1. An apparatus for producing polyethylene, the apparatus comprising a main reactor having an inlet for receiving gaseous olefin monomer and an outlet for outputting polyethylene, and a preliminary reactor connected to a second inlet of the main reactor, the preliminary reactor being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor to provide for removal of the waste gases from the preliminary reactor wherein said main reactor is a loop-type reactor.
2. An apparatus for producing polyethylene, the apparatus comprising a main reactor having an inlet for receiving gaseous olefin monomer and an outlet for outputting polyethylene, and a preliminary reactor connected to a second inlet of the main reactor, the preliminary reactor being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor to provide for removal of the waste gases from the preliminary reactor further comprising a second main reactor connected in series with said first main reactor and connected to the outlet of said first recited main reactor to receive the reaction product from said first recited main reactor.
3. An apparatus for producing polyethylene, the apparatus comprising a main reactor having an inlet for receiving gaseous olefin monomer and an outlet for outputting polyethylene, and a preliminary reactor connected to a second inlet of the main reactor, the preliminary reactor having a different configuration and shape than said main reactor, being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor to provide for removal of the waste gases from the preliminary reactor wherein said main reactor is a loop-type reactor.
4. An apparatus for producing polyethylene, the apparatus comprising a main reactor having an inlet for receiving gaseous olefin monomer and an outlet for outputting polyethylene, and a preliminary reactor connected to a second inlet of the main reactor, the preliminary reactor having a different configuration and shape than said main reactor, being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor to provide for removal of the waste gases from the preliminary reactor further comprising a second main reactor connected in series with said first main reactor and connected to the outlet of said first recited main reactor to receive the reaction product from said first recited main reactor.
5. An apparatus for producing polyethylene, the apparatus comprising a preliminary reactor and a main reactor having an inlet for receiving gaseous olefin monomer, a second inlet and an outlet for outputting polyethylene, wherein said preliminary reactor is connected to the second inlet of the main reactor, the preliminary reactor being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor and from the apparatus for producing polyethylene to provide for removal of the waste gases from the preliminary reactor and from the apparatus for producing polyethylene.
6. An apparatus for producing polyethylene, the apparatus comprising a preliminary reactor and a main reactor having an inlet for receiving gaseous olefin monomer, a second inlet and an outlet for outputting polyethylene, wherein said preliminary reactor has an outlet connected to the second inlet of the main reactor, the preliminary reactor being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor and from the apparatus for producing polyethylene to provide for removal of the waste gases from the preliminary reactor and from the apparatus for producing polyethylene, and said preliminary reactor further having another outlet connected to a recycle line connected back to said preliminary reactor.
7. An apparatus for producing polyethylene, the apparatus comprising a preliminary reactor and a main reactor having an inlet for receiving gaseous olefin monomer, a second inlet and an outlet for outputting polyethylene, wherein said preliminary reactor is connected to the second inlet of the main reactor, the preliminary reactor having a different configuration and shape than said main reactor, being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor to provide for removal of the waste gases from the preliminary reactor.
8. An apparatus for producing polyethylene, the apparatus comprising a preliminary reactor, a main reactor having an inlet for receiving gaseous olefin monomer, a second inlet and an outlet for outputting polyethylene, wherein a preliminary reactor has an outlet connected to the second inlet of the main reactor, the preliminary reactor having a different configuration and shape than said main reactor, being arranged to be operable in the gas phase and having at least one respective inlet for receiving a solid catalyst and at least one treatment agent and a respective separate outlet for releasing waste gases from the preliminary reactor to provide for removal of the waste gases from the preliminary reactor, and said preliminary reactor further having another outlet connected to a recycle line connected back to said preliminary reactor.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula
wherein
R1 is \u2014(CH2CH2O)aX, \u2014(CH2)bOX or \u2014(CH2)cCH(CH2)dOX2;
R2 is hydrogen, methyl, ethyl, \u2014(CH2CH2O)aX, \u2014(CH2)bOX or \u2014CH2O(C\u2550O)NH(CH2CH2O)aX;
X is NO2 or N\u2550(NO)\u2014R3;
R3 is di(C1-C18-alkyl)amino, di(2-aminoethyl)amino, N-2-aminoethyl-N-2-hydroxyethyl-amino, pyrrolidino, piperidino, piperazino, 4-(C1-C4-alkyl)piperazino, 4-phenylpiperazino, 4-(2-pyridyl)piperazino or morpholino;
a is 1, 2 or 3;
b is between 1 and 6;
c is 1 or 2;
d is between 1 and 4;
and pharmaceutically acceptable salts thereof.
2. The compound of formula (I), (IIA) or (IIB) according to claim 1 wherein
R1 is \u2014(CH2CH2O)aX, \u2014(CH2)bOX or \u2014(CH2)cCH(CH2)dOX2;
R2 is hydrogen, \u2014(CH2CH2O)aX, \u2014(CH2)bOX or \u2014CH2O(C\u2550O)NH(CH2CH2O)aX;
X is NO2 or N\u2550(NO)\u2014R3;
R3 is di(C1-C18-alkyl)amino, di(2-aminoethyl)amino, N-2-aminoethyl-N-2-hydroxyethyl-amino, pyrrolidino, piperidino, piperazino, 4-(C1-C4-alkyl)piperazino, 4-phenylpiperazino, 4-(2-pyridyl)piperazino or morpholino;
a is 1, 2 or 3;
b is between 1 and 6;
c is 1 or 2;
d is between 1 and 4;
and pharmaceutically acceptable salts thereof.
3. The compound of formula (I), (IIA) or (IIB) according to claim 1 wherein
R1 is \u2014(CH2CH2O)aX or \u2014(CH2)bOX;
R2 is hydrogen, \u2014(CH2CH2O)aX, \u2014(CH2)bOX or \u2014CH2O(C\u2550O)NH(CH2CH2O)aX;
X is NO2 or N\u2550(NO)\u2014R3;
R3 is diethylamino, di(2-aminoethyl)amino, N-2-aminoethyl-N-2-hydroxyethyl-amino, pyrrolidino, piperidino, piperazino, 4-methylpiperazino or morpholino;
a is 1, 2 or 3;
b is between 1 and 6;
and pharmaceutically acceptable salts thereof.
4. The compound of formula (I), (IIA) or (IIB) according to claim 1 wherein
R1 is \u2014(CH2CH2O)aX or \u2014(CH2)bOX;
R2 is hydrogen, \u2014(CH2CH2O)aX, \u2014(CH2)bOX or \u2014CH2O(C\u2550O)NH(CH2CH2O)aX;
X is NO2 or N\u2550(NO)\u2014R3;
R3 is diethylamino or pyrrolidino;
a is 1 or 2;
b is 2, 3 or 4;
and pharmaceutically acceptable salts thereof.
5. The compound of formula (I), (IIA) or (IIB) according to claim 1 wherein
R1 is \u2014CH2CH2ONO2; and
R2 is hydrogen, \u2014CH2CH2ONO2 or \u2014CH2O(C\u2550O)NHCH2CH2ONO2; and
pharmaceutical acceptable salts thereof.
6. The compound of formula (I) according to claim 1 wherein
R1 is \u2014CH2CH2ONO2; and
R2 is hydrogen or \u2014CH2CH2ONO2.
7. (2-Nitrooxyethyl)carbamic acid 5-(4-2-ethylpyridin-2-yl)ethoxybenzyl)-2,4-dioxothiazolidin-3-ylmethyl ester according to claim 1.
8. A pharmaceutical composition comprising a compound of formula (I), (IIA) or (IIB), or a pharmaceutically acceptable salt thereof according to claim 1 and at least one pharmaceutically acceptable carrier.
9. A method for the treatment of type 2 diabetes, which comprises administering a compound of formula (I), (IIA) or (IIB), or a pharmaceutically acceptable salt thereof according to claim 1 in an effective amount, to a warm-blooded animal requiring the treatment.