1. A method comprising:
detecting a cursor in a proximity of a geometry piece of a computer aided design, the cursor separate from and movable relative to the computer aided design;
in response to detecting the cursor in the proximity of the geometry piece, determining whether multimedia is associated with the geometry piece of the computer aided design; and
in response to a positive determination that multimedia is associated with the geometry piece, automatically generating an icon associated with the geometry piece of the computer aided design for accessing the associated multimedia.
2. The method of claim 1, wherein said automatically generating the icon comprises automatically generating a leader line entity from the geometry piece.
3. The method of claim 2 further comprising automatically generating the icon at an end of the leader line entity opposite the geometry piece.
4. The method of claim 1, wherein said automatically generating the icon comprises automatically generating an icon corresponding to a type of multimedia associated with the geometry piece.
5. The method of claim 1, wherein said icon includes a hyperlink to an application to execute the multimedia.
6. The method of claim 1 further comprising:
determining if a request to associate multimedia with the geometry piece is received;
facilitating association of multimedia with the geometry piece upon determining that the request to associate multimedia with the geometry piece is received;
receiving a selection of a type of multimedia to be associated with the geometry piece; and
automatically generating an icon associated with the geometry piece for accessing the associated multimedia.
7. The method of claim 6, wherein said receiving the request comprises receiving a cursor selection on the geometry piece.
8. The method of claim 6, wherein said facilitating comprises generating and displaying a menu for selection of a type of multimedia to be associated with the geometry piece.
9. The method of claim 8, wherein said receiving the selection of the type of multimedia comprises receiving the selection of at least one of an audio note, a textual note, and an animation note.
10. The method of claim 6 further comprising receiving an inputted leader line entity.
11. An article comprising a machine accessible medium having instructions encoded therein, said instructions, which when executed by a machine, operate to:
detect a cursor in a proximity of a geometry piece of a computer aided design, the cursor separate from and movable relative to the computer aided design;
in response to detecting the cursor in the proximity of the geometry piece, determine whether multimedia is associated with the geometry piece of the computer aided design; and
in response to a positive determination that multimedia is associated with the geometry piece, automatically generate an icon associated with the geometry piece of the computer aided design for accessing the associated multimedia.
12. The article of claim 11, wherein said executing instructions operate to automatically generate a leader line entity from the geometry piece.
13. The article of claim 12, wherein said executing instructions further operate to automatically generate the icon at an end of the leader line entity opposite the geometry piece.
14. The article of claim 11, wherein said executing instructions operate to automatically generate an icon corresponding to a type of multimedia associated with the geometry piece.
15. The article of claim 11, wherein said executing instructions operate to include a hyperlink to an application to execute the multimedia.
16. The article of claim 11, wherein said executing instructions further operate to determine if a request to associate multimedia with the geometry piece is received, facilitate association of multimedia with the geometry piece upon determining that the request to associate multimedia with the geometry piece is received, receive a selection of a type of multimedia to be associated with the geometry piece, and automatically generate an icon associated with the geometry piece for accessing the associated multimedia.
17. The article of claim 16, wherein said executing instructions operate to receive a cursor selection on the geometry piece.
18. The article of claim 16, wherein said executing instructions operate to generate and display a menu for selection of a type of multimedia to be associated with the geometry piece.
19. The article of claim 18, wherein said receiving the selection of the type of multimedia comprises receiving the selection of at least one of an audio note, a textual note, and an animation note.
20. The article of claim 16, wherein said executing instructions further operate to receive an inputted leader line entity.
21. An apparatus comprising:
a machine accessible medium having instructions encoded therein, said instructions, which when executed by a machine, operate to:
detect a cursor in a proximity of a geometry piece of a computer aided design, the cursor separate from and movable relative to the computer aided design;
in response to detecting the cursor in the proximity of the geometry piece, determine whether multimedia is associated with the geometry piece of the computer aided design; and
in response to a positive determination that multimedia is associated with the geometry piece, automatically generate an icon associated with the geometry piece of the computer aided design for accessing the associated multimedia; and
a processor coupled to the machine accessible medium to execute said instructions.
22. The apparatus of claim 21, wherein said executing instructions further operate to determine if a request to associate multimedia with the geometry piece is received, facilitate association of multimedia with the geometry piece upon determining that the request to associate multimedia with the geometry piece is received, receive a selection of a type of multimedia to be associated with the geometry piece, and automatically generate an icon associated with the geometry piece for accessing the associated multimedia.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A pharmaceutical formulation comprising haptoglobin Hp enriched in at least one polymeric form.
2. The pharmaceutical formulation according to claim 1, comprising Hp enriched in smaller polymeric forms.
3. The pharmaceutical formulation according to claim 2, which in liquid form has a pH between about 6.5 and about 7.5 and comprises a buffer that contains no more than about 12 mmolL phosphate ions.
4. The pharmaceutical formulation according to claim 2 wherein the Hp is derived from Cohn fraction V precipitate.
5. The pharmaceutical formulation according to claim 2 wherein the Hp is recombinant.
6. The pharmaceutical formulation according to claim 2 wherein a majority of alpha chains in the Hp are of the alpha-1 type.
7. A method of treating a patient suffering from a disease selected from the group consisting of: sickle cell disease, thalassemia, hereditary spherocytosis, hereditary stomatocytosis, microangiopathic hemolytic anemia, pyruvate kinase deficiency, paroxysmal cold hemoglobinuria, severe idiopathic autoimmune hemolytic anemia, infection-induced anemia, malaria, and cerebral vasospasm, comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 2.
8. A method of treating a patient or patients requiring dialysis, comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 2.
9. A method of promoting extravasation of Hp or Hb-Hp complexes in a patient comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 2.
10. A method of promoting production of IL-10 in a patient comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 2.
11. A method of promoting production of HO-1 enzyme in a patient comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 2.
12. A method of reducing the amount of heme leaching in a patient comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 2.
13. A method of protecting a patient against cerebral vasospasm comprising the step of administering to said patient a therapeutically effective amount of formulation of claim 2.
14. The method according to claim 12 wherein the patient carries an Hp2 allele.
15. The pharmaceutical formulation according to claim 1, comprising Hp enriched in larger polymeric forms.
16. The pharmaceutical formulation according to claim 14 wherein the Hp has an average molecular weight of greater than about 350 kDa.
17. The pharmaceutical formulation according to claim 14 wherein a majority of alpha chains in the Hp are of the alpha-2 type.
18. The pharmaceutical formulation according to claim 14 wherein the Hp is derived from Cohn fraction IV precipitate.
19. The pharmaceutical formulation according to claim 14 wherein the Hp is recombinant.
20. A method of protecting organ function in a patient during acute hemolysis occurring as a result of surgery, or hemolysis occurring as a result of some other insult, comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 15.
21. A method of promoting improvement of vasculature, or to improve development of coronary artery collaterals or other such vessel formation in a patient, comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 15.
22. A method of promoting healing of chronic wounds in a patient such as chronic venous ulcers, acute wounds or mechanical heart valve-induced anemia comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 15.
23. A method of treating a patient suffering from systemic infection comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 15.
24. A method of stimulating angiogenesis in a patient comprising the step of administering to said patient a therapeutically effective amount of the formulation of claim 15.