1. A semiconductor package comprising:
a board (12) which mounts a semiconductor chip on one surface thereof and arranges many external terminals (14) at a predetermined pitch on the other surface,
wherein positioning holes (13) are formed in at least two positions on said board (12) while securing the accuracy of the dimensions between said hole and any one of said external terminals (14a).
2. The semiconductor package according to claim 1, wherein said positioning hole (13) is either a notch or a hole.
3. The semiconductor package according to claim 2, wherein said semiconductor package is a BGA package, an LGA package, an SON package or a KGD package.
4. In a device socket (15) which is capable of fitting the semiconductor package (11) according to any one of claims 1, 2 and 3, the improvement comprising:
a plurality of contact elements (17), each being capable of contacting with the corresponding one of the external terminals (14) of said semiconductor package (11): and
positioning pins (18), each being engaged with the corresponding one of said positioning holes (13) to guide said external terminal (14) to said contact element (17).
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of treating cancer selected from acute myeloid leukaemia, myelo-dysplastic syndrome, myelo-proliferative diseases, chronic myeloid leukaemia, T-cell acute lymphoblastic leukaemia, B-cell acute lymphoblastic leukaemia, non-hodgkins lymphoma, B-cell lymphoma, solid tumors and breast cancer, comprising the step of administering a compound having the structure:
or any pharmaceutically-acceptable salt thereof, wherein:
Y is N(R11), O or S;
R1 is phenyl substituted by R2, and the phenyl is additionally substituted by 0, 1, 2 or 3 substituents independently selected from halo, nitro, cyano, C1-4alkyl, OC1-4alkyl, OC1-4haloalkyl, NHC1-4alkyl, N(C1-4alkyl)C1-4alkyl and C1-4haloalky
R2 is selected from halo, C1-4haloalkyl, cyano, nitro, \u2014C(\u2550O)Ra, \u2014C(\u2550O)ORa, \u2014C(\u2550O)NRaRa, \u2014C(\u2550NRa)NRaRa, \u2014ORa, \u2014OC(\u2550O)Ra, \u2014OC(\u2550O)NRaRa, \u2014OC(\u2550O)N(Ra)S(\u2550O)2Ra, \u2014OC2-6alkylNRaRa, \u2014OC2-6alkylORa, \u2014SRa, \u2014S(\u2550O)Ra, \u2014S(\u2550O)2Ra, \u2014S(\u2550O)2NRaRa, \u2014S(\u2550O)2N(Ra)C(\u2550O)Ra, \u2014S(\u2550O)2N(Ra)C(\u2550O)ORa, \u2014S(\u2550O)2N(Ra)C(\u2550O)NRaRa, \u2014NRaRa, \u2014N(Ra)C(\u2550O)Ra, \u2014N(Ra)C(\u2550O)ORa, \u2014N(Ra)C(\u2550O)NRaRa, \u2014N(Ra)C(\u2550NRa)NRaRa, \u2014N(Ra)S(\u2550O)2Ra,
R3 is selected from F, Cl, C1-6alkyl, phenyl, benzyl, heteroaryl and heterocycle, wherein the C1-6alkyl, phenyl, benzyl, heteroaryl and heterocycle are additionally substituted by 0, 1, 2 or 3 substituents selected from C1-6haloalkyl, OC1-6alkyl, Br, Cl, F, I and C1-6alkyl
R5 is methyl;
R6 is H;
R7 is selected from C1-6haloalkyl, Br, Cl, F, I, ORa, NRaRa, C1-6alkyl, phenyl, benzyl, heteroaryl and heterocycle, wherein the C1-6alkyl, phenyl, benzyl, heteroaryl and heterocycle are additionally substituted by 0, 1, 2 or 3 substituents selected from C1-6haloalkyl, OC1-6alkyl, Br, Cl, F, I and C1-6alkyl;
R8 is selected from H, halo, C1-4haloalkyl, cyano, nitro, \u2014C(\u2550O)Ra, \u2014C(\u2550O)ORa, \u2014C(\u2550O)NRaRa, \u2014C(\u2550NRa)NRaRa, \u2014S(\u2550O)Ra, \u2014S(\u2550O)2Ra, \u2014S(\u2550O)2NRaRa, \u2014S(\u2550O)2N(Ra)C(\u2550O)Ra, \u2014S(\u2550O)2N(Ra)C(\u2550O)ORa and \u2014S(\u2550O)2N(Ra)C(\u2550O)NRaRa;
R9 is H;
R11 is H or C1-4alkyl;
Ra is independently, at each instance, H or Rb; and
Rb is independently, at each instance, phenyl, benzyl or C1-6alkyl, the phenyl, benzyl and C1-6alkyl being substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4alkyl, C1-3haloalkyl, \u2014OC1-4alkyl, \u2014NH2, \u2014NHC1-4alkyl, \u2014N(C1-4alkyl)C1-4 alkyl.
2. A method of treating according to claim 1, wherein R3 is F, Cl or Br.
3. A method of treating according to claim 1, wherein Y is N(R11).
4. A method of treating according to claim 3, wherein R1 is phenyl substituted by halo, C1-4haloalkyl, cyano, nitro, \u2014C(\u2550O)Ra, \u2014C(\u2550O)ORa, \u2014C(\u2550O)NRaRa, \u2014C(\u2550NRa)NRaRa, \u2014ORa, \u2014OC(\u2550O)Ra, \u2014OC(\u2550O)NRaRa, \u2014OC(\u2550O)N(Ra)S(\u2550O)2Ra, \u2014OC2-6alkylNRaRa, \u2014OC2-6alkylORa, \u2014SRa, \u2014S(\u2550O)Ra, \u2014S(\u2550O)2Ra, \u2014S(\u2550O)2NRaRa, \u2014S(\u2550O)2N(Ra)C(\u2550O)Ra, \u2014S(\u2550O)2N(Ra)C(\u2550O)ORa, \u2014S(\u2550O)2N(Ra)C(\u2550O)NRaRa, \u2014NRaRa, \u2014N(Ra)C(\u2550O)Ra, \u2014N(Ra)C(\u2550O)ORa, \u2014N(Ra)C(\u2550O)NRaRa, \u2014N(Ra)C(\u2550NRa)NRaRa, \u2014N(Ra)S(\u2550O)2Ra, \u2014N(Ra)S(\u2550O)2NRaRa, \u2014NRaC2-6alkylNRaRa or \u2014NRaC2-6alkylORa.
5. A method of treating according to claim 3, wherein R1 is phenyl substituted by cyano, nitro, \u2014C(\u2550O)Ra, \u2014C(\u2550O)ORa, \u2014C(\u2550O)NRaRa, \u2014C(\u2550NRa)NRaRa, \u2014ORa, \u2014OC(\u2550O)Ra, \u2014SRa, \u2014S(\u2550O)Ra or \u2014S(\u2550O)2Ra.
6. A method of treating according to claim 5, wherein R3 is selected from F, Cl, and C1-6alkyl.
7. A method of treating according to claim 6, wherein R7 is selected from ORa and NRaRa.
8. A method of treating according to claim 7, wherein R8 is selected from halo, C1-4haloalkyl, cyano, nitro, \u2014C(\u2550O)Ra, \u2014C(\u2550O)ORa and \u2014C(\u2550O)NRaRa.