What is claimed is:
1. A method for inhibiting HIV infection in a patient in need thereof comprising the administration of at least one antagonist specific for the neurokinin receptor family in an effective amount to said patient.
2. The method of claim 1, wherein said at least one antagonist has specific binding affinity for the NK1 receptor.
3. The method of claim 2, wherein said antagonist is Cp-96,345.
4. The method of claim 1, wherein said antagonist is a combined antagonist and has binding affinity for the NK1, NK2 and NK3 receptors.
5. The method of claim 4, wherein said antagonist is R-113281.
6. The method of claim 1, wherein said at least one antagonist comprises both CP-96,345 and R-113281.
7. The method of claim 1, wherein said antagonist is administered to said patient via a route selected from the group consisting of intravenous administration, topical administration, parenteral administration and oral administration.
8. The method of claim 1, wherein said at least one antagonist is administered in combination with at least one additional anti-retroviral agents.
9. The method of claim 1, wherein said at least one NK receptor antagonist is administered with an AIDS vaccine.
10. A method for inhibiting HIV infection of a monocyte derived macrophage, comprising contacting said macrophage with at least one NK receptor antagonist.
11. The method of claim 10, wherein said at least one antagonist has specific binding affinity for the NK1 receptor.
12. The method of claim 11, wherein said antagonist is CP-96,345.
13. The method of claim 10, wherein said antagonist is a combined antagonist and has binding affinity for the NK1, NK2 and NK3 receptors.
14. The method of claim 13, wherein said antagonist is R-113281.
15. The method of claim 10, wherein said at least one antagonist comprises both CP-96,345 and R-113281.
16. The method of claim 10, wherein said at least one antagonist is administered in combination with at least one other anti-retroviral agent.
17. The method of claim 10, wherein said at least one NK receptor antagonist is administered with an AIDS vaccine.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A latch assembly which is suitable for use with doors, windows and other movable members adapted for movement between one or more positions, the assembly including a latch bolt movable in a direction of travel between an extended position and a retracted position and a bolt actuating mechanism operable to cause the movement of the latch bolt, the bolt actuating mechanism including drive means and a control member which operatively interconnects the latch bolt and the drive means, the control member including a latch bolt mounting region which enables the latch bolt to be operatively connected to the control member in selected one of a plurality of mounting positions arranged laterally with respect to the direction of travel of the latch bolt.
2. A latch assembly according to claim 1 wherein the control member includes an elongated bar with the mounting positions disposed therealong, the mounting region being in the form of one or more slots in the elongated bar.
3. A latch assembly according to claim 1 or claim 2 wherein the latch bolt includes means for releasably connecting the bolt to a selected one of the mounting positions, said means including one or more notches which in a first position enables the bolt end to be inserted into the aperture or slot and then rotate it to a position wherein removal from the mounting position is inhibited.
4. A latch assembly according to any preceding claim 1 wherein including spring means for urging the control member and latch bolt into the extended position.
5. A latch assembly according to any preceding claim 1 wherein the drive means includes a housing for a rotatable member which is operatively connected to the latch bolt so that rotation of the rotatable member causes the control bar to move so as to cause the latch bolt to move between the extending and retracted positions, a handle operatively connected to the rotatable member, the handle being manually operable.
6. A latch assembly according to any preceding claim 1 further including guide means for assisting in guiding the movement of the control member.
7. A latch assembly according to claim 1 wherein the control member includes an elongated bar with a slot therein, the latch bolt including one or more locating pins, the latch bolt being mounted so that it can slide relative to the bar but is held captive in the direction of the longitudinal axis of the latch bolt, a latch bolt guide which limits movement of the latch bolt in the direction of its longitudinal axis, the latch bolt guide being in the form of a bar having a series of guide holes therein and arranged so that the end of the latch bolt can be received within a selected one of the guide holes so that the bolt can move relative thereto in the direction of the longitudinal axis of the bolt.