1. An adjunct for retrofitting to an oximetry sensor to improve at least one of useful life, restored adhesion integrity, and patient tolerance thereof, comprising:
an adhesive patient contact layer, wherein a first side of the adhesive patient contact layer is configured to attach to a patient’s skin and a second side of the adhesive patient contact layer is configured to attach to an oximetry sensor, directly or through an intermediate layer; and
a photo-opaque layer for application over the oximetry sensor.
2. The adjunct of claim 1, wherein the adhesive patient contact layer is configured to transmit energy from an energy-emitting component and to an energy-detecting component of the oximetry sensor.
3. The adjunct of claim 1, wherein the adhesive patient contact layer has at least one aperture therein, such that when retrofitted to the oximetry sensor the aperture is aligned with at least one of an energy-emitting component and an energy-detecting component of the oximetry sensor to facilitate energy from the energy-emitting component or energy to the energy-detecting component passing through the aperture.
4. The adjunct of claim 1, wherein the adhesive patient contact layer comprises a hydrocolloid.
5. The adjunct of claim 4, wherein the hydrocolloid adhesive patient contact layer has a thickness of 10 to 30 mil.
6. The adjunct of claim 3, wherein the adhesive patient contact layer comprises a hydrocolloid.
7. The adjunct of claim 6, wherein the hydrocolloid adhesive patient contact layer has a thickness of 10 to 30 mil.
8. The adjunct of claim 1, wherein the photo-opaque layer comprises polyethylene terephthalate (PET).
9. The adjunct of claim 1, further comprising at least one intermediate layer between the adhesive patient contact layer and the oximetry sensor.
10. The adjunct of claim 9, further comprising two intermediate layers between the adhesive patient contact layer and the oximetry sensor, a barrier layer in direct contact with the adhesive patient contact layer, and a double-sided adhesive layer in direct contact with the oximetry sensor.
11. The adjunct of claim 10, wherein the intermediate barrier layer comprises polypropylene.
12. The adjunct of claim 11, wherein the intermediate barrier layer has a thickness of 1 to 2 mil.
13. The adjunct of claim 9, further comprising a label liner layer above the intermediate layer and a liner layer below the adhesive patient contact layer, wherein the liner layer is removed in order to attach the adhesive patient contact layer to a patient’s skin and the label liner layer is removed in order to attach the intermediate layer to the oximetry sensor.
14. The adjunct of claim 2, wherein the energy-emitting component of the oximetry sensor is selected from the group consisting of: a near infrared spectrum light emitting diode and a near infrared spectrum light emitting optode.
15. The adjunct of claim 2, wherein the energy-detecting component of the oximetry sensor is selected from the group consisting of: a near infrared spectrum photodiode and a near infrared spectrum photo-optode.
16. A dispensing roll comprising a plurality of sheets along the roll, the plurality of sheets being separated from each other by perforations that permit one sheet to be removed from adjacent sheets, each sheet of said plurality of sheets having the adjunct of claim 1 disposed thereon.
17. The dispensing roll of claim 16, wherein the adjunct is disposed on each sheet in two sections, a first section comprising the adhesive patient contact layer and a second section comprising the photo-opaque layer, or in one section comprising the adhesive patient contact layer or the photo-opaque layer.
18. A method for improving at least one of useful life, restored adhesion integrity, and patient tolerance of an oximetry sensor and reducing replacement cost thereof, comprising:
applying an adhesive patient contact layer to a skin surface of a patient, the adhesive patient contact layer being separate from an oximetry sensor;
applying the oximetry sensor above the adhesive patient contact layer, directly or indirectly through intermediate layers; and
applying a photo-opaque layer over the oximetry sensor.
19. The method of claim 18, further comprising sensing oxygen saturation with the oximetry sensor through the adhesive patient contact layer.
20. An oximetry sensor comprising:
an adhesive patient contact layer comprising a hydrocolloid;
a photo-opaque layer; and
an energy-emitting component and an energy-detecting component, the energy-emitting component and the energy-detecting component both positioned between the hydrocolloid adhesive patient contact layer and the photo-opaque layer.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for the synthesis of 1,3-di(chloropropyl)-5-tert-butyl benzene comprising:
conducting Friedl-Crafts alkylation of 1,3-diisopropylbenzene by tert-butyl chloride in the presence of an alkylation catalyst to obtain 1-tert-butyl-3,5-diisopropylbenzene;
peroxidizing the 1-tert-butyl-3,5-diisopropylbenzene by gaseous oxygen in the presence of a peroxidation catalyst in a basic solution to obtain 1,3-di(peroxypropyl)-5-tert-butylbenzene;
reducing the 1,3-di(peroxypropyl)-5-tert-butylbenzene with a reducing agent to 1,3-di(hydroxypropyl)-5-tert-butylbenzene; and
chlorinating the 1,3-di(hydroxpropyl)-5-tert-butylbenzene to obtain 1,3-di(chloropropyl)-5-tert-butyl benzene.
2. The method according to claim 1, wherein the alkylation catalyst is an Iron(III) salt, such as, for example, FeCl3.
3. The method according to claim 1, wherein said peroxidation catalyst in the basic solution is a Cobalt(II) salt and a tertiary amine in water.
4. The method according to claim 3, wherein the Colbalt(II) salt is CoCl2 and the tertiary amine is pyridine.
5. The method according to claim 1, wherein the step of peroxidizing further includes the steps of:
adjusting a pH of the 1,3-di(peroxypropyl)-5-tert-butylbenzene in solution with the addition of a base solution to a pH=10; and
extracting the water phase with ether to provide a mixture containing 1,3-di(peroxypropyl)-5-tert-butylbenzene dissolved in ether.
6. The method according to claim 1, wherein the reducing agent is sodium sulfite.
7. The method according to claim 5, wherein the step of reducing includes reducing the mixture with sodium sulfite to provide 1,3-di(hydroxypropyl)-5-tert-butylbenzene,
separating and extracting the water with additional ether; and
evaporating and drying the 1,3-di(hydroxypropyl)-5-tert-butylbenzene.
8. The method according to claim 7, wherein the step of reducing further includes washing with hexane and recrystallizing with ethyl acetate the 1,3-di(hydroxpropyl)-5-tert-butylbenzene.
9. The method according to claims 1 wherein the step of chlorinating includes dissolving 1,3-di(hydroxypropyl)-5-tert-butylbenzene in methyl chloride to provide a solution and bubbling the solution in HCl
10. The method according to claim 1, wherein the step of chlorinating includes purifying the 1,3-di(chloropropyl)-5-tert-butyl benzene by evaporating and recrystallizing the 1,3-di(chloropropyl)-5-tert-butyl benzene in hexane.
11. A composition of 1-tert-butyl-3,5-diisopropylbenzene.
12. A composition of 1,3-di(chloropropyl)-5-tert-butyl benzene made from the method of claim 1.
13. (canceled)
14. (canceled)