1460918269-9e97ebfe-f42e-410a-b709-8076d0454cac

1. An optical filter system which filters out at least a part of one of two spectral side-bands of a coded optical signal spectrum having a carrier wavelength, the system comprising:
a first filter which transmits a first one of said side-bands which is a transmitted side-band; and
a second filter which filters out a second one of said side-bands which is a vestigial side-band,
wherein the first and second filters generate a transmission response in intensity having a maximum value at a central filter wavelength distinct from said carrier wavelength and located in said transmitted side-band, wherein the transmission response further comprises:
a first filter part associated with a wavelength region including said carrier wavelength; and
a second filter part associated with a wavelength region which does not include said carrier wavelength,
wherein at a given value of transmission response distinct from said maximum value, said second filter part has a filter width smaller than the filter width of said first filter part.
2. The optical filter system in accordance with claim 1 wherein said transmitted side-band is the highest wavelength side-band of said optical signal spectrum.
3. The optical filter system in accordance with claim 1 wherein said transmitted side-band is the lowest wavelength side-band of said optical signal spectrum.
4. The optical filter system in accordance with claim 1 wherein said filter width of said second filter part is equal to 0.43 of said filter width of said first filter part.
5. The optical filter system in accordance with claim 1 wherein a shift between said carrier wavelength and said central filter wavelength is proportional to said filter width of said first filter part.
6. The optical filter system in accordance with claim 1 wherein said transmission response has a Full Width Half Maximum (FWHM) lower than the optical signal spectrum FWHM.
7. A transmission system in which at least two coded optical signals are multiplexed and transmitted, the system comprising:
an emitter from which a first one of said coded signals comprising a first spectrum having a first carrier wavelength and two side-bands, and a second one of said coded signals comprising a second spectrum having a second carrier wavelength higher than said first carrier wavelength and two side-bands are transmitted;
at least two optical filters outputting filtered optical signals, wherein a first one of said filters filters out one of said first spectrum side-bands, and a second one of said filters filters out one of said second spectrum side-bands;
a receiver which receives the output filtered signals from the at least two optical filters;
wherein each of the at least two optical filters comprises:
a first filter which transmits a first one of said side-bands which is a transmitted side-band; and
a second filter which filters out a second one of said side-bands which is a vestigial side-band,
wherein the first and second filters generate a transmission response in intensity having a maximum value at a central filter wavelength which is distinct from a carrier wavelength of a corresponding coded optical signal and located in said transmitted side-band,
wherein the transmission response comprises:
a first filter part associated with a wavelength region including the carrier wavelength of the corresponding coded optical signal; and
a second filter part associated with a wavelength region which does not include the carrier wavelength of the corresponding coded optical signal,
wherein at a given value of transmission response distinct from said maximum value, said second filter part has a filter width smaller than the filter width of said first filter part.
8. The transmission system in accordance with claim 7, wherein said first and second spectra partially overlap each other, and wherein a lowest wavelength side-band of said first spectrum and a highest wavelength side-band of said second spectrum are transmitted side-bands.
9. The transmission system in accordance with claim 7, wherein said optical filters are located close to said receiver.
10. The transmission system in accordance with claim 7, wherein said first or said second optical filter has a tunable central filter wavelength.
11. The transmission system in accordance with claim 10, wherein said first or said second optical filter has filter widths which are tunable, and said first optical filter and said second optical filter are implemented in a single optical filter.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound of formula (I):
or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein:
b is a single bond;
X is \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, or \u2014S(\u2550O)2\u2014;
R1 is selected from
H,
C(\u2550O)R2,
C(\u2550O)OR2,
C1-8 alkyl,
C2-8 alkenyl,
C2-8 alkynyl,
C3-7 cycloalkyl,
C1-6 alkyl substituted with 0-2 R2,
C2-6 alkenyl substituted with 0-2 R2,
aryl substituted with 0-2 R2, and
5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R2;

R2, at each occurrence, is independently selected from
F, Cl, CH2F, CHF2, CF3,
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloakyl,
phenyl substituted with 0-5 R42;
C3-10 carbocyclic group substituted with 0-3 R41, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R42;

R5 is H, methyl, ethyl, propyl, or butyl;
R6a is selected from H;
H, \u2014OH, \u2014NR46R47, \u2014CF3,
C1-4 alkyl, C1-4 alkoxy, C3-4 haloalkyl, and
aryl substituted with O-3 R44;

R6b is H;
R7 and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-4 haloalkyl, C1-8 alkoxy, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 0-2 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O) NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14) NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R8 is selected from
\u2014OH, \u2014CN, \u2014NO2,
C2-8 alkenyl, C2-8 alkynyl, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 1-2 R33,
C2-4 alkenyl substituted with 0-2 R13,
C2-4 alkynyl substituted with 0-1 R11,
C3-10 carbocyclic group substituted wit 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O) NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14) NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
\u2014CN, \u2014NO2,
C2-8 alkenyl, C2-8 alkynyl, C1-8 alkoxy, C3-10 cycloalkyl,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O) NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14) NR12R13, S(O)R12, S(O)NR12R13, SO(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R12, at each occurrence, is independently selected from C1-4 alkyl substituted with 0-1 R12a,
C2-4 alkenyl substituted with 0-1 R12a,
C2-4 alkynyl substituted with 0-1 R12a,
C3-6 cycloalkyl substituted with 0-3 R33,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R12a, at each occurrence, is independently selected from phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R14, at each occurrence, is independently selected from H and C1-4 alkyl;
R15, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;
R16, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl,

C1-3 haloalkyl-oxy-, and C1-3 alkyloxy;
R32, at each occurrence, is independently selected from H, OH, halo, CF3, SO2R45, NR46R47, and C1-4 alkyl;
R33, at each occurrence, is independently selected from H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-6 alkyl, C2-4 alkenyl, C2-6 alkynyl,
C2-6 cycloalkyl, C1-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy,
C1-4 alkylthio-, C1-4 alkyl-C(\u2550)\u2014, C1-4 alkyl-C(\u2550O)NH\u2014, C1-4 alkyl-OC(\u2550)\u2014,
C1-4 alkyl-C(\u2550O)O\u2014, C3-6 cycloalkyl-oxy-, C3-6 cycloalkylmethyl-oxy-;
C1-4 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and
C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;
R41, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, NR46R47 , NO2, CN; C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl C1-4 alkyl substituted with 0-1 R43;
aryl substituted with 0-3 R42, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R42, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2,
C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl,
C1-4 alkyl substituted with 0-1 R43;
aryl substituted with 0-3 R44, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R43 is C2-6 cycloalkyl or aryl substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, C1-4 alkyl, and C1-4 alkoxy;
R45 is C1-4 alkyl;
R46, at each occurrence, is independently selected from H and C1-4 alkyl;
R47, at each occurrence, is independently selected from H and C1-4 alkyl;
k is 1 or 2;
m is 0, 1, or 2; and
n is 1, 2, or 3;
provided when m is 0 or 1 then k is 1 or 2;
provided when m is 2 then k is 1.
2. A compound of claim 1 wherein:
X is \u2014O\u2014 or \u2014S\u2014;
R1 is selected from H,
C(\u2550O)R2,
C(\u2550O)OR2,
C1-6 alkyl,
C2-6 alkenyl,
C2-6 alkynyl,
C3-6 cycloalkyl,
C1-4 alkyl substituted with 0-2 R2,
C2-4 alkenyl substituted with 0-2 R2, and
C2-4 alkynyl substituted with 0-2 R2;

R2, at each occurrence, is independently selected from
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloakyl,
phenyl substituted with 0-5 R42;
C3-10 carbocyclic group substituted with 0-3 R41, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R5 is H, methyl, ethyl, propyl, or butyl;
R6a is selected independently from
H, \u2014OH, \u2014NR46R47, \u2014CF3, C1-3 alkyl, and C1-3 alkoxy;

R6b is H;
R7 and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 0-2 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O) NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14) NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12;

R8 is selected from
\u2014OH, \u2014CN, \u2014NO2,
C2-6 alkenyl, C2-6 alkynyl, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 1-2 R11,
C2-4 alkenyl substituted with 0-2 R11,
C2-4 alkynyl substituted with 0-1 R11,
C3-10 carbocyclic group substituted wit 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O) NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14) NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
\u2014CN, \u2014NO2,
C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-10 cycloalkyl,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O) NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14) NR12R13, S(O)R12, S(O)2R12, SO(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, and NR14S(O)2R12;

R12, at each occurrence, is independently selected from
C1-4 alkyl substituted with 0-1 R12a,
C1-4 alkenyl substituted with 0-1 R12a,
C2-4 alkynyl substituted with 0-1 R12a,
C3-6 cycloalkyl substituted with 0-3 R33,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R13, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;
alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R14)\u2014;
alternatively, R12 and R13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-3 R16;
R14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R15, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;
R16, at each occurrence, is independently selected from
H, OH, F, Cl, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;
R31, at each occurrence, is independently selected from H, OH, halo, CF3, SO2R45, NR46R47, and C1-4 alkyl;
R33, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,
C3-6 cycloalkyl, C1-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy-,

C1-4 alkylthio-, C1-4 alkyl-C(\u2550)\u2014, C1-4 alkyl-C(\u2550O)NH\u2014, C1-4 alkyl-OC(\u2550)\u2014, C1-4 alkyl-C(\u2550O)O\u2014, C3-6 cycloalkyl-oxy-, C3-6 cycloalkylmethyl-oxy-;
C1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and
C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;
R41, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47 , NO2, CN,
C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R42, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R2, at each occurrence, is independently selected from
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloakyl,
phenyl substituted with 0-5 R42;
C3-6 carbocyclic group substituted with 0-3 R41, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R5 is H, methyl, ethyl, propyl, or butyl;
R6a is H, methyl, ethyl, methoxy, \u2014OH, or \u2014CF3;
R6b is H;
R7 and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 0-2 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R8 is selected from
\u2014OH, \u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 1-2 R11,
C2-4 alkenyl substituted with 0-2 R11,
C2-4 alkynyl substituted with 0-1 R11,
C3-10 carbocyclic group substituted wit 0-3 R33,
aryl substituted with 0-5 R33,
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
\u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33, and
5-6 membered heterocyclic ring system containing 1, 2, or 3, heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R12, at each occurrence, is independently selected from
C1-4 alkyl substituted with 0-1 R12a,
C2-4 alkenyl substituted with 0-1 R12a,
C2-4 alkynyl substituted with 0-1 R12a,
C3-6 cycloalkyl substituted with 0-3 R33,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R13, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;
alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R14)\u2014;
alternatively, R12 and R13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of one N, two N, three N, one N one O, and one N one S; wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-2 R16;
R14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R15, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;
R31, at each occurrence, is independently selected from H, OH, halo, CF3, methyl, ethyl, and propyl;
R33, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,
C3-6 cycloalkyl, C1-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy-, C1-4 alkylthio-, C1-4 alkyl-C(\u2550)\u2014,
C1-4 alkyl-C(\u2550O)NH\u2014, C1-4 alkyl-OC(\u2550)\u2014,
C1-4 alkyl-C(\u2550O)O\u2014, C3-6 cycloalkyl-oxy-,
C3-6 cycloalkylmethyl-oxy-;
C1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and
C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;

R41, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47 , NO2, CN,
C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 alkyl;

R42, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2,
C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 haloalkyl, C3-6 cycloalkyl, and C1-3 alkyl;

R43 is cycloalkyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;
R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;
k is 1;
m is 1; and
n is 1 or 2.
4. A compound of claim 1 wherein:
X is \u2014S\u2014;
R1 is selected from
H,
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-4 cycloalkyl,
C1-3 alkyl substituted with 0-1 R2,
C2-3 alkenyl substituted with 0-1 R2, and
C2-3 alkynyl substituted with 0-1 R2;

R2, at each occurrence, is independently selected from C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloalkyl,
phenyl substituted with 0-5 R42;
C3-6 carbocyclic group substituted with 0-3 R41, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R5 is H, methyl, ethyl, propyl, or butyl;
R6a is H, methyl, ethyl, methoxy, \u2014OH, or \u2014CF3;
R6b is H;
R7 and R9, at each occurrence, are independently selected from
H, F, Cl, \u2014CH3, \u2014OCH3, \u2014CF3, \u2014OCF3, \u2014CN, and \u2014NO2,

R8 is selected from
\u2014OH, \u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 1-2 R11,
C2-4 alkenyl substituted with 0-2 R11,
C2-4 alkynyl substituted with 0-1 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-6 membered heterocyclic ring system comprising 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
\u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, (C1-4 haloalkyl) oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O , and S substituted with 0-3 R31;

R31, at each occurrence, is independently selected from
H, OH, halo, CF3, methyl, ethyl, and propyl;

R33, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,
C3-6 cycloalkyl, C1-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy;
C1-4 alkylthio-, C1-4 alkyl-C(\u2550O)\u2014, C1-4 alkyl-C(\u2550O)NH\u2014, C1-4 alkyl-OC(\u2550O)\u2014,
C1-4 alkyl-C(\u2550O)O\u2014, C3-6 cycloalkyl-oxy-, C3-6 cycloalkylmethyl-oxy-;
C1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and
C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;

R41, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN,
C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 alkyl;

R42, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 haloalkyl, C3-6 cycloalkyl, and C1-3 alkyl;

R43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;
R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;
k is 1;
m is 1; and
n is 1 or 2.
5. A compound of claim 1 wherein:
X is \u2014S\u2014;
R1 is selected from H,
C1-5 alkyl substituted with 0-1 R2,
C2-5 alkenyl substituted with 0-1 R2, and
C2-3 alkynyl substituted with 0-1 R2;

R2 is C3-6 cycloalkyl;
R5 is H, methyl, ethyl, or propyl;
R6a is H, methyl, or ethyl;
R6b is H;
R7 and R9, at each occurrence, are independently selected from
H, F, Cl, \u2014CH3, \u2014OCH3, \u2014CF3, \u2014OCF3, \u2014CN, and \u2014NO2,

R8 is selected from
methyl substituted with R11;
ethenyl substituted with R11;
OR12, SR12, NR12R13, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
phenyl-substituted with 0-5 fluoro;
2-(H3CCH2C(\u2550O))-phenyl substituted with R33;
2-(H3CC(\u2550O))-phenyl-substituted with R33;
2-(HC(\u2550O))-phenyl-substituted with R32;
2-(H3CCH(OH))-phenyl-substituted with R32;
2-(H3CCH2CH(OH))-phenyl-substituted with R33;
2-(HOCH2)-phenyl-substituted with R33;
2-(HOCH2CH2)-phenyl-substituted with R33;
2-(H3COCH2)-phenyl-substituted with R33;
2-(H3COCH2CH2)-phenyl-substituted with R33;
2-(H3CCH(OMe))-phenyl-substituted with R33;
2-(H3COC(\u2550O))-phenyl-substituted with R33;
2-(HOCH-CH\u2550CH)-phenyl-substituted with R33;
2-((MeOC\u2550O)CH\u2550CH)-phenyl-substituted with R33;
2-(methyl)-phenyl-substituted with R33;
2-(ethyl)-phenyl-substituted with R33;
2-(i-propyl)-phenyl-substituted with R33;
2-(F3C)-phenyl-substituted with R33;
2-(NC)-phenyl-substituted with R33;
2-(H3CO)-phenyl-substituted with R33;
2-(fluoro)-phenyl-substituted with R33;
2-(chloro)-phenyl-substituted with R33;
3-(NC)-phenyl-substituted with R33;
3-(H3CO)-phenyl-substituted with R33;
3-(fluoro)-phenyl-substituted with R33;
3-(chloro)-phenyl-substituted with R33;
4-(NC)-phenyl-substituted with R33;
4-(fluoro)-phenyl-substituted with R33;
4-(chloro)-phenyl-substituted with R32;
4-(H3CS)-phenyl-substituted with R33;
4-(H3CO)-phenyl-substituted with R33;
4-(ethoxy)-phenyl-substituted with R33;
4-(i-propoxy)-phenyl-substituted with R33;
4-(i-butoxy)-phenyl-substituted with R33;
4-(H3CCH2CH2C(\u2550O))-phenyl-substituted with R33;
4-((H3)2CHC(\u2550O))-phenyl-substituted with R33;
4-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
4-(H3CC(\u2550O)-phenyl-substituted with R33;
4-(H3CCH2CH2CH(OH))-phenyl-substituted with R33;
4-((H3C)2CHCH(OH)-phenyl-substituted with R32;
4-(H3CCH2CH(OH))-phenyl-substituted with R33;
4-(H3CCH(OH))-phenyl-substituted with R33;
4-(cyclopropyloxy)-phenyl-substituted with R33;
4-(cyclobutyloxy)-phenyl-substituted with R33; and
4-(cyclopentyloxy)-phenyl-substituted with R33;

R12 is selected from
phenyl-substituted with 0-5 fluoro;
2-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
2-(H3CC(\u2550O))-phenyl-substituted with R33;
2-(HC(\u2550O))-phenyl-substituted with R33;
2-(H3CCH(OH))-phenyl substituted with R33;
2-(H3CCH2CH(OH))-phenyl-substituted with R33;
2-(HOCH2)-phenyl-substituted with R33;
2-(HOCH2CH2)-phenyl-substituted with R33;
2-(H3COCH2)-phenyl-substituted with R33;
2-(H3COCH2CH2)-phenyl-substituted with R33;
2-(H3CCH(OMe))-phenyl-substituted with R33;
2-(H3COC(\u2550O))-phenyl-substituted with R33;
2-(HOCH2CH\u2550CH)-phenyl-substituted with R33;
2-((MeOC\u2550O)CH\u2550CH)-phenyl-substituted with R33;
2-(methyl)-phenyl-substituted with R33;
2-(ethyl)-phenyl-substituted with R33;
2-(i-propyl)-phenyl-substituted with R33;
2-(F3C)-phenyl-substituted with R33;
2-(NC)-phenyl-substituted with R33;
2-(H3CO)-phenyl-substituted with R33;
2-(fluoro)-phenyl-substituted with R33;
2-(chloro)-phenyl-substituted with R33;
3-(NC)-phenyl-substituted with R33;
3-(H3CO)-phenyl-substituted with R33;
3-(fluoro)-phenyl-substituted with R33;
3-(chloro)-phenyl-substituted with R33;
4-(NC)-phenyl-substituted with R33;
4-(fluoro)-phenyl-substituted with R33;
4-(chloro)-phenyl-substituted with R33;
4-(H3CS)-phenyl-substituted with R33;
4-(H3CO)-phenyl-substituted with R33;
4-(ethoxy)-phenyl-substituted with R33;
4-(i-propoxy)-phenyl-substituted with R33;
4-(i-butoxy)-phenyl-substituted with R33;
4-(H3CCH2CH2C(\u2550O))-phenyl-substituted with R33;
4-((H2C)2CHC(\u2550O) )-phenyl-substituted with R33;
4-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
4-(H3CC(\u2550))-phenyl-substituted with R33;
4-(H3CCH2CH2CH(OH))-phenyl-substituted with R33;
4-((H3C)2CHCH(OH))-phenyl-substituted with R33;
4-(H3CCH2CH(OH))-phenyl-substituted with R33;
4-(H3CCH(OH))-phenyl-substituted with R33;
4-(cyclopropyloxy)-phenyl-substituted with R33;
4-(cyclobutyloxy)-phenyl-substituted with R33; and
4-(cyclopentyloxy)-phenyl-substituted with R33;

R2, at each occurrence, is independently selected from C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloalkyl,
phenyl substituted with 0-5 R42;
C3-6 carbocyclic group substituted with 0-3 R42, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R5 is H, methyl, ethyl, propyl, or butyl;
R6a is H, methyl, ethyl, methoxy, \u2014OH, or \u2014CF3;
R6b is H;
R7 and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 0-2 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R8 is selected from
\u2014OH, \u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 1-2 R11,
C2-4 alkenyl substituted with 0-2 R11,
C2-4 alkynyl substituted with 0-1 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R15, C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
\u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, (C1-4 haloalkyl) oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R12, at each occurrence, is independently selected from
C1-4 alkyl substituted with 0-1 R12a,
C2-4 alkenyl substituted with 0-1 R12a,
C2-4 alkynyl substituted with 0-1 R12a,
C3-6 cycloalkyl substituted with 0-3 R13,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R12a, each occurrence, is independently selected from phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R13, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;
alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R14)\u2014;
alternatively, R12 and R13 when attached to N may be combined to form a 9-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of one N, two N, three N, one N one O, and one N one S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-2 R16;
R14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R15, at each occurrence, is independently selected from H, methyl, ethyl propyl, and butyl;
R16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;
R31, at each occurrence, is independently selected from H, OH, halo, CF3, methyl, ethyl, and propyl;
R33, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,
C3-6 cycloalkyl, C3-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy-,
C1-4 alkylthio-, C1-4 alkyl-C(\u2550O)\u2014, C1-4 alkyl-C(\u2550O)NH\u2014, C1-4 alkyl-OC(\u2550O)\u2014,
C1-4 alkyl-C(\u2550O)O\u2014, C3-6 cycloalkyl-oxy-, C3-6 cycloalkylmethyl-oxy-;
C1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butyoxy; and
C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;

R41, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 alkyl;
R42, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 haloalkyl, C3-6 cycloalkyl, and C1-3 al
R43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;
R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;
k is 1;
m is 1; and
n is 1 or 2.
7. A compound of claim 1 wherein
X is \u2014O\u2014;
R1 is selected from
H,
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-4 cycloalkyl,
C1-3 alkyl substituted with 0-1 R2,
C2-3 alkenyl substituted with 0-1 R2, and
C2-3 alkynyl substituted with 0-1 R2,

R8 is selected from
\u2014OH, \u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, (C1-4 haloalkyl)oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C1-4 alkyl substituted with 1-2 R11,
C2-4 alkenyl substituted with 0-2 R11,
C2-4 alkynyl substituted with 0-1 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
\u2014CN, \u2014NO2,
C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, (C1-4 haloalkyl) oxy,
C3-10 cycloalkyl substituted with 0-2 R33,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33, and
5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R12, at each occurrence, is independently selected from
C1-4 alkyl substituted with 0-1 R12a,
C2-4 alkenyl substituted with 0-1 R12a,
C2-4 alkynyl substituted with 0-1 R12a,
C3-6 cycloalkyl substituted with 0-3 R33,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R12a, each occurrence, is independently selected from phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
b 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R13, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;
alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R14)\u2014;
alternatively, R12 and R13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is benzimidazolyl, benzimidazolinyl, benztriazolyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, and dioxobenzthiazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R16;
R14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R15, at each occurrence, is independently selected from H, methyl, ethyl propyl, and butyl;
R16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;
R31, at each occurrence, is independently selected from H, OH, halo, CF3, methyl, ethyl, and propyl;
R33, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47, \u2014C(\u2550O)H,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,
C3-6 cycloalkyl, C3-4 haloalkyl, C1-4 haloalkyl-oxy-, C1-4 alkyloxy-,
C1-4 alkylthio-, C1-4 alkyl-C(\u2550O)\u2014, C1-4 alkyl-C(\u2550O)NH\u2014, C1-4 alkyl-OC(\u2550O)\u2014,
C1-4 alkyl-C(\u2550O)O\u2014, C3-6 cycloalkyl-oxy-, C3-6 cycloalkylmethyl-oxy-;
C1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butyoxy; and
C2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;

R43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;
R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;
k is 1;
m is 1; and
n is 1 or 2.
8. A compound of claim 1 wherein:
X is \u2014O\u2014;
R1 is selected from H,
C1-5 alkyl substituted with 0-1 R2,
C2-5 alkenyl substituted with 0-1 R2, and
C2-3 alkynyl substituted with 0-1 R2;

R8 is selected from
methyl substituted with R11;
ethenyl substituted with R11;
OR12, SR12, NR12R13, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
phenyl-substituted with 0-5 fluoro;
2-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
2-(H3CC(\u2550O))-phenyl-substituted with R33;
2-(HC(\u2550O))-phenyl-substituted with R33;
2-(H3CCH(OH))-phenyl-substituted with R33;
2-(H3CCH2CH(OH))-phenyl substituted with R33;
2-(HOCH2)-phenyl-substituted with R33;
2-(HOCH2)-phenyl-substituted with R33;
2-(HOCH3CH2)-phenyl-substituted with R33;
2-(H3COCH2)-phenyl-substituted with R33;
2-(H3COCH2CH2)-phenyl-substituted with R33;
2-(H3CCH(OMe))-phenyl-substituted with R33;
2-(H3COC(\u2550O))-phenyl-substituted with R33;
2-(HOCH2CH\u2550CH)-phenyl-substituted with R33;
2-((MeOC\u2550O)CH\u2550CH)-phenyl-substituted with R33;
2-(methyl)-phenyl-substituted with R33;
2-(ethyl)-phenyl-substituted with R33;
2-(i-propyl)-phenyl-substituted with R33;
2-(F3C)-phenyl-substituted with R33;
2-(NC)-phenyl-substituted with R33;
2-(H3CO)-phenyl-substituted with R33;
2-(fluoro)-phenyl-substituted with R33;
2-(chloro)-phenyl-substituted with R33;
3-(NC)-phenyl-substituted with R33;
3-(H3CO)-phenyl-substituted with R33;
3-(fluoro)-phenyl-substituted with R33;
3-(chloro)-phenyl-substituted with R33;
4-(NC)-phenyl-substituted with R33;
4-(fluoro)-phenyl-substituted with R33;
4-(chloro)-phenyl-substituted with R33;
4-(H3CS)-phenyl-substituted with R33;
4-(H3CO)-phenyl-substituted with R33;
4-(ethoxy)-phenyl-substituted with R33;
4-(i-propoxy)-phenyl-substituted with R33;
4-(i-butoxy)-phenyl-substituted with R33;
4-(H3CCH2CH2C(\u2550O))-phenyl-substituted with R33;
4-((H3C)2CHC(\u2550O))-phenyl-substituted with R33;
4-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
4-(H3CC(\u2550O)-phenyl-substituted with R33;
4-(H3CCH2CH2CH(OH))-phenyl-substituted with R33;
4-((H3C)2CHCH(OH)-phenyl-substituted with R33;
4-(H3CCH2CH(OH))-phenyl-substituted with R33;
4-(H3CCH(OH))-phenyl-substituted with R33;
4-(cyclopropyloxy)-phenyl-substituted with R33;
4-(cyclobutyloxy)-phenyl-substituted with R33; and
4-(cyclopentyloxy)-phenyl-substituted with R33;

R12 is selected from
phenyl-substituted with 0-5 fluoro;
2-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
2-(H3CC(\u2550O))-phenyl-substituted with R33;
2-(HC(\u2550O))-phenyl-substituted with R33;
2-(H3CCH(OH))-phenyl substituted with R33;
2-(H3CCH2CH(OH))-phenyl-substituted with R33;
2-(HOCH2)-phenyl-substituted with R33;
2-(HOCH2CH2)-phenyl-substituted with R33;
2-(H3COCH2)-phenyl-substituted with R33;
2-(H3COCH2CH2)-phenyl-substituted with R33;
2-(H3CCH(OMe))-phenyl-substituted with R33;
2-(H3COC(\u2550O))-phenyl-substituted with R33;
2-(HOCH2CH\u2550CH)-phenyl-substituted with R33;
2-((MeOC\u2550O)CH\u2550CH)-phenyl-substituted with R33;
2-(methyl)-phenyl-substituted with R33;
2-(ethyl)-phenyl-substituted with R33;
2-(i-propyl)-phenyl-substituted with R33;
2-(F3C)-phenyl-substituted with R33;
2-(NC)-phenyl-substituted with R33;
2-(H3CO)-phenyl-substituted with R33;
2-(fluoro)-phenyl-substituted with R33;
2-(chloro)-phenyl-substituted with R33;
3-(NC)-phenyl-substituted with R33;
3-(H3CO)-phenyl-substituted with R33;
3-(fluoro)-phenyl-substituted with R33;
3-(chloro)-phenyl-substituted with R33;
4-(NC)-phenyl-substituted with R33;
4-(fluoro)-phenyl-substituted with R33;
4-(chloro)-phenyl-substituted with R33;
4-(H3CS)-phenyl-substituted with R33;
4-(H3CO)-phenyl-substituted with R33;
4-(ethoxy)-phenyl-substituted with R33;
4-(i-propoxy)-phenyl-substituted with R33;
4-(i-butoxy)-phenyl-substituted with R33;
4-(H3CCH2CH2C(\u2550O))-phenyl-substituted with R33;
4-((H3C)2CHC(\u2550O) )-phenyl-substituted with R33;
4-(H3CCH2C(\u2550O))-phenyl-substituted with R33;
4-(H3CC(\u2550))-phenyl-substituted with R33;
4-(H3CCH2CH2CH(OH))-phenyl-substituted with R33;
4-((H3C)2CHCH(OH))-phenyl-substituted with R33;
4-(H3CCH2CH(OH))-phenyl-substituted with R33;
4-(H3CCH(OH))-phenyl-substituted with R33;
4-(cyclopropyloxy)-phenyl-substituted with R33;
4-(cyclobutyloxy)-phenyl-substituted with R33; and
4-(cyclopentyloxy)-phenyl-substituted with R33;

R13 is H, methyl, or ethyl;
alternatively, R12 and R13 join to form a 5- or 6-membered ring selected from pyrrolyl, pyrrolidinyl, imidazolyl, piperidinyl, piperizinyl, methylpiperizinyl, and morpholinyl;
alternatively, R12 and R13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing form 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, and dioxobenzthiazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R16;
R15 is H, methyl, ethyl, propyl, or butyl;
R16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;
R33, at each occurrence, is independently selected from H, F, Cl, \u2014CH3, \u2014OCH3, \u2014CF3, \u2014OCF3, \u2014CN, and \u2014NO2;
k is 1;
m is 1; and
n is 1 or 2.
9. A compound of claim 2 of Formula
wherein:
b is a single bond;
X is \u2014S\u2014 or \u2014O\u2014;
R1 is selected from
hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl,
t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 2-methylpentyl, 3-methylbutyl,
4-methylpentyl, 2-fluoroethyl, 2,2-difluoroethyl,
2,2,2-trifluoroethyl,
2-propenyl, 2-methyl-2-propenyl, trans-2-butenyl,
3-methyl-butenyl, 3-butenyl, trans-2-pentenyl,
cis-2-pentenyl, 4-pentenyl, 4-methyl-3-pentenyl,
3,3-dichloro-2-propenyl, trans-3-phenyl-2-propenyl,
cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl,

benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 2,5-dimethylbenzyl, 2,4-dimethylbenzyl, 3,5-dimethylbenzyl,
2,4,6-trimethyl-benzyl, 3-methoxy-benzyl, 3,5-dimethoxy-benzyl, pentafluorobenzyl, 2-phenylethyl, 1-phenyl-2-propyl, 4-phenylbutyl, 4-phenylbenzyl, 2-phenylbenzyl,
(2,3-dimethoxy-phenyl)C(\u2550O)\u2014, (2,5-dimethoxy-phenyl)C(\u2550O)\u2014,
(3,5-dimethoxy-phenyl)C(\u2550O)\u2014, cyclopropyl-C(\u2550O)\u2014,
isopropyl-C(\u2550O)\u2014, ethyl-CO2\u2014, propyl-CO2\u2014, t-butyl-CO2\u2014,
2,6-dimethoxy-benzyl, 2,4-dimethoxy-benzyl,
2,4,6-trimethoxy-benzyl, 2,3-dimethoxy-benzyl,
2,4,5-trimethoxy-benzyl, 2,3,4-trimethoxy-benzyl,
3,4-dimethoxy-benzyl, 3,4,5-trimethoxy-benzyl,
(4-fluoro-phenyl)ethyl,
\u2014CH\u2550CH2, \u2014CH2\u2014CH\u2550CH2, \u2014CH\u2550CH\u2014CH3, \u2014C\u2550CH, \u2014C\u2550CH\u2014CH3, and \u2014CH2C\u2550\u2014CH;

R8 is selected from
cyano, nitro, trifluoromethoxy, phenyl,
methylC(\u2550)\u2014, ethylC(\u2550)\u2014, propylC(\u2550O)\u2014, isopropylC(\u2550O)\u2014, butylC(\u2550O)\u2014, phenylC(\u2550O)\u2014,
methylCO2\u2014, ethylCO2\u2014, propylCO2\u2014, isopropylCO2\u2014, butylCO2\u2014, phenylCO2\u2014,
dimethylamino-S(\u2550O)\u2014, diethylamino-S(\u2550O)\u2014,
dipropylamino-S(\u2550O)\u2014, di-isopropylamino-S(\u2550O)\u2014, dibutylamino-S(\u2550O)\u2014, diphenylamino-S(\u2550O)\u2014,
dimethylamino-SO2\u2014, diethylamino-SO2\u2014, dipropylamino-SO2\u2014, di-isopropylamino-SO2\u2014, dibutylamino-SO2\u2014,
diphenylamino-SO2\u2014, dimethylamino-C(\u2550O)\u2014, diethylamino-C(\u2550O)\u2014,
dipropylamino-C(\u2550O)\u2014, di-isopropylamino-C(\u2550O)\u2014, dibutylamino-C(\u2550O)\u2014, diphenylamino-C(\u2550O)\u2014,
2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-cyanophenyl, 2-methylphenyl, 2-trifluoromethylphenyl,
2-methoxyphenyl, 2-trifluoromethoxyphenyl,
3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl,
3-cyanophenyl, 3-methylphenyl, 3-ethylpropyl,
3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl,
3-trifluoromethylphenyl, 3-methoxyphenyl,
3-isopropoxyphenyl, 3-trifluoromethoxyphenyl,
3-thiomethoxyphenyl,
4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl,
4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl,
4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl,
4-trifluoromethylphenyl, 4-methoxyphenyl,
4-isopropoxyphenyl, 4-trifluoromethoxyphenyl,
4-thiomethoxyphenyl,
2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl,
2,3-ditrifluoromethylphenyl-2,3-dimethoxyphenyl,
2,3-ditrifluoromethoxyphenyl,
2,4-dichlorophenyl, 2,4-difluorophenyl, 2,4-dimethylphenyl,
2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl,
2,4-ditrifluoromethoxyphenyl,
2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl,
2,5-trifluoromethylphenyl, 2,5-dimethoxyphenyl,
2,5-ditrifluoromethoxyphenyl,
2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl,
2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl,
2,6-ditrifluoromethoxyphenyl,
3,4-dichlorophenyl, 3,4-difluorophenyl, 3,4-dimethylphenyl,
3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl,
3,4-ditrifluoromethoxyphenyl,
2,4,6-trichlorohenyl, 2,4,6-trifluorophenyl,
2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl,
2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl,
2-chloro-4-CF3-phenyl, 2-fluoro-3-chloro-phenyl,
2-chloro-4-CF3-phenyl, 2-chloro-4-methoxy-phenyl,
2-methoxy-4-isopropyl-butyl, 2-CF3-4-methoxy-phenyl,
2-methyl-4-methoxy-5-fluoro-phenyl,
2-methyl-4-methoxy-phenyl, 2-chloro-4-CF3O-phenyl,
2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl,
methyl-C(\u2550O)NH\u2014, ethyl-C(\u2550O)NH\u2014, propyl-C(\u2550O)NH\u2014,
isopropyl-C(\u2550O)NH\u2014, butyl-C(\u2550O)NH\u2014, phenyl-C(\u2550O)NH\u2014,
4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl,
2-thiophenyl, 2-naphthyl;
2-Me-4-F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl,
2-Me-3-Cl-phenyl, 3-NO2-phenyl, 2-NO2-phenyl,
2-Cl-3-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,
2-Cl-6-F-phenyl, 2-Cl-4-(CHF2)O-phenyl,
2,4-diMeO-6-F-phenyl, 2-CF3-6-F-phenyl,
2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl,
2,3,4-triF-phenyl, 2,6-diF-4-Cl-phenyl,
2,3,4,6-tert-F-phenyl, 2,3,4,5,6-pentaF-phenyl,
2-CF3-4-EtO-phenyl, 2-CF3-4-iPrO-phenyl,
2-CF3-4-Cl-phenyl, 2-CF3-4-F-phenyl, 2-Cl-4-EtO-phenyl,
2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl,
2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl,
2-CHO(OMe)Me-4-MeO-phenyl, 2-C(\u2550O)Me-4-MeO-phenyl,
2-CH2(OH)-4-MeO-phenyl, 2-CH2(OMe)-4-MeO-phenyl,
2-CH(OH)Et-4-MeO-phenyl, 2-C(\u2550O)Et-4-MeO-phenyl,
(Z)-2-CH\u2550CHCO2Me-4-MeO-phenyl,
2-CH2CH2CO2Me-4-MeO-phenyl,
(Z)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl,
(E)-2-CH\u2550CHCO2Me-4-MeO-phenyl,
(E)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl,
2-CH2CH2OMe-4-MeO-phenyl,
2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl,
(2-Cl-phenyl)-CH\u2550CH\u2014, (3-Cl-phenyl)-CH\u2550CH\u2014,
(2,6-diF-phenyl)-CH\u2550CH\u2014, \u2014CH2CH\u2550CH2,
phenyl-CH\u2550CH\u2014, (2-Me-4-MeO-phenyl)-CH\u2550CH\u2014,
cyclohexyl, cyclopentyl, cyclohexylmethyl,
\u2014CH2CH2CO2Et, \u2014(CH2)3CO2Et, \u2014(CH2)4CO2Et,
benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl,
3-MeO-benzyl, 3-OH-benzyl, 2-MeO-benzyl,
2-OH-benzyl, 2-CO2Me-3-MeO-phenyl,
2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF3-4-CN-phenyl,
3-CHO-phenyl, 3-CH2(OH)-phenyl, 3-CH2(OMe)-phenyl,
3-CH2(NMe2)-phenyl, 3-CN-4-F-phenyl,
3-CONH2-4-F-phenyl, 2-CH2(NH2)-4-MeO-phenyl-,
phenyl-NH\u2014, (4-F-phenyl)-NH\u2014, (2,4-diCl-phenyl)-NH\u2014,
phenyl-C(\u2550O)NH\u2014, benzyl-NH\u2014, (2,4-Me-4-MeO-phenyl)-NH\u2014,
(2-F-4-MeO-phenyl)-NH\u2014, (2-Me-4-F-phenyl)-NH\u2014,
phenyl-S\u2014, \u2014NMe2, 1-pyrrolidinyl, and
-N(tosylate)2,

R7 and R9, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, and trifluoromethoxy;
m is 1; and
n is 1 or 2.
10. A compound of claim 9 of Formula (II)
wherein:
b is a single bond, wherein the bridge hydrogens are in a cis position;
R1 is selected from
hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl,
t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 3-methylpentyl, 3-methylbutyl,
4-methylphenyl, 2-fluoroethyl, 2,2-difluoroethyl,
2,2,2-trifluoroethyl, 2-propyl, 2-methyl-2-propenyl, trans-2-butenyl, 3-methyl-butenyl, 3-butenyl,
trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl,
4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl,
trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl,
\u2014CH\u2550CH2, \u2014CH2\u2014CH\u2550CH2, \u2014CH\u2550CH\u2014CH3, \u2014C\u2261CH, \u2014C\u2261C\u2014CH3,
\u2014CH\u2550CH2, \u2014CH2\u2014CH\u2550CH2, \u2014CH\u2550CH\u2014CH3, \u2014C\u2261\u2014CH, \u2014C\u2261\u2014C\u2014CH3, and \u2014CH2\u2014CH\u2261CH;

R7 and R9, at each occurrence, are independently selected from hydrogen, fluoro, methyl, trifluoromethyl, and methoxy;
R8 is selected from
cyano, nitro, trifluoromethoxy, phenyl,
methylC(\u2550O)\u2014, ethylC(\u2550O)\u2014, propylC(\u2550O)\u2014, isopropylC(\u2550O)\u2014, butylC(\u2550O)\u2014, phenylC(\u2550)\u2014,
methylCo2\u2014, ethylCO2\u2014, propylCO2\u2014, isopropylCO2\u2014, butylCO2\u2014, phenylCO2\u2014,
dimethylamino-S(\u2550O)\u2014, diethylamino-S(\u2550O)\u2014,
dipropylamino-S(\u2550O)\u2014, di-isopropylamino-S(\u2550O)\u2014, dibutylamino-S(\u2550O)\u2014, diphenylamino-S(\u2550O)\u2014,
dimethylamino-SO2\u2014, diethylamino-SO2\u2014, dipropylamino-SO2\u2014, di-isopropylamino-SO2\u2014, dibutylamino-SO2\u2014,

diphenylamino-SO2\u2014,
dimethylamino-C(\u2550O)\u2014, diethylamino-C(\u2550O)\u2014,
dipropylamino-C(\u2550O)\u2014, di-isopropylamino-C(\u2550O)\u2014, dibutylamino-C(\u2550O)\u2014, diphenylamino-C(\u2550O)\u2014,
2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-cyanophenyl, 2-methylphenyl, 2-trifluromethylphenyl,
2-methoxyphenyl, 2-trifluoromethoxyphenyl,
3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl,
3-cyanophenyl, 3-methylphenyl, 3-ethylphenyl,
3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl,
3-trifluoromethyl, 3-methoxyphenyl,
3-isopropoxyphenyl, 3-trifluoromethoxyphenyl,
3-thiomethoxyphenyl,
4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl,
4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl,
4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl,
4-trifluoromethylphenyl, 4-methoxyphenyl,
4-isopropoxyphenyl, 4-trifluoromethoxyphenyl,
4-thiomethoxyphenyl,
2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl,
2,3-ditrifluoromethylphenyl, 2,3-dimethoxyphenyl,
2,3-ditrifluoromethoxyphenyl,
2,4-dichlorophenyl, 2,4-difluorophenyl, 2,4-dimethylphenyl,
2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl,
2,4-ditrifluoromethoxyphenyl,
2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl,
2,5-trifluoromethylphenyl, 2,5-dimethoxyphenyl,
2,5-ditrifluoromethoxyphenyl,
2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl,
2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl,
2,6-ditrifluoromethoxyphenyl,
3,4-dichlorophenyl, 3,4-difluorophenyl, 3,4-dimethylphenyl,
3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl,
3,4-ditrifluoromethoxyphenyl,
2,4,6-trichlorohenyl, 2,4,6-trifluorophenyl,
2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl,
2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl,
2-chloro-4-CF3-phenyl, 2-fluoro-3-chloro-phenyl,
2-chloro-4-CF3-phenyl, 2-chloro-4-methoxy-phenyl,
2-methoxy-4-isopropyl-butyl, 2-CF3-4-methoxy-phenyl,
2-methyl-4-methoxy-5-fluoro-phenyl,
2-methyl-4-methoxy-phenyl, 2-chloro-4-CF3O-phenyl,
2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl,
methyl-C(\u2550O)NH\u2014, ethyl-C(\u2550O)NH\u2014, propyl-C(\u2550O)NH\u2014,
isopropyl-C(\u2550O)NH\u2014, butyl-C(\u2550O)NH\u2014, phenyl-C(\u2550O)NH\u2014;
4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl,
2-thiophenyl, 2-naphthyl;
2-Me-4-F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl,
2-Me-3-Cl-phenyl, 3-NO2-phenyl, 2-NO2-phenyl,
2-Cl-3-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,
2-Cl-6-F-phenyl, 2-Cl-4-(CHF2)O-phenyl,
2,4-diMeO-6-F-phenyl, 2-CF3-6-F-phenyl,
2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl,
2,3,4-triF-phenyl, 2,6-diF-4-Cl-phenyl,
2,3,4,6-tert-F-phenyl, 2,3,4,5,6-pentaF-phenyl,
2-CF3-4-EtO-phenyl, 2-CF3-4-iPrO-phenyl,
2-CF3-4-Cl-phenyl, 2-CF3-4-F-phenyl, 2-Cl-4-EtO-phenyl,
2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl,
2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl,
2-CHO(OMe)Me-4-MeO-phenyl, 2-C(\u2550O)Me-4-MeO-phenyl,
2-CH2(OH)-4-MeO-phenyl, 2-CH2(OMe)-4-MeO-phenyl,
2-CH(OH)Et-4-MeO-phenyl, 2-C(\u2550O)Et-4-MeO-phenyl,
(Z)-2-CH\u2550CHCO2Me-4-MeO-phenyl,
2-CH2CH2CO2Me-4-MeO-phenyl,
(Z)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl,
(E)-2-CH\u2550CHCO2Me-4-MeO-phenyl,
(E)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl,
2-CH2CH2OMe-4-MeO-phenyl,
2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl,
(2-Cl-phenyl)-CH\u2550CH\u2014, (3-Cl-phenyl)-CH\u2550CH\u2014,
(2,6-diF-phenyl)-CH\u2550CH\u2014, \u2014CH2CH\u2550CH2,
phenyl-CH\u2550CH\u2014, (2-Me-4-MeO-phenyl)-CH\u2550CH\u2014,
cyclohexyl, cyclopentyl, cyclohexylmethyl,
\u2014CH2CH2CO2Et, \u2014(CH2)3CO2Et, \u2014(CH2)4CO2Et,
benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl,
3-MeO-benzyl, 3-OH-benzyl, 2-MeO-benzyl,
2-OH-benzyl, 2-CO2Me-3-MeO-phenyl,
2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF3-4-CN-phenyl,
3-CHO-phenyl, 3-CH2(OH)-phenyl, 3-CH2(OMe)-phenyl,
3-CH2(NMe2)-phenyl, 3-CN-4-F-phenyl,
3-CONH2-4-F-phenyl, 2-CH2(NH2)-4-MeO-phenyl,
phenyl-NH\u2014, (4-F-phenyl)-NH\u2014, (2,4-diCl-phenyl)-NH\u2014,
phenyl-C(\u2550O)NH\u2014, benzyl-NH\u2014, (2,4-Me-4-MeO-phenyl)-NH\u2014,
(2-F-4-MeO-phenyl)-NH\u2014, (2-Me-4-F-phenyl)-NH\u2014,
phenyl-S\u2014, \u2014NMe2, 1-pyrrolidinyl, and
-N(tosylate)2; and

n is 1 or 2.
11. A compound of claim 9 of Formula (III)
wherein:
b is a single bond, wherein the bridge hydrogens are in a cis position;
R1 is selected from
hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl,
t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 3-methylpentyl, 3-methylbutyl,
4-methylphenyl, 2-fluoroethyl, 2,2-difluoroethyl,
2,2,2-trifluoroethyl, 2-propyl, 2-methyl-2-propenyl, trans-2-butenyl, 3-methyl-butenyl, 3-butenyl,
trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl,
4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl,
trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl,
\u2014CH\u2550CH2, \u2014CH2\u2014CH\u2550CH2, \u2014CH\u2550CH\u2014CH3, \u2014C\u2261CH, \u2014C\u2261C\u2014CH3,
and \u2014CH2\u2014CH\u2261CH;

R7 and R9, at each occurrence, are independently selected from hydrogen, fluoro, methyl, trifluoromethyl, and methoxy; and
R8 is selected from
cyano, nitro, trifluoromethoxy, phenyl,
methylC(\u2550O)\u2014, ethylC(\u2550O)\u2014, propylC(\u2550O)\u2014, isopropylC(\u2550O)\u2014, butylC(\u2550O)\u2014, phenylC(\u2550)\u2014,
methylCO2\u2014, ethylCO2\u2014, propylCO2\u2014, isopropylCO2\u2014, butylCO2\u2014, phenylCO2\u2014,

dimethylamino-S(\u2550O)\u2014, diethylamino-S(\u2550O)\u2014,
dipropylamino-S(\u2550O)\u2014, di-isopropylamino-S(\u2550O)\u2014, dibutylamino-S(\u2550O)\u2014, diphenylamino-S(\u2550O)\u2014,
dimethylamino-SO2\u2014, diethylamino-SO2\u2014,
dipropylamino-SO2\u2014, di-isopropylamino-SO2\u2014,
dibutylamino-SO2\u2014, diphenylamino-SO2\u2014,
dimethylamino-C(\u2550O)\u2014, diethylamino-C(\u2550O)\u2014,
dipropylamino-C(\u2550O)\u2014, di-isopropylamino-C(\u2550O)\u2014, dibutylamino-C(\u2550O)\u2014, diphenylamino-C(\u2550O)\u2014,
2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl,
2-cyanophenyl, 2-methylphenyl, 2- trifluoromethylphenyl,
2-methoxyphenyl, 2-trifluoromethoxyphenyl,
3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl,
3-cyanophenyl, 3-methylphenyl, 3-ethylphenyl,
3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl,
3-trifluoromethylphenyl, 3-methoxyphenyl,
3-isopropoxyphenyl, 3-trifluoromethoxyphenyl,
3-thiomethoxyphenyl,
4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl,
4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl,
4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl,
4-trifluoromethylphenyl, 4-methoxyphenyl,
4-isopropoxyphenyl, 4-trifluoromethoxyphenyl,
4-thiomethoxyphenyl,
2,3-dichlorophenyl, 2,3-difluorophenyl,
2,3-dimethylphenyl, 2,3-ditrifluoromethylphenyl,
2,3-dimethoxyphenyl, 2,3-ditrifluoromethoxyphenyl,
2,4-dichlorophenyl, 2,4-difluorophenyl,
2,4-dimethylphenyl, 2,4-ditrifluoromethylphenyl,
2,4-dimethoxyphenyl, 2,4-ditrifluoromethoxyphenyl,
2,5-dichlorophenyl, 2,5-difluorophenyl,
2,5-dimethylphenyl, 2,5-ditrifluoromethylphenyl,
2,5-dimethoxyphenyl, 2,5-ditrifluoromethoxyphenyl,
2,6-dichlorophenyl, 2,6-difluorophenyl,
2,6-dimethylphenyl, 2,6-ditrifluoromethylphenyl,
2,6-dimethoxyphenyl, 2,6-trifluoromethoxyphenyl,
3,4-dichlorophenyl, 3,4-difluorophenyl,
3,4-dimethylphenyl, 3,4-ditrifluoromethylphenyl,
3,4-dimethoxyphenyl, 3,4-ditrifluoromethoxyphenyl,
2,4,6-trichlorophenyl, 2,4,6-trifluorophenyl,
2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl,
2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl,
2-chloro-4-CF3-phenyl, 2-fluoro-3-chloro-phenyl,
2-chloro-4-CF3-phenyl, 2-chloro-4-methoxy-phenyl,
2-methoxy-4-isopropyl-phenyl, 2-CF3-4-methoxy-phenyl,
2-methyl-4-methoxy-5-fluoro-phenyl,
2-methyl-4-methoxy-phenyl, 2-chloro-4-CF3O-phenyl,
2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl,
methyl-C(\u2550O)NH\u2014, ethyl-C(\u2550O)NH\u2014, propyl-C(\u2550O)NH\u2014,
isopropyl-C(\u2550O)NH\u2014, butyl-C(\u2550O)NH\u2014, phenyl-C(\u2550O)NH\u2014,
4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl,
2-thiophenyl, 2-naphthyl;
2-Me-5F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl,
2-Me-3-Cl-phenyl, 3-NO2-phenyl, 2-NO2-phenyl,
2-Cl-3-Me-phenyl, 2-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,
2-Cl-6-F-phenyl, 2-Cl-4-(CHF2)O-phenyl,
2,4-diMeO-6-F-phenyl, 2-CF3-6-F-phenyl,
2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl,
2,3,4-triF-phenyl, 2,6-diF-5-Cl-phenyl,
2,3,4-tetraF-phenyl, 2,3,4,5,6-pentaF-phenyl,
2-CF3-4-EtO-phenyl, 2-CF3-iPrO-phenyl,
2-CF3-4-Cl-phenyl, 2-CF3-4-F-phenyl, 2-Cl-4-EtO-phenyl,
2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl,
2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl,
2-CH(OMe)Me-4-MeO-phenyl, 2C(\u2550O)Me-4-MeO-phenyl,
2-CH2(OH)-4-O-phenyl, 2-CH3(OMe)-phenyl,
2-CH(OH)Et-4-MeO-phenyl, 2-C(\u2550O)Et-4-MeO-phenyl,
(Z)-2-CH\u2550CHCO2Me-4-MeO-phenyl,
2-CH2CH2CO2Me-4-MeO-phenyl,
(Z)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl,
(E)-2-CH\u2550CHCO2Me-4-MeO-phenyl,
(E)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl,
2-CH2C2OMe-4-MeO-phenyl,
2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl,
(2-Cl-phenyl)-CH\u2550CH\u2014, (3-Cl-phenyl)-CH\u2550CH\u2014,
(2,6-diF-phenyl)-CH\u2550CH\u2014, \u2014CH2CH\u2550CH2,
phenyl-CH\u2550CH\u2014, (2-Me-4-MeO-phenyl)CH\u2550C\u2014,
cyclohexyl, cyclopentyl, cyclohexylmethyl,
13 CH2CH2CO2Et, \u2014(CH2)3CO2Et, \u2014(CH2)4CO2Et,
benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl,
3-MeO-benyzl, 3-OH-benzyl, 2-MeO-benzyl,
2-OH-benzyl, 2-CO2Me-3-MeO-phenyl,
2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF3-4-CN-phenyl,
3-CHO-phenyl, 3-CH2(OH)-phenyl, 3-CH2(OMe)-phenyl,
3-CH2(NMe2)-phenyl, 3-CN-4-F-phenyl,
3-CONH2-4-F-phenyl, 2-CH2(NH2)-4-MeO-phenyl-,
phenyl-NH\u2014, (4-F-phenyl)-NH\u2014, (2,4-diCl-phenyl)-NH\u2014,
phenyl-C(\u2550O)NH\u2014, benzyl-NH\u2014, (2-Me-4-MeO-phenyl)-NH\u2014,
(2-F-4-MeO-phenyl)-NH\u2014, (2-Me-4-F-phenyl)-NH\u2014,
phenyl-S\u2014, \u2014NM2, 1-pyrrolidinyl, and \u2014N(tosylate)2; and
n is 1 or 2.
12. A compound of formula (I):
or steroisomers or pharmaceutically acceptable salt forms thereof, wherein:
b is a single bond;
X is \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, or \u2014S(\u2550O)2\u2014,
R1 is selected from
C1-6 alkyl substituted with Z,
C2-6 alkenyl substituted with Z,
C2-6 alkynyl substituted with Z,
C3-6 cycloalkyl substituted with Z,
aryl substituted with Z,
5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z,
C1-6 alkyl substituted with 1-2 R2, but R2 cannot be alkyl;
C2-6 alkenyl substituted with 0-2 R2,
C2-6 alkynyl substituted with 0-2 R2,
aryl substituted with 0-2 R2, and
5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R2,

Z is selected from
\u2014CH(OH)2,
\u2014C(ethylenedioxy)R2,
\u2014OR2,
\u2014SR2,
\u2014NR2R3,
\u2014C(O)R2,
\u2014C(O)N2R3,
\u2014NR3C(O)R2,
\u2014C(O)OR2,
\u2014OC(O)R2,
\u2014CH(\u2550NR4)NR2R3,
\u2014NHC(\u2550NR4)NR2R3,
\u2014S(O)R2,
\u2014S(O)2R2,
\u2014S(O)2NR2R3, and \u2014NR3S(O)2R2,

R2, at each occurrence, is independently selected from
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloalkyl,
aryl substituted with 0-5 R42;
C3-10 carbocyclic group substituted with 0-3 R41, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R3, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, and
C3-4 alkoxy;
alternatively, R2 and R3 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R4)\u2014;

R4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R5 is H, methyl, ethyl, propyl, or butyl;
R6a is selected from
H, \u2014OH, \u2014NR46R47, \u2014CF3,
C1-4 alkyl, C2-4 alkenyl, C1-4 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl, and
aryl substituted with 0-3 R44;

R6b is H;
R7, R8, and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-4 haloalkyl, C1-8 alkoxy, (C1-4 haloalkyl)oxy,
C1-4 alkyl substituted with 0-2 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, C(O)OR12, OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14)NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
H, halo, \u2014CF3, \u2014CN, \u2014NO2,
C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-4 haloalkyl, C1-8 alkoxy, C3-10 cycloalkyl,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, (O)OR12,
OC(O)R12, OC(O)OR12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14)NR12R13, S(O)R12, S(O)2R12, S(O)NR12R13, S(O)2NR12R13, NR14S(O)R12, and NR14S(O)2R12,

R12, at each occurrence, is independently selected from
C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloalkyl,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31; p1 R13, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;

alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R14)\u2014;
R14, at each occurrence, is independently selected from H and C1-4 alkyl;
R31, at each occurrence, is independently selected from
H, OH, halo, CF3SO2R45, NR46R47, methyl, ethyl, and propyl;

R33, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, SO2R45, NR46R47,
C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C3-5 cycloalkyl, C1-3 haloalkyl, C1-3 haloalkyl-oxy-, C1-3 alkyloxy-, C1-3 alkylthio, C1-3 alkyl-C(\u2550O)\u2014, and C1-3 alkyl- C(\u2550O)NH\u2014;

R41, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, \u2550O,
C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R42, and
5-10 membered heterocycle ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R42, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, SR45, NR46R47, OR48, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2,
C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl,
C1-4 alkyl substituted with 0-1 R45,
aryl substituted with 0-3 R44, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R43 is C3-6 cycloalkyl or aryl substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, C1-4 alkyl, and C1-4 alkoxy;
R45 is C1-4 alkyl;
R46, at each occurrence, is independently selected from H and C1-4 alkyl;
R47, at each occurrence, is independently selected from H, C1-4 alkyl, \u2014C(\u2550O)NHC(C1-4 alkyl), \u2014SO2(C1-4 alkyl), \u2014SO2(phenyl), \u2014C(\u2550O)O(C1-4 alkyl), \u2014C(\u2550O)(C1-4 alkyl), and \u2014C(\u2550O)H;
R48, at each occurrence, is independently selected from H, C1-4 alkyl, \u2014C(\u2550O)NH(C1-4 alkyl), \u2014C(\u2550O)O(C1-4 alkyl), \u2014C(\u2550O)(C1-4alkyl), and \u2014C(\u2550O)H;
k is 1 or 2;
m is 0, 1, or 2; and
n is 1 or 2;
provided when m is 0 or 1 then k is 1 or 2;
provided when m is 2 then l is 1;
provided that when b is a single bond; n is 1 or 2; m is 1; k is 1; X is O or S; and R1 is C1-4 alkyl or cyclopropyl, then R8 is a substituent other than H.
13. A compound of claim 12 wherein:
X is \u2014O\u2014 or \u2014S\u2014;
R1 is selected from
C2-5 alkyl substituted with Z,
C2-5 alkenyl substituted with Z,
C2-5 alkynyl substituted with Z,
C3-6 cycloalkyl substituted with Z,
aryl substituted with Z,
5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z;
C1-5 alkyl substituted with 1-2 R2, but R2 cannot be alkyl;
C2-5 alkenyl substituted with 0-2 R2, and
C2-5 alkynyl substituted with 0-2 R2;

Z is selected from
\u2014CH(OH)R2,
\u2014C(ethylenedioxy)R2,
\u2014OR2,
\u2014SR2,
\u2014NR2R3,
\u2014C(O)R2,
\u2014C(O)NR2R3,
\u2014NR3C(O)R2,
\u2014C(O)OR2,
\u2014OC(O)R2,
CH(\u2550NR4)NR2R3,
\u2014NHC(\u2550NR4)NR2R3,
\u2014S(O)R2,
\u2014S(O)R2R2,
\u2014S(O)2NR2R3, and \u2014NR3S(O)2R2;

R3, at each occurrence, is independently selected from C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloalkyl,
aryl substituted with 0-5 R42;
C3-10 carbocyclic group substituted with 0-3 R43, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R3, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, and C1-4 alkoxy;
alternatively, R2 and R3 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R6)\u2014;
R4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R5 is H, methyl, or ethyl;
R6a is selected from
H, \u2014OH, \u2014NR46R47, \u2014CF3,
C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, and C3-6 cycloalkyl;

R6b is H;
R7, R8, and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014OCH3, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-6 alkoxy, (C1-4 haloalkyl)oxy,
C1-4 alkyl substituted with 0-2 R11,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;
OR12, SR12, NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, C(O)OR12OC(O)R12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14)NR12R13, S(O)R12, S(O)2R12, S(O)2NR12R13, NR14S(O)2R12, NR14S(O)R12, NR14S(O)2R12, NR12C(O)R15, NR12C(O)OR15, NR12S(O)2R15, and NR12C(O)NHR15;

R11 is selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014OCH3, \u2014CN, \u2014NO2, \u2014NR46R47,
C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-6 alkoxy, (C1-4 haloalkyl)oxy,
C3-10 carbocyclic group substituted with 0-3 R33,
aryl substituted with 0-5 R33,
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the groups consisting of N, O, and S substituted with 0-3 R31,
OR12, SR12NR12R13, C(O)H, C(O)R12, C(O)NR12R13, NR14C(O)R12, C(O)R12, OC(O)R12, CH(\u2550NR14)NR12R13, NHC(\u2550NR14)NR12R13, S(O)R12, S(O)2R12, S(O)2NR12R13, and NR14S(O)2R12;

R12, at each occurrence, is independently selected from C1-4 alkyl,
C2-4 alkenyl,
C2-4 alkynyl,
C3-6 cycloalkyl,
phenyl substituted with 0-5 R33;
C3-10 carbocyclic group substituted with 0-3 R33, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R31;

R13, at each occurrence, is independently selected from
H, C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl;

alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R14)\u2014;
R14, at each occurrence, is independently selected from H and C1-4 alkyl;
R33, at each occurrence, is independently selected from H, OH, halo, CF3, methyl, and ethyl;
R13, at each occurrence, is independently selected from
H, OH, halo, CN, NO2, CF3, methyl, and ethyl;

R41, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO22R45, NR46R47, NO2, CN, \u2550O,
C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl,
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R42, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R42, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, SR45, NR46R47, OR48, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2,
C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl,
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R44, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R48, at each occurrence, is independently selected from H,
C1-4 alkyl, \u2014C(\u2550O)NH(C1-4 alkyl),
\u2014C(\u2550O)O(C1-4 alkyl),
\u2014C(\u2550O)(C1-4 alkyl), and \u2014C(\u2550O)H;
k is 1 or 2;

m is 0, 1, 2; and
n is 1 or 2.
14. A compound of claim 12 wherein:
X \u2014O\u2014;
R1 is selected from
C2-4 alkyl substituted with Z,
C2-4 alkenyl substituted with Z,
C2-4 alkynyl substituted with Z,
C3-6 cycloalkyl substituted with Z,
aryl substituted with Z,
5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z;

C2-4 alkyl substituted with 1-2 R2, but R2 is other than alkyl; and
C2-4 alkenyl substituted with 0-2 R2;

Z is selected from
\u2014CH(OH)R2, \u2014C(ethylenedioxy)R2,
\u2014OR2,
\u2014SR2,
\u2014NR2R3,
\u2014C(O)R2,
\u2014C(O)NR2R3,
\u2014NR3C(O)R2, \u2014\u2014C(O)OR2,
\u2014S(O)R2,
\u2014S(O)2R2,
\u2014S(O)2NR2R3, and \u2014NR3S(O)2R2;

R2, at each occurrence, is independently selected from phenyl substituted with 0-5 R42;
C3-10 carbocyclic group substituted with 0-3 R41, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R41;

R3, at each occurrence, is independently selected from
H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, and
C1-4 alkoxy;

alternatively, R2 and R3 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or \u2014N(R4)\u2014;
R4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl,
R5 is H;
R6a is selected from H, \u2014OH, \u2014CF3, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;
R6b is H;
R7, R8, and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014OCH3, \u2014CN, \u2014NO2,
C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, (C1-3 haloalkyl) oxy, and
C1-4 alkyl substituted with 0-2 R11;

R11 is selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014OCH3, \u2014CN, \u2014NO2,
C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and (C1-3 haloalkyl)oxy;

R33, at each occurrence, is independently selected from H, OH, halo, CF3, and methyl;
R41, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, \u2550O,
C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl,
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R42, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R42, at each occurrence, is independently selected from
H, CF3, halo, OH, CO2H, SO2R45, SR45, NR46R47, OR48, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2,
C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl,
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R44, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;
R43 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, \u2014C(\u2550O)NH(methyl), \u2014C(\u2550O)NH(ethyl), \u2014SO2(methyl), \u2014SO2(ethyl), \u2014SO2(phenyl), \u2014C(\u2550O)O(methyl), \u2014C(\u2550O)O(ethyl), \u2014C(\u2550O)(methyl),
\u2014C(\u2550O)(ethyl), and \u2014C(\u2550O)H;

R48, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, \u2014C(\u2550O)NH(methyl), \u2014C(\u2550O)NH(ethyl), \u2014C(\u2550O)O(methyl), \u2014C(\u2550O)O(ethyl), \u2014C(\u2550O)(methyl), \u2014C(\u2550O)(ethyl), and \u2014C(\u2550O)H;
k is 1;
m is 0, 1, or 2; and
n is 1 or 2.
15. A compound of claim 12 wherein:
X is \u2014O\u2014;
R1 is selected from
ethyl substituted with Z,
propyl substituted with Z,
butyl substituted with Z,
propenyl substituted with Z,
butenyl substituted with Z,
ethyl substituted with R2,
propyl substituted with R2,
butyl substituted with R2,
propenyl substituted with R2, and
butenyl substituted with R2; provided that with respect to ethyl, propyl and butyl, R2 is other than alkyl;
Z is selected from
\u2014CH(OH)R2,
\u2014OR2,
\u2014SR2,
\u2014NR2R3,
\u2014C(O)R2,
\u2014C(O)NR2R3,
\u2014NR3C(O)R2,
C(O)OR2,
\u2014S(O)R2,
\u2014S(O)2R2,
\u2014S(O)2NR2R3, and \u2014NR3S(O)2R2;

R2, at each occurrence, is independently selected from phenyl substituted with 0-3 R42;
naphthyl substituted with 0-3 R42;
cyclopropyl substituted with 0-3 R41;
cyclobutyl substituted with 0-3 R41;
cyclopentyl substituted with 0-3 R41;
cyclohexyl substituted with 0-3 R41;
pyridyl substituted with 0-3 R41;
indolyl substituted with 0-3 R41;
indolinyl substituted with 0-3 R41;
benzimidazolyl substituted with 0-3 R41;
benzotriazolyl substituted with 0-3 R41;
benzothienyl substituted with 0-3 R41;
benzofuranyl substituted with 0-3 R41;
phthalimid-1-yl substituted with 0-3 R41;
inden-2-yl substituted with 0-3 R41;

2,3-dihydro-1H-inden-2-yl substituted 0-3 R41;
indazolyl substituted with 0-3 R41;
tetrahydroquinolinyl substituted with 0-3 R41; and
tetrahydro-isoquinolinyl substituted with 0-3 R41;

R3, at each occurrence, is independently selected from H, methyl, and ethyl;
R3 is H;
R6a is selected from H, \u2014OH, methyl, and methoxy;
R6b is H;
R7, R8, and R9, at each occurrence, are independently selected from H, F, Cl, methyl, ethyl,
methoxy, \u2014CF3,
and \u2014OCF3;

R41, at each occurrence, is independently selected from H, F, Cl, Br, OH, CF3, NO2, CN, \u2550O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;
R42, at each occurrence, is independently selected from
H, F, Cl, Br, OH, CF3, SO2R45, SR45, NR46R47, OR48, NO2, CN, \u2550O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;

R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from
H, methyl, ethyl, n-propyl, i-propyl, n-butyl,
i-butyl, \u2014C(\u2550O)NH(methyl), \u2014C(\u2550O)NH(ethyl),
\u2014SO2(methyl), \u2014SO2(ethyl), \u2014SO2(phenyl),
\u2014C(\u2550O)O(methyl), \u2014C(\u2550O)O(ethyl), \u2014C(\u2550O)(methyl),
\u2014C(\u2550O)(ethyl), and \u2014C(\u2550O)H;

k is 1;
m is 0, 1, or 2; and
n is 1 or 2.
16. A compound of claim 12 wherein:
X is \u2014S\u2014;
R1 is selected from
C2-4 alkyl substituted with Z,
C2-4 alkenyl substituted with Z,
C2-4 alkynyl substituted with Z,
C3-6 cycloalkyl substituted with Z,
aryl substituted with Z,
5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z;
C2-4 alkyl substituted with 1-2 R2, where R2 is other than alkyl; and
C2-4 alkenyl substituted with 0-2 R2;

Z is selected from
\u2014CH(OH)R2,
\u2014C(ethylenedioxy)R2,
\u2014OR2,
\u2014SR2,
\u2014NR2R3,
\u2014C(O)R2,
\u2014S(O)R2,
\u2014S(O)R2,
\u2014S(O)2NR2R3, and \u2014NR3S(O)2R2;

R3, at each occurrence, is independently selected from
H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, and
C1-4 alkoxy;

alternatively, R2 and R3 join to form a 5- or 6-membered ring optionally substituted with \u2014O\u2014 or N(R4)\u2014;
R4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R5 is H;
R6a is selected from H, \u2014OH, \u2014CF3, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;
R6b is H;
R7, R8, and R9, at each occurrence, are independently selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014OCH3, \u2014CN, \u2014NO2,
C1-4 alkyl, C3-4 haloalkyl, C1-4 alkoxy, (C1-3 haloalkyl) oxy, and
C1-4 alkyl substituted with 0-2 R11;

R11 is selected from
H, halo, \u2014CF3, \u2014OCF3, \u2014OH, \u2014OCH3, \u2014CN: \u2014NO2,
C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and (C1-3 haloalkyl)oxy;

R33, at each occurrence, is independently selected from H, OH, halo, CF3, and methyl;
R42, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, NR46R47, NO2, CN, \u2550O,
C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, C1-4 haloalkyl,
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R42, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R42, at each occurrence, is independently selected from H, CF3, halo, OH, CO2H, SO2R45, SR45, NR46R47, OR48, NO2, CN, CH(\u2550NH)NH2, NHC(\u2550NH)NH2,
C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl,
C1-4 alkyl substituted with 0-1 R43,
aryl substituted with 0-3 R44, and
5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R44;

R43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R44;
R44, at each occurrence, is independently selected from H, halo, \u2014OH, NR46R47, CO2H, SO2R45, \u2014CF3, \u2014OCF3, \u2014CN, \u2014NO2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;
R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl,
R47, at each occurrence, is independently selected from
H, methyl, ethyl, n-propyl, i-propyl, n-butyl,
i-butyl, \u2014C(\u2550O)NH(methyl), \u2014C(\u2550O)NH(ethyl),
\u2014SO2(methyl), \u2014SO2(ethyl), \u2014SO2(phenyl),
\u2014C(\u2550O)O(methyl), \u2014C(\u2550O)O(ethyl), \u2014C(\u2550O)(methyl),

\u2014C(\u2550O)(ethyl), and \u2014C(\u2550O)H;
R49, at each occurrence, is independently selected from
H, methyl, ethyl, n-propyl, \u2014C(\u2550O)NH(methyl),
\u2014C(\u2550O)NH(ethyl), \u2014C(\u2550O)O(methyl),\u2014
C(\u2550O)O(ethyl), \u2014C(\u2550O)O(methyl),
\u2014C(\u2550O)(ethyl), and \u2014C(\u2550)H;

k is 1;
m is 0, 1 or 2; and
n is 1 or 2.
17. A compound of claim 12 wherein:
X is \u2014O\u2014;
R1 is selected from
ethyl substituted with Z;
propyl substituted with Z;
butyl substituted with Z;
propenyl substituted with Z;
butenyl substituted with Z;
ethyl substituted with R2;
propyl substituted with R2;
butyl substituted with R2; provided that with respect to ethyl, propyl and butyl, R2 is other than alkyl;
propenyl substituted with R2; and
butenyl substituted with R2;

Z is selected from
\u2014CH(OH)R2,
\u2014OR2,
\u2014SR2,
\u2014NR2R3,
\u2014C(O)R2,
\u2014(O)NR2R3,
\u2014NR3C(O)R2,
\u2014C(O)OR2,
\u2014S(O)R2,
\u2014S(O)2R2,
\u2014S(O)2NR2R3, and \u2014NR3S(O)2R2;

R2, at each occurrence, is independently selected from
phenyl substituted with 0-3 R42,
naphthyl substituted with 0-3 R42;
cyclopropyl substituted with 0-3 R41;
cyclobutyl substituted with 0-3 R41;
cyclopentyl substituted with 0-3 R41;
cyclohexyl substituted with 0-3 R41;
pyridyl substituted with 0-3 R41;
indolyl substituted with 0-3 R41;
indolinyl substituted with 0-3 R41;
benzimidazolyl substituted with 0-3 R41;
benzotriazolyl substituted with 0-3 R41;
benzothienyl substituted with 0-3 R41;
benzofuranyl substituted with 0-3 R41;
phthalimid-1-yl substituted with 0-3 R41;
inden-2-yl substituted with 0-3 R41;

2,3-dihydro-1H-inden-2-yl substituted 0-3 R41;
indazolyl substituted with 0-3 R41;
tetrahydroquinolinyl substituted with 0-3 R41; and
tetrahydro-isoquinolinyl substituted with 0-3 R41;

R3, at each occurrence, is independently selected from H, methyl, and ethyl;
R5 is H;
R6a is selected from H, \u2014OH, methyl, and methoxy;
R6b is H;
R7, R8, and R9, at each occurrence, are independently
selected from H, F, Cl, methyl, ethyl,
methoxy, \u2014CF3,
and \u2014OCF3,

R41, at each occurrence, is independently selected from H, F, Cl, Br, OH, CF3, NO2, CN, \u2550O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;
R42, at each occurrence, is independently selected from
H, F, Cl, Br, OH, CF3, SO2R45, SR45, NR46R47, OR48,
NO2, CN, \u2550O, methyl, ethyl, propyl, butyl,
methoxy, and ethoxy;

R45 is methyl, ethyl, propyl, or butyl;
R46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;
R47, at each occurrence, is independently selected from
H, methyl, ethyl, n-propyl, i-propyl, n-butyl,
i-butyl, \u2014(C\u2550O)NH(methyl), \u2014C(\u2550O)NH(ethyl),
\u2014SO2(methyl), \u2014SO2(ethyl), \u2014SO2(phenyl),
\u2014C(\u2550O)O(methyl), \u2014C(\u2550O)O(ethyl), \u2014C(\u2550O)(methyl),
\u2014C(\u2550O)(ethyl), and \u2014C(\u2550O)H;

R48, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, \u2014C(\u2550O)NH (methyl), \u2014C(\u2550O)H(ethyl), \u2014C(\u2550O)O(methyl), \u2014C(\u2550O)O(ethyl), \u2014C(\u2550O)(methyl), \u2014C(\u2550O)(ethyl), and \u2014C(\u2550O)H;
k is 1;
m is 0, 1, or 2; and
n is 1 or 2.
18. A compound of claim 12 of Formula (I-a)
wherein:
b is a single bond;
X is \u2014S\u2014 or \u2014O\u2014;
R1 is selected from
\u2014C(CH2)3C(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(4-bromo-phenyl),
\u2014(CH2)3C(\u2550O)(4-methyl-phenyl),
\u2014(CH2)3C(\u2550O)(4-methoxy-phenyl),
\u2014(CH2)3C(\u2550O)(4-(3,4-dichloro-phenyl)phenyl),
\u2014(CH2)3C(\u2550O)(3-methyl-4-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(2,3-dimethoxy-phenyl),
\u2014(CH2)3C(\u2550O)(phenyl),
\u2014(CH2)3C(\u2550O)(4-chloro-phenyl),
\u2014(CH2)3C(\u2550O)(3-methyl-phenyl),
\u2014(CH2)3C(\u2550O)(4-t-butyl-phenyl),
\u2014(CH2)3C(\u2550O)(3,4-difluoro-phenyl),
\u2014(CH2)3C(\u2550O)(2-methoxy-5-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(4-fluoro-1-naphthyl),
\u2014(CH2)3C(\u2550O)(benzyl),
\u2014(CH2)3C(\u2550O)(4-pyridyl),
\u2014(CH2)3C(\u2550O)(3-pyridyl),
\u2014(CH2)3CH(OH)(4-fluoro-phenyl),
\u2014(CH2)3CH(OH)(4-pyridyl),
\u2014(CH2)3CH(OH)(2,3-dimethoxy-phenyl),
\u2014(CH2)3S(3-fluoro-phenyl),
\u2014(CH2)3S(4-fluoro-phenyl),
\u2014(CH2)3S(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)3SO2(3-fluoro-phenyl),
\u2014(CH2)3SO2(4-fluoro-phenyl),
\u2014(CH2)3O(4-fluoro-phenyl),
\u2014(CH2)3O(phenyl),
\u2014(CH2)3O(3-pyridyl),
\u2014(CH2)3O(4-pyridyl),
\u2014(CH2)3O(2-NH2-phenyl),
\u2014(CH2)2O(2-NH2-5-F-phenyl),
\u2014(CH2)3O(2-NH2-4-F-phenyl),
\u2014(CH2)3O(2-NH2-3-F-phenyl),
\u2014(CH2)3O(2-NH2-4-Cl-phenyl),
\u2014(CH2)3O(2-NH2-4-OH-phenyl),
\u2014(CH2)3O(2-NH2-4-Br-phenyl),
\u2014(CH2)3O(2-NHC(\u2550O)Me-4-phenyl),
\u2014(CH2)3O(2-NHC(\u2550O)Me-phenyl),
\u2014(CH2)3NH(4-fluoro-phenyl),
\u2014(CH2)3N(methyl)(4-fluoro-phenyl),
\u2014(CH2)3CO2(ethyl),
\u2014(CH2)3C(\u2550O)N(methyl)(methoxy),
\u2014(CH2)3C(\u2550O)NH(4-fluoro-phenyl),
\u2014(CH2)3NHC(\u2550O)(phenyl),
\u2014(CH2)2(NMeC(\u2550O)(phenyl),
\u2014(CH2)2NHC(\u2550O)(2-fluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(2-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(2,4-difluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(2,4-difluoro-phenyl),
\u2014(CH2)3(3-indolyl),
\u2014(CH2)3(1-methyl-3-indolyl),
\u2014(CH2)3(1-indolyl),
\u2014(CH2)3(1-indolinyl),
\u2014(CH2)3(1-benzimidazolyl),
\u2014(CH2)3(1H-1,2,3-benzotriazol-1-yl),
\u2014(CH2)3(1H-1,2,3-benzotriazol-2-yl),
\u2014(CH2)2(1H-1,2,3-benzotriazol-1-yl),
\u2014(CH2)2(1H-1,2,3-benzotriazol-2-yl),
\u2014(CH2)3(3,4 dihydro-1(2H)-quinolinyl),
\u2014(CH2)2C(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2C(\u2550O)NH(4-fluoro-phenyl),
\u2014CH2CH2(3-indolyl),
\u2014CH2CH2(1-phthalimidyl),
\u2014(CH2)4C(\u2550O)N(methyl)(methoxy),
\u2014(CH2)4CO2(ethyl),
\u2014(CH2)4C(\u2550O)(phenyl),
\u2014(CH2)3CH(phenyl)2,
\u2014CH2CH2CH\u2550C(phenyl)2,
\u2014CH2CH2CH\u2550CMe(4-F-phenyl),
\u2014(CH2)3CH(4-fluoro-phenyl)2,
\u2014CH2CH2CH\u2550C(4-fluoro-phenyl)2,
\u2014(CH2)2(2,3-dihydro-1H-inden-2-yl), \u2014(CH2)3C(\u2550O)(2-NH2-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-5-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH4-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-3-F-phenyl),
\u2014(CH2)3C(\u2550O((2-NH2-4-Cl-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-OH-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-Br-phenyl),
\u2014(CH2)3(1H-indazol-3-yl),
\u2014(CH2)3(5-F-1H-indazol-3-yl),
\u2014(CH2)3(7-F-1H-indazol-3-yl),
\u2014(CH2)3(6-Cl-1H-indazol-3-yl),
\u2014(CH2)3(6-Br-1H-indazol-3-yl),
\u2014(CH2)3C(\u2550O)(2-NHMe-phenyl),
\u2014(CH2)3(1-benzothien-3-yl),
\u2014(CH2)3(6-F-1H-indazol-1-yl),
\u2014(CH2)3(5-F-1H-indazol-1-yl),
\u2014(CH2)3(6-F-2,3-dihydro-1H-indol-1-yl),
\u2014(CH2)3(5-F-2,3-dihydro-1H-indol-1-yl),
\u2014(CH2)3(6-F-1H-indol-3-yl),
\u2014(CH2)3(5-F-1H-indol-3-yl),
\u2014(CH2)3(5-F-1H-indol-3-yl),
\u2014(CH2)3(9H-purin-9-yl),
\u2014(CH2)3(7H-purin-7-yl),
\u2014(CH2)3(6-F-1H-indazol-3-yl),
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)Me-4-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)Me-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHCO2Et-4-F-phenyl),
\u2014(CH2)3C(\u2550O) (2-NHC(\u2550O)NHEt-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHCHO-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-OH-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-MeS-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl),
\u2014(CH2)2C(Me)CO2Me,
\u2014(CH2)2C(Me)CH(OH)(4-F-phenyl)2,
\u2014(CH2)2C(Me)C(OH)(4-Cl-phenyl)2,
\u2014(CH2)2C(Me)C(\u2550O)(4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(2-MeO-4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(3-Me-4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(2-Me-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)phenyl,
R7, R8, and R9, at each occurrence, are independently selected from
hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluromethyl, methoxy, ethoxy, isopropoxy, trifluoromethoxy, phenyl, benzyl,
HC(\u2550O)\u2014, methylC(\u2550O)\u2014, ethylC(\u2550O)\u2014, propylC(\u2550O)\u2014, isopropylC(\u2550O)\u2014, n-butylC(\u2550O)\u2014, isobutylC(\u2550O)\u2014, secbutylC(\u2550O)\u2014, tertbutylC(\u2550O)\u2014, phenylC(\u2550O)\u2014,
methylC(\u2550O)NH\u2014, ethylC(\u2550O)NH\u2014, propylC(\u2550O)NH\u2014, isopropylC(\u2550O)NH\u2014, n-butylC(\u2550O)NH\u2014, isobutylC(\u2550O)NH\u2014, secbutylC(\u2550O)NH\u2014, tertbutylC(\u2550O)NH\u2014, phenylC(\u2550O)NH\u2014,
methylamino-, ethylamino-, propylamino-, isopropylamino-, n-butylamino-, isobutylamino-, secbutylamino-, tertbutylamino-, phenylamino-, p2 provided that two of substituents R7, R8, and R9, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, and trifluoromethoxy;

k is 1 or 2;
m is 1 or 2; and
n is 1 or 2.
19. A compound of claim 18 of Formula (II-a)
wherein:
b is a single bond, wherein the bridge hydrogens are in a cis position;
R1 is selected from
\u2014(CH2)3C(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(4-bromo-phenyl),
\u2014(CH2)3C(\u2550O)(4-methyl-phenyl),
\u2014(CH2)3C(\u2550O)(4-methoxy-phenyl),
\u2014(CH2)3C(\u2550O)(4-(4-dichloro-phenyl)phenyl),
\u2014(CH2)3C(\u2550O)(3-methyl-4-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(2,3-dimethoxy-phenyl),
\u2014(CH2)3C(\u2550O)(phenyl),
\u2014(CH2)3C(\u2550O)(4-chloro-phenyl),
\u2014(CH2)3C(\u2550O)(3-methyl-phenyl),
\u2014(CH2)3C(\u2550O)(4-t-butyl-phenyl),
\u2014(CH2)3C(\u2550O)(3,4-difluoro-phenyl),
\u2014(CH2)3C(\u2550O)(2-methoxy-5-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(4-fluoro-1-naphthyl),
\u2014(CH2)3C(\u2550O)(benzyl),
\u2014(CH2)3C(\u2550O)(4-pyridyl),
\u2014(CH2)3C(\u2550O)(3-pyridyl),
\u2014(CH2)3CH(OH)(4-fluoro-phenyl),
\u2014(CH2)3CH(OH)(4-pyridyl),
\u2014(CH2)3CH(OH)(2,3-dimethoxy-phenyl),
\u2014(CH2)3S(3-fluoro-phenyl),
\u2014(CH2)3S(4-fluoro-phenyl),
\u2014(CH2)3S(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)3SO2(3-fluoro-phenyl),
\u2014(CH2)3SO2(4-fluoro-phenyl),
\u2014(CH2)3O(4-fluoro-phenyl),
\u2014(CH2)3O(phenyl),
\u2014(CH2)3NH(4-pyridyl),
\u2014(CH2)3N(methyl)(4-fluoro-phenyl),
\u2014(CH2)3CO2(ethyl),
\u2014(CH2)3C(\u2550O)N(methyl)(methoxy),
\u2014(CH2)3C(\u2550O)NH(4-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(phenyl),
\u2014(CH2)2NMeC(\u2550O)(phenyl),
\u2014(CH2)2NHC(\u2550O)(2-fluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(2-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)4-fluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(2,4-difluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(2,4-difluoro-phenyl),
\u2014(CH2)3(3-indolyl),
\u2014(CH2)3(1-methyl-3-indolyl),
\u2014(CH2)3(1-indolyl),
\u2014(CH2)3(1-indolinyl),
\u2014(CH2)3(1-benzimidazolyl),
\u2014(CH2)3(1H-1,2,3-benzotriazol-1-yl),
\u2014(CH2)3(1H-1,2,3-benzotriazol-2-yl),
\u2014(CH2)2(1H-1,2,3-benzotriazol-1-yl),
\u2014(CH2)2(1H-1,2,3-benzotriazol-2-yl),
\u2014(CH2)3(3,4 dihydro-1(2H)-quinolinyl),
\u2014(CH2)2C(\u2550)(4-fluoro-phenyl),
\u2014(CH2)2C(\u2550O)NH(4-fluoro-phenyl),
\u2014CH2CH2(3-indolyl),
\u2014CH2CH2(1-phthalimidyl),
\u2014(CH2)4C(\u2550O)N(methyl)(methoxy),
\u2014(CH2)4CO2(ethyl),
\u2014(CH2)4C(\u2550O)(phenyl),
\u2014(CH2)3CH(phenyl)2,
\u2014CH2CH2CH\u2550C(phenyl)2,
\u2014CH2CH2CH\u2550CMe(4-F-phenyl),
\u2014(CH2)3CH(4-fluoro-phenyl)2,
\u2014CH2CH2CH\u2550C(4-fluoro-phenyl)2,
\u2014(CH2)2(2,3-dihydro-1H-inden-2-yl),
\u2014(CH2)3C(\u2550O)(2-NH2-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-5-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-3-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-Cl-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-OH-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-Br-phenyl),
\u2014(CH2)3(1H-indazol-3-yl),
\u2014(CH2)3(5-F-1H-indazol-3-yl),
\u2014(CH2)3(7-F-1H-indazol-3-yl),
\u2014(CH2)3(6-Cl-1H-indazol-3-yl),
\u2014(CH2)3(6-Br-1H-indazol-3-yl),
\u2014(CH2)3C(\u2550O)(2-NHMe-phenyl),
\u2014(CH2)3(1-benzothien-3-yl),
\u2014(CH2)3(6-F-1H-indol-1-yl),
\u2014(CH2)3(5-F-1H-indol-1-yl),
\u2014(CH2)3(6-F-2,3-dihydro-1H-indol-1-yl),
\u2014(CH2)3(5-F-2,3-dihydro-1H-indol-1-yl),
\u2014(CH2)3(6-F-1H-indol-3-yl),
\u2014(CH2)3(5-F-1H-indol-3-yl),
\u2014(CH2)3(5-F-1H-indol-3-yl),
\u2014(CH2)3(9H-purin-9-yl),
\u2014(CH2)3(7H-purin-7-yl),
\u2014(CH2)3(6-F-1H-indazol-3-yl),
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHCO2Et-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)NHEt-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHCHO-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-OH-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-MeS-4-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl),
\u2014(CH2)2C(Me)CO2Me,
\u2014(CH2)2C(Me)CH(OH)(4-F-phenyl)2,
\u2014(CH2)2C(ME)CH(OH)(4-Cl-phenyl)2,
\u2014(CH2)2C(Me)C(\u2550O)(4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(2-MeO-4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(3-Me-4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(2-Me-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)phenyl,
R7, R8, and R9, at each occurrence, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropyoxy, trifluoromethoxy, methylC(\u2550O)\u2014, ethylC(\u2550O)\u2014, propylC(\u2550O)\u2014, isopropylC(\u2550O)\u2014, methylC(\u2550O)NH\u2014, ethylC(\u2550O)NH\u2014, propylC(\u2550O)NH\u2014, isopropylC(\u2550O)NH, methylamino-, ethylamino-, propylamino-, and isopropylamino-, provided that two of substituents R7, R8, and R9, are independently selected from hydrogen, fluoro, chloro, methyl, trifluoromethyl, methoxy, and trifluoromethoxy;
m is 1 or 2; and
n is 1 or 2.
20. A compound of claim 18 of Formula (III-a)
wherein:
b is a single bond, wherein the bridge hydrogens are in a cis position;
R1 is selected from
\u2014(CH2)3C(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(4-bromo-phenyl),
\u2014(CH2)3C(\u2550O)(4-methyl-phenyl),
\u2014(CH2)3C(\u2550O)(4-methoxy-phenyl),
\u2014(CH2)3C(\u2550O)(4-(3,4-dichloro-phenyl)phenyl),
\u2014(CH2)3C(\u2550O)(3-methyl-4-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(2,3-dimethoxy-phenyl),
\u2014(CH2)3C(\u2550O)(phenyl),
\u2014(CH2)3C(\u2550O)(4-chloro-phenyl),
\u2014(CH2)3C(\u2550O)(3-methyl-phenyl),
\u2014(CH2)3C(\u2550O)(4-t-butyl-phenyl),
\u2014(CH2)3C(\u2550O)(3,4-difluoro-phenyl),
\u2014(CH2)3C(\u2550O)(2-methoxy-5-fluoro-phenyl),
\u2014(CH2)3C(\u2550O)(4-fluoro-1-naphthyl),
\u2014(CH2)3C(\u2550O)(benzyl),
\u2014(CH2)3C(\u2550O)(pyridyl),
\u2014(CH2)3C(\u2550O)(3-pyridyl),
\u2014(CH2)3CH(OH)(4-fluoro-phenyl),
\u2014(CH2)3CH(OH)(4-pyridyl),
\u2014(CH2)3CH(OH)(2,3-dimethoxy-phenyl),
\u2014(CH2)3S(3-fluoro-phenyl),
\u2014(CH2)3S(4-fluoro-phenyl),
\u2014(CH2)3S(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)3SO2(3-fluoro-phenyl),
\u2014(CH2)3SO2(4-fluoro-phenyl),
\u2014(CH2)3O(4-fluoro-phenyl),
\u2014(CH2)3O(phenyl),
\u2014(CH2)3NH(4-fluoro-phenyl),
\u2014(CH2)3N(methyl)(4-fluoro-phenyl),
\u2014(CH2)3CO2(ethyl),
\u2014(CH2)3C(\u2550O)N(methyl)(methoxy),
\u2014(CH2)3C(\u2550O)NH(4-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(phenyl),
\u2014(CH2)2NMeC(\u2550O)(phenyl),
\u2014(CH2)2NHC(\u2550O)(2-fluorophenyl),
\u2014(CH2)2NMeC(\u2550O)(2-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2NHC(\u2550O)(2,4-difluoro-phenyl),
\u2014(CH2)2NMeC(\u2550O)(2,4-difluoro-phenyl),
\u2014(CH2)3(3-incolyl),
\u2014(CH2)3(1-methyl-3-indolyl),
\u2014(CH2)3(1-indolyl),
\u2014(CH2)3(1-indolinyl),
\u2014(CH2)3(1-benzimidazolyl),
\u2014(CH2)3(1H-1,2,3-benzotriazol-1-yl),
\u2014(CH2)3(1H-1,2,3-benzotriazol-2-yl),
\u2014(CH2)2(1H-1,2,3-benzotriazol-1-yl),
\u2014(CH2)2(1H-1,2,3-benzotriazol-2-yl),
\u2014(CH2)3(3,4-dihydro-1(2H)-quinolinyl),
-(CH2)2C(\u2550O)(4-fluoro-phenyl),
\u2014(CH2)2C(\u2550O)NH(4-fluoro-phenyl),
\u2014CH2CH2(3-indolyl),
\u2014CH2CH2(1-phthalimidyl),
\u2014(CH2)4C(\u2550O)N(methyl)(methoxy),
\u2014(CH2)4CO2(ethyl),
\u2014(CH2)4C(\u2550O)(phenyl),
\u2014(CH2)3CH(phenyl)2,
\u2014CH2CH2CH\u2550C(phenyl)2,
\u2014CH2CH2CH\u2550CMe(4-F-phenyl),
\u2014(CH2)3CH(4-fluoro-phenyl)2,
\u2014CH2CH2CH\u2550C(4-fluoro-phenyl)2,
\u2014(CH2)2(2,3-dihydro-1H-inden-2-yl),
\u2014(CH2)3C(\u2550O)(2-NH2-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-5-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-3-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-Cl-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-OH-phenyl),
\u2014(CH2)3C(\u2550O)(2-NH2-4-Br-phenyl),
\u2014(CH2)3(1H-indazol-3-yl),
\u2014(CH2)3(5-F-1H-indazol-3-yl),
\u2014(CH2)3(7-F-1H-indazol-3-yl),
\u2014(CH2)3(6-Cl-1H-indazol-3-yl),
\u2014(CH2)3(6-Br-1H-indazol-3-yl),
\u2014(CH2)3C(\u2550O)(2-NHMe-phenyl),
\u2014(CH2)3(1-benzothien-3-yl),
\u2014(CH2)3(6-F-1H-indol-1-yl),
\u2014(CH2)3(5-F-1H-indol-1-yl),
\u2014(CH2)3(6-F-2,3-dihydro-1H-indol-1-yl),
\u2014(CH2)3(5-F-2,3-dihydro-1H-indol-1-yl),
\u2014(CH2)3(6-F-1H-indol-3-yl),
\u2014(CH2)3(5-F-1H-indol-3-yl),
\u2014(CH2)3(5-F-1H-indol-3-yl),
\u2014(CH2)3(9H-purin-9-yl),
\u2014(CH2)3(7H-purin-7-yl),
\u2014(CH2)3(6-F-1H-indazol-3-yl),
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)Me-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHCO2-Et-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHC(\u2550O)NHEt-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHCHO-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-OH-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-MeS-4-F-phenyl),
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl),
\u2014(CH2)2C(Me)CO2Me,
\u2014(CH2)2C(Me)CH(OH)(4-F-phenyl)2,
\u2014(CH2)2C(Me)CH(OH)(4-Cl-phenyl)2,
\u2014(CH2)2C(Me)C(\u2550O)(4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(2-MeO-4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(3-Me-4-F-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)(2-Me-phenyl),
\u2014(CH2)2C(Me)C(\u2550O)phenyl,
R7, R8, R9, at each occurrence, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, trifluoromethoxy, methylC(\u2550O)\u2014, ethylC(\u2550O)\u2014, propylC(\u2550O)\u2014, isopropylC(\u2550O)\u2014, methylC(\u2550O)NH\u2014, ethylC(\u2550O)NH\u2014, propylC(\u2550O)NH\u2014, isopropyl-C(\u2550O)NH, methylamino-, ethylamino-, propylamino-, and isopropylamino-,
provided that two of substituents R7, R8, and R9, are independently selected from hydrogen, fluoro, chloro, methyl, trifluoromethyl, methoxy, and trifluoromethoxy;
m is 1 or 2; and
n is 1 or 2.
21. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claims 1-20 or a pharmaceutically acceptable salt thereof.
22. A method for treating a human suffering from a disorder associated with 5HT2C receptor modulation selected from obesity, anorexia, bulemia, depression, anxiety, psychosis, schizophrenia, migraine, addictive behavior, obsessive-compulsive disorder, and sexual disorders; comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims 1-11 or a pharmaceutically acceptable salt thereof.
23. A method for treating a human suffering from a disorder associated with 5HT2A receptor modulation selected from depression, psychosis, schizophrenia, migraine, attention deficit disorder, attention deficit hyperactivity disorder, obsessive-compulsive disorder, and sleep disorders; comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims 12-20, or a pharmaceutically acceptable salt thereof.
24. A method for treating obesity comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims 1-11, or a pharmaceutically acceptable salt thereof.
25. A method for treating schizophrenia comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims 12-20 or a pharmaceutically acceptable salt thereof.
26. A method for treating depression comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims 12-20 or a pharmaceutically acceptable salt thereof.
27. A compound of claim 12 selected from the compounds disclosed in Table 1:
TABLE 1
Ex #
R7
R8
R9
b
R1
25
H
H
H
sgl
\u2014C(\u2550O)(3,4-diMeO-phenyl)
26
H
H
H
sgl
\u2014C(\u2550O)(2,5-diMeO-phenyl)
27
H
H
H
sgl
\u2014C(\u2550O)(3,5-diMeO-phenyl)
28
H
H
H
sgl
2,6-diMeO-benzyl
29
H
H
H
sgl
2,4-diMeO-benzyl
30
H
H
H
sgl
2,4,6-triMeO-benzyl
31
H
H
H
sgl
2,3-diMeO-benzyl
32
H
H
H
sgl
2,4,5-triMeO-benzyl
33
H
H
H
sgl
cyclohexylmethyl
34
H
H
H
sgl
2,3,4-triMeO-benzyl
35
H
H
H
sgl
3,4-diMeO-benzyl
36
H
H
H
sgl
3,4,5-triMeO-benzyl
39
H
H
H
sgl
\u2014CO2Et
40
H
\u2014C(\u2550O)CH3
H
sgl
\u2014CO2Et
41
H
\u2014NHC(\u2550O)CH3
H
sgl
\u2014CO2Et
42
H
H
H
sgl
\u2014CH2CH2(4-F-phenyl)
46
H
H
H
sgl
pentyl
47
H
H
H
sgl
hexyl
50
H
H
H
sgl
2-pentyl
51
H
H
H
sgl
2-hexyl
53
H
H
H
sgl
2-Me-butyl
54
H
H
H
sgl
2-Me-pentyl
55
H
H
H
sgl
2-Et-butyl
56
H
H
H
sgl
3-Me-pentyl
57
H
H
H
sgl
3-Me-butyl
58
H
H
H
sgl
4-Me-pentyl
59
H
H
H
sgl
cyclopropylmethyl
60
H
H
H
sgl
cyclobutylmethyl
61
H
H
H
sgl
cyclohexylmethyl
62
H
H
H
sgl
2-propenyl
63
H
H
H
sgl
2-Me-2-propenyl
64
H
H
H
sgl
trans-2-butenyl
65
H
H
H
sgl
3-Me-butenyl
66
H
H
H
sgl
3-butenyl
67
H
H
H
sgl
trans-2-pentenyl
68
H
H
H
sgl
cis-2-pentenyl
69
H
H
H
sgl
4-pentenyl
70
H
H
H
sgl
4-Me-3-pentenyl
71
H
H
H
sgl
3,3-diCl-2-propenyl
72
H
H
H
sgl
benzyl
73
H
H
H
sgl
2-Me-benzyl
74
H
H
H
sgl
3-Me-benzyl
75
H
H
H
sgl
4-Me-benzyl
76
H
H
H
sgl
2,5-diMe-benzyl
77
H
H
H
sgl
2,4-diMe-benzyl
78
H
H
H
sgl
3,5-diMe-benzyl
79
H
H
H
sgl
2,4,6-triMe-benzyl
80
H
H
H
sgl
3-MeO-benzyl
81
H
H
H
sgl
3,5-diMeO-benzyl
82
H
H
H
sgl
pentafluorobenzyl
83
H
H
H
sgl
2-phenylethyl
84
H
H
H
sgl
1-phenyl-2-propyl
85
H
H
H
sgl
trans-3-phenyl-2-propenyl
86
H
H
H
sgl
4-phenylbutyl
87
H
H
H
sgl
4-phenylbenzyl
88
H
H
H
sgl
2-phenylbenzyl
178
Cl
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
179
Me
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
180
H
H
H
sgl
\u2014(CH2)3S(3-F-phenyl)
181
H
H
H
sgl
\u2014(CH2)3CH(OH)(4-F-phenyl)
186
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
187
H
MeO
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
192
H
H
H
sgl
\u2014(CH2)3(\u2550O)(4-Br-phenyl)
193
H
H
H
sgl
\u2014(CH2)3SO2(3-F-phenyl)
194
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-(3,4-diCl-phenyl)phenyl)
197
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-Me-phenyl)
198
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
199
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-MeO-phenyl)
200
H
H
H
sgl
\u2014(CH2)2C(\u2550O)(4-F-phenyl)
201
H
H
H
sgl
\u2014(CH2)3SO2(4-F-phenyl)
202
H
H
H
sgl
\u2014(CH2)3S(\u2550O)(4-F-phenyl)
203
H
H
H
sgl
\u2014(CH2)3O(4-F-phenyl)
204
H
H
H
sgl
\u2014(CH2)3O(phenyl)
205
H
H
H
sgl
\u2014(CH2)3S(4-F-phenyl)
206
H
H
H
sgl
\u2014(CH2)3NH(4-F-phenyl)
207
H
H
H
sgl
\u2014(CH2)3N(CH3)(4-F-phenyl)
208
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-pyridyl)
209
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(3-pyridyl)
214
H
H
H
sgl
215
H
H
H
sgl
219
H
H
H
sgl
\u2014(CH2)3CO2Et
220
H
H
H
sgl
\u2014(CH2)4CO2Et
221
H
H
H
sgl
\u2014(CH2)3C(\u2550O)N(CH3)(OCH3)
222
H
H
H
sgl
\u2014(CH2)4C(\u2550O)N(CH3)(OCH3)
223
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(3-Me-4-F-phenyl)
224
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(phenyl)
225
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-Cl-phenyl)
226
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(3-Me-phenyl)
227
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-tBu-phenyl)
228
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(3,4-diF-phenyl)
229
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-MeO-5-F-phenyl)
230
H
H
H
sgl
\u2014(CH2)4C(\u2550O)(phenyl)
231
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-1-naphthyl)
232
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(benzyl)
233
H
H
H
sgl
\u2014(CH2)2C(\u2550O)NH(4-F-phenyl)
234
H
H
H
sgl
\u2014(CH2)3C(\u2550O)NH(4-F-phenyl)
235
H
H
H
sgl
\u2014(CH2)3CH(OH)(4-F-phenyl)
236
H
H
H
sgl
\u2014(CH2)3CH(OH)(4-pyridyl)
237
H
H
H
sgl
\u2014(CH2)3CH(OH)(2,3-diMeO-phenyl)
238
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2,3-diMeO-phenyl)
239
H
H
H
sgl
\u2014(CH2)4(cyclohexyl)
240
H
H
H
sgl
\u2014(CH2)3CH(phenyl)2
241
H
H
H
sgl
\u2014CH2CH2CH\u2550C(phenyl)2
242
H
H
H
sgl
\u2014(CH2)3CH(4-F-phenyl)2
243
H
H
H
sgl
\u2014CH2CH2CH\u2550C(4-F-phenyl)2
244
H
H
H
sgl
\u2014(CH2)2NHC(\u2550O)(phenyl)
245
H
H
H
sgl
\u2014(CH2)2NHC(\u2550O)(2-F-phenyl)
246
H
H
H
sgl
\u2014(CH2)2NHC(\u2550O)(4-F-phenyl)
247
H
H
H
sgl
\u2014(CH2)3(3-indolyl)
248
H
H
H
sgl
\u2014(CH2)3(1-Me-3-indolyl)
249
H
H
H
sgl
\u2014CH2CH2(3-indolyl)
250
H
H
H
sgl
\u2014(CH2)3(1-indolyl)
251
H
H
H
sgl
\u2014(CH2)3(1-indolinyl)
252
H
H
H
sgl
\u2014(CH2)3(1-benzimidazolyl)
253
H
H
H
sgl
254
H
H
H
sgl
268
H
F
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
286
H
H
H
sgl
\u2014(CH2)2NHO(\u2550O)(2,4-diF-phenyl)
287
H
H
H
sgl
\u2014(CH2)2NMeO(\u2550O)-phenyl
288
H
H
H
sgl
\u2014(CH2)2NMeO(\u2550O)(2-F-phenyl)
289
H
H
H
sgl
\u2014(CH2)2NMeO(\u2550O)(2,4-diF-phenyl)
290
H
H
H
sgl
\u2014(CH2)2NMeO(\u2550O)(4-F-phenyl)
291
H
H
H
sgl
\u2014(CH2)3(1H-1,2,3-benzotriazol-1-yl)
292
H
H
H
sgl
\u2014(CH2)3(1H-1,2,3-benzotriazol-2-yl)
293
H
H
H
sgl
294
H
H
H
sgl
295
H
H
H
sgl
296
H
H
H
sgl
297
H
H
H
sgl
\u2014(CH2)2(1H-1,2,3-benzotriazol-1-yl)
298
H
H
H
sgl
\u2014(CH2)2(1H-1,2,3-benzotriazol-2-yl)
299
H
H
H
sgl
\u2014(CH2)3(3,4-dihydro-1(2H)-quinolyl)
300
H
H
H
sgl
\u2014CH2CH2CH\u2550CMe(4-F-phenyl)
301
H
H
H
sgl
\u2014(CH2)2(2,3-dihydro-1H-inden-2-yl)
302
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-phenyl)
303
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-phenyl)
304
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-5-F-phenyl)
305
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-3-F-phenyl)
306
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-Cl-phenyl)
307
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-OH-phenyl)
308
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-Br-phenyl)
309
H
H
H
sgl
\u2014(CH2)3(1H-indazol-3-yl)
310
H
H
H
sgl
\u2014(CH2)3(5-F-1H-indazol-3-yl)
311
H
H
H
sgl
\u2014(CH2)3(7-F-1H-indazol-3-yl)
312
H
H
H
sgl
\u2014(CH2)3(6-Cl-1H-indazol-3-yl)
313
H
H
H
sgl
\u2014(CH2)3(6-Br-1H-indazol-3-yl)
314
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHMe-phenyl)
315
H
H
H
sgl
\u2014(CH2)3(1-benzothien-3-yl)
355
H
H
H
sgl
356
H
H
H
sgl
\u2014(CH2)3(6-F-1H-indol-1-yl)
357
H
H
H
sgl
\u2014(CH2)3(5-F-1H-indol-1-yl)
358
H
H
H
sgl
\u2014(CH2)3(6-F-2,3-dihydro-1H-indol-1-yl)
359
H
H
H
sgl
\u2014(CH2)3(5-F-2,3-dihydro-1H-indol-1-yl)
360
H
H
H
sgl
\u2014(CH2)3(6-F-1H-indol-3-yl)
361
H
H
H
sgl
\u2014(CH2)3(6-F-1H-indol-3-yl)
362
H
H
H
sgl
\u2014(CH2)3(5-F-1H-indol-3-yl)
363
H
H
H
sgl
\u2014(CH2)3(5-F-1H-indol-3-yl)
364
H
H
H
sgl
\u2014(CH2)3(9H-purin-9-yl)
365
H
H
H
sgl
\u2014(CH2)3(7H-purin-7-yl)
366
H
H
H
sgl
367
H
H
H
sgl
\u2014(CH2)3(6-F-1H-indazol-3-yl)
368
H
H
H
sgl
\u2014(CH2)3(6-F-1H-indazol-3-yl)
369
H
H
H
sgl
\u2014(CH2)3(6-F-1H-indazol-3-yl)
370
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-F-phenyl)
371
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-F-phenyl)
372
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl)
373
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHO(\u2550O)Me-4-F-phenyl)
374
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHO(\u2550O)Me-4-F-phenyl)
375
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHCO2Et-4-F-phenyl)
376
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHO(\u2550O)NHEt-4-F-phenyl)
377
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHCHO-4-F-phenyl)
378
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-OH-4-F-phenyl)
379
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-MeS-4-F-phenyl)
442
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NHSO2Me-4-F-phenyl)
485
H
H
H
sgl
\u2014(CH2)2C(Me)CO2Me
486
H
H
H
sgl
\u2014(CH2)2C(Me)C(OH)(4-F-phenyl)2
487
H
H
H
sgl
\u2014(CH2)2C(Me)C(OH)(4-Cl-phenyl)2
489
H
H
H
sgl
\u2014(CH2)2C(Me)C(\u2550O)(4-F-phenyl)
490
H
H
H
sgl
\u2014(CH2)2C(Me)C(\u2550O)(2-MeO-4-F-phenyl)
491
H
H
H
sgl
\u2014(CH2)2C(Me)C(\u2550O)(3-Me-4-F-phenyl)
492
H
H
H
sgl
\u2014(CH2)2C(Me)C(\u2550O)(2-Me-phenyl)
493
H
H
H
sgl
\u2014(CH2)2C(Me)C(\u2550O)phenyl
591
Cl
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-phenyl
or pharmaceutically acceptable salt forms thereof.
28. A compound of claim 12 selected from the compounds closed in Table 2:
TABLE 2
Ex #
n
k
m
R7
R8
R9
b
R1
472
2
2
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
473
2
2
1
H
H
H
sgl
\u2014(CH2)3O(4-F-phenyl)
474
2
2
1
H
H
H
sgl
\u2014(CH2)3(6-F-benzisoxazol-
3-yl)
475
2
2
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-pyridyl)
483
2
2
1
H
Br
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
484
2
2
1
H
Br
H
sgl
\u2014(CH2)3O(4-F-phenyl)
488
1
2
1
H
Br
H
sgl
\u2014CO2\u2014tBu
or pharmaceutically acceptable salt forms thereof.
29. A compound of claim 12 selected from the compounds closed in Table 3:
TABLE 3
Ex #
n
k
m
R7
R8
R9
b
R1
182
1
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-
phenyl)
266
1
1
1
H
H
Me
sgl
\u2014(CH2)3C(\u2550O)(4-F-
phenyl)
270
1
1
1
H
H
H
sgl
\u2014(CH2)3O(4-F-
phenyl)
272
1
1
1
H
H
H
sgl
H
494
1
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-
phenyl)
495
1
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-
phenyl)
496
1
1
1
H
H
H
sgl
\u2014(CH2)3(1H-indazol-3-yl)
528
1
1
1
H
H
H
sgl
\u2014(CH2)3(6-F-1H-
indazol-3-yl)
529
1
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-
4-F-phenyl)
530
1
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-
4-F-phenyl)
531
1
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-OH-
4-F-phenyl)
539
1
2
1
H
H
H
sgl
\u2014(CH2)3O(4-F-phenyl)
540
1
2
1
H
H
H
sgl
\u2014(CH2)3(6-F-1,2-
benzisoxazol-3-yl)
544
2
1
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-
phenyl)
546
1
2
1
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-
phenyl
or pharmaceutically acceptable salt forms thereof.
30. A compound of claim 12 selected from the compounds closed in Table 4:
TABLE 4
Ex #
R7
R8
R9
b
R1
185
H
H
CF3
sgl
\u2014(CH2)4(4-F-phenyl)
188
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
213
H
CH3
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
438
H
H
H
sgl
\u2014(CH2)3C(\u2550O)((2-NH2-phenyl)
439
H
H
H
sgl
\u2014(CH2)3C(\u2550O)((2-NH2-phenyl)
440
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-F-phenyl)
441
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(2-NH2-4-F-phenyl)
456
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
457
H
H
H
sgl
\u2014(CH2)3C(\u2550O)(4-F-phenyl)
or pharmaceutically acceptable salt forms thereof.
31. A compound of claim 1 selected from the compounds disclosed in Table 1A:
TABLE 1A
Ex #
R7
R8
R9
b
R1
125
H
H
Br
sgl
\u2014CO2\u2014tBu
126
H
H
2,6-diF-phenyl
sgl
\u2014CO2\u2014tBu
128
H
2,4-diCl-phenyl
H
sgl
H
129
H
phenyl
H
sgl
H
130
H
4-F-phenyl
H
sgl
H
131
H
4-Cl-phenyl
H
sgl
H
132
H
2-Cl-phenyl
H
sgl
H
133
H
2-MeO-phenyl
H
sgl
H
134
H
2-Cl-4-CF3-phenyl
H
sgl
H
135
H
2,4-diMe-phenyl
H
sgl
H
136
H
2-Cl-4-MeO-phenyl
H
sgl
H
137
H
4-iPr-phenyl
H
sgl
H
138
H
4-Bu-phenyl
H
sgl
H
139
H
2-Me-4-MeO-5-F-phenyl
H
sgl
H
140
H
2-Me-4-MeO-phenyl
H
sgl
H
141
H
2-Cl-4-CF3O-phenyl
H
sgl
H
142
H
2,4,5-triMe-phenyl
H
sgl
H
143
H
3-Cl-phenyl
H
sgl
H
144
H
4-Me-phenyl
H
sgl
H
145
H
2-Me-4-Cl-phenyl
H
sgl
H
146
H
2,5-diCl-phenyl
H
sgl
H
147
H
2-MeO-4-iPr-phenyl
H
sgl
H
148
H
2,6-diCl-phenyl
H
sgl
H
149
H
2,6-diF-phenyl
H
sgl
H
150
H
2-CF3-4-MeO-phenyl
H
sgl
H
151
H
2-CF3-phenyl
H
sgl
H
152
H
4-pyridyl
H
sgl
H
153
H
2-furanyl
H
sgl
H
154
H
2-thiophenyl
H
sgl
H
155
H
4-F-phenyl
H
sgl
H
156
H
2,3-diCl-phenyl
H
sgl
H
157
H
4-Et-phenyl
H
sgl
H
158
H
2,4-diMeO-phenyl
H
sgl
H
159
H
2-F-3-Cl-phenyl
H
sgl
H
160
H
4-MeO-phenyl
H
sgl
H
161
H
4-MeS-phenyl
H
sgl
H
162
H
4-CN-phenyl
H
sgl
H
163
H
3-CF3-phenyl
H
sgl
H
164
H
2-MeO-phenyl
H
sgl
H
165
H
2-naphthyl
H
sgl
H
166
H
4-acetylphenyl
H
sgl
H
167
H
3-acetamidophenyl
H
sgl
H
168
H
2,4-diCl-phenyl
H
sgl
Me
316
H
2,3-diMe-phenyl
H
sgl
H
317
H
2-Me-5-F-phenyl
H
sgl
H
318
H
2-F-5-Me-phenyl
H
sgl
H
319
H
2-MeO-5-F-phenyl
H
sgl
H
320
H
2-Me-3-Cl-phenyl
H
sgl
H
321
H
3-NO2-phenyl
H
sgl
H
322
H
2-NO2-phenyl
H
sgl
H
323
H
2-Cl-3-Me-phenyl
H
sgl
H
324
H
2-MeO-phenyl
H
sgl
H
325
H
2,3-diCl-phenyl
H
sgl
H
326
H
2-Cl-4-CF3-phenyl
H
sgl
H
327
H
2-Me-4-EtO-phenyl
H
sgl
H
328
H
2-Me-4-F-phenyl
H
sgl
H
329
H
4-Bu-phenyl
H
sgl
H
330
H
2-CF3-phenyl
H
sgl
H
331
H
2-Cl-6-F-phenyl
H
sgl
H
332
H
2-Cl-4-(CHF3)O-phenyl
H
sgl
H
333
H
4-CF3-phenyl
H
sgl
H
334
H
4-Me-phenyl
H
sgl
H
335
H
4-CF3O-phenyl
H
sgl
H
336
H
2,4-diMeO-6-F-phenyl
H
sgl
H
337
H
2-Me-phenyl
H
sgl
H
338
H
2-CF3-6-F-phenyl
H
sgl
H
339
H
2-MeS-phenyl
H
sgl
H
340
H
2,4,6-triF-phenyl
H
sgl
H
341
H
2,4,6-triCl-phenyl
H
sgl
H
342
H
2,6-diCl-4-MeO-phenyl
H
sgl
H
343
H
2,3,4-triF-phenyl
H
sgl
H
344
H
2,6-diF-4-Cl-phenyl
H
sgl
H
345
H
2,3,4,6-tetraF-phenyl
H
sgl
H
346
H
2,3,4,5,6-pentaF-phenyl
H
sgl
H
347
H
2,6-diCF3-phenyl
H
sgl
H
348
H
2-CF3O-phenyl
H
sgl
H
349
H
2-CF3-4-EtO-phenyl
H
sgl
H
350
H
2-CF3-4-iPrO-phenyl
H
sgl
H
351
H
2-naphtyl
H
sgl
H
352
H
2-CF3-4-Cl-phenyl
H
sgl
H
353
H
2-CF3-4-F-phenyl
H
sgl
H
354
H
2,4-diF-phenyl
H
sgl
Me
380
H
2-Cl-4-EtO-phenyl
H
sgl
H
381
H
2-Cl-4-iPrO-phenyl
H
sgl
H
382
H
2-Et-4-MeO-phenyl
H
sgl
H
383
H
2-CHO-4-MeO-phenyl
H
sgl
H
384
H
2-CH(OH)Me-4-MeO-phenyl
H
sgl
H
385
H
2-CH(OMe)Me-4-MeO-phenyl
H
sgl
H
386
H
2-C(\u2550O)Me-4-MeO-phenyl
H
sgl
H
387
H
2-CH2(OH)Me-4-MeO-phenyl
H
sgl
H
388
H
2-CH2(OMe)Me-4-MeO-phenyl
H
sgl
H
389
H
2-CH(OH)Et-4-MeO-phenyl
H
sgl
H
390
H
2-C(\u2550O)Et-4-MeO-phenyl
H
sgl
H
391
H
(Z)-2-CH\u2550CHCO2Me-4-MeO-phenyl
H
sgl
H
392
H
2-CH2CH2CO2Me-4-MeO-phenyl
H
sgl
H
393
H
(Z)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl
H
sgl
H
394
H
(E)-2-CH\u2550CHCO2Me-4-MeO-phenyl
H
sgl
H
395
H
(E)-2-CH\u2550CHCH2(OH)-4-MeO-phenyl
H
sgl
H
396
H
2-CH2CH2OMe-4-MeO-phenyl
H
sgl
H
397
H
2-F-4-MeO-phenyl
H
sgl
H
403
H
2-Cl-4-phenyl
H
sgl
H
405
H
(2-Cl-phenyl)-CH\u2550CH\u2014
H
sgl
H
406
H
(3-Cl-phenyl)-CH\u2550CH\u2014
H
sgl
H
407
H
(2,6-diF-phenyl)-CH\u2550CH\u2014
H
sgl
H
410
H
cyclohexyl
H
sgl
H
411
H
cyclopentyl
H
sgl
H
412
H
cyclohexylmethyl
H
sgl
H
413
H
\u2014CH2CH2CO2Et
H
sgl
H
414
H
\u2014(CH2)3CO2Et
H
sgl
H
415
H
\u2014(CH2)4CO2Et
H
sgl
H
416
H
\u2014CH2CH\u2550CH2
H
sgl
H
417
H
Pr
H
sgl
H
418
H
benzyl
H
sgl
H
419
H
2-F-benzyl
H
sgl
H
420
H
3-F-benzyl
H
sgl
H
421
H
4-F-benzyl
H
sgl
H
422
H
3-MeO-benzyl
H
sgl
H
423
H
3-OH-benzyl
H
sgl
H
424
H
2-MeO-benzyl
H
sgl
H
425
H
2-OH-benzyl
H
sgl
H
426
H
2-CO2Me-3-MeO-phenyl
H
sgl
H
427
H
2,6-diF-phenyl
H
sgl
H
428
H
phenyl-CH\u2550CH\u2014
H
sgl
H
429
H
(2-Me-4-MeO-phenyl)-CH\u2550CH\u2014
H
sgl
H
430
H
\u2014NMe2
H
sgl
H
431
H
1-pyrrolidinyl
H
sgl
H
432
H
\u2014NTa2
H
sgl
H
433
H
MeO
H
sgl
H
445
H
2-Me-4-MeO-phenyl
Me
sgl
H
446
H
2-CF3-4-MeO-phenyl
Me
sgl
H
458
Me
2-CF3-4-MeO-phenyl
H
sgl
H
459
Me
2,4-diCl-phenyl
H
sgl
H
460
H
3-CN-phenyl
H
sgl
H
461
H
2-Me-4-CN-phenyl
H
sgl
H
462
H
2-Me-3-CN-phenyl
H
sgl
H
463
H
2-CN-phenyl
H
sgl
H
464
H
2-CF3-4-CN-phenyl
Me
sgl
H
465
H
3-CHO-phenyl
Me
sgl
H
466
H
3-CH2(OH)-phenyl
Me
sgl
H
467
H
3-CH2(OMe)-phenyl
Me
sgl
H
468
H
3-CH2(NMe2)-phenyl
Me
sgl
H
469
H
3-CN-4-F-phenyl
Me
sgl
H
470
H
3-CONH2-4-F-phenyl
Me
sgl
H
581
H
phenyl-NH\u2014
H
sgl
H
583
H
(4-F-phenyl)-NH\u2014
H
sgl
H
584
H
(2,4-diCl-phenyl)-NH\u2014
H
sgl
H
585
H
phenyl-C(\u2550O)NH\u2014
H
sgl
H
586
H
benzyl-NH\u2014
H
sgl
H
587
H
phenyl-S\u2014
H
sgl
H
589
H
2-CH2(NH2)4-MeO-phenyl-
H
sgl
H
590
H
2-Me-4-MeO-phenyl-
H
sgl
H
592
H
(2-Me-4-MeO-phenyl)-NH\u2014
H
sgl
H
593
H
(2-F-4-MeO-phenyl)-NH\u2014
H
sgl
H
595
H
(2-Me-4-F-phenyl)-NH\u2014
H
sgl
H
596
H
2-CH(OH)Me-4-F-phenyl
H
sgl
H
or pharmaceutically acceptable salt forms thereof.
32. A compound of claim 1 selected from the compounds closed in Table 2A:
TABLE 2A
Ex #
n
k
m
R7
R8
R9
b
R1
479
2
2
1
H
2,4-diCl-phenyl
H
sgl
H
480
2
2
1
H
2-Cl-4-MeO-phenyl
H
sgl
H
481
2
2
1
H
2-Me-4-MeO-phenyl
H
sgl
H
482
2
2
1
H
Br
H
sgl
H
497
1
1
1
H
2-Cl-phenyl
H
sgl
H
498
1
1
1
H
3-Cl-phenyl
H
sgl
H
499
1
1
1
H
3-F-phenyl
H
sgl
H
500
1
1
1
H
4-Cl-phenyl
H
sgl
H
501
1
1
1
H
4-F-phenyl
H
sgl
H
502
1
1
1
H
2,3-diCl-phenyl
H
sgl
H
503
1
1
1
H
2,4-diF-phenyl
H
sgl
H
504
1
1
1
H
3,5-diCl-phenyl
H
sgl
H
505
1
1
1
H
3,5-diF-phenyl
H
sgl
H
506
1
1
1
H
3,4-diCl-phenyl
H
sgl
H
507
1
1
1
H
3,4-diF-phenyl
H
sgl
H
508
1
1
1
H
3-Cl-4-F-phenyl
H
sgl
H
509
1
1
1
H
2-F-4-Cl-phenyl
H
sgl
H
or pharmaceutically acceptable salt forms thereof.
33. A compound of claim 1 selected from the compounds disclosed in Table 3A:
TABLE 3A
Ex #
n
k
m
R7
R8
R9
b
R1
173
1
1
1
H
2,4-diCl-phenyl
H
sgl
H
174
1
1
1
H
2-Cl-4-MeO-phenyl
H
sgl
H
436
1
1
1
H
2-Cl-phenyl
H
sgl
H
497
1
1
1
H
2-Cl-phenyl
H
sgl
H
498
1
1
1
H
3-Cl-phenyl
H
sgl
H
499
1
1
1
H
3-F-phenyl
H
sgl
H
500
1
1
1
H
4-Cl-phenyl
H
sgl
H
501
1
1
1
H
4-F-phenyl
H
sgl
H
502
1
1
1
H
2,3-diCl-phenyl
H
sgl
H
503
1
1
1
H
2,3-diF-phenyl
H
sgl
H
504
1
1
1
H
3,5-diCl-phenyl
H
sgl
H
505
1
1
1
H
3,5-diF-phenyl
H
sgl
H
506
1
1
1
H
3,4-diCl-phenyl
H
sgl
H
507
1
1
1
H
3,4-diF-phenyl
H
sgl
H
508
1
1
1
H
3-Cl-4-F-phenyl
H
sgl
H
509
1
1
1
H
2-F-4-Cl-phenyl
H
sgl
H
510
1
1
1
H
2-Cl-4-F-phenyl
H
sgl
H
511
1
1
1
H
2,5-diCl-phenyl
H
sgl
H
512
1
1
1
H
2,6-diCl-phenyl
H
sgl
H
513
1
1
1
H
2-CF3-phenyl
H
sgl
H
514
1
1
1
H
4-CF3-phenyl
H
sgl
H
515
1
1
1
H
2,4-diCF3-phenyl
H
sgl
H
516
1
1
1
H
2-Cl-4-CF3-phenyl
H
sgl
H
517
1
1
1
H
2-MeO-phenyl
H
sgl
H
518
1
1
1
H
2,4-diMeO-phenyl
H
sgl
H
519
1
1
1
H
2-MeO-5-iPr-phenyl
H
sgl
H
520
1
1
1
H
3-NO2-phenyl
H
sgl
H
521
1
1
1
H
2-CHO-phenyl
H
sgl
H
522
1
1
1
H
2-CH(Me)(OH)-phenyl
H
sgl
H
523
1
1
1
H
2-CH2(OH)-phenyl
H
sgl
H
524
1
1
1
H
2-CHO-4-MeO-phenyl
H
sgl
H
525
1
1
1
H
2-OH-phenyl
H
sgl
H
526
1
1
1
H
2-CF3-4-EtO-phenyl
H
sgl
H
527
1
1
1
H
2-CF3-4-iPrO-phenyl
H
sgl
H
532
1
1
1
H
2-Me-4-MeO-phenyl
H
sgl
H
533
1
1
1
H
2-CF3-4-MeO-phenyl
H
sgl
H
534
1
2
1
H
3,4,5-triMeo-phenyl
H
sgl
H
535
1
2
1
H
1-naphthyl
H
sgl
H
536
1
2
1
H
3-MeO-phenyl
H
sgl
H
537
1
2
1
H
2,4-diCl-phenyl
H
sgl
H
543
2
1
1
H
2,6-diF-phenyl
H
sgl
H
547
2
1
1
H
2-CF3-4-MeO-phenyl
H
sgl
H
548
2
1
1
H
2-Me-4-MeO-phenyl
H
sgl
H
549
2
1
1
H
2-Cl-4-CF3-phenyl
H
sgl
H
550
2
1
1
H
2,3-diCl-phenyl
H
sgl
H
551
2
1
1
H
2,4-diMeO-phenyl
H
sgl
H
552
2
1
1
H
3,4-diMeO-phenyl
H
sgl
H
553
2
1
1
H
2,4-diCl-phenyl
H
sgl
H
554
2
1
1
H
3,4-diCl-phenyl
H
sgl
H
555
2
1
1
H
2,5-diCl-phenyl
H
sgl
H
556
2
1
1
H
2-CF3-phenyl
H
sgl
H
557
2
1
1
H
2-Me-phenyl
H
sgl
H
558
2
1
1
H
2-Cl-phenyl
H
sgl
H
559
2
1
1
H
3-F-phenyl
H
sgl
H
560
2
1
1
H
phenyl
H
sgl
H
561
2
1
1
H
2-CF3-4-EtO-phenyl
H
sgl
H
562
2
1
1
H
2-CF3-4-iPrO-phenyl
H
sgl
H
563
2
1
1
H
2-MeO-4-iPr-phenyl
H
sgl
H
564
2
1
1
H
2-F-4-Cl-phenyl
H
sgl
H
565
2
1
1
H
2-Cl-4-MeO-phenyl
H
sgl
H
566
2
1
1
H
2-CHO-phenyl
H
sgl
H
567
2
1
1
H
2-CHO-4-MeO-phenyl
H
sgl
H
568
2
1
1
H
2-CH2(OH)-4-MeO-
H
sgl
H
phenyl
569
2
1
1
H
2-CH2(OH)-phenyl
H
sgl
H
570
2
1
1
H
2-CF3-4-NHMe-
H
sgl
H
phenyl
571
2
1
1
H
2-CF3-4-NH2-phenyl
H
sgl
H
572
2
1
1
H
2-C(\u2550O)Me-phenyl
H
sgl
H
573
2
1
1
H
2-C(\u2550O)Me-4-MeO-
H
sgl
H
phenyl
574
2
1
1
H
2-CH(Me)(OH)-phenyl
H
sgl
H
575
2
1
1
H
2-CH(Me)(OH)-4-
H
sgl
H
MeO-phenyl
576
2
1
1
H
2-CF3-4-OH-phenyl
H
sgl
H
577
2
1
1
H
2-CF3-4-O(C\u2550O)Me-
H
sgl
H
phenyl
or pharmaceutically acceptable salt forms thereof.