1. A socket comprising:
an insulating shell;
a connecting base mounted on the bottom of said insulating shell, said connecting base comprising a pillar extending upwardly from the top of said connecting base, a lower groove disposed on the top of said connecting base, and a hole disposed in said pillar;
a conducting strip arranged in said hole;
an inner connecting ring disposed around the surface of said pillar; and
an outer connecting ring inserted in said lower groove.
2. The socket according to claim 1, further comprising a spring disposed on the upper portion of said connecting base and surrounding said pillar.
3. The socket according to claim 1, further comprising a moveable lid covering on said spring.
4. The socket according to claim 1, wherein said insulating shell further comprising an upper groove disposed in the inner wall of the insulating shell, the upper portion of the outer conducting ring inserted into said upper groove.
5. A socket comprising:
an insulating shell having an inner wall, which shell is provided with an upper groove disposed in the inner wall;
a connecting base mounted on the bottom of said insulating shell, wherein said connecting base comprises a pillar extending upwardly from the top of said connection base;
a hole disposed in said pillar;
a conducting strip arranged in said hole;
an inner conducting ring disposed around the surface of said pillar; and
an outer conducting ring inserted in said upper groove.
6. The socket according to claim 5, further comprising a spring disposed on the upper portion of said connecting base and surrounded said pillar.
7. The socket according to claim 5, further comprising a moveable lid covering on said spring.
8. A socket comprising:
an insulating shell having a bottom;
a connecting base mounted on the bottom of said insulating shell, wherein said connecting base comprises a pillar extending upwardly from the top of the connection base;
a hole disposed in said pillar,
a conducting strip arranged in said hole; and
an inner conducting ring disposed around the surface of said pillar.
9. The socket according to claim 8, further comprising a spring disposed on the upper portion of said connecting base and surrounded said pillar.
10. The socket according to claim 8, further comprising a moveable lid covering on said spring.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A composition for the percutaneous administration of an opioid analgesic which includes a component susceptible to co-extraction with the opioid analgesic and which, when administered orally or by injection after extraction by an abuser will distress the abuser.
2. A composition for the percutaneous administration of an opioid analgesic which comprises a therapeutic amount of the opioid analgesic in association with a vehicle or means for providing a transdermal flux of the opioid analgesic when applied to a human body surface or membrane and a quantity of a distressing substance which, when ingested orally or as parenteral bolus injection together with the opioid analgesic will produce a distressful reaction in the recipient.
3. A composition according to claim 1 or 2, wherein the distressing substance is chosen from emetics, nauseants and flavouring or bitter substances.
4. A composition according to claim 3, wherein the distressing substance chosen from ergolides; quaternary ammonium compounds; non-permeant opioid antagonists; other opioid antagonists; emetics; and atropine or salts thereof.
5. A composition according to any preceding claim, wherein the distressing substance is non-permeant and is incorporated in a vehicle being the same vehicle as for the opioid analgesic.
6. A composition according to claim 5, wherein the vehicle includes a penetration enhancer.
7. A composition according to any preceding claim, wherein the opioid analgesic is chosen from morphine, hydromorphone, buprenorphine, ketamine, fentanyl, tramadol, or pharmaceutically acceptable and percutaneously transmissible salts thereof.
8. A composition according to any preceding claim wherein the opioid analgesic is a narcotic opioid analgesic.
9. A composition according to any preceding claim, wherein the opioid analgesic is in an aqueous andor alcoholic solution, or incorporated in a matrix including a pressure sensitive adhesive.
10. A transdermal device containing a composition according to any preceding claim.
11. A device according to claim 10, which is an adhesive matrix patch and comprises an impermeable backing layer, a matrix layer which contains the opioid analgesic and a penetration enhancer and distressing substance.
12. A device according to claim 10, which is a reservoir device.
13. A device according to claim 10, which is monolithic patch.
14. A composition according to any of claims 1 to 9, or a device according to any of claims 10 to 13, which contains buprenorphine or pharmaceutically acceptable salt thereof as the opioid analgesic and atropine or pharmaceutically acceptable salt thereof, or an ergolide or pharmaceutically acceptable salt thereof as the distressing substance.