That which is claimed is:
1. Amplifier device with gain switching, comprising an amplification means (Q1), a configurable load circuit (M1, M2) including an inductive element (L2) and capable of exhibiting two different configurations having two different impedance values respectively, and a controllable switching means (Q2, Q3) connected between the amplification means and the load circuit in order to select one or other of the two configurations of the load circuit, characterized in that the load circuit includes two insulated-gate field-effect load transistors (M1, M2) connected in series and operating in triode mode, the inductive element being connected in parallel with the pair of load transistors between a power-supply terminal and the switching circuit.
2. Device according to claim 1, characterized in that the two load transistors are both controllable on the gate by the same control signal (Vg), in that a first terminal of the inductive element is connected to the power-supply terminal (Bal) and the second terminal of the inductive element is connected to a first switching input of the switching means (EC1), in that the common terminal of the two load transistors is connected to a second switching input of the switching means (EC2), and in that the device also includes selection means (MS) able:
to deliver a selection signal (Vp1, Vp2) to the switching means so as to select said configuration, and
to deliver said control signal (Vg) in such a way as to turn the two transistors off or on depending on the configuration selected.
3. Device according to claim 2, characterized in that the switching means includes a first switching transistor (Q2) connected between the amplification means and said first input, and a second switching transistor (Q3) connected between the amplification means and said second input, and in that, in a first configuration of the load circuit, the load transistors are turned off, the first switching transistor is turned on and the second switching transistor is turned off, while, in a second configuration of the load circuit, the load transistors are turned on, the first switching transistor is turned off and the second switching transistor is turned on.
4. Device according to claim 3, characterized in that the load transistor (M2) connected between the power-supply terminal (Bal) and the second switching input (EC2) features a channel width which is greater than that of the other load transistor (M1).
5. Device according to one of the preceding claims, characterized in that the two load transistors are PMOS transistors, which are controlled on their gate via a control voltage the value of which is at least equal to that of the power-supply voltage increased by the threshold voltage of the drain-substrate diode of a load transistor.
6. Radio-frequency receiver, characterized in that it incorporates an amplifier device according to one of claims 1 to 5.
7. Receiver according to claim 6, characterized in that it is a cellular mobile telephone.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An isolated polynucleotide consisting of nucleotide 3090 to nucleotide 3329 of SEQ ID NO: 4.
2. A method of determining a patient’s relative risk of a cardiovascular disorder, comprising:
a. obtaining a nucleic acid sample from the patient; and
b. determining the presence in the nucleic acid sample of at least one single nucleotide polymorphism of the PAR1 gene, selected from the group of polymorphisms corresponding to a C for T substitution at position 3090 and a C for A substitution at position 3329 of SEQ ID NO: 1;
wherein the presence of the at least one polymorphism is diagnostic of a patient’s relative risk of atrial fibrillation, acute coronary syndrome, cardiomyopathy or unstable angina.
3. The method of claim 2, wherein the step of determining the presence of at least one single nucleotide polymorphism comprises amplification of a portion of the nucleic acid sample comprising position 3090 of SEQ ID NO: 1 by polymerase chain reaction.
4. The method of claim 2, wherein the step of determining the presence of at least one single nucleotide polymorphism comprises amplification of a portion of the nucleic acid sample comprising position 3329 of SEQ ID NO: 1 by polymerase chain reaction.
5. The method of claim 2, wherein the step of determining the presence of at least one single nucleotide polymorphism comprises sequencing of a portion of the nucleic acid sample comprising position 3090 of SEQ ID NO: 1.
6. The method of claim 2, wherein the step of determining the presence of at least one single nucleotide polymorphism comprises sequencing of a portion of the nucleic acid sample comprising position 3329 of SEQ ID NO: 1.