What is claimed is:
1. A molding tray for use in making a dental prostheses model from an impression mold having formed therein imprints of a patient’s teeth, said molding tray comprising;
a. a hollow body having an upper surface, and a peripheral wall protruding downwardly from said upper surface to a lower surface,
b. a base frame located within said body, said base frame having an upper surface located below said upper surface of said body and forming between said base frame, said upper surface and an inner surface of said peripheral wall of said body a shallow upper trough, said base frame having an outer ring-shaped peripheral portion which circumscribes an aperture communicating with a hollow lower interior space within said body,
c. a plurality of longitudinally spaced apart protuberances protruding inwardly from inner surfaces of opposed sides of said peripheral wall of said body, said protuberances alternating with grooves formed between said protuberances,
d. an insert which has a lug portion that is adapted to be insertably received in said aperture in said base frame in a liquid-tight seal therewith, thus forming with said base frame a bottom wall for said upper trough, and
e. whereby said insert my be inserted into said aperture in said base frame, liquid die stone is poured into said upper trough and hardened to comprise a base of a dental model cast, force exerted on said insert received in said base frame to remove said insert from said aperture in said base frame, pins installed in a lower surface of said cast base, said cast base returned to a predetermined index position within said tray enabled by engagement of said protuberances and spaces of said tray with complementary shaped spaces and protuberance molded into sides of said cast base, said cast and tray inverted, and liquid die stone poured into said hollow lower interior space of said tray to form upon hardening a base stone matrix for releasably receiving said pins protruding from said base of said cast.
2. The molding tray of claim 1 further including releasable attachment means for releasably attaching said tray to a second of said trays.
3. The molding tray of claim 2 wherein said releasable attachment means is further defined as comprising in combination a bracket protruding outwardly from a side wall of said body, and hinge mechanism means for pivotably coupling said bracket of said tray to a bracket of a second tray to thereby enable pivotable relative motion between said trays in a plane perpendicular to upper edge walls of said trays.
4. A re-usable molding tray for use in making a dental prostheses model from an impression mold having formed therein imprints of a patient’s teeth, said molding tray comprising;
a. a hollow body having an upper surface, and a peripheral wall protruding downwardly from said upper surface to a lower surface,
b. a base frame located within said body, said base frame having an upper surface located below said upper surface of said body and forming between said base frame, said upper surface and an inner surface of said peripheral wall a shallow upper trough, said base frame having an outer ring-shaped peripheral portion which circumscribes an aperture communicating with a hollow lower interior space within said body,
c. a plurality of longitudinally spaced apart protuberances protruding inwardly from inner surfaces of opposed sides of said peripheral wall of said body, said protuberances alternating with grooves formed between said protuberances,
d. an insert which has a lug portion that is adapted to be insertably received in said aperture in said base frame in a liquid-tight seal, thus forming with said base frame a bottom wall for said upper trough,
e. whereby said insert may be inserted into said aperture in said base frame, liquid die stone is poured into said upper trough and hardened to comprise a base of a dental model cast, a force exerted on said insert received in said base frame to remove said insert from said aperture in said base frame, pins installed in a lower surface of said cast base, said cast base returned to a predetermined index position within said tray enabled by engagement of said protuberances and spaces of said tray with complementary shaped spaces and protuberance molded into sides of said cast base, said cast and tray inverted, and liquid die stone poured into said hollow lower interior space of said tray to form upon hardening a base stone matrix for releasably receiving said pins protruding from said base of said cast, and
f. said base stone matrix being removable from said tray to thereby enable re-use of said tray to make another dental prostheses model.
5. The molding tray of claim 4 further including in combination ejection tool means for removing a die stone matrix base from said tray.
6. The molding tray of claim 5 wherein said ejection tool means is further described as including a template anvil which has a base and an upwardly protruding lug for supporting the upper surface of a base stone matrix in an inverted tray, and knock-out tool means for exerting downward force on said tray relative to said template anvil to thereby cause an upwardly directed reaction force to be exerted on said inverted upper surface of said stone matrix base sufficient to at least partially eject said matrix stone base from said tray.
7. The molding tray of claim 4 further including at least one pair of abutment flanges which protrude outwardly from an opposed pair of sides of said tray.
8. The molding tray of claim 7 further including in combination ejection tool means for removing a die stone matrix base from said tray.
9. The molding tray of claim 8 wherein said ejection tool means is further described as including a template anvil which has a base and an upwardly protruding lug for supporting the upper surface of a base stone matrix in an inverted tray, and knock-out tool means for exerting downward force on said tray relative to said template anvil to thereby cause an upwardly directed reaction force to be exerted on said inverted upper surface of said stone matrix base sufficient to at least partially eject said matrix stone bore from said tray.
10. The molding tray of claim 9 wherein said knock-out tool means is further described as including a block-shaped body which has an upper impacting surface adapted ro receive an impact force, and at a lower part of said body a pair of laterally protruding foot flanges which have lower surfaces adapted to press simultaneously against surfaces of said abutment flanges of said tray.
11. The molding tray of claim 4 wherein said aperture through said base frame is further defined as being formed by breaking from said outer ring-shaped peripheral portion thereof a center panel joined to said ring-shaped peripheral portion thereof by frangible members.
12. The molding tray of claim 11further including at least one pair of abutment flanges which protrude from an opposed pair of sides of said tray.
13. A dental prostheses modeling apparatus including the molding tray of claim 12 and force applying means for applying a compressive force on said flanges relative to said center panel of said base frame sufficient to break said center panel away from said outer ring-shaped peripheral portion of said base frame.
14. The dental prostheses modeling apparatus of claim 13 wherein said force applying means is further defined as comprising in combination a template including a base having protruding upwardly from an upper surface thereof a lug having an upper surface for abutting a lower surface of said center panel, and a knock-out tool for exerting a downward force on said abutment flanges of said tray relative to said template lug.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of treating hypoglycemia comprising administering an effective amount of a compound that activates an ionotropic glutamate receptor to stimulate glucagon release.
2. The method of claim 1, wherein the compound activates the glutamate receptor subunit GluR6.
3. The method of claim 1, wherein the ionotropic glutamate receptor is a AMPAkainate type receptor.
4. The method of claim 1, wherein the compound is selected from the group consisting of kainate, AMPA, and (2S,4R)-4-Methylglutamic acid, (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid, 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid, (\xb1)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine, 1-(4\u2032-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one, 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride, GABA, and Bicuculline.
5. The method of claim 1, wherein the compound is a glutamate analog.
6. The method of claim 1, wherein the compound is administered at a dose of about 5 mgkgday to about 200 mgkgday.
7. The method of one of the preceding claims, wherein the hypoglycemia is associated with diabetes mellitus.
8. Use of a compound that activates an ionotropic glutamate receptor to stimulate glucagon release in the manufacture of a manufacture of a medicament to treat hypoglycemia.
9. A method of stimulating glucagon release comprising administering a compound that activates glutamate receptor subunit GluR6 of an ionotropic glutamate receptor to stimulate glucagon release.
10. The method of claim 9, wherein the ionotropic glutamate receptor is a AMPAkainate type receptor.
11. The method of claim 9, wherein the compound is selected from the group consisting of kainate, AMPA, and GABA.
12. The method of claim 9, wherein the compound is a glutamate analog.
13. The method of claim 9, wherein the compound is administered at a dose of about 5 mgkgday to about 200 mgkgday.
14. An assay for in vitro screening for modulators useful in treating diabetes comprising: providing islet cells in two groups, wherein the first group is a control and the second group is administered a dose of streptozotocin sufficient to destroy the \u03b2 cells present; administering a test compound to both the first and second group; and measuring the potentiation of glucagon release in the first and second groups to determine the effect of the test compound, wherein a decreased in cytoplasmic calcium mobilization andor glucagon release is indicative of a compound that is useful as a modulator.