1. A method of receiving a paging message of an idle-mode mobile station (MS) in a multicarrier system, the method comprising:
receiving the paging message from a network via a first carrier corresponding to a predetermined condition in a paging listening interval;
transmitting, to the network, a first ranging request message including control information indicating a location update procedure for informing that reception of enhanced multicast and broadcast service (E-MBS) service starts;
setting a second carrier for transmitting the E-MBS service as a paging carrier; and
receiving the paging message from the network via the set second carrier.
2. The method according to claim 1, wherein the setting the second carrier as the paging carrier further includes receiving, from the network, paging carrier setting information indicating that the paging message is transmitted via the second carrier for transmitting the E-MBS service.
3. The method according to claim 2, wherein the paging carrier setting information is received from the network via a ranging response (RNG-RSP) message.
4. The method according to claim 1, further comprising:
transmitting a second ranging request message including control information indicating a location update procedure for informing that reception of the E-MBS service ends;
setting the first carrier as the paging carrier; and
receiving the paging message from the network via the set first carrier.
5. The method according to claim 4, wherein the setting the first carrier as the paging carrier further includes receiving, from the network, a second ranging response message including paging carrier setting information indicating that the paging message is transmitted via the first carrier.
6. The method according to claim 1, wherein the predetermined condition is a deregistration identifier (DID) used to identify the idle-mode MS modulo the number N of carriers in a paging group to which the network belongs.
7. The method according to claim 1, wherein the network is a base station or a paging controller.
8. The method according to claim 1, wherein the first carrier is a fully configured carrier and the second carrier is a fully configured carrier or a partially configured carrier.
9. The method according to claim 8, wherein, if the second carrier is a fully configured carrier, the first ranging request message is transmitted via the first carrier and the second ranging request message is transmitted via the second carrier.
10. The method according to claim 8, wherein, if the second carrier is a partially configured carrier, the first and second ranging request messages are transmitted via the first carrier.
11. The method according to claim 1, further comprising:
transmitting a deregistration request message including E-MBS service reception status information to a base station; and
receiving a deregistration response message from the base station in response to the deregistration request message.
12. The method according to claim 11, wherein the E-MBS service reception status information indicates start or end of reception of the E-MBS service.
13. The method according to claim 11, wherein the deregistration request message further includes paging carrier selection mode information indicating a request for transmitting the paging message via any one of the first carrier or the second carrier.
14. The method according to claim 11, wherein the deregistration response message further includes paging carrier selection mode information indicating that the paging message is transmitted via any one of the first carrier or the second carrier.
15. A mobile station (MS) for receiving a paging message in a multicarrier system, the MS comprising:
a radio frequency unit configured to transmit and receive a radio signal to and from an external device; and
a controller connected to the radio frequency unit,
wherein the controller controls the radio frequency unit to receive a paging message from a network via a first carrier corresponding to a predetermined condition, controls the radio frequency unit to transmit, to the network, a first ranging request message including control information indicating a location update procedure for informing that reception of enhanced multicast and broadcast service (E-MBS) service starts, sets a second carrier for transmitting the E-MBS service as a paging carrier, and controls reception of a paging message from the network via the set second carrier.
16. The MS according to claim 15, wherein the controller controls the radio frequency unit to transmit a second ranging request message including control information indicating a location update procedure for informing that reception of the E-MBS service ends, sets the first carrier as a paging carrier, and controls the radio frequency unit to receive the paging message from the network via the set first carrier.
17. The MS according to claim 15, wherein the predetermined condition is a deregistration identifier (DID) used to identify the idle-mode MS modulo the number N of carriers in a paging group to which the network belongs.
18. The MS according to claim 15, wherein the network is a base station or a paging controller.
19. The MS according to claim 15, wherein the first carrier is a fully configured carrier and the second carrier is a fully configured carrier or a partially configured carrier.
20. The MS according to claim 19, wherein, if the second carrier is a fully configured carrier, the first ranging request message is transmitted via the first carrier and the second ranging request message is transmitted via the second carrier.
21. The MS according to claim 19, wherein, if the second carrier is a partially configured carrier, the first and second ranging request messages are transmitted via the first carrier.
22. A method of performing network reentry at an idle-mode mobile station in a multi-carrier system, the method comprising:
receiving a paging message including carrier information indicating a carrier for network reentry from a base station via a paging carrier; and
performing network reentry to the base station based on the carrier information,
wherein the paging carrier is a partially configured carrier.
23. The method according to claim 22, wherein the carrier information is a physical carrier index.
24. The method according to claim 22, further comprising, if there is a plurality of carriers for network reentry, selecting any one of the carriers.
25. The method according to claim 24, wherein any one of the carriers is selected randomly or by performing a deregistration identifier (DID) used to identify the idle-mode MS modulo the number N of carriers in a paging group to which the network belongs.
26. The method according to claim 22, wherein the paging carrier is a carrier for transmitting the E-MBS or a carrier corresponding to an identifier of the idle-mode MS modulo the number of carriers of a paging group.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of increasing lean muscle mass in a subject comprising administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of a myostatin binding agent wherein the myostatin binding agent has the structure:
(X1)a\u2014F1\u2014(X2)b, or multimers thereof;
wherein F1 is a vehicle; and X1 and X2 are each independently selected from
-(L1)c-P1;
-(L1)c-P1-(L2)d-P2;
-(L1)c-P1-(L2)d-P2-(L3)e-P3;
and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4;
wherein P1, P2, P3, and P4 are peptides capable of binding myostatin, wherein L1, L2, L3, and L4 are each linkers; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1, and
wherein one or more of the peptides capable of binding myostatin comprise the amino acid sequence Cb1b2Wb3WMCPP (SEQ ID NO: 353), wherein
b1 is selected from any one of the amino acids T, I, or R;
b2 is selected from any one of R, S, Q;
b3 is selected from any one of P, R and Q,
and wherein the peptide is between 10 and 50 amino acids in length, and physiologically acceptable salts thereof.
2. A method of increasing the ratio of lean muscle mass to fat in a subject comprising administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of a myostatin binding agent wherein the myostatin binding agent has the structure:
(X1)a\u2014F1\u2014(X2)b, or multimers thereof;
wherein F1 is a vehicle; and X1 and X2 are each independently selected from
-(L1)c-P1;
-(L1)c-P1-(L2)d-P2;
-(L1)c-P1-(L2)d-P2-(L3)e-P3;
and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4;
wherein P1, P2, P3, and P4 are peptides capable of binding myostatin, wherein L1, L2, L3, and L4 are each linkers; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1, and
wherein, the one or more of the peptides capable of binding myostatin comprise the amino acid sequence Cb1b2Wb3WMCPP (SEQ ID NO: 353), wherein
b1 is selected from any one of the amino acids T, I, or R;
b2 is selected from any one of R, S, Q;
b3 is selected from any one of P, R and Q,
and wherein the peptide is between 10 and 50 amino acids in length, and physiologically acceptable salts thereof.
3. A method of treating a muscle-wasting disease in a subject comprising administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of a myostatin binding agent wherein the myostatin binding agent has the structure:
(X1)a\u2014F1\u2014(X2)b, or multimers thereof;
wherein F1 is a vehicle; and X1 and X2 are each independently selected from
-(L1)c-P1;
-(L1)c-P1-(L2)d –P2;
-(L1)c-P1-(L2)d-P2-(L3)e-P3;
and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4;
wherein P1, P2, P3, and P4 are peptides capable of binding myostatin, wherein L1, L2, L3, and L4 are each linkers; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1, and
wherein, the one or more of the peptides capable of binding myostatin comprise the amino acid sequence Cb1b2Wb3WMCPP (SEQ ID NO: 353), wherein
b1 is selected from any one of the amino acids T, I, or R;
b2 is selected from any one of R, S, Q;
b3 is selected from any one of P, R and Q,
and wherein the peptide is between 10 and 50 amino acids in length, and physiologically acceptable salts thereof.
4. The method of claim 3, wherein the disease is selected from muscular dystrophy, amyotrophic lateral sclerosis, congestive obstructive pulmonary disease, chronic heart failure, cancer, AIDs, renal failure, uremia, rheumatoid arthritis, age-related sarcopenia, and muscle-wasting due to prolonged bedrest, spinal chord injury, stroke, bone fracture, and aging.