1. A process for preparation of a 18F-FACBC precursor compound of Formula IVa:
from a compound of Formula IIIa:
wherein:
R denotes an alkyl group with 1 to 5 carbon atoms; Y denotes a protecting group for an amine; and,
X denotes a protecting group for an alcohol;
wherein the process is used to prepare at least 100 gram batch sizes of Formula IVa and goes to completion based on TLC in five or less days, and includes using an acid to adjust the pH of a reaction medium comprising the compound of Formula IIIa and ethanol to 2.0-5.0, adjusting the amounts of Formula IIIa and ethanol, and performing a hydrogenolysis of X using a wet palladium on carbon catalyst.
2. A process as defined in claim 1 wherein R is an ethyl group, Y is BOC and X is benzyl.
3. A process as defined in claim 1 wherein said catalyst has a palladium loading of 1-10%.
4. A process as defined in claim 1 wherein the acid is acetic acid.
5. A process as defined in claim 1 wherein the pH is adjusted to 2.5-3.5.
6. A process as defined in claim 1 wherein said catalyst is in the form of a slurry comprising 30% to 70% water by weight.
7. A process as defined in claim 6 wherein said slurry comprises about 50% water by weight.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An optical film comprised of a light transmissible polymeric material having a microstructured surface wherein the film is a substantially non-polarizing film having a single sheet relative gain of at least 1.78.
2. The optical film of claim 1 wherein at least the microstructured surface comprises the reaction product of a polymerizable resin wherein the polymerizable resin has a refractive index of at least 1.61.
3. The optical film of claim 1 wherein the microstructured surface comprises a repeating pattern of linear prisms.
4. The optical film of claim 3 wherein the prisms have apexes that are sharp, rounded, or truncated.
5. The optical film of claim 3 wherein the prisms have apex angles that range from 80\xb0 to 100\xb0.
6. The optical film of claim 3 wherein the prisms have an apex angle of about 90\xb0, a mean distance between adjacent apices of about 50 micrometers, and the prisms have heights that are substantially the same or vary.
7. The optical film of claim 1 wherein at least the microstructured surface comprises the reaction product of a polymerizable composition wherein the polymerizable composition has an absorbance of less than 2.5 for a wavelength of 450 nm and an absorbance of less than 1 for wavelengths ranging from about 575 nm to 800 nm.
8. The optical film of claim 1 wherein at least the microstructured surface comprises a polymerizable composition comprising fully condensed surface modified inorganic nanoparticles.
9. The optical film of claim 8 wherein the inorganic nanoparticles comprise zirconia.
10. The optical film of claim 1 wherein the film comprises a base layer coupled to the microstructured surface.
11. The optical film of claim 10, where the base layer has a high-index axis and the microstructured surface comprises parallel prisms aligned 90 degrees +\u221220 degrees to the high-index axis of the base layer.
12. The optical film of claim 10 wherein the base layer comprises styrene-acrylonitrile polymer, cellulose triacetate, polymethyl methacrylate, polyester, polycarbonate, polyethylene naphthalate, copolymers of naphthalene dicarboxylic acids, norbornene polymer, or mixtures thereof.
13. An assembly comprising the microstructured optical film of claim 1 proximate a second optical film.
14. The assembly of claim 13 wherein the second optical film is a turning film, a polarizing film, a diffuser film, or combination thereof.
15. An assembly comprising a first microstructured optical film proximate a non-structured reflective polarizing film wherein the assembly of the first film and polarizing film has a relative gain of at least 2.59.
16. The assembly of claim 15 wherein the first microstructured optical film comprises a pattern of substantially parallel prisms, the reflective polarizing film has a pass axis, and the prisms of the microstructured optical film are orthogonal to the pass axis of the reflective polarizing film.
17. An assembly comprising a first substantially non-polarizing microstructured optical film proximate a second substantially non-polarizing microstructured optical film wherein the assembly of the first and second films has a relative gain of at least 2.80.
18. The assembly of claim 17 wherein each optical film has an unstructured surface and the microstructured surface of the second film is proximate the unstructured surface of the first film.
19. The assembly of claim 18 wherein the microstructured surface of each film comprises a pattern of substantially parallel prisms and the second film is positioned such that the prisms of the second sheet are nonparallel to the prisms of the first film.
20. The assembly of claim 19 wherein the prisms of the second film are positioned at angles ranging from 90\xb0+\u221220\xb0 relative to the prisms of the first film.
21. The assembly of optical films of claim 17 wherein the first microstructured optical film is the same or different than the second microstructured optical film.
22. The assembly of claim 17 further comprising a third optical film proximate the first or second optical film.
23. The assembly of claim 22 wherein the third optical film is a non-structured reflective polarizer.
24. The assembly of claim 23 wherein the assembly of the first, second, and third optical films has a relative gain of at least 3.40.
25. The assembly of claim 19 further comprising a non-structured reflective polarizer having a pass axis positioned above the assembly of substantially non-polarizing microstructured optical films wherein the prisms of the non-polarizing microstructured optical film adjacent the non-structured reflective polarizer are orthogonal to the pass axis of the reflective polarizing film.