1. A method of treating a traumatic brain injury in a human subject in need thereof, said method comprising administering to said subject at least one cycle of therapy, wherein said cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone, said two-level dosing regime comprising a first time period, wherein a higher hourly infusion dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly infusion dose of progesterone is administered to said subject.
2. The method of claim 1, wherein the first time period comprises an infusion dose of progesterone of about 0.1 mgkghr to about 7 mgkghr.
3. The method of claim 2, wherein the first time period comprises an infusion dose of progesterone of about 0.5 mgkghr to about 1 mgkghr.
4. The method of claim 3, wherein the first time period comprises an infusion dose of progesterone of about 0.7 mgkghr.
5. The method of claim 1, wherein the second time period comprises an infusion dose of progesterone of about 0.05 mgkghr to about 5 mgkghr.
6. The method of claim 5, wherein the second time period comprises an infusion dose of progesterone of about 0.5 mgkghr to about 1 mgkghr.
7. The method of claim 6, wherein the second time period comprises an infusion dose of about 0.5 mgkghr.
8. The method of claim 1, wherein the second time period comprises about a 24 hour to about a 120 hour period.
9. The method of claim 8, wherein the second time period comprises about a 71 hour period.
10. The method of claim 1, wherein the first time period comprises an infusion dose of progesterone of about 0.7 mgkghr, the second time period comprises an infusion dose of about 0.5 mgkghr, the first time period comprises about 1 hour, and the second time period comprises about a 71 hour period.
11. The method of claim 1, wherein the two-level intravenous dosing regime of progesterone results in a progesterone serum level in said subject of about 100 ngml to about 2000 ngml.
12. The method of claim 11, wherein the progesterone serum level is about 100 ngml to about 1000 ngml.
13. The method of claim 12, wherein the progesterone serum level is about 200 ngml to about 450 ngml.
14. The method of claim 12, wherein the progesterone serum level is about 350 ngml to about 450 ngml.
15. The method of claim 1, wherein the two-level intravenous dosing regime of progesterone results in a progesterone serum level in said subject of less than 450 ngml.
16. The method of claim 1, further comprising a third time period, wherein said third time period comprises a tapered administration of the progesterone to the subject.
17. The method of claim 1, wherein the first and the second time periods are continuous.
18. The method of claim 1, wherein the first and the second time periods are discontinuous.
19. The method of claim 1, wherein said first time period comprises a bolus injection.
20. A method for treating a traumatic brain injury in a human subject in need thereof comprising administering to said subject a therapeutically effective concentration of progesterone.
21. The method of claim 20, wherein said effective concentration of progesterone is administered intravenously.
22. The method of claim 21, wherein said effective concentration of progesterone comprises a daily dose of 12 mgkg of body weight.
23. The method of claim 22, wherein said daily dose is administered within 24 hours post injury.
24. The method of claim 20, wherein said progesterone is in a cyclodextrin carrier.
25. The method claim 21, further comprising administering to said human subject a subsequent daily dose comprising an effective concentration of progesterone, wherein the effective concentration of progesterone in the subsequent daily dose unit is about 12 mgkg of body weight.
26. The method of claim 21, said method comprising administering to said subject at least one cycle of therapy, wherein said cycle of therapy comprises administering a therapeutically effective constant intravenous dosing regime of progesterone.
27. The method of claim 26, wherein the constant intravenous dosing regime comprises an infusion dose of progesterone of about 0.1 mgkghr to about 7 mgkghr.
28. The method of claim 27, wherein the constant intravenous dosing regime comprises an infusion dose of progesterone of about 0.5 mgkghr to about 1 mgkghr.
29. The method of claim 28, wherein the constant intravenous dosing regime comprises an infusion dose of progesterone of about 0.7 mgkghr.
30. The method of claim 26, wherein the constant intravenous dosing regime of progesterone results in a progesterone serum level in said subject of about 100 ngml to about 2000 ngml.
31. The method of claim 30, wherein the progesterone serum level is about 100 ngml to about 1000 ngml.
32. The method of claim 31, wherein the progesterone serum level is about 200 ngml to about 450 ngml.
33. The method of claim 31, wherein the progesterone serum level is about 350 ngml to about 450 ngml.
34. The method of claim 26, wherein the constant intravenous dosing regime of progesterone results in a progesterone serum level in said subject of less than 450 ngml.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An optoelectronic code reader for the reading in of codes (27, 29, 31, 33), which move relative to the code reader within a reading zone (25), by scanning the reading zone at least along one scan direction (35),
wherein, for the reading in of codes (29, 31) which are arranged along the scan direction (35) at different distances to the code reader, at least one first scanning device (3) and one second scanning device (39) are provided which can be controlled for the scanning along the scan direction (35) at different focal positions.
2. A code reader in accordance with, claim 1, characterized in that the scanning devices (39, 39) can be controlled such that the focal positions of the first scanning device (39) and of the second scanning device (39) are alternately focused on the respectively next code (27, 29, 31) moved into the reading zone.
3. A code reader in accordance with claim 1, characterized in that the focal positions of the scanning devices (39, 39) can be controlled in dependence on the number of codes (29, 31) in the reading zone (25), in dependence on the mutual spacing of the codes andor in dependence on the relative arrangement of the codes with respect to the scanning device.
4. A code reader in accordance with claim 1, characterized in that the scanning devices (39, 39) can be controlled such that
on the presence of a pre-determined minimum number of codes (29, 31) in the reading zone (25), when a pre-determined minimum mutual spacing of the codes in the reading zone is not achieved andor when a plurality of codes are arranged next to one another along the scan direction, the focal positions of the first scanning device (39) and of the second scanning device (39) are focused on different codes (29, 31); and
otherwise, andor after a successful reading in of the codes, the first scanning device (39) and the second scanning device (39) are focused on a common focal position.
5. A code reader in accordance with claim 1, characterized in that the code reader has an image detection sensor or an object detection sensor for the detection of the number of codes (29, 31) in the reading zone, for the detection of the mutual spacing of the code in the reading zone andor for the detection of the relative arrangement of the codes with respect to the scan direction.
6. A code reader in accordance with claim 1, characterized in that the code reader has at least one distance measurement device for the determination of the distance between a code (29, 31) and the code reader.
7. A code reader in accordance with claim 1, characterized in that, for the avoidance of a geometrical shadowing of a scanning device (39, 39) by an object (17, 19) located in the reading zone, or for the avoidance of reflection effects at the code to be scanned,
the first scanning device (39) and the second scanning device (39) have scan beam paths extending inclined to one another;
andor the first scanning device (39) and the second scanning device (39) are arranged spaced apart from one another.
8. A code reader in accordance with claim 7, characterized in that the angle of inclination of the scan beam path of a scanning device (39, 39) with respect to the orthogonal at the direction (23) of the relative movement of the code reader and the codes amounts to between 2 and 20, in particular to approximately 10; andor in that the scan beam path of the first scanning device (39) extends inclined in the direction (23) of the relative movement of the code reader and of the codes, and the scan beam path of the second scanning device (39) extends inclined opposite to this direction (23).
9. A code reader in accordance with claim 7, characterized in that the first scanning device (39) and the second scanning device (39) are arranged spaced apart from one another with respect to the direction (23) of the relative movement of the code reader and of the codes.
10. A code reader in accordance with claim 1, characterized in that the first scanning device (39) and the second scanning device (39) are formedat least in partby separate units.
11. A code reader in accordance with claim 1, characterized in that the first scanning device (39) and the second scanning device (39) are formedat least in partby a common scanning unit.
12. A code reader in accordance with claim 1, characterized in that the first scanning unit (39) and the second scanning unit (39) are formed for the scanning of the reading zone (25) along scan lines (37, 37; 43, 43) adjacent in parallel.
13. A code reading in accordance with claim 1, characterized in that the first scanning device and the second scanning device are formed for the scanning of the reading zone along coinciding scan lines.
14. A code reader in accordance with claim 1, characterized in that the first scanning device and the second scanning device are formed for the scanning of the reading zone along scan lines which extend inclined to one another at an acute angle.
15. A code reader in accordance with claim 1, characterized in that the scanning device (35) extends diagonally with respect to the direction (23) of the relative movement of the code reader and of the codes.
16. A code reader in accordance with claim 1, characterized in that the code reader is additionally formed for the scanning of the reading zone (25) at least along a further scan direction (41).
17. A code reader in accordance with claim 16, characterized in that the scan direction (35) and the further scan direction (41) extend diagonally or perpendicular to one another.
18. A code reader in accordance with claim 16, characterized in that the code reader is also provided for scanning in different focal positions with respect to the further scan direction (41).
19. A code reader in accordance with claim 16, characterized in that the first scanning device (39) and the second scanning device (39) are also provided for the scanning of the reading zone (25) along the further scan direction (41); or
in that at least one additional scanning device is provided for the scanning of the reading zone (25) along the further scan direction (41).
20. A code reader in accordance with claim 1, characterized in that the code reader is formed as a barcode scanner (39, 39), as a line scan camera or a matrix camera.
21. A method for the reading in of codes (27, 29, 31, 33), which move within a reading zone (25) relative to a code reader, by scanning the reading zone at least along one scan direction (35), in particular using a code reader in accordance with claim 1, wherein, for the reading in of codes (29, 31) which are arranged along the scan direction (35) at different distances to the code reader, at least one first scanning device (39) and one second scanning device (39) scan the reading zone at different focal positions along the scan direction (35).
22. A method in accordance with claim 21, characterized in that the focal positions of the first scanning device (39) and of the second scanning device (39) are alternately focused on the respective next code (27, 29, 31) moved into the reading zone.
23. A method in accordance with claim 21, characterized in that the focal positions of the scanning devices (39, 39) are controlled in dependence on the number of codes (29, 31) in the reading zone (25), in dependence on the mutual spacing of the codes andor in dependence on the relative arrangement of the codes with respect to the scan direction.
24. A method in accordance with claim 21, characterized in that the scanning devices (39, 39) are controlled such that
on the presence of a pre-determined minimum number of codes (29, 31) in the reading zone (25), when a pre-determined minimum mutual spacing of the codes in the reading zone is not achieved andor when a plurality of codes are arranged next to one another along the scan direction, the focal positions of the first scanning device (39) and of the second scanning device (39) are focused on different codes (29, 31); and
otherwise, andor after a successful reading in of the codes, the first scanning device (39) and the second scanning device (39) are focused on a common focal position.
25. A method in accordance with claim 21, characterized in-that, for the avoidance of a geometrical shadowing of a scan beam of a scanning device (39, 39) by an object (17, 19) located in the reading zone (25), or for the avoidance of reflection effects at the code to be scanned, the first scanning device (39) and the second scanning device (39) scan the reading zone (25) with scan beams extending inclined to one another.
26. A method in accordance with claim 21, characterized in that the first scanning device (39) and the second scanning device (39) scan the reading zone (25) along scan lines (37, 37; 43, 43) adjacent in parallel, along coinciding scan lines or along scan lines extending obliquely to one another at an acute angle.
27. A method in accordance with claim 21, characterized in that the reading zone (25) is additionally scanned at least along a further scan direction (41), wherein the scan direction (35) and the further scan direction (41) preferably extend diagonally or perpendicular to one another;
andor
wherein the code reader is preferably also controlled with respect to the further scan direction (41) for scanning at different focal positions.