1. A compound of Formula (I):
wherein:
Ar is phenyl, unsubstituted or substituted with one, two or three substituents independently selected from halogen and alkoxy; and
Ar\u2032 is phenyl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl, haloalkyl, \u2014SO2N(CH3)2, \u2014CN and halogen, or heteroaryl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl, haloalkyl and halogen,
or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1, wherein Ar is phenyl substituted with one, two or three substituents independently selected from chlorine, fluorine and \u2014OCH3.
3. The compound according to claim 1, wherein Ar is phenyl substituted with one or two substituents independently selected from chlorine and fluorine.
4. The compound according to claim 1, wherein Ar\u2032 is phenyl substituted with one or two substituents independently selected from methyl, \u2014CF3, \u2014SO2N(CH3)2, \u2014CN, chlorine and fluorine.
5. The compound according to claim 1, wherein Ar\u2032 is pyrazolyl or pyridinyl, substituted with one or two substituents independently selected from methyl and \u2014CF3.
6. The compound according to claim 1, wherein said compound is:
2-(E)-2-(2-Chloro-phenyl)-vinyl-6-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-pyridin-3-yl-methyl-amine;
2-(2-Chloro-6-fluoro-phenyl)-5-(6-chloro-4-methyl-pyridin-3-yl)-1H-pyrrolo3,2bpyridine;
2-(2-Chloro-6-fluoro-phenyl)-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-pyrrolo3,2-bpyridine;
2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo3,2-bpyridine;
4-(2-(2-chloro-6-fluorophenyl)-1H-pyrrolo3,2-bpyridin-5-yl)-3-methylbenzonitrile;
4-(2-(2-chloro-6-fluorophenyl)-1H-pyrrolo3,2-bpyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide;
4-2-(2-Chloro-phenyl)-1H-pyrrolo3,2-bpyridin-5-yl-3,N,N-trimethyl-benzenesulfonamide;
2-(2-Chloro-4-fluoro-phenyl)-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-pyrrolo3,2-bpyridine;
4-2-(2-Chloro-4-fluoro-phenyl)-1H-pyrrolo3,2-bpyridin-5-yl-3,N,N-trimethyl-benzenesulfonamide;
4-2-(2,6-Difluoro-phenyl)-1H-pyrrolo3,2-bpyridin-5-yl-3,N,N-trimethyl-benzenesulfonamide;
4-2-(2,6-Difluoro-phenyl)-1H-pyrrolo3,2-bpyridin-5-yl-3-methyl-benzonitrile;
2-(2,6-Difluoro-phenyl)-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-pyrrolo3,2-bpyridine; or
4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo3,2-bpyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide.
7. A pharmaceutical composition, comprising a therapeutically effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier.
8. A method for treating arthritis, comprising the step of administering a therapeutically effective amount of a compound according to claim 1 to a subject in need thereof.
9. A method for treating a respiratory disorder, comprising the step of administering a therapeutically effective amount of a compound according to claim 1 to a subject in need thereof.
10. The method according to claim 9, wherein said respiratory disorder is chronic obstructive pulmonary disorder (COPD), asthma or bronchospasm.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A mortise lock, comprising:
a housing;
a live bolt slidably mounted in the housing for movement between extended and retracted positions;
an actuator for moving the live bolt;
a mortise plate mounted to the housing and having an opening through which the live bolt extends;
a finger pivotally mounted in the housing for movement between a first position to limit retraction of the live bolt and a second position to allow full retraction of the live bolt beyond the mortise plate;
the finger pivoting by gravity between the first and second positions; and
the live bolt being pivotally mounted in the housing for 180\xb0 rotation when the finger is in the second position and the live bolt is fully retracted, whereby the mortise lock is usable on opposite edges of the door.
2. The mortise lock of claim 1 wherein the finger is in the first position when the housing is upright and the finger is in the second position when the housing is inverted.
3. The mortise lock of claim 1 further comprising a dead bolt mounted in the housing.
4. The mortise lock of claim 1 wherein the live bolt is spring biased towards the extended position.
5. A mortise lock, comprising:
a housing;
a live bolt pivotally and slidably mounted in the housing;
the live bolt sliding between an extended position beyond the housing and a fully retracted position within the housing;
a finger pivotally mounted on the housing for movement between a first position to engage the live bolt upon partial retractions and preclude further retraction to the fully retracted position when the mortise lock is installed and a second position disengaged from the live bolt before the mortise lock is installed to allow rotation of the live bolt;
the finger pivoting by gravity between the first and second positions; and
the live bolt being rotatable 180\xb0 when in the fully retracted position to reverse the mortise lock from left-handed to right-handed.
6. The mortise lock of claim 5 wherein the finger is in the first position when the housing is upright and the finger is in the second position when the housing is inverted.
7. The mortise lock of claim 5 further comprising a dead bolt mounted in the housing.
8. The mortise lock of claim 5 wherein the live bolt is spring biased towards the extended position.
9. The mortise lock of claim 5 further comprising a mortise plate mounted on the housing and having an opening through which the live bolt extends when in the extended position.
10. The mortise lock of claim 9 wherein the live bolt has a leading edge which is substantially flush with the mortise plate when the live bolt engages the finger and is behind the mortise plate when in the fully retracted position.
11. A method of reversing a mortise lock from left to right sides, the mortise lock having a housing with a live bolt rotatably and slidably mounted in the housing, the method comprising:
sliding the live bolt from an extended position outside the housing to a retracted position within the housing; then
rotating the live bolt 180\xb0 top to bottom;
moving a finger from a blocking position to a non-blocking position before the mortise lock is installed for rotating, the live bolt; and
moving the finger between the blocking and non-blocking positions by gravity;
then sliding the live bolt to the extended position.
12. The method of claim 11 further comprising blocking the live bolt from movement to the retracted position after the mortise lock is installed in a door.
13. The method of claim 12 wherein the blocking is accomplished with the finger engaging the live bolt upon partial retraction from the extended position.
14. The method of claim 11 wherein the finger moves between the blocking and non-blocking position by turning the housing 180\xb0 top to bottom about a horizontal axis.
15. A mortise lock, comprising:
a housing;
a live bolt slidably mounted in the housing for movement between extended and retracted positions;
an actuator for moving the live bolt;
a mortise plate mounted to the housing and having an opening through which the live bolt extends;
a finger pivotally mounted in the housing for movement between a first position to limit retraction of the live bolt and a second position to allow full retraction of the live bolt beyond the mortise plate;
the live bolt being pivotally mounted in the housing for 180\xb0 rotation when the finger is in the second position and the live bolt is full retracted, whereby the mortise lock is usable on opposite edges of the door; and
the finger being in the first position when the housing is upright and the finger being in the second position when the housing is inverted.
16. The mortise lock of claim 15 wherein the finger pivots by gravity between the first and second positions.
17. The mortise lock of claim 15 further comprising a dead bolt mounted in the housing.
18. The mortise lock of claim 15 wherein the live bolt is spring biased towards the extended position.
19. A mortise lock, comprising:
a housing; and
a live bolt pivotally and slidably mounted in the housing;
the live bolt sliding between an extended position beyond the housing and a fully retracted position within the housing;
the live bolt being rotatable 180\xb0 when in the fully retracted position to reverse the mortise lock from left-handed to right-handed;
a finger pivotally mounted on the housing for movement between a first position to engage the live bolt upon partial retractions and preclude further retraction to the fully retracted position when the mortise lock is installed and a second position disengaged from the live bolt before the mortise lock is installed to allow rotation of the live bolt; and
the finger being in the first position when the housing is upright and the finger being in the second position when the housing is inverted.
20. The mortise lock of claim 19 wherein the finger pivots by gravity between the first and second positions.
21. The mortise lock of claim 19 further comprising a dead bolt mounted in the housing.
22. The mortise lock of claim 19 wherein the live bolt is spring biased towards the extended position.
23. The mortise lock of claim 19 further comprising a mortise plate mounted on the housing and having an opening through which the live bolt extends when in the extended position.
24. The mortise lock of claim 23 wherein the live bolt has a leading edge which is substantially flush with the mortise plate when the live bolt engages the finger and is behind the mortise plate when in the fully retracted position.
25. A method of reversing a mortise lock from left to right sides, the mortise lock having a housing with a live bolt rotatably and slidably mounted in the housing, the method comprising:
sliding the live bolt from an extended position outside the housing to a retracted position within the housing; then
rotating the live bolt 180\xb0 top to bottom;
then sliding the live bolt to the extended position;
moving a finger from a blocking position to a non-blocking position before the mortise lock is installed for rotating the live bolt; and
moving the finger between the blocking and non-blocking position by turning the housing 180\xb0 top to bottom about a horizontal axis.
26. The method of claim 25 further comprising blocking the live bolt from movement to the retracted position after the mortise lock is installed in a door.
27. The method of claim 25 wherein the blocking is accomplished with the finger engaging the live bolt upon partial retraction from the extended position.
28. The method of claim 25 wherein the finger moves between the blocking and non-blocking positions by gravity.