1. A biocompatible polymer comprising:
a) one or more ECM-mimetic peptides; and
b) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;
wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da.
2. The polymer according to claim 1, having the formula:
wherein:
Mim is the ECM-mimetic peptide and has the formula:
-Xaa-Xbb-Xcc-Xdd-Xeex-
wherein Xaa, Xbb, Xcc, Xdd, and Xee are each independently an amino acid residue chosen from:
i) glycine or a conservative substitution thereof,
ii) valine or a conservative substitution thereof, and
iii) proline or a conservative substitution thereof,
BioDeg is the non-amino acid or residue thereof containing one or more biodegradable moieties;
the index x is an integer from 1 to 30;
the index y is an integer from 1 to 10; and
the index z is an integer from 1 to 2000.
3. The polymer according to claim 1, wherein the ECM-mimetic peptide comprises residues of amino acids chosen from alanine, \u03b3-aminobutyric acid, 2-aminohexanoic acid, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, homoserine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, phenylgylcine, proline, serine, threonine, tryptophan, tyrosine, and valine.
4. The polymer according to claim 1, wherein the one or more ECM-mimetic peptides are chosen from:
i) Val-Pro-Gly-Val-Gly;
ii) Val-Pro-Gly-Gly-Val;
iii) Val-Pro-Val-Gly-Gly;
iv) Gly-Pro-Gly-Val-Val;
v) Gly-Pro-Val-Gly-Val;
vi) Gly-Pro-Val-Val-Gly;
vii) Pro-Val-Gly-Val-Gly;
viii) Pro-Val-Gly-Gly-Val;
ix) Pro-Val-Val-Gly-Gly;
x) Pro-Gly-Gly-Val-Val;
xi) Pro-Gly-Val-Gly-Val;
xii) Pro-Gly-Val-Val-Gly;
xiii) Val-Gly-Pro-Val-Gly;
xiv) Val-Gly-Pro-Gly-Val;
xv) Val-Val-Pro-Gly-Gly;
xvi) Gly-Gly-Pro-Val-Val;
xvii) Gly-Val-Pro-Gly-Val;
xviii) Gly-Val-Pro-Val-Gly;
xix) Val-Gly-Val-Pro-Gly;
xx) Val-Gly-Gly-Pro-Val;
xxi) Val-Val-Gly-Pro-Gly;
xxii) Gly-Gly-Val-Pro-Val;
xxiii) Gly-Val-Gly-Pro-Val;
xxiv) Gly-Val-Val-Pro-Gly;
xxv) Val-Gly-Val-Gly-Pro;
xxvi) Val-Gly-Gly-Val-Pro;
xxvii) Val-Val-Gly-Gly-Pro;
xxviii) Gly-Gly-Val-Val-Pro;
xxix) Gly-Val-Gly-Val-Pro; and
xxx) Gly-Val-Val-Gly-Pro.
5. The polymer according to claim 1, wherein the one or more biodegradable moieties comprise a hydroxy acid or a residue thereof.
6. The polymer according to claim 1, wherein the one or more biodegradable moieties comprise one or more residues of lactic acid, glycolic acid, lactide, glycolide, valerolactone, caprolactone, hydroxybutyrate, or a mixture thereof.
7. The polymer according to claim 1, wherein the one or more biodegradable moieties comprise a residue of lactic acid or lactide.
8. The polymer according to claim 1, wherein the one or more biodegradable moieties has the formula:
the index w is an integer from is from 0 to 9.
9. The polymer according to claim 1, having the formula:
wherein R1, R2, R3, and R4 are each independently chosen from:
viii) hydrogen;
ix) \u2014CH3;
x) \u2014CH2CH3;
xi) \u2014CH2CH2CH3;
xii) \u2014CH(CH3)2;
xiii) \u2014CH(CH3)CH2CH3; and
xiv) \u2014CH2CH2CH(CH3)2;
the index w is an integer from 0 to 9;
the index x is an integer from 1 to 30; and
the index z is an integer from 1 to 2000.
10. The polymer according to claim 1, having the formula:
wherein R1, R2, R3, and R4 are each independently chosen from:
i) hydrogen;
ii) \u2014CH3;
iii) \u2014CH2CH3;
iv) \u2014CH2CH2CH3;
v) \u2014CH(CH3)2;
vi) \u2014CH(CH3)CH2CH3; and
vii) \u2014CH2CH2CH(CH3)2;
the index w is an integer from 0 to 9;
the index x is an integer from 1 to 30; and
the index z is an integer from 1 to 2000.
11. The polymer according to claim 1, having the formula:
wherein R1, R2, R3, and R4 are each independently chosen from:
i) hydrogen;
ii) \u2014CH3;
iii) \u2014CH2CH3;
iv) \u2014CH2CH2CH3;
v) \u2014CH(CH3)2;
vi) \u2014CH(CH3)CH2CH3; and
vii) \u2014CH2CH2CH(CH3)2;
the index w is an integer from 0 to 9;
the index x is an integer from 1 to 30; and
the index z is an integer from 1 to 2000.
12. The polymer according to claim 1, having the formula:
wherein R1, R2, R3, and R4 are each independently chosen from:
i) hydrogen;
ii) \u2014CH3;
iii) \u2014CH2CH3;
iv) \u2014CH2CH2CH3;
v) \u2014CH(CH3)2;
vi) \u2014CH(CH3)CH2CH3; and
vii) \u2014CH2CH2CH(CH3)2;
the index w is an integer from 0 to 9;
the index x is an integer from 1 to 30; and
the index z is an integer from 1 to 2000.
13. The polymer according to claim 1, having the formula:
wherein R1, R2, R3, and R4 are each independently chosen from:
hydrogen;
i) hydrogen;
ii) \u2014CH3;
iii) \u2014CH2CH3;
iv) \u2014CH2CH2CH3;
v) \u2014CH(CH3)2;
vi) \u2014CH(CH3)CH2CH3; and
vii) \u2014CH2CH2CH(CH3)2;
the index w is an integer from 0 to 9;
the index x is an integer from 1 to 30; and
the index z is an integer from 1 to 2000.
14. The polymer according to claim 2, further comprising a biodegradable or non-biodegradable linker that links the one or more ECM-mimetic peptides to the one or more biodegradable moieties.
15. The polymer according to claim 14, having the formula:
wherein BioDeg is a residue of:
i) lactic acid;
ii) glycolic acid;
iii) lactide;
iv) glycolide;
v) caprolactone;
vi)hydroxybutyrate;
vii) valerolactone;
viii) a hydroxy acid;
ix) a hydroxy fatty acid;
x) lactide-co-glycolide;
xi) lactide-co-caprolactone;
xii) lactide-co-valerolactone;
xiii) glycolide-co-caprolactone;
xiv) glycolide-co-valerolactone;
xv) lactide-co-glycolide-co-caprolactone; or
xvi) lactide-co-glycolide-co-valerolactone;
the index t is an integer from 1 to 10;
the index y is an integer from 1 to 10; and
the index z is an integer from 1 to 2000.
16. The polymer according to claim 1, having the formula:
Xaa-Xbb-Xcc-Xdd-Xeex-BioDegy
wherein:
at least one of Xaa, Xbb, Xcc, Xdd, and Xee is a proline residue; the balance of Xaa, Xbb, Xcc, Xdd, and Xee are independently chosen from glycine, alanine, valine, leucine, and isoleucine;
BioDeg comprises one or more residues of lactide, glycolide, valerolactone, caprolactone, hydroxybutyrate, or mixtures thereof;
the index x is an integer from 1 to 30; and
the index y is an integer from 1 to 10.
17. The polymer according to claim 1, having a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da.
18. The polymer according to claim 1, having a weight-average molecular weight of from about 1,000 Da to about 20,000 Da.
19. The polymer according to claim 1, having a weight-average molecular weight of from about 10,000 Da to about 100,000 Da.
20. The polymer according to claim 1, having a weight-average molecular weight of from about 100,000 Da to about 400,000 Da.
21. The polymer according to claim 1, having a weight-average molecular weight of from about 800,000 Da to about 2,000,000 Da.
22. The polymer according to claim 1, having a weight-average molecular weight of from about 5000 Da to about 20,000 Da.
23. The polymer according to claim 1, having a weight-average molecular weight of from about 10,000 Da to about 20,000 Da.
24. The polymer according to claim 1, having a weight-average molecular weight of from about 50,000 Da to about 2,000,000 Da.
25. The polymer according to claim 16, wherein at least one of Xaa, Xbb, Xcc, Xdd, and Xee is a valine residue.
26. The polymer according to claim 16, wherein at least one of Xaa, Xbb, Xcc, Xdd, and Xee is a glycine residue.
27. The polymer according to claim 2, wherein the conservative substitution for glycine is alanine.
28. The polymer according to claim 2, wherein the conservative substitutions for valine is leucine or isoleucine.
29. The polymer according to claim 1, having the formula:
–Xaa-Xbb-Xcc-Xdd-Xeex-BioDegy-z-
wherein each Xaa, Xbb, Xcc, Xdd, and Xee is an amino acid residue;
BioDeg comprises one or more residues of lactide, glycolide, valerolactone, caprolactone, hydroxybutyrate, or a mixture thereof;
the index x is an integer from 1 to 30;
the index y is an integer from 1 to 10; and
the index z is an integer from 1 to 2,000.
30. The polymer according to claim 29, wherein the index z is an integer from 2 to 6.
31. The polymer according to claim 29, wherein the index z is an integer from 3 to 5.
32. The polymer according to claim 29, wherein the index x is 4.
33. The polymer according to claim 29, wherein the index x is 5.
34. The polymer according to claim 29, wherein the index x is 6.
35. The polymer according to claim 29, comprising an amino acid sequence having the formula chosen from:
i) Val-Pro-Gly-Val-Glyx;
ii) Val-Pro-Gly-Gly-Valx;
iii) Val-Pro-Val-Gly-Glyx;
iv) Gly-Pro-Gly-Val-Valx;
v) Gly-Pro-Val-Gly-Valx;
vi) Gly-Pro-Val-Val-Glyx;
vii) Pro-Val-Gly-Val-Glyx;
viii) Pro-Val-Gly-Gly-Valx;
ix) Pro-Val-Val-Gly-Glyx;
x) Pro-Gly-Gly-Val-Valx;
xi) Pro-Gly-Val-Gly-Valx;
xii) Pro-Gly-Val-Val-Glyx;
xiii) Val-Gly-Pro-Val-Glyx;
xiv) Val-Gly-Pro-Gly-Valx;
xv) Val-Val-Pro-Gly-Glyx;
xvi) Gly-Gly-Pro-Val-Valx;
xvii) Gly-Val-Pro-Gly-Valx;
xviii) Gly-Val-Pro-Val-Glyx;
xix) Val-Gly-Val-Pro-Glyx;
xx) Val-Gly-Gly-Pro-Valx;
xxi) Val-Val-Gly-Pro-Glyx;
xxii) Gly-Gly-Val-Pro-Valx;
xxiii) Gly-Val-Gly-Pro-Valx;
xxiv) Gly-Val-Val-Pro-Glyx;
xxv) Val-Gly-Val-Gly-Prox;
xxvi) Val-Gly-Gly-Val-Prox;
xxvii) Val-Val-Gly-Gly-Prox;
xxviii) Gly-Gly-Val-Val-Prox;
xxix) Gly-Val-Gly-Val-Prox; and
xxx) Gly-Val-Val-Gly-Prox;
wherein the index x is an integer from 2 to 6.
36. The polymer according to claim 2, further comprising a biodegradable or non-biodegradable linker that links the BioDeg moieties to the ECM-mimetic peptides.
37. The polymer according to claim 36, having the formula:
wherein L is the biodegradable or non-biodegradable linker;
BioDeg comprises one or more residues of lactide, glycolide, valerolactone, caprolactone, hydroxybutyrate, or copolymers thereof;
y is an integer from 1 to 10; and
z is an integer from 1 to 2000.
38. The polymer according to claim 37, wherein the linker L is formed by the reaction of Mim and BioDeg with a linking reagent and wherein the linker L comprises one or more chemical bonds chosen from:
i) an alkyl;
ii) an alkoxy;
iii) a carbonyl;
iv) a halogen comprising leaving group;
v) an ester;
vi) an orthoester;
vii) an anhydride;
viii) a phosphate;
ix) a phosphazene;
x) a phosphoester;
xi) a dioxanaone;
xii) a carbonate;
xiii) an orthocarbonate;
xiv) an amide;
xv) an amine;
xvi) an ester amide;
xvii) a isocyanate;
xviii) a urethane;
xix) an etherester;
xx) a pyrrolidone; or
xxi) a unit comprising a combination of two or more units (i) to (xx).
39. The polymer according to claim 37, wherein the linker has the formula:
and the index t is an integer from 1 to 10.
40. The polymer according to claim 37, wherein the linker has the formula:
and the index t is from 1 to 10.
41. The polymer according to claim 37, wherein the linker has the formula:
and the index t is from 1 to 10.
42. The polymer according to claim 37, wherein the linker has the formula:
and the index t is from 1 to 10.
43. The polymer according to claim 37, wherein the linker has the formula:
and the index t is from 1 to 10.
44. The polymer according to claim 37, wherein the linker has the formula:
and the index t is from 1 to 10.
45. The polymer according to claim 37, wherein the linker has the formula:
and the index t is from 1 to 10.
46. The polymer according to claim 1, wherein the one or more biodegradable moieties comprise one or more crosslinking moieties that are crosslinked to another biodegradable polymer.
47. The polymer according to claim 1, wherein the one or more ECM-mimetic peptides comprise one or more crosslinking moieties that are crosslinked to another ECM mimetic peptide.
48. The polymer according to claim 1, further comprising a bioactive agent.
49. The polymer according to claim 1, wherein the one or more ECM-mimetic peptide comprises an elastin-mimetic, a fibrinogen-mimetic, a fibroin-mimetic, a silk-mimetic, a collagen-mimetic, a keratin-mimetic, or a mixture thereof.
50. The polymer according to claim 2, wherein the one or more biodegradable or non-biodegradable linker can be branched or may be multi-functional so as to introduce branching the potential for performing chemical crosslinking to the resulting polymer.
51. The polymer according to claim 1, having the formula:
wherein the ECM-mimetic peptide Mim comprises 3 or more amino acid residues having the formula:
BioDeg is the non-amino acid residue containing biodegradable moiety;
the index x is an integer from 1 to 30;
the index y is an integer from 1 to 10; and
the index z is an integer from 1 to 2000.
52. The polymer according to claim 1, wherein the ECM-mimetic peptide comprises an amino acid sequence having the formula chosen from:
i) Val-Pro-Gly-Gly;
ii) Xxx-Pro-Gly-Gly;
iii) Ala-Pro-Gly-Val-Gly-Val; and
iv) Gly-Ala-Gly-Ala-Gly-Ser;
wherein Xxx represents any amino acid.
53. A method for preparing a biocompatible polymer comprising:
a) one or more ECM-mimetic peptides;
b) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid;
wherein the polymer has an weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da,
comprising:
a) providing an ECM-mimetic peptide-comprising reagent having the formula:
HN-Xaa-Xbb-Xcc-Xdd-Xee-OH
\u2003wherein Xaa, Xbb, Xcc, Xdd, and Xee are each independently an amino acid residue;
b) coupling a biodegradable reagent that does not comprise an \u03b1-amino acid to the ECM-mimetic peptide of step (a); and
c) polymerizing the product of step (b).
54. A method for preparing a biocompatible polymer comprising:
i) one or more ECM-mimetic peptides; and
ii) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid;
wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da,
comprising:
a) providing an ECM-mimetic peptide-comprising reagent having the formula:
HN-(Xaa-Xbb-Xcc-Xdd-Xee)x-OH
\u2003wherein Xaa, Xbb, Xcc, Xdd, and Xee are each independently an amino acid residue, and the index x is an integer from 1 to 100;
b) coupling a biodegradable reagent that does not comprise an \u03b1-amino acid to the ECM-mimetic peptide of step (a); and
c) polymerizing the product of step (b).
55. An article comprising the biocompatible polymer of claim 1.
56. The article of claim 55, wherein the article is a stent, implant, film, foam, sponge, patch, matrix, fabric, mesh, membrane, or felt.
57. The article of claim 55, where in the article is a stent that is coated with the biocompatible polymer.
58. The article of claim 57, further comprising a bioactive agent.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An adjustment method of a stereoscopic display which stereoscopically display images for right eye and left eye having parallax with respect to each other, the display having a light output unit for the right eye which outputs a light signal for the right eye to display the image for the right eye, and a light output unit for the left eye which outputs a light signal for the left eye to display the image for the left eye, wherein the method comprising steps of;
performing first measurement for measuring the luminance of the light signal for the right eye;
performing second measurement for measuring the luminance of the light signal for the left eye;
acquiring first and second representative luminance values corresponding to each other by the first and second measurements, respectively; and
adjusting an output of the light output unit for the right eye andor the light output unit for the left eye such that a difference between the first and second representative luminance values falls within a predetermined range.
2. The adjustment method of a stereoscopic display according to claim 1,
wherein the first measurement is performed while outputting the one or more light signals for the right eye which displays one or more reference images respectively, and
the second measurement is performed while outputting the one or more light signals for the left eye which displays the one or more reference images respectively.
3. The adjustment method of a stereoscopic display according to claim 2,
wherein in the first measurement, a first luminance value is measured while outputting the light signal for the right eye for displaying a black image as the reference image, and a second luminance value is measured while outputting the light signal for the right eye for displaying a white image as the reference image,
the first representative luminance value is set in a range of the first luminance value to the second luminance value,
in the second measurement, a third luminance value is measured while outputting the light signal for the left eye for displaying a black image as the reference image, and a fourth luminance value is measured while outputting the light signal for the left eye for displaying a white image as the reference image, and
the second representative luminance value is set in a range of the third luminance value to the fourth luminance value.
4. The adjustment method of a stereoscopic display according to claim 3,
wherein the first luminance value, the second luminance value, or an average value of the first and second luminance values is set as the first representative luminance value, and
the third luminance value, the fourth luminance value, or an average value of the third and fourth luminance values is set as the second representative luminance value.
5. The adjustment method of a stereoscopic display according to claim 2,
wherein an average value of the luminance of the light signal for the right eye in a predetermined period for which the one or more reference images are displayed is extracted as the first representative luminance value, and
an average value of the luminance of the light signal for the left eye in a predetermined period for which the one or more reference images are displayed is extracted as the second representative luminance value.
6. The adjustment method of a stereoscopic display according to claim 1,
wherein the first measurement is performed in a state where the light signal for the left eye is not output, and the second measurement is performed in a state where the light signal for the right eye is not output.
7. The adjustment method of a stereoscopic display according to claim 2,
wherein the first measurement is performed in a state where the light signal for the left eye is not output, and the second measurement is performed in a state where the light signal for the right eye is not output.
8. The adjustment method of a stereoscopic display according to claim 3,
wherein the first measurement is performed in a state where the light signal for the left eye is not output, and the second measurement is performed in a state where the light signal for the right eye is not output.
9. The adjustment method of a stereoscopic display according to claim 4,
wherein the first measurement is performed in a state where the light signal for the left eye is not output, and the second measurement is performed in a state where the light signal for the right eye is not output.
10. The adjustment method of a stereoscopic display according to claim 5,
wherein the first measurement is performed in a state where the light signal for the left eye is not output, and the second measurement is performed in a state where the light signal for the right eye is not output.
11. The adjustment method of a stereoscopic display according to claim 1,
wherein the stereoscopic display is a display using a polarizing filter method, a lenticular display, or a head mounted display.
12. The adjustment method of a stereoscopic display according to claim 2,
wherein the stereoscopic display is a display using a polarizing filter method, a lenticular display, or a head mounted display.
13. The adjustment method of a stereoscopic display according to claim 3,
wherein the stereoscopic display is a display using a polarizing filter method, a lenticular display, or a head mounted display.
14. An adjustment device of a stereoscopic display which stereoscopically display images for right eye and left eye having parallax with respect to each other, the display having a light output unit for the right eye which outputs a light signal for the right eye to display the image for the right eye, and a light output unit for the left eye which outputs a light signal for the left eye to display the image for the left eye, wherein the adjustment device comprising:
measurement means for performing first measurement for measuring the luminance of the light signal for the right eye, performing second measurement for measuring the luminance of the light signal for the left eye, and acquiring first and second representative luminance values corresponding to each other by the first and second measurements; respectively; and
adjustment means for adjusting an output of the light output unit for the right eye andor the light output unit for the left eye such that a difference between the first representative luminance value acquired by the first measurement and the second representative luminance value acquired by the second measurement falls within a predetermined range.
15. The adjustment device of a stereoscopic display according to claim 14,
wherein the measurement means performs the first measurement while outputting the light signal for the right eye which displays one or more reference images respectively, and performs the second measurement while outputting the light signal for the left eye which displays the one or more reference images respectively.
16. The adjustment device of a stereoscopic display according to claim 15,
wherein in the first measurement, the measurement means measures a first luminance value while outputting the light signal for the right eye for displaying a black image as the reference image and measures a second luminance value while outputting the light signal for the right eye for displaying a white image as the reference image,
the measurement means sets the first representative luminance value in a range of the first luminance value to the second luminance value,
in the second measurement, the measurement means measures a third luminance value while outputting the light signal for the left eye for displaying a black image as the reference image and measures a fourth luminance value while outputting the light signal for the left eye for displaying a white image as the reference image, and
the measurement means sets the second representative luminance value in a range of the third luminance value to the fourth luminance value.
17. The adjustment device of a stereoscopic display according to claim 15,
wherein the measurement means extracts, as the first representative luminance value, an average value of the luminance of the light signal for the right eye in a predetermined period for which the one or more reference images are displayed and extracts, as the second representative luminance value, an average value of the luminance of the light signal for the left eye in a predetermined period for which the one or more reference images are displayed.
18. A stereoscopic image display method of displaying a stereoscopic image including an image for a right eye and an image for a left eye with parallax for stereoscopic viewing using a stereoscopic display, the stereoscopic image display method comprising:
adjusting the stereoscopic display using the adjustment method of a stereoscopic display according to claim 1; and
displaying the stereoscopic image on the stereoscopic display for stereoscopic viewing.
19. A stereoscopic image display method of displaying a stereoscopic image including an image for a right eye and an image for a left eye with parallax for stereoscopic viewing using a stereoscopic display, the stereoscopic image display method comprising:
adjusting the stereoscopic display using the adjustment method of a stereoscopic display according to claim 2; and
displaying the stereoscopic image on the stereoscopic display for stereoscopic viewing.
20. A stereoscopic image display device comprising:
a stereoscopic display;
a display controller which displays a stereoscopic image, which includes an image for a right eye and an image for a left eye with parallax, on the stereoscopic display for stereoscopic viewing; and
the adjustment device of a stereoscopic display according to claim 14 which adjusts the stereoscopic display.