1. An implantable medical device for delivery of cardiac therapy to a patient, the device comprising:
electrode apparatus comprises at least one left ventricular electrode configured to be located proximate the left ventricle of a patient’s heart and at least one right ventricular electrode configured to be located proximate the right ventricle of a patient’s heart;
a therapy delivery module configured to deliver pacing therapy using the electrode apparatus;
a sensing module configured to sense electrical activity of the patient’s heart using the electrode apparatus; and
a control module coupled to the therapy delivery module and to the sensing module and configured to:
deliver one or more left ventricular paces to the patient’s left ventricle with a cross-chamber pacing vector using a selected left ventricular electrode of the at least one left ventricular electrode and a selected right ventricular electrode of the least one right ventricular electrode, wherein the selected left ventricular electrode is the cathode and the selected right ventricular electrode is the anode in the cross-chamber pacing vector;
measure one or more first cross-chamber sense times between the one or more left ventricular paces and one or more right ventricular senses in response to the one or more left ventricular paces;
deliver one or more right ventricular paces to the patient’s right ventricle using the selected right ventricular electrode;
measure one or more second cross-chamber sense times between the one or more right ventricular paces and one or more left ventricular senses in response to the one or more right ventricular paces; and
determine whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector based on the measured one or more first cross-chamber sense times and the measured one or more second cross-chamber sense times.
2. The device of claim 1, wherein delivering one or more right ventricular paces to the patient’s right ventricle using the selected right ventricular electrode comprises delivering one or more right ventricular paces to the patient’s right ventricle using the selected right ventricular electrode and another right ventricular electrode of the at least one right ventricular electrode in a short bipolar pacing vector.
3. The device of claim 1, wherein delivering one or more left ventricular paces to the patient’s left ventricle comprises delivering one or more left ventricular paces to the patient’s left ventricle using a selected short AV delay and delivering one or more right ventricular paces to the patient’s right ventricle comprises delivering one or more right ventricular paces to the patient’s right ventricle using the selected short AV delay.
4. The device of claim 1, wherein the one or more left ventricular paces comprises a plurality of left ventricular paces, wherein the one or more first cross-chamber sense times comprise a plurality of first cross-chamber sense times, wherein the one or more right ventricular paces comprises a plurality of right ventricular paces, wherein the one or more second cross-chamber sense times comprise a plurality of second cross-chamber sense times.
5. The device of claim 1, wherein the control module is further configured to:
compute at least one statistical metric for the one or more first cross-chamber sense times and the one or more second cross-chamber sense times, wherein the at least one statistical metric comprises at least one of a mean, median, and mode; and
determine whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector by comparing the at least one statistical metric of the one or more first cross-chamber sense times to the at least one statistical metric of the one or more second cross-chamber sense times.
6. The device of claim 1, wherein determining whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector comprises determining that anodal capture of the right ventricle is occurring if the one or more second cross-chamber sense times are greater than or equal to the one or more first cross-chamber sense times plus a selected timed period, wherein the selected time period is greater than or equal to 20 milliseconds.
7. The device of claim 1, wherein the control module is further configured to:
store at least one left ventricular paced evoked response in response to the one or more left ventricular paces;
store at least one right ventricular paced evoked response in response to the one or more right ventricular paces; and
determine whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector by comparing the at least one left ventricular paced evoked response and the at least one right ventricular paced evoked response.
8. The device of claim 7, wherein the electrode apparatus comprises at least one far-field electrode for monitoring far-field electrical activity configured to capture the at least one left ventricular evoked response and the at least one right ventricular evoked response.
9. The device of claim 1, wherein the control module is further configured to determine that anodal capture of the right ventricle is not occurring if the one or more first cross-chamber sense times are greater than or equal to a selected time interval.
10. The device of claim 9, wherein the selected time interval value is greater than or equal to about 60 milliseconds.
11. The device of claim 1, wherein the control module is further configured to provide an alert if the one or more second cross-chamber sense times are less than a selected time interval.
12. The device of claim 11, wherein the selected time interval is greater than or equal to about 60 milliseconds.
13. A method for use in providing cardiac therapy to a patient comprising:
providing electrode apparatus comprising at least one left ventricular electrode configured to be located proximate the left ventricle of a patient’s heart and at least one right ventricular electrode configured to be located proximate the right ventricle of a patient’s heart;
delivering one or more left ventricular paces to the patient’s left ventricle with a cross-chamber pacing vector using a selected left ventricular electrode of the at least one left ventricular electrode and a selected right ventricular electrode of the least one right ventricular electrode, wherein the selected left ventricular electrode is the cathode and the selected right ventricular electrode is the anode in the cross-chamber pacing vector;
measuring one or more first cross-chamber sense times between the one or more left ventricular paces and one or more right ventricular senses in response to the one or more left ventricular paces;
delivering one or more right ventricular paces to the patient’s right ventricle using the selected right ventricular electrode;
measuring one or more second cross-chamber sense times between the one or more right ventricular paces and one or more left ventricular senses in response to the one or more right ventricular paces; and
determining whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector based on the measured one or more first cross-chamber sense times and the measured one or more second cross-chamber sense times.
14. The method of claim 13, wherein delivering one or more right ventricular paces to the patient’s right ventricle using the selected right ventricular electrode comprises delivering one or more right ventricular paces to the patient’s right ventricle using the selected right ventricular electrode and another right ventricular electrode of the at least one right ventricular electrode in a short bipolar pacing vector.
15. The method of claim 13, wherein delivering one or more left ventricular paces to the patient’s left ventricle comprises delivering one or more left ventricular paces to the patient’s left ventricle using a selected short AV delay and delivering one or more right ventricular paces to the patient’s right ventricle comprises delivering one or more right ventricular paces to the patient’s right ventricle using the selected short AV delay.
16. The method of claim 13, wherein the one or more left ventricular paces comprises a plurality of left ventricular paces, wherein the one or more first cross-chamber sense times comprise a plurality of first cross-chamber sense times, wherein the one or more right ventricular paces comprises a plurality of right ventricular paces, wherein the one or more second cross-chamber sense times comprise a plurality of second cross-chamber sense times.
17. The method of claim 13, wherein the method further comprises:
computing at least one statistical metric for the one or more first cross-chamber sense times and the one or more second cross-chamber sense times, wherein the at least one statistical metric comprises at least one of a mean, median, and mode; and
determining whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector by comparing the at least one statistical metric of the one or more first cross-chamber sense times to the at least one statistical metric of the one or more second cross-chamber sense times.
18. The method of claim 13, wherein determining whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector comprises determining that anodal capture of the right ventricle is occurring if the one or more second cross-chamber sense times are greater than or equal to the one or more first cross-chamber sense times plus a selected timed period, wherein the selected time period is greater than or equal to 20 milliseconds.
19. The method of claim 13, wherein method further comprises:
storing at least one left ventricular paced evoked response in response to the one or more left ventricular paces;
storing at least one right ventricular paced evoked response in response to the one or more right ventricular paces; and
determining whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector by comparing the at least one left ventricular paced evoked response and the at least one right ventricular paced evoked response.
20. The method of claim 19, wherein the electrode apparatus comprises at least one far-field electrode for monitoring far-field electrical activity configured to capture the at least one left ventricular evoked response and the at least one right ventricular evoked response.
21. The method of claim 13, wherein the method further comprise determining that anodal capture of the right ventricle is not occurring if the one or more first cross-chamber sense times are greater than or equal to a selected time interval.
22. The method of claim 21, wherein the selected time interval value is greater than or equal to about 60 milliseconds.
23. The method of claim 13, wherein the method further comprises providing an alert if the one or more second cross-chamber sense times are less than a selected time interval.
24. The method of claim 23, wherein the selected time interval is greater than or equal to about 60 milliseconds.
25. An implantable medical device for delivery of cardiac therapy to a patient, the device comprising:
electrode apparatus comprises at least one left ventricular electrode configured to be located proximate the left ventricle of a patient’s heart and at least one right ventricular electrode configured to be located proximate the right ventricle of a patient’s heart;
a therapy delivery module configured to deliver ventricular pacing to at least the patient’s left ventricle using a cross-chamber pacing vector using a selected left ventricular electrode of the at least one left ventricular electrode and a selected right ventricular electrode of the least one right ventricular electrode, wherein the selected left ventricular electrode is the cathode and the selected right ventricular electrode is the anode in the cross-chamber pacing vector;
a sensing module configured to sense electrical activity of the patient’s heart using the electrode apparatus; and
a control module coupled to the therapy delivery module and to the sensing module and configured to determine whether anodal capture of the right ventricle is occurring when delivering ventricular pacing with the cross-chamber pacing vector based on at least:
one or more cross-chamber sense times between one or more left ventricular paces and one or more right ventricular senses in response to the one or more left ventricular paces, and
one or more second cross-chamber sense times between one or more right ventricular paces and one or more left ventricular senses in response to the one or more right ventricular paces.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A soybean meat composition produced from soybeans comprising lipoxygenases 1, 2 and 3, wherein the composition comprises greater than 10% linoleic acid as a percentage of total fatty acids and less than 20 \u03bcg of total 2,4 decadienal plus hexanal plus hexanol per gram following oxidation under mild aqueous conditions.
2. The composition of claim 1, comprising less than 4% linolenic acid as percent of total fatty acids.
3. The composition of claim 1, comprising less than 2000 \u03bcg per gram free arginine and less than 400 \u03bcg free asparagine per gram.
4. The composition of claim 1, having color measured as b* value of less than 30 and an L* value greater than 80, as monitored by the CIE-L*a*b* system where L* indicates lightness and b* indicates hue on a blue (\u2212) to yellow (+) axis.
5. The composition of claim 1, comprising less than 4 \u03bcg of 1-octen-3-ol content per gram following oxidation under mild aqueous conditions.
6. The composition of claim 1, having greater than 30% of the protein as \u03b2-conglycinin.
7. The composition of claim 1, having less than 25% of the protein as glycinin.
8. The composition of claim 1, having a linoleic acid concentration between 10% and 60% of the total fatty acids.
9. A soybean meat composition having greater than 30% of the protein as \u03b2-conglycinin and less than 25% of the protein as glycinin, less than 5,000 \u03bcg per gram of free arginine, and less than 900 \u03bcg per gram free asparagine, further defined as comprising less than 4 \u03bcg per gram 1-octen-3-ol content following oxidation under mild aqueous conditions, or comprising less than 20 \u03bcg of total 2,4 decadienal plus hexanal plus hexanol per gram following oxidation under mild aqueous conditions.
10. The composition of claim 9, having less than 2,000 \u03bcg per gram of free arginine and less than 400 \u03bcg per gram free asparagine.
11. The composition of claim 9, having a linolenic acid concentration between 1.5% and 14% of the total fatty acids.
12. The composition of claim 9, having a linoleic acid concentration between 10% and 60% of the total fatty acids.
13. The composition of claim 9, having a color characterized by b* value less than 30 and an L* value greater than 80 as monitored by the CIE-L*a*b* system where L* indicates lightness and b* indicates hue on a blue (\u2212) to yellow (+) axis.
14. The composition of claim 9, comprising 67-69 mg lysine per gram of protein.
15. The composition of claim 9, comprising 72-80 mg arginine per gram of protein.
16. The composition of claim 9, comprising 28-30 mg histidine per gram of protein.
17. A soybean meat composition having greater than 30% of the protein as \u03b2-conglycinin and less than 25% of the protein as glycinin and less than 20 \u03bcg of total 2,4 decadienal plus hexanal plus hexanol per gram following oxidation under mild aqueous conditions.
18. The composition of claim 17, having a linolenic acid concentration between 1.5% and 14% of the total fatty acids.
19. The composition of claim 17, having a linoleic acid concentration between 10% and 60% of the total fatty acids.
20. The composition of claim 17, having a color characterized by b* value less than 30 and an L* value greater than 80 as monitored by the CIE-L*a*b* system where L* indicates lightness and b* indicates hue on a blue (\u2212) to yellow (+) axis.