1. A compound represented by the formula (I):
wherein
R1 is lower alkyl, cycloalkyl or aromatic hydrocarbon ring,
each of which is optionally substituted with one or more substituents;
R2 is halogen atom, lower alkyl, halo(lower)alkyl or lower alkoxy; and
R3 is
(1) a group represented by the formula:
wherein
R4 is lower alkyl, lower alkoxy, cycloalkyl, aromatic hetero ring, non-aromatic hetero ring or aromatic hydrocarbon ring, each of which is optionally substituted with one or more substituents;
(2) a group represented by the formula:
wherein
R5 is lower alkyl, cycloalkyl, aromatic hydrocarbon ring, aromatic hetero ring or non-aromatic hetero ring, each of which is optionally substituted with one or more substituents;
(3) a group represented by the formula:
wherein
R6 is lower alkyl, cycloalkyl, aromatic hydrocarbon ring or non-aromatic hetero ring, each of which is optionally substituted with one or more substituents; or
(4) a group selected from halogen atom, carboxy, hydroxy and lower alkoxy,
or a salt thereof.
2. The compound of claim 1, wherein
R1 is lower alkyl, cycloalkyl or aromatic hydrocarbon ring,
each of which is optionally substituted with one or more substituents;
R2 is halogen atom or lower alkyl; and
R3 is
(1) a group represented by the formula:
wherein
R4 is lower alkoxy, cycloalkyl, aromatic hetero ring or aromatic hydrocarbon ring, each of which is optionally substituted with one or more substituents,
(2) a group represented by the formula:
wherein
R5 is cycloalkyl, aromatic hydrocarbon ring or aromatic hetero ring, each of which is optionally substituted with one or more substituents; or
(3) a group represented by the formula:
wherein
R6 is cycloalkyl, which is optionally substituted with one or more substituents,
or a salt thereof.
3. The compound of claim 2, wherein
R1 is
(1) (C1-6) alkyl optionally substituted with one (C6-16) aryl,
(2) (C3-7) cycloalkyl, or
(3) (C6-16) aryl optionally substituted with 1 to 3 substituents selected from halogen atom, (C1-6)alkyl and (C6-16) aryl;
R2 is halogen atom or (C1-6)alkyl, and
R3 is
(1) a group represented by the formula:
wherein
R4 is (C1-6)alkoxy, (C3-7) cycloalkyl, 5- to 14-membered aromatic hetero ring or (C6-16)aryl, each of which is optionally substituted with 1 to 3 substituents selected from (C1\u20146) alkyl, (C3-7) cycloalkyl and (C6-16) aryl,
(2) a group represented by the formula:
wherein
R5 is (C3-7)cycloalkyl, (C6-16)aryl or 5- to 14-membered aromatic hetero ring, each of which is optionally substituted with 1 to 3 substituents selected from (C1-6)alkyl and (C6-16)aryl which is optionally substituted with (C1-6)alkyl, or
(3) a group represented by the formula:
wherein
R6 is (C3-7)cycloalkyl,
or a salt thereof.
4. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 4, which is for the prevention or the treatment of a disease selected from the group consisting of pain, rheumatoid arthritis, other conditions associated with inflammation, Crohn’s disease, inflammatory bowel disease and psoriasis.
6. A method for preventing or treating a disease selected from the group consisting of pain, rheumatoid arthritis, other conditions associated with inflammation, Crohn’s disease, inflammatory bowel disease and psoriasis, which comprises administering an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof to a mammal in need thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A gas turbine, comprising:
a plurality of turbine bladesvanes respectively combined to form bladevane rows, each turbine bladevane including an integrated cooling air duct, wherein the turbine bladesvanes forming a first turbine bladevane row and the turbine bladesvanes forming a second bladevane row downstream thereof, viewed in the flow direction of a working medium, are connected one behind the other on a cooling air side, with an intermediate connection of an injection device for water.
2. The gas turbine as claimed in claim 1, wherein the first and the second bladevane rows are respectively formed as a guide vane row by a plurality of guide vanes connected to a turbine casing.
3. The gas turbine as claimed in claim 1, wherein the first and the second bladevane rows are respectively formed as a rotor blade row by a number of rotor blades arranged on a turbine shaft.
4. The gas turbine as claimed in claim 3, wherein both rotor blade rows following one another, viewed in the flow direction of the working medium, and guide vane rows following one another, viewed in the flow direction of the working medium, are respectively connected one behind the other on the cooling air side with the intermediate connection of an associated injection device for water.
5. The gas turbine as claimed in claim 1, wherein a number of the turbine bladesvanes have a number of cooling air outlets in a region of a rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoils.
6. A method of operating a gas turbine as claimed in claim 1, comprising:
intercooling the cooling air, flowing out of the turbine bladesvanes forming the first bladevane row, by the injection of water, and
supplying the intercooled water to the cooling air ducts of the turbine bladesvanes forming the second bladevane row.
7. The method as claimed in claim 6, wherein, within a turbine bladevane, a partial flow of the cooling air flowing through this turbine bladevane is branched off and mixed into the working medium by a number of cooling air outlets arranged in the region of the rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoil.
8. The gas turbine as claimed in claim 2, wherein a number of the turbine bladesvanes have a number of cooling air outlets in a region of a rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoils.
9. The gas turbine as claimed in claim 3, wherein a number of the turbine bladesvanes have a number of cooling air outlets in a region of a rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoils.
10. The gas turbine as claimed in claim 4, wherein a number of the turbine bladesvanes have a number of cooling air outlets in a region of a rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoils.
11. A method of operating a gas turbine as claimed in claim 2, comprising:
intercooling the cooling air, flowing out of the turbine bladesvanes forming the first bladevane row, by the injection of water, and
supplying the intercooled water to the cooling air ducts of the turbine bladesvanes forming the second bladevane row.
12. The method as claimed in claim 11, wherein, within a turbine bladevane, a partial flow of the cooling air flowing through this turbine bladevane is branched off and mixed into the working medium by a number of cooling air outlets arranged in the region of the rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoil.
13. A method of operating a gas turbine as claimed in claim 3, comprising:
intercooling the cooling air, flowing out of the turbine bladesvanes forming the first bladevane row, by the injection of water, and
supplying the intercooled water to the cooling air ducts of the turbine bladesvanes forming the second bladevane row.
14. The method as claimed in claim 13, wherein, within a turbine bladevane, a partial flow of the cooling air flowing through this turbine bladevane is branched off and mixed into the working medium by a number of cooling air outlets arranged in the region of the rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoil.
15. A method of operating a gas turbine as claimed in claim 4, comprising:
intercooling the cooling air, flowing out of the turbine bladesvanes forming the first bladevane row, by the injection of water, and
supplying the intercooled water to the cooling air ducts of the turbine bladesvanes forming the second bladevane row.
16. The method as claimed in claim 15, wherein, within a turbine bladevane, a partial flow of the cooling air flowing through this turbine bladevane is branched off and mixed into the working medium by a number of cooling air outlets arranged in the region of the rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoil.
17. A method of operating a gas turbine as claimed in claim 5, comprising:
intercooling the cooling air, flowing out of the turbine bladesvanes forming the first bladevane row, by the injection of water, and
supplying the intercooled water to the cooling air ducts of the turbine bladesvanes forming the second bladevane row.
18. The method as claimed in claim 17, wherein, within a turbine bladevane, a partial flow of the cooling air flowing through this turbine bladevane is branched off and mixed into the working medium by a number of cooling air outlets arranged in the region of the rear edge, viewed in the flow direction of the working medium, of their bladevane aerofoil.