1. A method of treating respiratory complaints comprised of the step of administering to a patient in need thereof a therapeutically effective amount of a medicament comprised of a substituted pteridine or a physiologically acceptable salt thereof.
2. The method of claim 1 wherein the respiratory complaint is an inflammatory or obstructive respiratory complaint.
3. The method of claim 2 wherein the respiratory complaint is COPD or asthma.
4. The method of claim 1 wherein the side-effects of said treatment are reduced.
5. The method of claim 4 wherein the reduced side effects are chosen from emesis and nausea.
6. The method of claim 1 wherein the medicament is administered once or twice a day.
7. The method according to claim 1, wherein the substituted pteridine is a compound of general formula 1,
wherein
X is CH2, O, NR1, S, S(O), S(O2);
Y is CH, N, N(O), N(S);
Z is CH2, O, NR1, S, S(O), S(O2);
R1 is H, \u2014C1-6-alkyl or \u2014COR2;
R2 independently of one another is H or \u2014C1-6-alkyl;
R3 and R4 independently of one another are H, \u2014C1-6-alkyl-R5, aryl, or
R3 and R4 together with the nitrogen form a 5-, 6- or 7-membered, saturated or unsaturated, heterocyclic ring, in each case optionally substituted by one or more substituents selected from the group COR2;
R5 is H, \u2014OH, phenyl, optionally substituted by one or more substituents independently of one another selected from among halogen, \u2014C1-6-alkyl or \u2014O\u2014C1-6-alkyl:
R6 is H, aryl, halogen, \u2014O\u2014C1-6-alkyl, \u2014S\u2014C1-6alkyl, \u2014S\u2014C1-6-alkyl-R5; and
n is 1, 2, 3 or 4;
and the pharmacologically acceptable acid addition salts, tautomeric and isomeric forms or mixtures and individual geometric or optical isomers, particularly racemic or non-racemic mixtures of the isomers thereof.
8. The method of claim 7 wherein the substituted pteridine is a compound of general formula 1 and
X is CH2, O, NR1, S, S(O), S(O2);
Y is CH, N, N(O), N(S);
Z is CH2, O, NR1, S, S(O), S(O2);
R1 is H, \u2014C1-6alkyl or \u2014COR2;
R2 independently of one another is H or \u2014C1-6-alkyl;
R3 and R4 independently of one another are H, \u2014C1-6-alkyl-R5, phenyl, or
R3 and R4 together with the nitrogen form a substituent selected from among pyrrole, pyrroline, pyrrolidine, piperidine, piperazine, morpholine, thiomorpholine, imidazole, imidazoline, imidazolidine, pyrazole, pyrazoline, pyrazolidine, N-oxidothiomorpholinyl, S-oxidothiomorpholinyl, in each case optionally substituted by one or more substituents selected from the group COR2;
R5 is H, \u2014OH, phenyl, optionally substituted by one or more substituents independently of one another selected from among halogen, \u2014C1-6-alkyl or \u2014O\u2014C1-6-alkyl;
R6 is H, phenyl, halogen, \u2014O\u2014C1-6-alkyl, \u2014S\u2014C1-6-alkyl, \u2014S\u2014C1-6alkyl-R5; and
n is 1, 2, 3 or 4;
and the pharmacologically acceptable acid addition salts, tautomeric and isomeric forms or mixtures and individual geometric or optical isomers, particularly racemic or non-racemic mixtures of the isomers thereof.
9. The method of claim 7 wherein the substituted pteridine is compound of general formula 1 and
X is CH2, O, S, S(O);
Y is N, N(O), N(S);
Z is NR1;
R1 is H or \u2014COR2;
R2 independently of one another is H or \u2014C1-6-alkyl;
R3 and R4 independently of one another are H, \u2014C1-6-alkyl-R5, phenyl, or
R3 and R4 together with the nitrogen form a substituent selected from among morpholine, thiomorpholine, N-oxidothiomorpholine, S-oxidothiomorpholine, piperazine, in each case optionally substituted by one or more substituents selected from the group COR2;
R5 is H, \u2014OH, phenyl, optionally substituted by one or more substituents independently of one another selected from among halogen, \u2014C1-6-alkyl or \u2014O\u2014C1-6-alkyl;
R6 is H, phenyl, Cl, \u2014O\u2014C1-6-alkyl, \u2014S\u2014C1-6-alkyl, \u2014S\u2014C1-6-alkyl-R5; and
n is 1, 2, 3 or 4;
and the pharmacologically acceptable acid addition salts, tautomeric and isomeric forms or mixtures and individual geometric or optical isomers, particularly racemic or non-racemic mixtures of the isomers thereof.
10. A method of treating respiratory complaints comprised of the step of administering to a patient in need thereof a therapeutically effective amount of medicament containing 1 to 200 mg of an active substance of general formula 1, of claim 7 or pharmacologically acceptable acid addition salts thereof.
11. A method of treating respiratory complaints to a patient in need thereof comprised of the step of successive, simultaneous, sequential or separate administration of a medicament comprised of one or more compounds of formula 1 according to claim 7, in combination with one or more additional active substances selected from among the anticholinergics, steroids or \u03b2-agonists.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An Apparatus for controlling the weight of fabric produced by a textile machine, said textile machine being of the type comprising a pick-up unit (6) for a folded or wound fabric piece characterized in that the apparatus comprises:
weighing means (11) for providing a value of weight for each fabric piece associated with the textile machine (2) dedicated to manufacture of said piece;
said weighing means comprising at least a weight sensor (12) detecting the weight reached by said piece during its manufacturing and pick-up stages, operatively connected to an electronic control group (13) to check functionality of the textile machine; and a support unit (16) consisting of at least a vertically sliding portion (17) supporting said pick-up unit (6) and a surface (17a) operatively contacted with said weight sensor (12), and a fixed base (18) defining a guide for said sliding portion (17).
2. Apparatus according to claim 1, characterized in that said vertically sliding portion (17) of the support unit (16) comprises:
a support base (20) connected to the pick-up unit (6) and turning together with the latter integrally with a needle bed (5) of the textile machine (2), a slide (21) slidably connected in vertical direction to said fixed base (18), and turning coupling means (22) around the vertical turning axis (4) of the pick-up unit (6) placed between said support base (20) and said slide (21).
3. Apparatus according to claim 2, characterized in that said support base (20) connected to the pick-up group (6) shows in its lower portion a vertical support shaft (23), and in that said turning coupling means (22) are connected to said vertical shaft (23) and suitable to support the axial load exerted onto said shaft.
4. Apparatus according to claim 3, characterized in that said slide (21) is defined by a substantially glass-shaped element housing said vertical support shaft (23) and said turning coupling means (22), said glass-shaped element showing a bottom wall defining said area (17a) operatively contacted with the weight sensor (12).
5. Apparatus according to claim 4, characterized in that said fixed based (18) comprises a substantially bush-shaped element slidably coupled with said glass-shaped slide (21), and in that anti-rotation means (25) are placed between said bush-shaped element (18) and the slide (21), said anti-rotation means (25) suitable to transmit the vertical translation direction to said slide (21).
6. Apparatus according to claim 5, characterized in that said glass-shaped slide (21) shows on its outer portion an abutment extension (21a) abutting against an upper edge (18a) of said bush-shaped element (18) to define a lower run end for the vertical translation of said slide (21).
7. Apparatus according to claim 3, characterized in that said support base (2) comprises a circular plate (28) integral in its lower portion with said vertical support shaft (23) and a pair of elongated elements (29) peripherally integral with said circular plate (28) and engaging a pair of parallel bars (10) defining the base of said pick-up unit (6).
8. Apparatus according to claim 1, characterized in that said weight sensor (12) consists of a load cell showing a flexible wall (12a) in contact with said sliding portion (17) of the support unit (16).
9. An Apparatus for controlling the weight of fabric produced by a textile machine, said textile machine being of the type comprising a pick-up unit (6) for a folded or wound fabric piece characterized in that the apparatus comprises:
weighing means (11) for providing a value of weight for each fabric piece associated with the textile machine (2) dedicated to manufacture of said piece;
a winding roll (7) to pick up the piece;
at least a pillar (9) divided into an upper portion (9a) supporting said winding roll (7), and a lower portion (9b);
a support element (39) integral with said lower portion (9b) and placed so as to support said upper portion (9a) instead of said weighing means (11) when the weight is over a given safety value;
said weighing means (11) being operatively placed between said upper portion (9a) and said lower portion 9(b).