1. A child resistant manually actuated dispensing device, comprising:
a rotatable nozzle cap having a radially extending flange which defines a notch; and
an outer shroud having a side wall and having an integral tab extending from and in a plane of said side wall, said tab being dimensioned to engage said flange and be recessed relative to or lie substantially flush with said notch so that said tab cannot be grasped and pulled out of said notch, wherein
said shroud is made of material which is sufficiently flexible such that said shroud can be pulled away from the nozzle cap to thereby lift the tab out of the notch, the tab is not movable out of the notch without pulling said shroud away from the nozzle cap, and the flange is substantially rectangular with chamfered corners and two notches are provided directly opposite each other.
2. A device according to claim 1, wherein:
said tab has a front edge, said flange has a front face, and said front edge is substantially flush with said front face.
3. A device according to claim 1, wherein:
said tab has a front edge, said flange has a front face, and said front edge is recessed from said front face.
4. A device according to claim 1, wherein:
said tab has a thickness, said notch has a depth, and said thickness and said depth are substantially equal.
5. A device according to claim 1, wherein:
said tab has a thickness, said notch has a depth, and said thickness is less than said depth.
6. A device according to claim 1, wherein:
said shroud has a portion which extends behind and down from said tab.
7. A child resistant manually actuated dispensing, comprising:
a rotatable nozzle cap having a radially extending flange which defines a pair of oppositely disposed ledges; and
an outer shroud having opposite side walls and having a pair of integral tabs extending from and in planes of said side walls, each of said pair of tabs being dimensioned to engage one of said flanges and be recessed relative to or lie substantially flush with said ledge, wherein
said shroud is made of material which is sufficiently flexible such that said shroud can be pulled away from the nozzle cap to thereby lift each of said pair of tabs away from its respective ledge, said pair of tabs are not movable away from their respective ledges without pulling said shroud away from the nozzle cap, and the flange is substantially rectangular with chamfered corners.
8. A device according to claim 7, wherein:
each tab has a front edge, said flange has a front face, and said front edge is substantially flush with said front face.
9. A device according to claim 7, wherein:
each tab has a front edge, said flange has a front face, and said front edge is recessed from said front face.
10. A device according to claim 7, wherein:
each tab has a thickness, each ledge has a depth, and said thickness and said depth are substantially equal.
11. A device according to claim 7, wherein:
each tab has a thickness, each notch has a depth, and said thickness is less than said depth.
12. A device according to claim 7, wherein:
said shroud has a portion which extends behind and down from said tab.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An aqueous neutral to mildly alkaline metal bicarbonate solution, comprising metal bicarbonate dissolved in the solution, said metal bicarbonate comprising bicarbonate anions and metal cations, and a pH adjusting agent in the solution in an amount whereby the solution is at a neutral to mildly alkaline pH.
2. The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein the metal bicarbonate is selected from the group consisting of magnesium bicarbonate, sodium bicarbonate, a mixture of sodium bicarbonate and magnesium bicarbonate, potassium bicarbonate, a mixture of potassium bicarbonate and magnesium bicarbonate, calcium bicarbonate, a mixture of calcium bicarbonate and magnesium bicarbonate, lithium bicarbonate, and a mixture of lithium bicarbonate and magnesium bicarbonate.
3. The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein the bicarbonate anions are 150 mg to 3500 mg per litre of the solution.
4. The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein the metal cations are 30 mg to 500 mg per litre of the solution.
5. The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein a stoichiometric concentration of metal cations is in association with the bicarbonate anions.
6.l The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein the pH adjusting agent is selected from the group consisting of carbon dioxide, hydrated carbon dioxide, carbonic acid and any mixture thereof.
7. The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein the aqueous metal bicarbonate solution has a pH 7 to 8.6.
8. The aqueous metal bicarbonate solution of claim 1, wherein the aqueous neutral to mildly alkaline metal bicarbonate solution has a pH of 8.0 to 8.6.
9. The aqueous metal bicarbonate solution of claim 1, wherein the aqueous neutral to mildly alkaline metal bicarbonate solution has a temperature in the range selected from the group consisting of 0 to 25 C., 0 to 20 C., 0.5 to 25 C., 0.5 to 20 C., 0.5 to 15 C., 0.5 to 10 C., 0.5 to 9 C., 0.5 to 8 C., 0.5 to 7 C., 1 to 20 C., 1 to 15 C., 1 to 10 C., 1.5 to 20 C., 1.5 to 15 C., 1.5 to 10 C., 2 to 20 C., 2 to 15 C., 2 to 10 C., 3 to 20 C., 3 to 15 C., 4 to 20 C., 4 to 15 C., 4 to 10 C., 5 to 20 C., 5 to 15 C., 6 to 20 C., 6 to 15 C., 6 to 10 C., 7 to 20 C., 7 to 15 C., 7 to 10 C., 8 to 20 C., 8 to 15 C., 8 to 10 C., 9 to 20 C., 9 to 15 C., 9 to 10 C., 10 to 15 C., 0 to 15 C., 0 to 10 C., 3 C. to 10 C. and 5 C. to 10 C.
10. The aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1, wherein the metal bicarbonate comprises a mixture of sodium bicarbonate and magnesium bicarbonate.
11. A solution for preventing andor treating certain inflammatory diseases andor degenerative diseases andor certain viral diseases in a mammal, comprising the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1 wherein the metal bicarbonate is in an amount effective to prevent andor treat said diseases.
12. A solution for decreasing andor treating senescence andor increasing longevity in a mammal, comprising the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1 wherein the metal bicarbonate is in an amount effective to decrease andor treat senescence andor increase longevity.
13. A solution for scavenging protons in a mammal, comprising the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1 wherein the metal bicarbonate is in an amount effective to scavenge protons.
14. A solution for decreasing proton concentrations in a mammal, comprising the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1 wherein the metal bicarbonate is in an amount effective to decrease proton concentrations.
15. A solution for decreasing inflammation and inflammatory conditions in a mammal, comprising the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1 in an amount effective to decrease inflammation andor inflammatory conditions.
16. A solution for increasing motor activity andor decrease fatigue in a mammal, comprising the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1 in an amount effective to increase motor activity.
17. A process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution comprising bicarbonate anions and metal cations, which process comprises reacting a compound selected from the group consisting of metal carbonate, metal carbonate hydroxide, metal oxide, metal hydroxide and any mixture thereof with an effective concentration of a pH adjusting agent to produce the aqueous neutral to mildly alkaline metal bicarbonate solution, wherein the pH adjusting agent is present in an amount whereby the solution is at a neutral to mildly alkaline pH.
18. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the pH adjusting agent is selected from the group consisting of carbon dioxide, hydrated carbon dioxide, carbonic acid and any mixture thereof.
19. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the metal bicarbonate is selected from the group consisting of magnesium bicarbonate, sodium bicarbonate, a mixture of sodium bicarbonate and magnesium bicarbonate, potassium bicarbonate, a mixture of potassium bicarbonate and magnesium bicarbonate, calcium bicarbonate, a mixture of calcium bicarbonate and magnesium bicarbonate, lithium bicarbonate, and a mixture of lithium bicarbonate and magnesium bicarbonate.
20. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the bicarbonate anions are 150 mg to 3500 mg per litre of aqueous neutral to mildly alkaline metal bicarbonate solution.
21. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the metal cations are 30 mg to 500 mg per litre of aqueous neutral to mildly alkaline metal bicarbonate solution
22. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the aqueous neutral to mildly alkaline metal bicarbonate solution has a pH of 7 to 8.6.
23. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the aqueous metal bicarbonate solution has a pH of 8.0 to 8.6.
24. The process of preparing an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 17, wherein the aqueous metal bicarbonate solution has a temperature in the range selected from the group consisting of 0 to 25 C., 0 to 20 C., 0.5 to 25 C., 0.5 to 20 C., 0.5 to 15 C., 0.5 to 10 C., 0.5 to 9 C., 0.5 to 8 C., 0.5 to 7 C., 1 to 20 C., 1 to 15 C., 1 to 10 C., 1.5 to 20 C., 1.5 to 15 C., 1.5 to 10 C., 2 to 20 C., 2 to 15 C., 2 to 10 C., 3 to 20 C., 3 to 15 C., 4 to 20 C., 4 to 15 C., 4 to 10 C., 5 to 20 C., 5 to 15 C., 6 to 20 C., 6 to 15 C., 6 to 10 C., 7 to 20 C., 7 to 15 C., 7 to 10 C., 8 to 20 C., 8 to 15 C., 8 to 10 C., 9 to 20 C., 9 to 15 C., 9 to 10 C., 10 to 15 C., 0 to 15 C., 0 to 10 C., 3 C. to 10 C. and 5 C. to 10 C.
25. An aqueous neutral to mildly alkaline metal bicarbonate solution whenever prepared by the process of claim 17.
26. A method of preventing andor treating certain inflammatory diseases andor degenerative diseases in a mammal in need of such prevention andor treatment comprising administering to said mammal an effective amount of an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
27. A method of preventing andor treating certain viral diseases in a mammal in need of such prevention andor treatment comprising administering to said mammal an effective amount of an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
28. A method of decreasing andor treating senescence andor of increasing longevity in a mammal comprising administering to said mammal an effective amount of an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
29. A method of scavenging protons in a mammal comprising administering to said mammal an effective amount of a proton scavenger.
30. The method of claim 29, wherein said proton scavenger comprises the aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
31. The method of claim 29, wherein said proton scavenger is a metal bicarbonate.
32. A method of decreasing proton concentrations in a mammal by altering carbonic anhydrase enzyme reactions in said mammal comprising administering to said mammal an effective amount of an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
33. A method of decreasing inflammation andor inflammatory conditions in a mammal comprising administering to said mammal an effective amount of an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
34. A method of increasing motor activity andor decreasing fatigue in a mammal comprising administering to said mammal an effective amount of an aqueous neutral to mildly alkaline metal bicarbonate solution of claim 1.
35. The method of any one of claims 26, 27, 30, 31, 32, 33 or 34, wherein said mammal is human and said aqueous neutral to mildly alkaline metal bicarbonate solution is administered to said human on an empty stomach.
36. The method of any one of claims 26, 27, 30, 31, 32, 33 or 34, wherein said mammal is human, said aqueous neutral to mildly alkaline metal bicarbonate solution is administered to said human on an empty stomach and the metal bicarbonate comprises a mixture of sodium bicarbonate and magnesium bicarbonate.
37. A combination comprising a substantially stable aqueous neutral to mildly alkaline metal bicarbonate solution, comprising metal bicarbonate dissolved in the solution, said metal bicarbonate comprising bicarbonate anions and metal cations, and a pH adjusting agent in the solution in an amount whereby the solution is at a neutral to mildly alkaline pH, in combination with a stabilising agent in an amount effective to maintain and stabilise the bicarbonate anions in the neutral to mildly alkaline solution.