1. A method of forming a closed tube head part having a closing material attached thereto by a compression method, the method comprising the steps of:
fitting a cup-shaped closing material having a convex section and a metal foil base material onto a protruding engagement section of a distal end of a mandrel in a manner that a clearance is provided between a rear side of a distal end surface of the convex section of the closing material and the protruding engagement section of the distal end of the mandrel;
disposing a molten resin in a cavity of a molding die;
pressing a holepin having an outer peripheral section of a distal end that is smaller than the outer periphery of the distal end section of the convex section of the closing material against a central portion of the distal end surface of the convex section of the closing material to pleat the distal end surface of the convex section of the closing material and form an annular corner protrusion at its outer peripheral section; and
inserting the mandrel under pressure into the cavity of the molding die while the holepin remains pressed to cause the molten resin to be pushed and charged into the cavity such that the molten resin envelops and flows completely over the annular corner protrusion section to become interlocked therewith, thus forming the closed tube head part with the closing material attached thereto.
2. The method of forming a head part according to claim 1, wherein the clearance between the rear side of the distal end surface of the convex section of the closing material and the distal end of the engagement section of the mandrel is 0.5 mm to 5.0 mm.
3. The method of forming a head part according to claim 1, wherein a concave section is formed in the distal end surface of the holepin.
4. The method of forming a head part according to claim 1, wherein the distal end surface of the mandrel onto which the closing material is fitted is a convex curved surface.
5. A method of manufacturing a closed tubular container having a head part with a closing material attached thereto by a compression method, the method comprising the steps of:
filling a cup-shaped closing material having a convex section and a metal foil base material onto a protruding engagement section of a distal end of a mandrel in a manner that a clearance is provided between a rear side of a distal end surface of the convex section of the closing material and the protruding engagement section of the distal end of the mandrel;
disposing a molten resin in a cavity of a molding die;
pressing a holepin having an outer peripheral section of a distal end that is smaller than the outer periphery of the distal end section of the convex section of the closing material against a central portion of the distal end surface of the convex section of the closing material to pleat the distal end surface of the convex section of the closing material and form an annular corner protrusion at its outer peripheral section;
inserting the mandrel under pressure into the cavity of the molding die while the holepin remains pressed to cause the molten resin to be pushed and charged into the cavity such that the molten resin envelops and flows completely over the annular corner protrusion section to become interlocked therewith, thus forming the closed tube head part with the closing material attached thereto; and
screwing a cap on the head part with a screwing device.
6. The method for manufacturing a closed tubular container according to claim 5, wherein the clearance between the rear side of the distal end surface of the convex section of the closing material and the distal end of the engagement section of the mandrel is 0.5 mm to 5.0 mm.
7. The method for manufacturing a closed tubular container according to claim 5, wherein a concave section is formed in the distal end surface of the holepin.
8. The method for manufacturing a closed tubular container according to claim 5, wherein the distal end surface of the mandrel onto which the closing material is fitted is a convex curved surface.
9. The method for manufacturing a closed tubular container according to claim 5, wherein from the time when the mandrel is inserted under pressure into the cavity of the molding die until the time when the head part is molded and cooled thereafter, the mandrel is pressed into the cavity.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An osmotic pump for drug delivery, especially for drug delivery to andor inside a patient comprising at least one chargeable material wherein osmotic pressure is caused by inducing andor de-inducing charges within the chargeable material.
2. The osmotic pump of claim 1 wherein said at least one chargeable material comprises a solid material.
3. The osmotic pump of claim 1 wherein said at least one chargeable material comprises water-soluble material.
4. The osmotic pump of Claim 1 herein the at least one chargeable material is located in a first reservoir comprising a first semi permeable material for the inflow of water into said reservoir
5. The osmotic pump of claim 1 wherein the osmotic pump comprises a second reservoir in which the drug to be released by the osmotic pump is located and wherein a movable piston is provided between the first reservoir and the second reservoir.
6. The osmotic pump of claim 1 wherein the second reservoir comprises a second semi permeable material through which the drug is released by the osmotic pump andor a flow restrictor through which the drug is released by the osmotic pump
7. The osmotic pump of claim 1 wherein said at least one chargeable material in at least its charged form is selected from the group comprising alkylsulfonates, iodine, sulfides metals, Fe, Ni, Cu, Zn, Co, Al, Cr, Mo, Ru, Mn, Ir, Ag and mixtures thereof and their oxides, hydroxides, iodides, chlorides, sulfides, acetates, oxalates, phtalocyanines and mixtures thereof.
8. The osmotic pump of claim 1 wherein said at least one chargeable material is a solid material selected from the group comprising polypyrrole, polyaniline, polyacrylonitrile, polythiophene and mixtures thereof
9. A method of releasing a drug from an osmotic pump of claim 1 wherein osmotic pressure is induced by charging the at least one chargeable material by use of an electrical current.
10. A system comprising an osmotic pump according to claim 1, the system having one or more applications selected from the group consisting of:
drug delivery systems
liquid absorbers
sample handling devices
micro valves
analytical devices
micropumps