What is claimed is:
1. A table for positioning a patient for a medical procedure on a breast, the table comprising:
a supporting platform having at least a front end for supporting said patient’s torso while said patient is in a prone position, and a cavity at said front end for allowing said breast and a surrounding axilla region to be pendantly suspended therethrough; and
an armrest for positioning and supporting a forearm such that a shoulder adjacent to said axilla region is at a desired height, wherein said armrest is lower than said platform.
2. A table as claimed in claim 1, wherein said armrest comprises a structure for immobilizing said arm such that said arm is maintained in a fixed position.
3. A table as claimed in claim 2, wherein said structure is a material covering a surface of said armrest and having a friction coefficient such that said arm remains in a position in which it is placed.
4. A table as claimed in claim 1, wherein said armrest is adjustable in height and position with respect to said supporting platform.
5. A table as claimed in claim 4, wherein said armrest is fixed with respect to a base and said supporting platform is adjustable in height.
6. A table as claimed in claim 1, wherein said table has a lateral depression for allowing an arm and a shoulder adjacent to said breast to extend over said table, rest on said armrest, and be lowered such that skin from said axilla region is relaxed and extends through said cavity.
7. A table as claimed in claim 6, wherein said table is configured to provide said depression on each side of said cavity in a position where a right shoulder would be when a right breast is in the cavity and a left shoulder would be when a left breast is in the cavity.
8. A table as claimed in claim 7, wherein said supporting platform further comprises a disc plate engaged into said front end and housing said cavity, said disc plate pivotable about an axis such that said lateral depression is provided on a left side of said table when a left breast is in said cavity and on a right side of said table when a right breast is in said cavity.
9. A table as claimed in claim 8, wherein said disc plate further comprises a smaller disc plate housing said cavity, wherein said smaller disc plate is adjacent to said lateral depression and is provided on a left side of said table when a left breast is in said cavity and on a right side of said table when a right breast is in said cavity, and said smaller disc plate is moveable about a plurality of axes independently from said disc plate such that said cavity is adjustable in position and size.
10. A table as claimed in claim 9, wherein said smaller disc plate is comprised of two compression members having linear movement relative to each other for adjusting said cavity in size, at least one of said compression members is removable to provide said lateral depression, and wherein said compression members have linear movement relative to said disc plate.
11. A table as claimed in claim 1, wherein said cavity is substantially pear-shaped such that a larger portion is for the breast and a narrower portion is for the axilla region, and said cavity is positioned at an angle such that said narrower portion faces an outer side of said table.
12. A table as claimed in claim 11, wherein said table is configured such that said pear-shaped cavity is displaced to provide said narrower portion on a left side of said table when a left breast is in said cavity and on a right side of said table when a right breast is in said cavity.
13. A table as claimed in claim 1, further comprising a headrest adjacent to said front end for supporting a head of said patient while in said prone position.
14. A table as claimed in claim 13, wherein said headrest is configured to be laterally displaceable with respect to said supporting platform.
15. A method for positioning a patient on a table for a medical procedure on a breast, the method comprising:
placing said patient face down in a prone position on a supporting platform such that at least said patient’s torso is supported;
providing a cavity in said supporting platform such that said breast and a surrounding axilla region are pendantly suspended therethrough; and
positioning an arm of said patient adjacent to said breast such that a shoulder is at a desired position to expose a maximum volume of said axilla region through said cavity.
16. A method as claimed in claim 15, wherein said positioning an arm comprises positioning said shoulder by positioning an elbow of said arm.
17. A method as claimed in claim 15, wherein said positioning an arm comprises placing a forearm and elbow of said arm on an armrest.
18. A method as claimed in claim 17, wherein said positioning an arm comprises positioning said elbow with respect to said armrest.
19. A method as claimed in claim 17, wherein said positioning an arm comprises changing a relative position between said armrest and said supporting platform.
20. A method as claimed in claim 17, wherein said positioning an arm comprises immobilizing said arm on said armrest such that it remains in a fixed position once it has been placed.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of Formula (I)
including stereochemically isomeric forms, and N-oxides, salts, hydrates, and solvates thereof, wherein:
R1 is a bivalent chain selected from
each R3 is independently selected from the group comprising hydrogen, C1-4alkyl and C3-5cycloalkyl;
a is 3, 4, 5 or 6;
each b is independently 1 or 2;
c is 1 or 2;
macrocycle A has 14 to 18 member atoms, in particular macrocycle A has 17 or 18 member atoms;
each R2 is independently hydrogen, halo or C1-4alkoxy;
R4 and R5 are hydrogen or R4 and R5 together form a double bond or a methylene group to form a fused cyclopropyl;
R6 is hydrogen or methyl; and
R7 is a C3-7cycloalkyl optionally substituted with halo.
2. A compound according to claim 1 wherein,
R1 is selected from \u2014N(R3)\u2014(CH2)4\u2014N(R3)\u2014,
and,
each R3 is independently selected from hydrogen and methyl.
3. A compound according to any of claim 1 or 2 wherein R2 is positioned the benzene group in para with respect to the bond linking this benzene to the indole group.
4. A compound according to any of claims 1 to 3 wherein R2 is selected from fluoro and methoxy.
5. A compound according to any of claims 1 to 4 wherein R7 is selected from cyclohexyl and 2-fluorocyclohexyl.
6. A compound according to any of claims 1 to 5 wherein R4 and R5 together form a double bond.
7. A compound according to any of claims 1 to 5 wherein the compounds of formula (I) have the stereochemical configuration as illustrated by formula (IA).
8. A compound according to any of claims 1 to 3, having one of the structural formula II-1, II-2, II-3, III-1, III-2, III-3, III-4, IV-1, IV-2 or IV-3
9. A pharmaceutical composition comprising a carrier, and as active ingredient an anti-virally effective amount of a compound as claimed in any of claims 1 to 8.
10. A pharmaceutical composition according to claim 9, further comprising at least one other anti-HCV compound.
11. A pharmaceutical composition according to claim 9 or 10, further comprising at least one anti HIV compound.
12. A compound according to any of claims 1 to 8 or a pharmaceutical composition according to any of claims 9 to 11, for use as a medicament.
13. A compound according to any of claims 1 to 8 or a pharmaceutical composition according to any of claims 9 to 11, for inhibiting HCV replication.
14. Use of a compound according to any of claims 1 to 8, for the manufacture of a medicament for inhibiting HCV replication.