1. An abrasive saw blade comprising:
a metal core having a central axial bore for rotation in a given, singular rotational direction and having a plurality of uniform, spaced apart peripheral mounting sections separated by uniform radial notches;
a plurality of abrasive segments of substantially uniform shape and size, and each having first and second ends, said segments being securely attached to said mounting sections of said metal core to form a bonding interface therewith of substantially uniform thickness with said first and second ends of said segments being at a preselected radius from said central axial bore;
a plurality of projections integral with said metal core which extend outwardly from said peripheral mounting sections to at least register with and extend through said preselected radius of said bonding interface at the ends of said segments;
whereby said projections provide undercut protection to said bonding interface between said segments and the mounting sections of said metal core to extend blade life and minimize premature segment loss; and
a plurality of regions spaced apart from one another proximate said segments on each side of said metal core coated with a layer of wear resistance material, said layer being discontinuous.
2. The abrasive blade as in claim 1, wherein at least one end of each said abrasive segment is adjacent one of said plurality of projections.
3. The abrasive blade as in claim 2, wherein each end of each said abrasive segment is adjacent one of said plurality of projections.
4. The abrasive blade as in claim 1, wherein said abrasive segments comprise diamonds dispersed in a metal matrix.
5. The abrasive blade as in claim 1, wherein said abrasive segments have an attachment surface having a uniform radius of curvature and said mounting sections include a peripheral attachment edge having a uniform radius of curvature matching that of said segments.
6. The abrasive blade as in claim 1, wherein each of said radial notches includes substantially parallel sidewalls which terminates interiorly of said metal core in an arcuate wall portion.
7. The abrasive blade as in claim 1, wherein each said segment is securely bonded to one of said mounting sections by soldering, brazing, resistance welding, electron beam welding, or laser welding.
8. The abrasive blade as in claim 1 wherein said layer of wear resistance material has a generally triangular shape.
9. The abrasive blade as in claim 8 wherein the layer of wear resistance material extends between successive radial notches in said metal core.
10. The abrasive blade as in claim 1 wherein said metal core has a first thickness, said thin layer of wear resistance material has a second thickness, and said segments have a thickness greater than or equal to said first thickness plus twice said second thickness.
11. The abrasive blade as in claim 1 wherein said projections are also coated with a layer of wear resistance material.
12. An abrasive saw blade comprising:
a metal core having a central axial bore for rotation in a given, singular rotational direction and having a plurality of uniform, spaced apart peripheral mounting sections separated by uniform radial notches;
a plurality of abrasive segments of substantially uniform shape and size, and each having first and second ends, said segments being securely attached to said mounting sections of said metal core to form a bonding interface therewith of substantially uniform thickness with said first and second ends of said segments being at a preselected radius from said central axial bore; and
a plurality of regions proximate said segments on each side of said metal core coated with a thin layer of wear resistance material, said layer being discontinuous;
whereby said regions provide undercut protection to said bonding interface between said segments and the mounting sections of said metal core to extend blade life and minimize premature segment loss.
13. The a abrasive blade as in claim 12 wherein said metal core has a first thickness, said thin layer of wear resistance material has a second thickness, and said segments have a thickness greater than or equal to said first thickness plus twice said second thickness.
14. The abrasive blade as in claim 12 wherein each region coated with a thin layer of wear resistance material extends between successive radial notches in said metal core.
15. The abrasive blade as in claim 12 further including a plurality of projections integral with said metal core which extend outwardly from said peripheral mounting sections to at least register with and extend through said preselected radius of said bonding interface at the ends of said segments, whereby said projections aid said regions to provide undercut protection to said bonding interface between said segments and the mounting sections of said metal core to extend blade life and minimize premature segment loss.
16. The abrasive blade as in claim 15, wherein at least one end of each said abrasive segment is adjacent one of said plurality of projections.
17. The abrasive blade as in claim 16, wherein each end of each said abrasive segment is adjacent one of said plurality of projections.
18. The abrasive blade as in claim 15, wherein said abrasive segments comprise diamonds dispersed in a metal matrix.
19. The abrasive blade as in claim 15, wherein said abrasive segments have an attachment surface having a uniform radius of curvature and said mounting sections include a peripheral attachment edge having a uniform radius of curvature matching that of said segments.
20. The abrasive blade as in claim 15, wherein each of said radial notches includes substantially parallel sidewalls which terminates interiorly of said metal core in an arcuate wall portion.
21. The abrasive blade as in claim 15, wherein each said segment is securely bonded to one of said mounting sections by soldering, brazing, resistance welding, electron beam welding, or laser welding.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (III):
wherein:
X is CH, N, or C\u2550O;
R1 is H or absent;
R2 is H, F, Cl, OCH3, OCH2CH3, or C1-4 alkyl, CF3, SCH3, substituted or unsubstituted phenyl or NR3R4;
R3 and R4 are H, C1-6 alkyl, or taken together with the nitrogen atom to which they are both attached form a 5\u20136 membered heterocyclyl with optionally 1\u20132 additional heteroatoms independently selected from O, S, or N;
Q is \u2014(CH2)n\u2014 where n is 1 or 2;
P is H, C1-7 acyl, or (C1-6 alkoxy)carbonyl; and
Z is substituted or unsubstituted, and is selected from C3-7 cycloalkyl, phenyl, 5- or 6-membered heteroaryl having 1 or 2 heteroatoms independently selected from N, O, and S, a biaryl, and a 9- or 10-membered fused bicyclyl or fused heterobicyclyl, wherein said fused heterobicyclyl has between 1 and 4 heteroatoms independently selected from N, O, and S; or a pharmaceutically acceptable salt thereof.
2. A compound of claim 1, wherein R1 is H or absent.
3. A compound of claim 1, wherein R2 is H, methyl, or ethyl.
4. A compound of claim 1, wherein Q is \u2014(CH2)n\u2014 and n is 1.
5. A compound of claim 1, wherein Z is independently substituted with between 1 and 3 substituents independently selected from C1-4 alkoxy, phenoxy, C1-4 alkyl, C3-6 cycloalkyl, halo, hydroxy, cyano, amino, C1-4 alkylthio, C1-4 alkylsulfonyl, C1-4 alkylsulfinyl, C1-4 aminoalkyl, mono- and di(C1-4 alkyl)amino, phenyl, C1-4 alkylaminosulfonyl (SO2NHR), amino-(alkylsulfonyl) (\u2014NHSO2R\u2014), C1-4 dialkylaminosulfinyl (SONHRR), C1-4 alkylamido (NHCOR), C1-4 alkylcarbamido (CONHR), 5\u20136 membered heterocyclyl containing between 1 and 3 heteroatoms independently selected from N, S, and O; and wherein the substituent(s) on Z can be further independently substituted with between 1 and 3 substituents independently selected from C1-4 alkoxy, C1-4 alkyl, halo, hydroxy, cyano, amino, mono or di C1-4 alkyl amino and C1-4 alkylthio.
6. A compound of claim 1, wherein Z is 4-substituted phenyl, 3,4-disubstituted phenyl, benzhydryl, substituted or unsubstituted thiophene, biaryl, benzofuranyl, dihydrobenzofuranyl, 4-substituted pyridyl, benzobthienyl, chromanyl, benzothiophenyl, indenyl, indanyl, naphthyl,or 2,3-dihydro-benzo1,4 dioxanyl.
7. A compound of claim 4, wherein Z is unsubstituted or substituted with between 1 and 2 substituents independently selected from methoxy, ethoxy, fluoro, chloro, methyl, ethyl, propyl, butyl and isopropyl.
8. A compound of claim 1, wherein Z is biphenyl, 4-(3-pyridyl) phenyl, 4-(2-thienyl)phenyl, 4-(1H-imidazole-1-yl)-phenyl, 4-(1H-pyrazol-1-yl)-phenyl, (4-ethyl)phenyl, (4-propyl)phenyl, (4-methoxyphenyl), dihydrobenzofuran-5-yl, or dihydrobenzofuran-6-yl.
9. A compound of claim 1, wherein R1 is absent; X is CH and R2 is H, methyl, ethyl, or methoxy.
10. A compound of claim 1, wherein Q is \u2014(CH2)n\u2014, n is 1 or 2; and R2 is H, methyl, or ethyl.
11. A compound of claim 10, wherein R1 is absent.
12. A compound of claim 1, wherein R1 is absent; Q is \u2014(CH2)n\u2014; n is 1 or 2; and R2 is H, methyl, or ethyl; and Z is 4-substituted phenyl, 3,4-disubstituted phenyl, benzhydryl, substituted or unsubstituted thiophene, biaryl, benzofuranyl, hydrobenzofuranyl, dihydrobenzofuranyl, 4-substituted pyridyl, benzobthienyl, chromanyl, benzothiophenyl, indenyl, indanyl, naphthyl, or 2,3-dihydro-benzo1,4dioxanyl.
13. A compound of claim 1, wherein Z is biphenyl, 4-(3-pyridyl) phenyl, 4-(2-thienyl)phenyl, 4-(1H-imidazole-1-yl)-phenyl, 4-(1H-pyrazol-1-yl)-phenyl, (4-ethyl)phenyl, (4-propyl)phenyl, (4-methoxyphenyl), dihydrobenzofuran-5-yl, or dihydrobenzofuran-6-yl; and Z is unsubstituted or substituted with between 1 and 2 substituents independently selected from methoxy, ethoxy, fluoro, chloro, methyl, ethyl, propyl, butyl and isopropyl.
14. A compound of claim 1, selected from 2-{3-2-(2,3-Dihydro-benzofuran-5-yl)-ethyl-3H-benzoimidazol-4-yloxy}-\u03b2-D glucopyranoside; 2-3-(4-Ethyl-benzyl)-3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside and 2-3-(4-Ethyl-benzyl)-3H-benzotriazol-4-yloxy-\u03b2-D-glucopyranoside.
15. A compound of claim 1, selected from 2-3-(4-Ethyl-benzyl) -6-methyl-3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-{3-2-(4-Methoxyphenyl) -ethyl-3H-benzoimidazol-4-yloxy}-\u03b2-D-glucopyranoside; 2-{3-2-(4-methoxy-phenyl) -ethyl-3H-benzotriazol-4-yloxy}-\u03b2-D-glucopyranoside; 2-3-(2-Naphthalen-2-yl-ethyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside and 2-3-(4-Ethyl-benzyl) -1,3-dihydro-benzoimidazol-2-one-4-yloxy-\u03b2-D-glucopyranoside.
16. A compound of claim 1, selected from 2-3-(2-Naphthalen-2-yl-ethyl) -1,3-dihydro-benzoimidazol-2-one-4-yloxy-\u03b2-D-glucopyranoside and 2-3-(2-(4-Methoxyphenyl) -ethyl)-1,3-dihydro-benzoimidazol-2-one-4-yloxy-\u03b2-D glucopyranoside.
17. A compound of claim 1, selected from 2-3-(5-Ethyl-thiophen-2-ylmethyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Ethoxy-benzyl)-3H -benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Ethoxy-benzyl)-3H-benzotriazol-4-yloxy-\u03b2-D-glucopyranoside; 2-{3-2-(2,3-Dihydro-benzofuran-5-yl)-ethyl-6-methyl-3H-benzoimidazol-4-yloxy}-\u03b2-D-glucopyranoside; 2-3-(4-Thiophen-3-yl-benzyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Pyrazol-1-yl-benzyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Pyridin-3-yl-benzyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Pyrrol-1-yl-benzyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Imidazol-1-yl-benzyl)-3H-benzoimidazol -4-yloxy-\u03b2-D-glucopyranoside; 2-(3-Biphenyl-4-ylmethyl-3H-benzoimidazol -4-yloxy)-\u03b2-D-glucopyranoside; 2-3-(4-Ethyl-benzyl)-6-methoxy-3H-benzoimidazol -4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Ethyl-benzyl)-6-trifluoromethyl-3H -benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Ethyl-benzyl)-3H-benzoimidazol -4-yloxy-6-O-ethoxycarbonyl-\u03b2-D-glucopyranoside; 2-3-(4-Ethyl-benzyl) -3H-benzotriazol-4-yloxy-6-O-ethoxycarbonyl-\u03b2-D-glucopyranoside and 2-3-(4-Ethyl-benzyl) -6-methyl-3H-benzotriazol-4-yloxy-\u03b2-D-glucopyranoside.
18. A compound of claim 1, selected from 2-3-(4-Ethyl-benzyl)-3H-benzoimidazol -4-yloxy-\u03b2-D-glucopyranoside; 2-{3-2-(2,3-Dihydro-benzofuran-5-yl)-ethyl-3H-benzoimidazol-4-yloxy}-\u03b2-D glucopyranoside; 2-3-(4-Ethyl-benzyl)-3H-benzotriazol -4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Ethyl-benzyl)-6-methyl-3H-benzoimidazol -4-yloxy-\u03b2-D-glucopyranoside; 2-{3-2-(4-methoxy-phenyl)-ethyl-3H-benzotriazol -4-yloxy}-\u03b2-D-glucopyranoside; 2-3-(5-Ethyl-thiophen-2-ylmethyl)-3H-benzoimidazol -4-yloxy-\u03b2-D-glucopyranoside; 2-{3-2-(2,3-Dihydro-benzofuran-5-yl)-ethyl-6-methyl-3H-benzoimidazol-4-yloxy}-\u03b2-D-glucopyranoside; 2-3-(4-Thiophen-3-yl-benzyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-3-(4-Pyrrol-1-yl-benzyl) -3H-benzoimidazol-4-yloxy-\u03b2-D-glucopyranoside; 2-{3-2-(2,3-Dihydro-benzofuran -5-yl)-ethyl-6-methyl-3H-benzoimidazol-4-yloxy}-\u03b2-D-glucopyranoside; 2-{3-2-(2,3-Dihydro-benzofuran-5-yl)-ethyl-6-methyl-3H-benzotriazol-4-yloxy}-\u03b2-D-glucopyranoside; 2-{3-2-(2,3-Dihydro-benzofuran-5-yl)-ethyl-3H-benzotriazol-4-yloxy}-\u03b2-D-glucopyranoside and 2-3-(4-Ethyl-benzyl)-6-methyl-3H-benzotriazol-4-yloxy-\u03b2-D-glucopyranoside.
19. A pharmaceutical composition, comprising a compound of claim 1, 5, 6, 11, 12, 14, 15, 16, 17, or 18 and a pharmaceutically acceptable carrier.
20. A pharmaceutical composition comprising a compound of claim 14 and a pharmaceutically acceptable carrier.