1. A variable camber vane system for a gas turbine engine, comprising:
a first airfoil portion having a first tip portion, a first root portion, a face extending at least partially between the first tip portion and the first root portion, and a groove in the face extending at least partially between the first tip portion and the first root portion, wherein the groove has a groove width;
a second airfoil portion arranged to rotate with respect to the first airfoil portion about a pivot axis, wherein the second airfoil portion includes a second tip portion; a second root portion; and a crown extending at least partially between the second tip portion and the second root portion, wherein the crown includes a crown radius centered about the pivot axis and positioned opposite the groove; and
a seal strip having a seal width greater than the groove width and a rubbing surface opposite the crown radius, wherein the seal strip is at least partially disposed in the groove with an interference fit; and wherein the seal strip is arranged to seal against fluid flow between the first airfoil portion and the second airfoil portion.
2. The variable camber vane system of claim 1, wherein the seal strip is a rigid structure.
3. The variable camber vane system of claim 1, wherein the rubbing surface has a rubbing surface radius the same as the crown radius.
4. The variable camber vane system of claim 1, wherein the crown is formed integrally with the second airfoil portion.
5. The variable camber vane system of claim 1, wherein the face is formed integrally with the first airfoil portion.
6. The variable camber vane system of claim 1, wherein the face is concave and operative to receive the crown therein.
7. The variable camber vane system of claim 1, wherein the first airfoil portion is stationary.
8. The variable camber vane system of claim 7, wherein the first airfoil portion and the second airfoil portion form at least part of an inlet guide vane having a fixed leading edge and a variable trailing edge; wherein the first airfoil portion includes the leading edge; and wherein the second airfoil portion includes the trailing edge.
9. The variable camber vane system of claim 7, wherein the first airfoil portion and the second airfoil portion form at least part of an outlet guide vane having a variable leading edge and a fixed trailing edge; wherein the first airfoil portion includes the leading edge; and wherein the second airfoil portion includes the trailing edge.
10. A gas turbine engine, comprising:
at least one of a fan and a compressor having a variable camber vane system, the variable camber vane system including:
at least two airfoil portions adapted to vary a camber of the variable camber vane system, wherein a first of the airfoil portions includes a groove and a second of the airfoil portions includes a crown having a crown radius; and
a seal strip at least partially disposed in the groove with an interference fit,
wherein the seal strip includes a rubbing surface opposite the crown radius and operative to seal against fluid flow between the first of the airfoil portions and the second of the airfoil portions.
11. The gas turbine engine of claim 10, wherein the rubbing surface contacts the crown at the crown radius.
12. The gas turbine engine of claim 10, wherein the seal strip is formed of a polymer material.
13. The gas turbine engine of claim 12, wherein the seal strip is formed of at least one of Vespel and Torlon.
14. The gas turbine engine of claim 10, wherein the at least two airfoil portions form an inlet guide vane.
15. The gas turbine engine of claim 10, wherein the at least two airfoil portions form an outlet guide vane.
16. A gas turbine engine, comprising:
at least one of a fan and a compressor having a variable camber vane system, the variable camber vane system including:
at least two airfoil portions adapted to vary a camber of the variable camber vane system, wherein a first of the airfoil portions includes a groove; and wherein a second of the airfoil portions includes a crown having a crown radius; and
a seal strip disposed in the groove; wherein the seal strip has a rubbing surface radius preformed thereon and configured for sealing engagement with the crown.
17. The gas turbine engine of claim 16, wherein the seal strip is a rigid structure formed of a polymer.
18. The gas turbine engine of claim 16, wherein the crown radius is convex, and wherein the rubbing surface radius is concave.
19. The gas turbine engine of claim 16, wherein the seal strip is fitted in the groove with an interference fit.
20. The gas turbine engine of claim 16, wherein the crown is nested within the first of the airfoil portions opposite the groove.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An isolated antibody or antibody fragment which specifically binds the peptide sequence of SEQ ID NO: 5, wherein said antibody or antibody fragment thereof does not bind membrane-anchored immunoglobulins other than membrane-anchored immunoglobulin E (mIgE) and wherein said antibody or antibody fragment thereof does not bind the polypeptide of SEQ ID NO:1, SEQ ID NO:6, SEQ ID NO:3 andor SEQ ID NO:4.
2. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment does not bind the same epitope as antibodies or antibody fragments comprising the variable regions of A1c (encoded by SEQ ID NOS: 50 and 51) and B1 (encoded by SEQ ID NOS: 60 and 61).
3. The isolated antibody or antibody fragment of claim 1, wherein the binding is not inhibited by antibodies or antibody fragments comprising the variable regions of A1c (encoded by SEQ ID NOS: 50 and 51) and B1 (encoded by SEQ ID NOS: 60 and 61).
4. The isolated antibody or antibody fragment of claim 1, wherein said antibody or fragment thereof depletes B cells or plasma cells expressing mIgE.
5. The isolated antibody or antibody fragment of claim 4, wherein said antibody or antibody fragment depletes said B cells or plasma cells through ADCC.
6. The isolated antibody or antibody fragment of claim 1, said antibody or antibody fragment comprising:
a. a light chain variable region having the 3 CDRs of the light chain of the antibody D5 encoded by SEQ ID NO: 7, and a heavy chain variable region having the 3 CDRs of the light chain of the antibody D5 encoded by SEQ ID NO: 8;
b. light chain variable region having the 3 CDRs of the light chain of the antibody F4 encoded by SEQ ID NO: 70, and a heavy chain variable region having the 3 CDRs of the light chain of the antibody F4 encoded by SEQ ID NO: 71;
c. a heavy chain variable region having the 3 CDRs of the heavy chain of the antibody D9 encoded by SEQ ID NO: 80; or
d. a heavy chain variable region having the 3 CDRs of the heavy chain of the antibody D9 encoded by SEQ ID NO: 80, and a light chain variable region.
7. The isolated antibody or antibody fragment of claim 1, wherein the antibody or antibody fragment comprises a heavy chain variable region, and a variable light chain region, wherein the light chain comprises the amino acid sequence of SEQ ID NO:9, or SEQ ID NO: 72.
8. The isolated antibody or antibody fragment of claim 1, wherein the antibody or antibody fragment comprises a light chain variable region, and a variable heavy chain region, wherein the heavy chain comprises the amino acid sequence of SEQ ID NO:10, SEQ ID NO: 73, or SEQ ID NO:81.
9. An isolated nucleic acid sequence coding for an amino acid sequence selected from the group consisting of SEQ ID NO: 9, 10, 72, 73 and 81.
10. An isolated cell comprising at least one nucleic acid sequence selected from the group consisting of SEQ ID NO: 7, 8, 70, 71 and 80.
11. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment is a humanized or human antibody or antibody fragment.
12. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment is selected from the group consisting of:
a. an scFv;
b. a Fab fragment;
c. an Fab\u2032 fragment;
d. an F(ab)2;
e. an Fv;
f. a disulfide linked Fv; and
g. a bi-specific antibody.
13. A pharmaceutical composition comprising the isolated antibody or antibody fragment of claim 1.
14. A method of ameliorating, or treating an IgE-mediated disease in a human comprising administering to an individual in need of such prevention, amelioration, or treatment an effective amount of the isolated antibody or antibody fragment of claim 1.
15. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment comprises:
a light chain complementarity determining region 1 (VLCDR1) comprising the amino acid sequence of SEQ ID NO: 11;
a light chain complementarity determining region 2 (VLCDR2) comprising the amino acid sequence of SEQ ID NO: 12;
a light chain complementarity determining region 3 (VLCDR3) comprising the amino acid sequence of SEQ ID NO: 13;
a heavy chain complementarity determining region 1 (VHCDR1) comprising the amino acid sequence of SEQ ID NO: 14;
a heavy chain complementarity determining region 2 (VHCDR2) comprising the amino acid sequence of SEQ ID NO: 15; and
a heavy chain complementarity determining region 3 (VHCDR3) comprising the amino acid sequence of SEQ ID NO: 16.
16. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO: 9 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 10.
17. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO: 72 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 73.
18. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 81.
19. The isolated antibody or antibody fragment of claim 7, wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 10 or SEQ ID NO: 73.
20. The isolated antibody or antibody fragment of claim 1, wherein said antibody or antibody fragment comprises:
a light chain complementarity determining region 1 (VLCDR1) comprising the amino acid sequence of SEQ ID NO: 74;
a light chain complementarity determining region 2 (VLCDR2) comprising the amino acid sequence of SEQ ID NO: 75;
a light chain complementarity determining region 3 (VLCDR3) comprising the amino acid sequence of SEQ ID NO: 76;
a heavy chain complementarity determining region 1 (VHCDR1) comprising the amino acid sequence of SEQ ID NO: 77;
a heavy chain complementarity determining region 2 (VHCDR2) comprising the amino acid sequence of SEQ ID NO: 78; and
a heavy chain complementarity determining region 3 (VHCDR3) comprising the amino acid sequence of SEQ ID NO: 79.