1. An integrated circuit device comprising:
a base comprising one or more non-metals;
at least one die attached to the base; and
a counterbalancing layer on at least a portion of at least one side of the base adapted to compensate for at least a portion of a thermal expansion difference existing between the base and the die, wherein said counterbalancing layer comprises at least one metal.
2. An integrated circuit device comprising:
a base comprising one or more of silicon carbide, aluminum nitride and chemical vapor deposited diamond;
at least one die attached to the base; and
a counterbalancing layer on at least a portion of at least one side of the base adapted to compensate for at least a portion of a thermal expansion difference existing between the base and the die, wherein said counterbalancing layer comprises at least one metal.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A Lactobacillus salivarius, which is belonging to Lactobacillus salivarius subsp. Salivarius and deposited in China General Microbiological Culture Collection Center with an accession number CGMCC No: 3606.
2. A metabolite of the Lactobacillus salivarius of claim 1, wherein the metabolite is prepared by the method comprising:
exposing the viable thalli of the Lactobacillus salivarius with liquid medium under the conditions allowing the Lactobacillus salivarius to survive;
obtaining the products of the exposure; and
isolating the liquid products from the products of the exposure.
3. (canceled)
4. The metabolite of claim 2, wherein the amount of the liquid medium used is 0.5-100 ml per 106 CFU of the viable thalli of the Lactobacillus salivarius, and the period for the exposure is 0.3-10 hours.
5. The metabolite of claim 2, wherein the liquid medium is one or more selected from the group consisting of water, physiological saline, and phosphate buffer saline.
6-10. (canceled)
11. A method for treating andor preventing cancers, comprising:
administering to a subject in need thereof, a formulation comprising
a viable thalli of a Lactobacillus salivarius, which is belonging to Lactobacillus salivarius subsp. Salivarius and deposited in China General Microbiological Culture Collection Center with an accession number CGMCC No: 3606,
the metabolite of Lactobacillus salivarius of claim 2, or
a combination thereof.
12. The method of claim 11, wherein the cancer is a cancer of digestive tract.
13. The method of claim 11, wherein the cancer is at least one selected from the group consisting of oral cancer, esophageal cancer, gastric cancer, and colon cancer.
14. The method of claim 11, wherein the viable thalli andor the metabolite is administered orally or rectally.