What is claimed is:
1. A general purpose engine comprising:
a crankcase comprising a case main body as a principal part thereof;
a cylinder block with which the case main body is integrally formed;
a crankshaft having a plurality of crank webs;
bearings;
a bearing support member mounted on the case main body, the crankshaft being rotatably supported via the bearings in the bearing support member and the case main body;
a valve operating mechanism; and
a drive transmission wheel housed within the crankcase so as to transmit rotational power to the valve operating mechanism, the drive transmission wheel being fixedly provided on the crankshaft so as to be outside the crank web that, among the crank webs, is at one end in the axial direction;
wherein the crankcase comprises the case main body and a cover secured to the case main body; and
wherein the bearing support member, which is disposed between the drive transmission wheel and the crank web that is at one end in the axial direction, is formed into a shape that allows oil held within the crankcase to flow between opposite sides of the bearing support member and is mounted on the case main body.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An injectable dermal filler composition comprising ascorbic acid 2-glucoside (AA2G) covalently conjugated to hyaluronic acid (HA) via 1,4-butanediol diglycidyl ether (BDDE), wherein the HA is crosslinked.
2. The composition of claim 1, wherein the HA is crosslinked via BDDE.
3. The composition of claim 1, having a degree of conjugation of between about 3 mol % and about 40 mol %.
4. The composition of claim 1, having a degree of conjugation of between about 3 mol % and about 15 mol %.
5. The composition of claim 1, having a degree of conjugation of between about 10 mol % and about 13 mol %.
6. The composition of claim 1, wherein the crosslinked HA comprises a combination of both high molecular weight hyaluronan polymers and low molecular weight hyaluronan polymers.
7. The composition of claim 6, having a ratio of high molecular weight hyaluronan polymers to low molecular weight hyaluronan polymers of about 1:1, about 1:5, about 1:10, about 1:15, or about 1:20.
8. The composition of claim 7, wherein the ratio of high molecular weight hyaluronan polymers to low molecular weight hyaluronan polymers is about 1:10.
9. The composition of claim 1, wherein the crosslinked HA is present at a concentration of about 10 mgg, about 11 mgg, about 12 mgg, about 13 mgg, about 14 mgg, about 15 mgg, about 16 mgg, about 17 mgg, about 18 mgg, about 19 mgg or about 20 mgg.
10. The composition of claim 9, wherein the crosslinked HA is present at a concentration of about 15 mgg.
11. The composition of claim 1, further comprising an anesthetic agent.
12. The composition of claim 11, wherein the anesthetic agent is lidocaine or a salt thereof.