1. A cartridge set for manufacturing a syringe, the cartridge set comprising:
a plurality of cartridges, each of which extends in an up-and-down direction, forms a cylindrical shape having an outer peripheral surface, and has annular ribs protruding radially outward from opening end portions thereof that correspond to both ends of the outer peripheral surface;
a plurality of holders, each of which has flexibility, has an upper end externally fitted to the outer peripheral surface of each of the cartridges, is gradually increased in diameter as it goes downward, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge;
a supporting plate that forms a plate shape that extends in a horizontal direction, has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough in the up-and-down direction, and has a top face on which the lower end faces of the plurality of holders are placed in a state where the plurality of cartridges are each inserted through the plurality of through-holes in the up-and-down direction;
a storage box that forms a box shape that opens upward, stores the supporting plate therein in a state where the supporting plate supports the plurality of cartridges via the plurality of holders, and has a supporting portion which supports an outer edge of the supporting plate; and
a lid member that blocks an upper end opening of the storage box.
2. The cartridge set according to claim 1,
wherein the holder has a slit that extends downward from the upper end of the holder.
3. A method for manufacturing a dual-chamber type combined container-syringe using the cartridge set having a plurality of cartridges, each of which extends in an up-and-down direction, forms a cylindrical shape having an outer peripheral surface, and has annular ribs protruding radially outward from opening end portions thereof that cones and to both ends of the outer peripheral surface; and a plurality of holders, each of which has flexibility, has an upper end externally fitted to the outer peripheral surface of each of the cartridges, is gradually increased in diameter as it goes downward, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge; and a supporting plate that forms a plate shape that extends in a horizontal direction, has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough in the up-and-down direction, and has a top face on which the lower end faces of the plurality of holders are placed in a state where the plurality of cartridges are each inserted through the plurality of through-holes in the up-and-down direction; and a storage box that forms a box shape that opens upward, stores the supporting plate therein in a state where the supporting plate supports the plurality of cartridges via the plurality of holders, and has a supporting portion which supports an outer edge of the supporting plate; and a lid member that blocks an upper end opening of the storage box, the method comprising:
a first step of taking out the supporting plate along with the plurality of holders and the plurality of cartridges from the cartridge set;
a second step of, after the first step, sequentially filling and inserting an end stopper, a solvent, and a middle stopper into each of the plurality of cartridges from above in a state where the plurality of cartridges is supported by the supporting plate via the plurality of holders, and sealing the solvent within the cartridge; and
a third step of, after the second step, inserting a drug and a front stopper into each of the plurality of cartridges from above, and sealing the drug within the cartridge.
4. The method for manufacturing a dual-chamber type combined container-syringe according to claim 3,
wherein the third step includes:
a filling step of filling an injection drug solution into each of the plurality of cartridges;
a sealing step of sealing the injection drug solution along with an internal gas within the cartridge by the middle stopper and the front stopper; and
a lyophilizing step of lyophilizing the injection drug solution to make the injection drug solution into a lyophilized preparation as the drug, and
wherein the lyophilizing step includes:
a freezing process of freezing the injection drug solution;
a pressure-reducing process of, after the freezing process, making the pressure of an external atmosphere lower than the pressure of the internal gas within the cartridge to bring the front stopper into a partially closed state with respect to the cartridge;
a drying process of changing the injection drug solution to the lyophilized preparation due to a sublimation action;
a replacement process of replacing the internal gas within the cartridge with pure nitrogen; and
a sealing process of pushing the front stopper in the partially closed state into the cartridge.
5. The method for manufacturing a dual-chamber type combined container-syringe according to claim 3, further comprising, between the second step and the third step, a autoclave sterilization step of exposing the plurality of cartridges to steam in a state where the plurality of cartridges is supported by the supporting plate via the plurality of holders.
6. The method for manufacturing a dual-chamber type combined container-syringe according to claim 3, further comprising, after the third step, a front assembly fitting step of removing the plurality of cartridges, to each of which a corresponding one of the plurality of holders is fitted, from the supporting plate, and externally fitting each of a plurality of front assemblies to a corresponding one of the plurality of cartridges while each of the plurality of holders is pressed downward by a corresponding one of the plurality of front assemblies.
7. The method for manufacturing a dual-chamber type combined container-syringe according to claim 6, further comprising, after the front assembly fitting step, a holder removing step of moving the plurality of holders downward relative to the plurality of cartridges to remove each of the plurality of holders from lower sides of the plurality of cartridges.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A combined pressure transducer, comprising:
a housing having an internal hollow and a first and second pressure port;
a first header having a first and second flexible isolation diaphragm;
a first pressure sensor on the first header having a first sensor diaphragm, said first sensor diaphragm communicating with the first flexible isolation diaphragm and the second flexible isolation diaphragm;
a second pressure sensor on the first header having a second sensor diaphragm, said second sensor diaphragm communicating with the first flexible isolation diaphragm;
the first header positioned in the hollow of the housing;
the first header coupled so that the first flexible isolation diaphragm communicates with the first pressure port of the housing;
the first header coupled so that the second flexible isolation diaphragm communicates with the second pressure port of the housing.
2. The pressure transducer of claim 1, wherein the housing has a first section coupled to a second section.
3. The pressure transducer of claim 1, wherein the housing is substantially cylindrical.
4. The pressure transducer of claim 1, further comprising a threaded section to engage another object.
5. The pressure transducer of claim 4, further comprising:
a first channel extending through the threaded section, said first channel communicating with the first flexible isolation diaphragm and the first pressure port;
a second channel extending through the threaded section, said second channel communicating with the second flexible isolation diaphragm and the second pressure port.
6. The pressure transducer of claim 1, wherein the first header has a substantially circular cross-section.
7. The pressure transducer of claim 1, further comprising a pressure sensing device which measures a reference pressure.
8. The pressure transducer of claim 7, further comprising a third pressure port, and wherein the pressure sensing device comprises:
a second header located in the hollow of the housing;
a third pressure sensor on the second header having a third sensor diaphragm, said third sensor diaphragm communicating with the reference pressure via the third pressure port.
9. The pressure transducer of claim 8, further comprising:
a first piezoresistive device on the second sensor diaphragm;
a second piezoresistive device on the third sensor diaphragm;
the first piezoresistive device communicating with the second piezoresistive device to produce a gage sensor.
10. The pressure transducer of claim 9, wherein the first and second piezoresistive devices are in a Wheatstone bridge configuration.
11. The pressure transducer of claim 10, wherein a half bridge of the first piezoresistive device communicates with a half bridge of the second piezoresistive device.
12. The pressure transducer of claim 1, further comprising a pressure transmitting fluid which is the medium by which the sensor diaphragms and the isolation diaphragms communicate.
13. The pressure transducer of claim 12, further comprising a tube extending from the first header, said tube adapted to hold pressure transmitting fluid.
14. The pressure transducer of claim 12, wherein the pressure transmitting fluid is oil.
15. The pressure transducer of claim 1, wherein a flexible isolation diaphragm and a pressure port communicate via a tube.
16. The pressure transducer of claim 1, wherein the first flexible isolation diaphragm and the second flexible isolation diaphragm are substantially the same size.
17. The pressure transducer of claim 1, wherein the first and second sensor diaphragms are silicon.
18. The pressure transducer of claim 1, wherein the first and second pressure sensors are fabricated on the same chip.