1. An aerosol antiperspirant composition, comprising:
a liquid propellant having a concentration from 30% to 65% by weight of aerosol antiperspirant composition;
an antiperspirant composition comprising
one or more liquid materials, wherein the one or more liquid materials comprise one or more non-volatile silicone fluids having a concentration from 40% to about 70% by weight of the antiperspirant composition;
antiperspirant active particulates;
one or more non-antiperspirant active particulates that are substantially inert; and
wherein the antiperspirant composition has a total particulate concentration from 30% to about 60% by weight of the antiperspirant composition and the antiperspirant composition has a viscosity from 1,000 centipoise to about 50,000 centipoise.
2. The aerosol antiperspirant composition of claim 1, wherein the antiperspirant composition is in the form of a dispersion.
3. An aerosol antiperspirant composition according to claim 1, wherein the one or more liquid materials of the antiperspirant composition consist essentially of the one or more non-volatile silicone fluids and optionally a liquid fragrance material and optionally a silicone gum.
4. An aerosol antiperspirant composition according to claim 1, further comprising a particulate fragrance material having a concentration from about 0.25% to about 5% by weight of the antiperspirant composition.
5. An aerosol antiperspirant composition according to claim 1, further comprising a liquid fragrance material having a concentration less than 4% by weight of the antiperspirant composition.
6. An aerosol antiperspirant composition according to claim 1, wherein the one or more non-volatile silicone fluids have a concentration from about 40% to 55% by weight of the antiperspirant composition.
7. An aerosol antiperspirant composition according to claim 1, wherein the total particulate concentration is from 40% to about 50% by weight of the antiperspirant composition.
8. An aerosol antiperspirant composition according to claim 1, wherein the antiperspirant composition is substantially or completely free of a silicone gum.
9. An aerosol antiperspirant composition according to claim 1, wherein the ratio of total liquid materials to total particulate materials is from about 0.6 to about 1.4.
10. An aerosol antiperspirant composition according to claim 1, wherein the one or more non-volatile silicone fluids consists essentially of a polydimethyl siloxane fluid having a viscosity of about 50 centistokes.
11. An antiperspirant composition according to claim 1, wherein the one or more liquid materials comprise less than 10% by weight of volatile silicone fluids.
12. An antiperspirant composition according to claim 1, wherein the antiperspirant composition is substantially or completely free of volatile silicone fluids.
13. An aerosol antiperspirant composition according to claim 1, wherein the particulates of the antiperspirant active have a concentration less than 34% by weight of the antiperspirant composition.
14. An aerosol antiperspirant composition according to claim 1, further comprising one or more bulking or suspending materials selected from the group consisting of a silica material, a clay material and combinations thereof.
15. An aerosol antiperspirant composition according to claim 1, wherein the one or more non-antiperspirant active particulates are selected from the group consisting of particulate fragrance materials, native starches and combinations thereof.
16. An aerosol antiperspirant composition according to claim 1, wherein the antiperspirant composition has a viscosity greater than 3,000 centipoises.
17. An aerosol antiperspirant composition according to claim 1, wherein the liquid propellant has a concentration from about 50% to 65% by weight of the aerosol antiperspirant composition.
18. An aerosol antiperspirant composition according to claim 1, wherein the ratio the antiperspirant particulate concentration to the total particulate concentration is less than or equal to about 0.75.
19. A product, comprising a reservoir, an actuator comprising a discharge orifice, and a valve in fluid communication with the discharge orifice and the reservoir, the reservoir storing an aerosol antiperspirant composition according to claim 1.
20. A method of using the product of claim 19, wherein the antiperspirant composition is sprayed onto an axillia surface.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
We claim:
1. A process for making Azithromycin monohydrate crystals, said process comprising the steps of:
(a) dissolving 9-Deoxo-9a-aza-9a-homoerythromycin A in a non-halogenated, water miscible, and non-aqueous solvent to form a solution;
(b) adding formic acid and formaldehyde to said solution;
(c) refluxing said solution to form a reaction mixture;
(d) adjusting the pH of said reaction mixture from about 10 to about 11 with alkaline solution;
(e) optionally filtering the pH adjusted reaction mixture of step (d);
(f) adding water to said reaction mixture to precipitate said Azithromycin monohydrate crystals;
(g) filtering out said Azithromycin monohydrate crystals precipitated in said step (f); and
(h) drying said Azithromycin monohydrate crystals.
2. The process of claim 1, wherein said drying step (h) comprises drying said Azithromycin monohydrate crystals at 50 C. under vacuum to attain a moisture content from about 4% to about 6% based on a total weight of said crystals.
3. The process of claim 1, wherein in said step (a), said non-halogenated solvent is selected from the group consisting of acetonitrile, acetone, N,N-dimethylformamide, N,N-dimethylacetamide, and iso-propanol.
4. The process of claim 3, wherein said non-halogenated solvent is acetonitrile.
5. The process of claim 1, wherein said alkaline solution is selected from the group consisting of sodium hydroxide solution, potassium hydroxide solution, and ammonium hydroxide solution.
6. The process of claim 5, wherein said alkaline solution is sodium hydroxide solution.
7. The process of claim 1, wherein said optional step (e) is conducted.
8. The process of claim 1, wherein said refluxing step (c) is conducted for 24 hours in acetonitrile.
9. The process of claim 1, wherein said drying step is conducted at a temperature and pressure sufficient to substantially remove said water and said acetonitrile from said crystals to yield substantially dry crystals of Azithromycin monohydrate having a moisture content from about 4 to about 6% by weight based on a total weight of said crystals.
10. A process for making Azithromycin monohydrate crystals, said process comprising the steps of:
(a) dissolving 9-Deoxo-9a-aza-9a-homoerythromycin A in a non-halogenated, water miscible, and non-aqueous solvent to form a solution;
(b) adding formic acid and formaldehyde to said solution;
(c) refluxing said solution to form a reaction mixture;
(d) adjusting the pH of said reaction mixture from about 10 to about 11 with alkaline solution; and
(e) optionally filtering the pH adjusted reaction mixture of step (d);
(f) adding water to said reaction mixture to precipitate said Azithromycin monohydrate crystals.
11. The process of claim 10, further comprising the step of:
(g) filtering out said Azithromycin monohydrate crystals precipitated from step (f).
12. The process of claim 11, further comprising the step of:
(h) drying said Azithromycin monohydrate crystals.
13. The process of claim 1, wherein, in said step (b), said formaldehyde is added to said solution after adding said formic acid.