapted to receive, as user input, a desired destination as an end location from a user-operated computing device, the user-operated computing device adapted to receive wireless positional information to calculate a current location of the user-operated device as a beginning location;
a processor operably connected to an instruction module and a memory adapted to store transit data received, by the processor, from a transit data source, wherein the instruction module is configured to calculate potential routes from the beginning location to the end location based on the stored transit data and to select one of the potential routes as a selected route, wherein the user-operated computing device is adapted to receive, as output from the network server, at least one of the selected route and real-time navigation instructions based on a then-current location of the user-operated computing device; and
a livery service utility operating on the network server and adapted to receive, as user input, a request for a livery service vehicle to the then-current location of the user-operated computing device, wherein the user-operated computing device is adapted to receive, as output from a corresponding livery service, a confirmation that the livery service will dispatch a livery service vehicle to the then-current location of the user-operated computing device.
13. A system according to claim 12, wherein the potential routes include at least one of a mass transit route portion, a motor vehicle route portion, and a pedestrian walking route portion, wherein the mass transit route portion includes at least one of a public and commercial bus route portion, a public and commercial train route portion, a public and commercial subway route portion, a public and commercial ferry route portion, a public and commercial taxi route portion, and a public and commercial air travel route portion.
14. A system according to claim 13, wherein the mass transit route portion is generated based on the transit data received from the transit data source.
15. A system according to claim 12, wherein the user-operated computing device is adapted to receive the wireless positional information from a GPS satellite.
16. A method comprising:
receiving information, including at least one of a user-desired destination as an end location and an air travel itinerary, from a user-operated computing device;
electronically determining a current location of a user as a beginning location based on positional information received from the user-operated computing device;
based on the information, electronically generating potential routes from the beginning location to the end location;
electronically selecting one of the potential routes as a selected route;
outputting, to the user-operated computing device, (1) the electronically selected route, wherein the electronically selected route includes at least one of a mass transit portion, a motor vehicle route portion, and a pedestrian walking route portion, and (2) navigation instructions based on at least one of the air travel itinerary and a then-current location of the user between the beginning location and the end location; and
dynamically regenerating the selected route based on the then-current location of the user.
17. A method according to claim 16, wherein the regenerating comprises electronically re-determining the current location based on least one of intermittent automated positioning and user input.
18. A method according to claim 16, further comprising:
receiving information, including a request for a livery vehicle, from the user-operated computing device; and
dispatching the livery vehicle to the then-current location of the user.
19. A method according to claim 16, wherein the mass transit portion includes at least one of a public and commercial bus portion, a public and commercial train portion, a public and commercial subway portions, a public and commercial air travel portion, a public and commercial ferry portion, and a public and commercial taxi portion.
20. A method according to claim 16, wherein the user-desired destination is received as one of a street address, a street intersection, a latitudelongitude location, and a point of interest.