1. A compound of the formula
6
wherein
R1 is (CH2)nXY,
where n is 0 to 4;
X is O or S or N, and
Y is CH2OC(O)(C1-C4)alkyl, (C1-C8)alkyl optionally substituted with 1-2 OH or 1-2 halo; a monosaccharide, CH2C(O)O(CH2)2OC(O)CH2SH, (CH2)2O(CH2)2W where W is halo; (C1-C8)alkylO(C1-C8)alkyl; (C6-C10)aryl, (C6-C10)aryl(C1-C4)alkyl or C(O)O(C6-C10)aryl wherein the aryl group is optionally substituted with 1-2 OH, halo, (C1-C4)alkyl, or O(C1-C4)alkyl; CH2CO2(C1-C4)alkyl, CH2CO2H, Si((C1-C4)alkyl)3 or an amino acid residue;
R3 is H or (C1-C4)alkyl;
R4 is SCH2CO2(C1-C4)alkyl, S(C6-C10)aryl optionally substituted with halo, OH or (C1-C4)alkyl, or H;
R5 is H, OH or absent;
R6 is (C1-C4)alkyl or absent;
R7 is OH or O(Si((C1-C4)alkyl)3; or
R6 and R7 together are ethylenedioxy;
R8 is (C1-C4)alkyl optionally comprising OH or halo;
the bond represented byis present or absent; or
a pharmaceutically acceptable salt thereof
2. A compound of claim 1 wherein n is 1, the bond represented byis present, and R5 is absent.
3. A compound of claim 2 wherein R3 is CH3, R4 is H, R6 is CH3, R7 is OH and R8 is CH3.
4. A compound of claim 3 wherein X is O.
5. A compound of claim 4 wherein Y is CH2OC(O)CH3.
6. A compound of claim 4 wherein Y is (C1-C4)alkyl.
7. A compound of claim 6 wherein Y is CHCH2CH3.
8. A compound of claim 4 wherein Y is a (C1-C8)alkyl substituted by 2 OH.
9. A compound of claim 8 wherein Y is CH2CH(OH)CH2OH.
10. A compound of claim 4 wherein Y is fructose.
11. A compound of claim 4 wherein Y is (CH2)2Br.
12. A compound of claim 4 wherein Y is (CH2)2OH.
13. A compound of claim 4 wherein Y is C(CH3)2O(C1-C4)alkyl.
14. A compound of claim 13 wherein Y is C(CH3)2OCH3.
15. A compound of claim 4 wherein Y is C(O)O-Phenyl.
16. A compound of claim 3 wherein X is S.
17. A compound of claim 16 wherein Y is phenyl substituted with OH or CH3.
18. A compound of claim 16 wherein Y is benzyl.
19. A compound of claim 16 wherein Y is CH2CO2CH3.
20. A compound of claim 16 wherein Y is CH2CO2H.
21. A compound of claim 16 wherein Y is (C1-C8)alkyl substituted by 2 OH.
22. A compound of claim 21 wherein Y is CH2CH(OH)CH2OH.
23. A compound of claim 1 wherein n is 1, the bond represented byis absent, X is S; Y is CH2CO2CH3; R3 is CH3; R4 is S, CO2CH3; R6 is CH3 and R7 is OH.
24. A compound of claim 23 wherein R5 is H.
25. A compound of claim 23 wherein R5 is OH.
26. A compound of the formula
7
where
R1 is (CH2)n(Y);
where n is 0 to 4; and
Y is CHO, NO2, NH2, COOH, (C2-C4)alkenyl-CHO, CH(O(C1-C4)alkyl)2, cyclo(C3-C6)alkyl or 5-membered heteroaryl comprising one or more heteroatoms selected from N, S, or non-peroxide O, where the cycloalkyl or heteroaryl is optionally substituted with 1-2 (C1-C4)alkyl, CHO, OH or halo;
R3 is (C1-C4)alkyl or H;
R4 is S, CH2CO2(C1-C4)alkyl or H;
R5 is H, OH or absent;
R6 is (C1-C4)alkyl or absent;
R7 is OH;.
R6 and R7 together are ethylenedioxy;
R8 is (C1-C4)alkyl optionally substituted with OH or halo; and
the bond represented byis present or absent; or
a pharmaceutically acceptable salt thereof.
27. A compound of claim 26 wherein the bond represented byis present.
28. A compound of claim 27 wherein R3 is CH3; R4 is H; R6 is CH3, R7 is OH and R8 is CH3.
29. A compound of claim 28 wherein n is 1.
30. A compound of claim 29 wherein Y is CHO.
31. A compound of claim 29 wherein Y is cyclohexyl.
32. A compound of claim 28 wherein n is 2 and Y is CHO.
33. A compound of claim 28 wherein n is O and Y is NO2.
34. A compound of the formula
8
where
R1 is (CH2)n(Y),
where n is 2 to 4;
Y is OH or OAc; and
R2 is absent; or
R1CCR2 together comprise a 5-7 membered cyclic ring, optionally comprising one or more heteroatoms selected from N, S, or non-peroxide O, and optionally substituted with (C1-C4)alkyl, OH or halo;
R3 is H or (C1-C4)alkyl;
R4 is H or CH2CO2(C1-C4)alkyl;
R5 is H, OH or absent;
R6 is (C1-C4)alkyl or absent;
R7 is OH; or
R6 and R7 together are ethylenedioxy; and
the bonds represented byare individually present or absent; or
a pharmaceutically acceptable salt thereof.
35. A compound of the formula
9
where
R1 is H;
R3 is (C1-C4)alkyl or H;
R4 is CH2CO2(C1-C4)alkyl or H;
R5 is H, OH or absent;
R6 is H or absent;
R7 is OH; or
R6 and R7 together are ethylenedioxy; and
the bond represented byis present or absent; or
a pharmaceutically acceptable salt thereof.
36. A compound of claim 35 wherein R1, R3 and R4 are H, the bond represented byis present; and R5 is absent.
37. A compound of claim 36 wherein R6 is H and R7 is OH.
38. A compound of claim 36 wherein R6 and R7 are ethylenedioxy.
39. A compound of the formula
10
40. A compound of the formula (II):
11
where
R1 is (C1-C4)alkyl-Z where Z is OH or halo, or S(C5-C12)aryl wherein aryl is optionally substituted with OH, halo or (C1-C4)alkyl;
R3 is (C1-C4)alkyl; and
R4 is S(CH2)nCOOH wherein n is 1-4; or S(C5-C12)aryl wherein aryl is optionally substituted with OH, halo or (C1-C4)alkyl; or
a pharmaceutically acceptable salt thereof.
41. The compound of claim 40 wherein R3 is CH3.
42. The compound of claim 40 wherein R1 and R4 are S-phenyl.
43. A compound of the formula (III):
12
where
L is a linker covalently attaching compounds A and B via the 3-, 5- or 7- position of one compound and the 3- or 7-position of the other compound; and
R1 and R1 are independently (CH2)nZ where n is 1-4, and Z is halo or OH; or absent.
44. The compound of claim 43 wherein is (CH2)mO(CH2)n, where m and n are independently 1-4.
45. The compound of claim 43 wherein is CH2SCH2C(O)O(CH2)2OC(O)CH2SCH2.
47. The compound of claim 43 wherein A and B are linked via the 5-position and 3-position.
48. The compound of claim 43 wherein A and B are linked via the 5-position and 7-position.
49. A compound of the formula (III):
13
where
L is (CH2)mO(CH2)n, where m and n are independently 1-4, or CH2SCH2C(O)O(CH2)2OC(O)CH2SCH2, covalently attaching compounds A and B via the 5-positions; and
R1 and R1 are independently (CH2)nZ where n is 1-4, and Z is halo or OH; or absent.
50. A pharmaceutical unit dosage form comprising an effective tumor growth inhibiting amount of the compound of claims 1, 26, 34, 35, 39, 40, 43 or 49 in combination with a pharmaceutically-acceptable carrier.
51. The pharmaceutical unit dosage form of claim 50 wherein the carrier is a liquid vehicle.
52. The pharmaceutical unit dosage form of claim 51 wherein the carrier is adapted for parenteral administration.
53. The pharmaceutical unit dosage form of claim 52 wherein the carrier is adapted for intravenous administration.
54. The pharmaceutical unit dosage form of claim 50 wherein the carrier is adapted for oral administration.
55. The pharmaceutical unit dosage form of claim 54, which is a tablet or a capsule.
56. A therapeutic method of inhibiting tumor cell growth in a subject in need of such therapy comprising administering a therapeutic amount of the compound of claims 1, 26, 34, 35, 39, 40, 43 or 49.
57. The therapeutic method of claim 55 wherein the subject is a human cancer patient.
58. The therapeutic method of claim 56 wherein the patient is afflicted with a solid tumor.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A wireless video monitoring system comprising:
a camera for capturing a live video image;
a computer coupled to the camera and comprising a software-based video encoder for encoding and streaming the video image and a software-based video decoder for decoding camera control information encoded in a video compression protocol; and
a mobile device comprising another software-based video decoder for receiving, decoding and displaying the video image and another software-based video encoder for encoding the camera control information in the video-compression protocol, the mobile device transmitting the video compressed encoded camera control information to the computer for full duplex video operation, and the mobile device not having a dedicated hardware-based video decoder, wherein
the video images are encoded by the computer as multi-packet MPEG frames and are streamed sequentially to the mobile device,
the mobile device decodes and completes assembly of each received complete multi-packet frame before signaling the computer with a one byte header to send the next multi-packet frame, and
the software-based video decoder for decoding camera control information encoded in a video compression protocol is based on software different from the software on which the another software-based video encoder for encoding the camera control information in the video-compression protocol is based.
2. A system as claimed in claim 1, wherein the control information controls basic camera functions.
3. A system as claimed in claim 1, wherein the mobile device comprises a display configured to best take advantage of the available storage capacity of the mobile device.
4. A system as claimed in claim 1, and further comprising a network of fixed location, short-range wireless devices for storing and tracking the location of a second mobile device when the second mobile device is not within the range of a conventional cellular or satellite communications network.
5. A system as claimed in claim 1, wherein the mobile device further comprises a location query module to obtain a location of the camera in conjunction with the streaming video image.
6. A system as claimed in claim 5, wherein the location of the camera is obtained by a global positioning system.
7. A system as claimed in claim 5, wherein the location query module obtains the location of the camera in response to a predetermined event.
8. A method for wireless monitoring on a mobile device comprising:
receiving an encoded video stream from a remote camera;
transmitting video-compression protocol encoded camera control information to the remote camera based on a software-based video encoder;
decoding and displaying the video stream on the mobile device based on a software-based video decoder for full duplex video operation, the mobile device not having a dedicated hardware-based video decoder, wherein the video stream is encoded as multi-packet MPEG frames and are streamed sequentially to the mobile device;
completing assembly of each received complete multi-packet frame; and
signaling a computer with a one byte header to send the next multi-packet frame after decoding and completing assembly of the each received complete multi-packet frame, wherein
the software-based video encoder is based on software different from the software on which the software-based video decoder for full duplex video operation is based.
9. A method as claimed in claim 8, wherein the encoded video stream comprises a real-time video feed.
10. A method as claimed in claim 8, wherein the encoded video stream comprises a summary file of images containing significant activity.
11. A method as claimed in claim 10, wherein the summary file contains images in which motion was detected.
12. A method as claimed in claim 8, wherein the encoded video stream is received only when significant activity occurs and is accompanied by an alert to the user of the mobile device.
13. A method as claimed in claim 8, and further comprising:
obtaining a location of the camera in conjunction with the received encoded video stream.
14. A method as claimed in claim 13, wherein the location of the camera is obtained by a global positioning system.
15. A method as claimed in claim 13, wherein the location of the camera is obtained in response to a predetermined event.