1. A crystalline form of lapatinib ditosylate (Form XIII) characterized by data selected from the group consisting of a PXRD pattern having peaks at about 5.9, 6.8, and 8.9\xb10.2 degrees 2-theta, and at least two peaks from the following list: 12.2, 13.5, 16.0, 18.7 and 22.9\xb10.2 degrees 2-theta; a PXRD pattern having peaks at about 5.9, 6.8, 8.9, 12.2 and 13.6\xb10.2 degrees 2-theta; a PXRD pattern having peaks at about 5.9, 6.8, 8.9, 12.2, 13.6, 14.6, 16.0, 19.0, 20.4 and 22.9\xb10.2 degrees 2-theta; a solid-state 13C NMR spectrum having signals at about 125.1, 129.6 and 150.7\xb10.2 ppm; and a solid-state 13C NMR spectrum having chemical shifts differences between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm of about 17.2, 21.7 and 42.8\xb10.1 ppm, wherein the signal exhibiting the lowest chemical shift in the chemical shift area of 100 to 180 ppm is typically at about 107.9\xb11 ppm.
2. The crystalline form of lapatinib ditosylate of claim 1, characterized by a PXRD pattern having peaks at about 5.9, 6.8, 8.9, 12.2 and 13.6\xb10.2 degrees 2-theta or a PXRD pattern having peaks at about 5.9, 6.8, 8.9, 12.2, 13.6, 14.6, 16.0, 19.0, 20.4 and 22.9\xb10.2 degrees 2-theta.
3. The crystalline form of lapatinib ditosylate of claim 1 having an X-ray diffraction diagram substantially as depicted in FIG. 23.
4. A process for preparing the crystalline lapatinib ditosylate of claim 1 comprising forming a solution of lapatinib ditosylate in dimethylacetamide; adding an antisolvent; and drying the obtained precipitate.
5. The process of claim 4 wherein the antisolvent is hexane.
6. The process of claim 4, wherein the lapatinib ditosylate is prepared in situ by a process comprising combining lapatinib base and p-toluenesulfonic acid in dimethylacetamide.
7. A pharmaceutical composition comprising the crystalline lapatinib ditosylate of claim 1.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A down-spout flow diverter for diverting water from a gutter system, through a down-spout, to a predetermined alternate location, the flow diverter comprising:
a main body defining an interior passage through which water, from a down-spout, flows to a primary location, the main body having an aperture disposed to define an outlet from which the water can be redirected from the interior passage to a predetermined alternate location;
a sliding jacket disposed for sliding engagement with the main body, the sliding jacket being movable from a first position covering the aperture, to a second adjacent position exposing the aperture to provide communication between the interior passage and the alternate location;
a diverter plate pivotally supported by the main body; the diverter plate disposed to pivot from a stowed position where the diverter plate is disengaged from the flow of water through the interior passage, to a diverting position where a portion of the diverter plate extends into the interior passage to divert the flow of water from the interior passage, through the outlet, to a predetermined alternate location; and
wherein the diverter plate pivots from the stowed position to the diverting position responsive to the sliding jacket being moved from the first position covering the aperture, to the second position exposing the aperture.
2. A down-spout flow diverter as recited in claim 1 wherein the sliding jacket comprises an opening lobe that extends inward toward the interior passage, and the diverter plate comprises a concave groove disposed to receive the opening lobe when the sliding jacket is in the first position covering the aperture, wherein as the sliding jacket is moved from the first position covering the aperture, to the second position exposing the aperture, the opening lobe urges the diverter plate from the stowed position to the diverting position responsive to the opening lobe disengaging the concave groove.
3. A down-spout flow diverter as recited in claim 2 wherein the main body comprises a bi-curved groove disposed to engage and receive the opening lobe when the sliding jacket is moved from the first position covering the aperture, to the second adjacent position exposing the aperture, thereby maintaining the sliding jacket in the second position.
4. A down-spout flow diverter as recited in claim 3 wherein the main body further comprises a seepage barrier disposed outwardly offset from the aperture, extending upward from the base of the main body to define a drain void for channeling water seepage, that flows through the aperture from the interior passage when the diverter plate is in the stowed position, back to the interior passage.
5. A down-spout flow diverter as recited in claim 1 wherein the main body further comprises a seepage barrier disposed outwardly offset from the aperture, extending upward from the base of the main body to define a drain void for channeling water seepage, that flows through the aperture from the interior passage when the diverter plate is in the stowed position, back to the interior passage.
6. A down-spout flow diverter as recited in claim 5 further comprising an installation collar for connecting a down-spout to the main body, the installation collar being formed to slide over the outer surface of a down-spout for sliding movement from a disengaged position around the outer surface of a down-spout, to an engaged position connecting the down-spout to the main body so that water flowing through the down-spout is directed into the interior passage of the main body.
7. A down-spout flow diverter as recited in claim 1 further comprising an installation collar for connecting a down-spout to the main body, the installation collar being formed to slide over the outer surface of a down-spout for sliding movement from a disengaged position around the outer surface of a down-spout, to an engaged position connecting the down-spout to the main body so that water flowing through the down-spout is directed into the interior passage of the main body.
8. A down-spout flow diverter as recited in claim 1 wherein the diverter plate comprises opposing side surfaces extending between a lower edge and an upper edge of the diverter plate, the diverter plate further comprising at least one pivot axle extending outward from a side surface to pivotally engage the main body, the pivot axle being disposed between the upper edge of the diverter plate and the lower edge of the diverter plate so that as the diverter plate pivots from the stowed position to the diverting position, the lower edge of the diverter plate shifts outward, and the upper edge shifts inward into the interior passage.
9. A down-spout flow diverter as recited in claim 8 wherein the pivot axle is offset on the side surface.
10. A method of making a down-spout flow diverter for diverting water collected from a gutter system to a predetermined alternate location, the method comprising the steps:
forming a main body to define an interior passage through which collected water flows to a primary location, the main body having an aperture disposed to define an outlet from which collected water can be redirected from the interior passage to a predetermined alternate location;
providing a sliding jacket disposed for sliding engagement with the main body, the sliding jacket being movable from a first position covering the aperture, to a second adjacent position exposing the aperture to provide communication between the interior passage and the alternate location;
pivotally supporting a diverter plate from the main body; the diverter plate disposed to pivot from a stowed position where the diverter plate is disengaged from the flow of water through the interior passage, to a diverting position where a portion of the diverter plate extends into the interior passage to divert the flow of water from the interior passage, through the outlet, to a predetermined alternate location; and
wherein the diverter plate is pivotal from the stowed position to the diverting position responsive to the sliding jacket being moved from the first position covering the aperture, to the second position exposing the aperture.
11. A method of making a down-spout flow diverter as recited in claim 10 wherein the sliding jacket is formed to define an opening lobe that extends inward toward the interior passage, and the diverter plate formed to define a concave groove disposed to receive the opening lobe when the sliding jacket is in the first position covering the aperture, wherein as the sliding jacket is moved from the first position covering the aperture, to the second position exposing the aperture, the opening lobe urges the diverter plate from the stowed position to the diverting position responsive to the opening lobe disengaging the concave groove.
12. A method of making a down-spout flow diverter as recited in claim 11 wherein the main body is formed to define a bi-curved groove disposed to engage and receive the opening lobe when the sliding jacket is moved from the first position covering the aperture, to the second adjacent position exposing the aperture, thereby maintaining the sliding jacket in the second position.
13. A method of making a down-spout flow diverter as recited in claim 12 wherein the main body is formed to further comprise a seepage barrier disposed outwardly offset from the aperture, extending upward from the base of the main body to define a drain void for channeling water seepage, that flows through the aperture from the interior passage when the diverter plate is in the stowed position, back to the interior passage.
14. A method of making a down-spout flow diverter as recited in claim 10 wherein the main body is formed to further comprise a seepage barrier disposed outwardly offset from the aperture, extending upward from the base of the main body to define a drain void for channeling water seepage, that flows through the aperture from the interior passage when the diverter plate is in the stowed position, back to the interior passage.
15. A down-spout flow diverter for diverting water from a gutter system, through a down-spout, to a predetermined alternate location, the flow diverter comprising:
a main body defining an interior passage through which water, from a down-spout, flows to a primary location, the main body having an aperture disposed to define an outlet from which the water can be redirected from the interior passage to a predetermined alternate location;
a sliding jacket disposed for sliding engagement with the main body, the sliding jacket being movable from a first position covering the aperture, to a second adjacent position exposing the aperture to provide communication between the interior passage and the alternate location;
a diverter plate pivotally supported by the main body; the diverter plate disposed to pivot from a stowed position where the diverter plate is disengaged from the flow of water through the interior passage, to a diverting position where a portion of the diverter plate extends into the interior passage to divert the flow of water from the interior passage, through the outlet, to a predetermined alternate location;
wherein the diverter plate pivots from the stowed position to the diverting position responsive to the sliding jacket being moved from the first position covering the aperture, to the second position exposing the aperture; and
wherein the sliding jacket comprises an opening lobe that extends inward toward the interior passage, and the diverter plate comprises a concave groove disposed to receive the opening lobe when the sliding jacket is in the first position covering the aperture, wherein as the sliding jacket is moved from the first position covering the aperture, to the second position exposing the aperture, the opening lobe urges the diverter plate from the stowed position to the diverting position responsive to the opening lobe disengaging the concave groove.
16. A down-spout flow diverter as recited in claim 15 wherein the main body further comprises a seepage barrier disposed outwardly offset from the aperture, extending upward from the base of the main body to define a drain void for channeling water seepage, that flows through the aperture from the interior passage when the diverter plate is in the stowed position, back to the interior passage.
17. A down-spout flow diverter as recited in claim 16 further comprising an installation collar for connecting a down-spout to the main body, the installation collar being formed to slide over the outer surface of a down-spout for sliding movement from a disengaged position around the outer surface of a down-spout, to an engaged position connecting the down-spout to the main body so that water flowing through the down-spout is directed into the interior passage of the main body.
18. A down-spout flow diverter as recited in claim 15 further comprising an installation collar for connecting a down-spout to the main body, the installation collar being formed to slide over the outer surface of a down-spout for sliding movement from a disengaged position around the outer surface of a down-spout, to an engaged position connecting the down-spout to the main body so that water flowing through the down-spout is directed into the interior passage of the main body.
19. A down-spout flow diverter as recited in claim 15 wherein the main body comprises a bi-curved groove disposed to engage and receive the opening lobe when the sliding jacket is moved from the first position covering the aperture, to the second adjacent position exposing the aperture, thereby maintaining the sliding jacket in the second position.
20. A down-spout flow diverter as recited in claim 19 wherein the main body further comprises a seepage barrier disposed outwardly offset from the aperture, extending upward from the base of the main body to define a drain void for channeling water seepage, that flows through the aperture from the interior passage when the diverter plate is in the stowed position, back to the interior passage.