1. A binder for a lithium ion secondary battery electrode that is obtained by emulsion polymerization of an ethylenically unsaturated monomer in an aqueous medium in the presence of a surfactant, the ethylenically unsaturated monomer being composed, with respect to the total mass of the ethylenically unsaturated monomer, of 15% by mass to 70% by mass of styrene, 1% by mass to 10% by mass of an N atom-containing ethylenically unsaturated monomer, 1% by mass to 10% by mass of an ethylenically unsaturated carboxylic acid, 0.1% by mass to 5% by mass of an internal crosslinking agent, and 22% by mass to 82.9% by mass of another ethylenically unsaturated monomer that is copolymerizable with these substances, and has a glass transition temperature of \u221255\xb0 C. to 30\xb0 C.
2. The binder for a lithium ion secondary battery electrode according to claim 1,
wherein the N atom-containing ethylenically unsaturated monomer is at least one unsaturated monomer selected from (meth)acrylamide, N-alkyl(meth)acrylamide having 1 to 4 carbon atoms in the alkyl group, N,N-dialkyl(meth)acrylamide having 1 or 2 carbon atoms in the alkyl group, N-hydroxyalkyl(meth)acrylamide having 1 or 2 carbon atoms in the alkyl group, diacetone(meth)acrylamide, and dimethylaminoalkyl(meth)acrylamide having 1 to 4 carbon atoms in the alkyl group in a moiety excluding the dimethylamino group, and (meth)acrylamide-2-methyl propane sulfonic acid or (meth)acrylamide ethyl ethylene urea.
3. The binder for a lithium ion secondary battery electrode according to claim 1,
wherein the ethylenically unsaturated carboxylic acid is at least one of unsaturated monocarboxylic acids selected from the group consisting of acrylic acid, methacrylic acid, and crotonic acid, and unsaturated dicarboxylic acids selected from the group consisting of maleic acid, fumaric acid, and itaconic acid, and half esters of the unsaturated dicarboxylic acids.
4. A slurry for a lithium ion secondary battery electrode comprising:
the binder for a lithium ion secondary battery electrode according to claim 1;
an active material; and
an aqueous medium.
5. The slurry for a lithium ion secondary battery electrode according to claim 4, further comprising
carboxymethyl cellulose.
6. An electrode for a lithium ion secondary battery that is formed by using the slurry for a lithium ion secondary battery electrode according to claim 4.
7. A lithium ion secondary battery comprising
the electrode for a lithium ion secondary battery according to claim 6.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for automatically checking a calibration of a mass spectrometer including an atmospheric pressure ion source, a first quadrupole device (Q1), a fragmentation cell and a mass analyzer comprising another quadrupole device (Q3) during a sequence of mass analyses of a plurality of samples introduced into the atmospheric pressure ion source and analyzed using the mass analyzer, comprising:
(a) providing a one of the plurality of samples having therein at least one known chemical entity;
(b) decreasing a kinetic energy applied to ions entering the fragmentation cell so as to prevent fragmentation therein;
(c) ionizing the at least one known chemical entity using the ion source so as to generate ions of a known ionic species;
(d) performing a mass scan of a portion of the ions using Q1;
(e) transmitting the scanned ions from Q1 to the fragmentation cell so as to be transmitted through the fragmentation cell to Q3 and through Q3 to a detector of the mass analyzer, wherein Q3 is operated in RF-only mode;
(f) detecting the scanned and transmitted ions by the detector; and
(g) comparing the results of the detection of the scanned transmitted ions with expected results, said expected results derived from a prior calibration.
2. A method as recited in claim 1, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises providing an analytical sample having therein an analyte and an internal standard that is chemically similar to but not identical to the analyte, wherein the at least one known chemical entity comprises the internal standard.
3. A method as recited in claim 1, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises interspersing a standard sample having an internal standard therein between two of the plurality of samples that do not contain the internal standard and that contain an analyte that is chemically similar to but not identical to the internal standard, wherein the at least one known chemical entity comprises the internal standard.
4. A method as recited in claim 1, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises providing an analyte-specific calibration sample, wherein the at least one known chemical entity is identical to an analyte.
5. A method as recited in claim 1, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises providing an Analytical Quality Control sample having a certified reference material therein, wherein the at least one known chemical entity comprises the certified reference material.
6. A method as recited in claim 1, wherein the step (e) of transmitting the scanned ions from Q1 to the fragmentation cell so as to be transmitted through the fragmentation cell comprises transmitting the scanned ions through the fragmentation cell under the application of a drag field to the fragmentation cell.
7. A method as recited in claim 6, wherein the transmitting of the scanned ions through the fragmentation cell under the application of a drag field to the fragmentation cell includes applying the drag field so as to urge the scanned ions to follow a non-linear path through the fragmentation cell.
8. A method as recited in claim 1, further comprising:
(h) determining, from the comparison, if any of a peak centroid position, peak intensity, peak width or peak resolution differs from a respective expected value derived from a prior calibration of mass-to-charge ratio or abundance by greater than a respective tolerance; and
(i) adjusting a calibration applied to one or more of the plurality of samples if any of the peak centroid position, peak intensity, peak width or peak resolution differs from the respective expected value by greater than the respective tolerance.
9. A method as recited in claim 8, further comprising:
(j) increasing a kinetic energy applied to ions entering the fragmentation cell so as to render the fragmentation cell operable to cause ion fragmentation therein;
(k) discontinuing application of the drag field, if any, applied to the fragmentation cell;
(l) introducing a next sample of the plurality of samples into the mass spectrometer;
(m) mass analyzing the next sample with the mass spectrometer using the adjusted calibration.
10. A method as recited in claim 1, further comprising:
(h) determining, from the comparison, if any of a peak centroid position, peak intensity, peak width or peak resolution differs from a respective expected value derived from a prior calibration of mass-to-charge ratio or abundance by greater than a respective tolerance; and
(i) providing a notification, if any of the peak centroid position, peak intensity, peak width or peak resolution differs from the respective expected value by greater than the respective tolerance.
11. A method as recited in claim 10, wherein the notification comprises a data quality score.
12. A method as recited in claim 11, wherein the data quality score may assume different values respectively indicating that the results are within tolerance, that the results are at the tolerance boundaries and that the results are out of tolerance.
13. A method as recited in claim 10, wherein the notification comprises a prediction of a time when a recalibration of the mass spectrometer will be necessary.
14. A method as recited in claim 10, wherein the notification comprises a record of a variation with time of the peak centroid position, peak intensity, peak width or peak resolution.
15. A method as recited in claim 1, wherein the calibration is a calibration of mass-to-charge ratio, wherein the plurality of samples comprises a plurality of clinical laboratory samples, and wherein each one of the at least one known chemical entity is either an internal standard, an analyte-specific calibrant that is provided in a known concentration or an Analytical Quality Control sample.
16. A method for automatically checking a calibration of a mass spectrometer including an atmospheric pressure ion source, a first quadrupole device (Q1), a fragmentation cell, and a mass analyzer during a sequence of mass analyses of a plurality of samples introduced into the atmospheric pressure ion source, comprising:
(a) providing a one of the plurality of samples having therein at least one known chemical entity;
(b) decreasing a kinetic energy applied to ions entering the fragmentation cell so as to prevent fragmentation therein;
(c) ionizing the at least one known chemical entity using the ion source so as to generate ions of a known ionic species;
(d) transmitting a portion of the ions through Q1;
(e) transmitting the portion of the ions from Q1 to the fragmentation cell so as to be transmitted through the fragmentation cell to the mass analyzer;
(f) performing a mass analysis of the transmitted ions by the mass analyzer and an ion detector configured to receive ions from the mass analyzer;
(g) comparing the results of the mass analysis with expected results; and
(h) determining, from the comparison, if any of a peak centroid position, peak intensity, peak width or peak resolution differs from a respective expected value derived from a prior calibration of mass-to-charge ratio or abundance by greater than a respective tolerance.
17. A method as recited in claim 16, wherein the step (f) of performing a mass analysis of the transmitted ions by the mass analyzer comprises performing the mass analysis using a time-of-flight (TOF) mass analyzer.
18. A method as recited in claim 16, wherein the step (f) of performing a mass analysis of the transmitted ions by the mass analyzer comprises performing the mass analysis using an electrostatic trap mass analyzer.
19. A method as recited in claim 16, wherein the step (f) of performing a mass analysis of the transmitted ions by the mass analyzer comprises performing the mass analysis using a quadropole mass analyzer.
20. A method as recited in claim 16, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises providing an analytical sample having therein an analyte and an internal standard that is chemically similar to but not identical to the analyte, wherein the at least one known chemical entity comprises the internal standard.
21. A method as recited in claim 16, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises interspersing a standard sample having an internal standard therein between two of the plurality of samples that do not contain the internal standard and that contain an analyte that is chemically similar to but not identical to the internal standard, wherein the at least one known chemical entity comprises the internal standard.
22. A method as recited in claim 16, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises providing an analyte-specific calibration sample, wherein the at least one known chemical entity is identical to an analyte.
23. A method as recited in claim 16, wherein the step (a) of providing a one of the plurality of samples having therein at least one known chemical entity comprises providing an Analytical Quality Control sample having a certified reference material therein, wherein the at least one known chemical entity comprises the certified reference material.
24. A method as recited in claim 16, wherein the step (e) of transmitting the ions from Q1 to the fragmentation cell so as to be transmitted through the fragmentation cell to the mass analyzer comprises transmitting the scanned ions through the fragmentation cell under the application of a drag field to the fragmentation cell.
25. A method as recited in claim 24, wherein the transmitting of the scanned ions through the fragmentation cell under the application of a drag field to the fragmentation cell includes applying the drag field so as to urge the scanned ions to follow a non-linear path through the fragmentation cell.
26. A method as recited in claim 16, further comprising:
(i) adjusting a calibration applied to one or more of the plurality of samples if any of the peak centroid position, peak intensity, peak width or peak resolution differs from the respective expected value by greater than the respective tolerance.
27. A method as recited in claim 26, further comprising:
(j) increasing a kinetic energy applied to ions entering the fragmentation cell so as to prevent fragmentation therein;
(k) discontinuing application of the drag field, if any, applied to the fragmentation cell;
(l) introducing a next sample of the plurality of samples into the mass spectrometer;
(m) mass analyzing the next sample with the mass spectrometer using the adjusted calibration.
28. A method as recited in claim 16, further comprising:
(i) providing a notification, if any of the peak centroid position, peak intensity, peak width or peak resolution differs from the respective expected value by greater than the respective tolerance.
29. A method as recited in claim 28, wherein the notification comprises a data quality score.
30. A method as recited in claim 29, wherein the data quality score may assume different values respectively indicating that the results are within tolerance, that the results are at the tolerance boundaries and that the results are out of tolerance.
31. A method as recited in claim 28, wherein the notification comprises a prediction of a time when a recalibration of the mass spectrometer will be necessary.
32. A method as recited in claim 28, wherein the notification comprises a record of a variation with time of the peak centroid position, peak intensity, peak width or peak resolution.
33. A method as recited in claim 16, wherein the calibration is a calibration of mass-to-charge ratio, wherein the plurality of samples comprises a plurality of clinical laboratory samples, and wherein each one of the at least one known chemical entity is either an internal standard, an analyte-specific calibrant that is provided in a known concentration or an Analytical Quality Control sample.