1. A method for cleaning and maintaining a set of rolls of a paper machine or board machine, wherein the set of rolls is equipped with a soiling monitoring apparatus, and a controllable cleaning device, which is controlled by a control system, the method comprising the steps of:
monitoring the surface of the web by a fault detection system, and delivering the detected information to the control system;
detecting and localizing the soiled part of a roll by the soiling monitoring apparatus; and
delivering information on the detection and location of soiling on the roils gathered by the soiling monitoring system to the control system of the cleaning device, and according to a control command of the control system, controlling the cleaning device to remove the detected soiling from the roll by spreading with liquid at least part of the width of the roll or web during the running of the machine at the same time as the web runs over the surface of said roll, and carrying away the spread liquid and possible extra substances with the web as the web runs over the roll.
2. The method of claim 1 wherein the cleaning device continues its cleaning action until the soiling monitoring apparatus detects that the soiling has been removed.
3. The method of claim 1 wherein the soiling of the roll is detected and localized by a measurement based on laser radiation andor on the basis of a vibration measurement andor by a CCD camera.
4. The method of claim 1 wherein the cleaning device is transferred to the soiled part of the roll.
5. A method for cleaning and maintaining a set of rolls of a paper machine or board machine, wherein the set of rolls is equipped with a soiling monitoring apparatus, and a controllable cleaning device, which is controlled by a control system, the method comprising the steps of:
monitoring the surface of the web by a fault detection system, and delivering the detected information to the control system;
detecting and localizing the soiled part of a roll by the soiling monitoring apparatus; and
delivering information on the detection and location of soiling on the rolls gathered by the soiling monitoring system to the control system of the cleaning device, and according to a control command of the control system, controlling the cleaning device to remove the detected soiling from the rolls, wherein the cleaning device cleans all the rolls of the set of rolls in turn.
6. A method for maintaining the surface of a roll of a paper machine or board machine, over which a web passes in a paper or board machine or paper or board finishing machinery executing a paper or board production process or a finishing process, comprising the steps of:
continuously monitoring the surface of the web andor the roll automatically in order to detect deviations;
if a deviation is detected on the web or on the surface of the roll in the automatic monitoring, momentarily spreading with liquid at least part of the width of the surface of the roll or the web during the running of the machine, at the same time as the web runs over the surface of said roll; and
allowing die spread liquid and possible extra substances to be carried away with the web that runs over the surface of the roll.
7. The method of claim 6 wherein the part of the web which contains the liquid and the possible extra substances is removed later in the process as broke.
8. The method of claim 6 wherein the liquid is spread as a routine operation.
9. The method of claim 8 wherein the spreading is scheduled to those moments when the web running over the roll will become broke due to some phase in the process.
10. The method of claim 9 wherein the phase in the process is selected from the group consisting of a roll change at a reel and changing the grade of paper or board in production.
11. The method of claim 8 wherein the spreading is performed automatically according to a command given by a process control system.
12. The method of claim 8 wherein the spreading is performed along the whole width of the web onto the surface of the roll or the web.
13. The method of claim 8 wherein the method is used to maintain at least one calender roll in a calender or to maintain one coating station counter roll in a coating station.
14. The method of claim 6 wherein the spreading of the liquid onto the surface of the roll or the web is performed as a result of deviation information received from monitoring the web or from monitoring the surface of the roll.
15. The method of claim 14 wherein the liquid is spread on the surface of the roll, or before the roll in the running direction of the web on the surface of the web which will come into contact with the roll.
16. The method of claim 15 wherein the method is used in a calender to maintain at least one calender roll or in a coating station to maintain the counter roll of the coating station.
17. The method of claim 14 wherein the method is used in a coating station to prevent deviations of the coating process from traveling to the rolls with which the web will later come into contact, in which case the liquid is spread in the running direction of the web before the spreading point of the coating color, onto that surface of the web that receives the coating color.
18. The method of claim 17 wherein the liquid is spread by spraying.
19. The method of claim 17 wherein by means of the cleaning liquid the coating color is prevented from sticking at the spreading point to said surface of the web in certain areas of the web.
20. The method of claim 17 wherein a continuous fault in the surface of the web as a result of a deviation in the spreading point of the coating color is removed with the liquid.
21. The method of claim 6 wherein a detector device based on receiving electromagnetic radiation andor a web fault detection system isare used in the automatic monitoring of the web or the surface of the roll.
22. The method of claim 21 wherein two-dimensional surface information is recorded at certain intervals by the detector device and the recorded surface information is compared to the information received of previous recordings for detecting deviations.
23. The method of claim 22 wherein the two-dimensional surface information comprises an image of the same part of the shell surface of the roll over the entire length of one revolution and said image is compared to the information received of previous recordings for detecting deviations.
24. The method of claim 22 wherein the recorded moments are synchronized with the rotation motion of the roll.
25. The method of claim 23 wherein rotation motion of the roll is provided by a rotation velocity detector.
26. The method of claim 6 wherein in addition to automatic monitoring of the surface of the roll, information received from a web fault detection system is used.
27. The method of claim 26 wherein automatic monitoring of die surface of the roll and the web fault detector system are combined into an automatically operating deductive machine.
28. The method of claim 26 wherein monitoring of the surface of the roll is performed by imaging, temperature measurement or vibration measurement or by any combination thereof.
29. The method of claim 27 wherein the automatically functioning deductive machine holds a deduction or computation algorithm capable of learning.
30. The method of claim 6 wherein it is used for maintaining a roll equipped with a flexible roll cover.
31. The method of claim 6 wherein it is used in a paper machine or board machine or in paper or board finishing machinery, in which a coating station and a calender are arranged in the same line so that the web continuously runs from the coating station to the calender.
32. The method of claim 30 wherein it is used in a paper machine or board machine in which a coating station and a calender are arranged in the same line after the paper machine or board machine so that the web produced by the paper machine or board machine continuously runs through the coating station to the calender.
33. The method of claim 6 wherein, in the method, a liquid is fed onto the surface of the roll and the surface of the roll is cleaned with at least two doctor blades, situated one after the other in the direction of rotation of the roll, and that the surface of the roll is cleaned with the doctor blades, which are fitted against the surface of the roll independently of one another.
34. The method of claim 33 wherein the independent movement of each doctor blade to and away from the surface of the roll andor the feed of the liquid isare adjusted based on the information received from a fault detection device.
35. The method of claim 33 wherein the liquid is fed before the first doctor blade in the direction of rotation of the roll andor between the first and the second doctor blade.
36. The method of claim 33 wherein the surface of the roll is fed with liquid which changes the surface of the roll to be more hydrophilic.
37. The method of claim 33 wherein the boiling point of the liquid is higher than the temperature of the roll surface in process conditions.
38. The method of claim 20 wherein the continuous fault which is removed is a coating color streak.
39. An apparatus for cleaning a roll of a paper machine or board machine comprising:
a cleaning device for cleaning the roll;
a control system for controlling the cleaning device;
a soiling monitoring apparatus for detecting the soiled part of the roll, and arranged to deliver the detected information to the control system; and
a fault detection system positioned to detect faults in the web and arranged to deliver the detected information to a control system, the control system being operable to control the cleaning device to remove soiled parts of the roll, wherein the cleaning device comprises a liquid spreading device and an arrangement far carrying away liquid and possible extra substances with the web as it runs over the surface of the roll.
40. The apparatus of claim 39 wherein the soiling monitoring apparatus comprises a measuring unit and a control unit.
41. The apparatus of claim 40 wherein the measuring unit of the soiling monitoring apparatus is a measuring device based on laser radiation andor a measuring device based on vibration measurement.
42. The apparatus of claim 39 wherein the cleaning device comprises at least one of the following doctor actuators: a laser doctor, a blade a washing doctor and a blow doctor.
43. The apparatus of claim 39 wherein the cleaning device comprises at least one doctor blade, and wherein the roll is a calender roll within a calender, and wherein the angle between the doctor blade and the calender roll, andor the doctoring pressure of the doctor blade against the calender roll is adjustable.
44. The apparatus of claim 39 further comprising a plurality of rolls in a roll stack, wherein a traversing cleaning device is arranged on both sides of the roll stark.
45. An apparatus for cleaning a roll of a paper machine or board machine comprising:
a cleaning device for cleaning the roll;
a control system for controlling the cleaning device;
a soiling monitoring apparatus for detecting the soiled next of the roll, and arranged to deliver the detected information to the control system; and
a fault detection system positioned to detect faults in the web and arranged to deliver the detected information to a control system, the control system being operable to controlling the cleaning device to remove soiled parts of the roll, wherein the cleaning device comprises a laser doctor comprising:
a laser light source; and
a lens in which the power and direction of the laser beam are adjustable.
46. An apparatus for cleaning a roll of a paper machine or board machine comprising:
a cleaning device for cleaning the roll;
a control system for controlling the cleaning device;
a soiling monitoring apparatus for detecting the soiled part of the roll, and arranged to deliver the detected information to the control system; and
a fault detection system positioned to detect faults in the web and arranged to deliver the detected information to a control system, the control system being operable to control the cleaning device to remove soiled parts of the roll, wherein the cleaning device has a doctor blade which comprises blade parts that can be placed in operation in zones for doctoring the rolls of a set of rolls over the whole length or part of the length of said rolls.
47. An apparatus far cleaning a roll of a paper machine or board machine comprising:
a cleaning device for cleaning the roll;
a control system for controlling the cleaning device;
a soiling monitoring apparatus for detecting the soiled part of the roll, and arranged to deliver the detected information to the control system;
a fault detection system positioned to detect faults in the web and arranged to deliver the detected information to a control system, the control system being operable to control the cleaning device to remove soiled parts of the roll; and
a plurality of rolls in a roll stack, and wherein the cleaning device is arranged to traverse in the vertical and horizontal directions along the whole dimension of the roll stack.
48. The apparatus of claim 47 wherein the traversing cleaning device is connected to a hoist.
49. An apparatus for maintaining the surface of a roll in a paper machine or board machine performing a paper or board production process or a finishing process or in paper or board finishing machinery, which includes members for guiding a web over the surface of a roll, the apparatus comprising:
at least one automatic monitoring device which is arranged to continuously monitor the web andor the surface of the roll;
a data processing device which is connected to the monitoring device;
a liquid spreading device which is connected to the data processing device and arranged to spread a liquid onto the surface of the roll or the web based on commands given by the data processing device; and
an arrangement that enables the liquid and possible extra substances to be carried away with the web that runs over the surface of the roll.
50. The apparatus of claim 49 further comprising at least two doctor blades which are situated one after the other in the direction of rotation of the roll, and which can be fitted independently of one another against the roll to be cleaned.
51. The apparatus of claim 49 further comprising:
at least two doctor blades which can be fitted against the roll; and
a fault detection device, which is arranged to adjust the movement of the doctor blades to the surface of the roll, away from the surface of the roll andor the feed of liquid onto the surface of the roll.
52. The apparatus of claim 49 further comprising:
a first doctor blade; and
a second doctor blade, wherein the doctor blades can be fitted against the roll, wherein the feed of the liquid is arranged before the first doctor blade in the direction of rotation of the roll andor between the first and the second doctor blade.
53. The apparatus of claim 52 wherein each of the first doctor blade and the second doctor blade have portions defining a frame, and wherein feed members for feeding the liquid are arranged in the frame of at least one of the doctors.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. (canceled)
2. An in vitro method for inducing NK cells to proliferate, the method comprising contacting a population of NK cells with a nanomatrix, the nanomatrix comprising
a) a matrix of mobile polymer chains; and
b) attached to said matrix of mobile polymer chains one or more stimulatory agents which provide activation signals to the NK cells;
wherein the nanomatrix is 1 to 500 nm in size
3. The method according to claim 2, wherein at least one first and one second stimulatory agents are attached to the same matrix of mobile polymer chains.
4. The method according to claim 2, wherein at least one first and one second stimulatory agents are attached to separate matrices of mobile polymer chains.
5. The method according to claim 4, wherein the ratio of nanomatrices to cells is larger than 100:1 allowing fine-tuning of NK cell proliferation.
6. The method according to claim 2, wherein one stimulatory agent is an anti-CD2 antibody or fragment thereof.
7. The method according to claim 6, wherein the second stimulatory agent is an anti-CD335 antibody or fragment thereof.
8. The method according to claim 2, wherein the matrix of mobile polymer chains consists of a polymer of dextran.
9. The method according to claim 2, wherein the nanomatrix carries magnetic, paramagnetic or superparamagnetic nano-crystalls, embedded into the matrix of mobile polymer chains.
10. The method according to claim 2 wherein the stimulatory agent is attached at high density with more than 25 \u03bcg per mg nanomatrix.
11. A method for inducing NK cells to proliferate in a closed cell culture system, the method comprising contacting a cell culture comprising a population of NK cells within said closed cell culture system with a dosage of nanomatrix, the nanomatrix comprising
a) a matrix of mobile polymer chains; and
b) attached to said matrix of mobile polymer chains one or more stimulatory agents which provide activation signals to the NK cells;
wherein the nanomatrix is 1 to 500 nm in size, and
wherein said dosage of nanomatrix is applied sterile to said closed cell culture system, and
wherein said dosage depends on the volume of the cell culture in said closed cell culture system.
12. A method according to claim 11, wherein said volume of the cell culture can be determined by a balance or a camera system without affecting the sterility barrier.
13. A method according to claims 11, wherein determining and applying said dosage are performed automatically.
14. A pharmaceutical composition comprising a population of proliferated NK cells produced according to the method of claim 11.