1. An insert of a housing assembly for diverting a fluid away from a wall of a building, said insert comprising:
a central body defining an aperture along an axis;
a coupling member disposed on said central body; and
a fluid diverter extending outwardly from said central body above and below said aperture and having a first portion spaced from a second portion for diverting the fluid away from the wall of the building;
said first portion defining an outer surface angled toward said central body for guiding the fluid toward said second portion;
said second portion including a plurality of surfaces extending angularly away from said central body and said second portion defining an inner surface angled away from said central body for receiving the fluid from said outer surface of said first portion and said surfaces to guide the fluid away from the wall;
said outer surface of said first portion being angled for guiding the fluid toward the wall, about said first portion, and into said surfaces with said inner surface of said second portion angled for guiding the fluid away from the wall.
2. An insert as set forth in claim 1 wherein said coupling member is further defined as a plurality of tangs spaced from each other and extending outwardly away from said central body.
3. An insert as set forth in claim 2 wherein said central body defines a recess adjacent said tangs.
4. An insert as set forth in claim 3 wherein said central body defines a plurality of holes spaced from one another and adjacent said recess.
5. An insert as set forth in claim 4 wherein said holes are spaced radially from each other about said axis and spaced from said aperture.
6. An insert as set forth in claim 4 wherein one of said tangs are disposed adjacent each of said holes such that said tangs are disposed between said holes and said aperture.
7. An insert as set forth in claim 2 wherein said tangs are affixedly connected to said central body.
8. An insert as set forth in claim 1 wherein said central body includes a plurality of spokes disposed in said aperture and extending radially away from said axis.
9. An insert as set forth in claim 1 wherein said first portion is disposed above said second portion for redirecting the fluid about said first portion and into said second portion with said second portion guiding the fluid away from the wall.
10. An insert as set forth in claim 9 wherein said first and second portions each define a semi-circular configuration extending radially outwardly such that the fluid flows about said first portion, into said second portion, and away from the wall.
11. An insert as set forth in claim 1 wherein said first and second portions each define a semi-circular configuration extending radially outwardly such that the fluid flows about said first portion, into said second portion, and away from the wall.
12. An insert as set forth in claim 1 wherein said coupling member is further defined as a plurality of tangs extending outwardly away from said central body and spaced from each other radially about said axis with said tangs surrounding said aperture.
13. An insert as set forth in claim 1 wherein said central body defines a plurality of holes spaced from each other radially about said axis with said holes surrounding said aperture.
14. An insert as set forth in claim 1 wherein said surfaces of said second portion are further defined as a plurality of wings extending angularly away from said central body.
15. An insert of a housing assembly for diverting a fluid away from a wall of a building, said insert comprising:
a central body defining an aperture along an axis;
a plurality of tangs spaced from each other and extending outwardly away from said central body; and
a fluid diverter extending outwardly from said central body about said aperture and having a first portion spaced from a second portion for diverting the fluid away from the wall of the building;
said central body defining a recess adjacent said tangs and a plurality of holes spaced from one another adjacent said recess such that said holes abut said recess.
16. An insert as set forth in claim 15 wherein said second portion includes a plurality of surfaces extending angularly away from said central body for receiving the fluid from said first portion.
17. An insert as set forth in claim 16 wherein said surfaces of said second portion are further defined as a plurality of wings extending angularly away from said central body.
18. An insert as set forth in claim 15 wherein said first portion defines an outer surface and said second portion defines an inner surface angled away from said central body for receiving the fluid from said outer surface and for guiding the fluid away from the wall.
19. An insert as set forth in claim 15 wherein said tangs are affixedly connected to said central body.
20. An insert as set forth in claim 15 wherein one of said tangs are disposed adjacent each of said holes such that said tangs are disposed between said holes and said aperture.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A pharmaceutical formulation comprising:
(i) a drug; and
(ii) a short-chain sphingolipid selected from compounds of the following formula:
wherein:
R1 is independently:
an O-linked saccharide group; or
an O-linked polyhydric alcohol group;
or:
R1 is independently:
an O-linked (optionally N\u2014(C1-4alkyl)-substituted amino)-C1-6alkyl-phosphate group; or
an O-linked (polyhydric alcohol-substituted)-C1-6alkyl-phosphate group;
R2 is independently C3-9alkyl,
and is independently unsubstituted or substituted;
R3 is independently C7-19alkyl,
and is independently unsubstituted or substituted;
R4 is independently \u2014H, \u2014OH, or \u2014O\u2014C1-4alkyl;
RN is independently \u2014H or C1-4alkyl;
the bond marked with an alpha (\u03b1) is independently a single bond or a double bond;
if the bond marked with an alpha (\u03b1) is a double bond, then R5 is \u2014H;
if the bond marked with an alpha (\u03b1) is a single bond, then R5 is \u2014H or \u2014OH;
the carbon atom marked (*) is independently in an R-configuration or an S-configuration;
the carbon atom marked (**) is independently in an R-configuration or an S-configuration;
and pharmaceutically acceptable salts, solvates, esters, ethers, chemically protected forms thereof.
2-91. (canceled)