1. A guidance issuing device comprising:
a guidance sound storage unit for storing a guidance sound set every guidance;
a sound volume setting unit for setting a volume of the guidance sound;
a sound volume storage unit for storing the volume set by the sound volume setting unit; and
an output unit for outputting the guidance sound at the set volume level corresponding to the guidance sound of the sound volume storage unit.
2. The guidance issuing device of claim 1, wherein
when the output unit continuously outputs a plurality of guidance sounds whose volumes are set by the sound volume setting unit, the output unit outputs the plurality of guidance sounds at a set volume level corresponding to one guidance sound set by the sound volume setting unit, among the plurality of guidance sounds.
3. The guidance issuing device of claim 1, further comprising:
a last-minute guidance sound storage unit for storing a guidance sound to be output; and
a last-minute guidance-sound set-volume changing unit for changing a set sound volume corresponding to the output guidance sound stored in the sound volume storage unit.
4. The guidance issuing device of claim 3, wherein
the sound volume storage unit stores a set sound volume to be digitized,
the last-minute guidance-sound set-volume changing unit has a switch for changing a set sound volume, and
the switch changes the digitized set sound volume.
5. The guidance issuing device of claim 3, wherein
the last-minute guidance-sound set-volume changing unit has a rotary switch for changing a volume of a guidance sound supplied from the output unit, and changes a set sound volume in the sound volume storage unit when the rotary switch is operated within a predetermined time of the supply of the guidance sound.
6. The guidance issuing device of claim 3, wherein
when the last-minute guidance-sound set-volume changing unit is continuously operated within a predetermined time, a sound volume set by the sound volume setting unit is not changed.
7. The guidance issuing device of claim 4, wherein
when the last-minute guidance-sound set-volume changing unit is continuously operated within a predetermined time, a sound volume set by the sound volume setting unit is not changed.
8. The guidance issuing device of claim 5, wherein
when the last-minute guidance-sound set-volume changing unit is continuously operated within a predetermined time, a sound volume set by the sound volume setting unit is not changed.
9. The guidance issuing device of claim 3, wherein
when the last-minute guidance-sound set-volume changing unit is operated during output of the guidance sound, the guidance sound is output at a set volume level.
10. The guidance issuing device of claim 4, wherein
when the last-minute guidance-sound set-volume changing unit is operated during output of the guidance sound, the guidance sound is output at a set volume level.
11. The guidance issuing device of claim 5, wherein
when the last-minute guidance-sound set-volume changing unit is operated during output of the guidance sound, the guidance sound is output at a set volume level.
12. An integrated circuit for issuing guidance comprising:
a guidance sound storage unit for storing a guidance sound set every guidance;
a sound volume setting unit for setting a volume of the guidance sound;
a sound volume storage unit for storing the volume set by the sound volume setting unit;
a last-minute guidance sound storage unit for storing a guidance sound to be output; and
a last-minute guidance-sound set-volume changing unit for changing the set volume,
wherein the guidance sound is supplied from an output unit at a set volume level corresponding to the guidance sound stored in the sound volume storage unit, and
wherein a set volume corresponding to the output guidance sound stored in the sound volume storage unit can be changed using the last-minute guidance-sound set-volume changing unit.
13. A guidance issuing method comprising:
a guidance sound storing step of storing a guidance sound set every guidance;
a sound volume setting step of setting a volume of the guidance sound;
a sound volume storing step of storing the volume set in the sound volume setting step;
an output step of outputting the guidance sound at a set volume level corresponding to the guidance sound stored in the sound volume setting step;
a last-minute guidance sound storing step of storing the output guidance sound; and
a last-minute guidance-sound set-volume changing step of changing a set volume corresponding to the output guidance sound stored in the sound volume storing step.
14. A program of issuing guidance comprising:
a guidance sound storing step of storing a guidance sound set every guidance;
a sound volume setting step of setting a volume of the guidance sound;
a sound volume storing step of storing the volume set in the sound volume setting step;
an output step of outputting the guidance sound at the set volume level corresponding to the guidance sound stored in the sound volume storing step;
a last-minute guidance sound storing step of storing the output guidance sound; and
a last-minute guidance-sound set-volume changing step of changing a set volume corresponding to the output guidance sound stored in the sound volume storing step.
15. The guidance issuing device of claim 2, further comprising:
a last-minute guidance sound storage unit for storing a guidance sound to be output; and
a last-minute guidance-sound set-volume changing unit for changing a set sound volume corresponding to the output guidance sound stored in the sound volume storage unit.
16. The guidance issuing device of claim 15, wherein
the sound volume storage unit stores a set sound volume to be digitized,
the last-minute guidance-sound set-volume changing unit has a switch for changing a set sound volume, and
the switch changes the digitized set sound volume.
17. The guidance issuing device of claim 15, wherein
the last-minute guidance-sound set-volume changing unit has a rotary switch for changing a volume of a guidance sound supplied from the output unit, and changes a set sound volume in the sound volume storage unit when the rotary switch is operated within a predetermined time of the supply of the guidance sound.
18. The guidance issuing device of claim 15, wherein
when the last-minute guidance-sound set-volume changing unit is continuously operated within a predetermined time, a sound volume set by the sound volume setting unit is not changed.
19. The guidance issuing device of claim 15, wherein
when the last-minute guidance-sound set-volume changing unit is operated during output of the guidance sound, the guidance sound is output at a set volume level.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A crystalline Form I of an ascorbic acid salt of sunitinib characterized by an XRPD pattern substantially as depicted in FIG. 1.
2. The crystalline Form I of an ascorbic acid salt of sunitinib according to claim 1, characterized by XRPD peaks at interplanar spacing (d) values at about 8.00, 7.84, 6.08, 3.99, 3.79, and 3.33 (\u212b).
3. The crystalline Form I of an ascorbic acid salt of sunitinib according to claim 2, further characterized by XRPD peaks at interplanar spacing (d) values at about 15.97, 11.47, 10.53, 9.65, 8.00, 7.84, 6.70, 6.08, 5.68, 5.31, 4.80, 4.52, 3.99, 3.79, 3.33, 2.82, and 2.42 (\u212b).
4. The crystalline Form I of an ascorbic acid salt of sunitinib according to claim 1, characterized by a DSC thermogram substantially as depicted in FIG. 2.
5. The crystalline Form I of an ascorbic acid salt of sunitinib according to claim 1, characterized by DSC endothermic peaks at about 90.78\xb0 C., 145.14\xb0 C., 155.95\xb0 C., 196.09\xb0 C., and about 211.33\xb0 C.
6. A process for the preparation of the crystalline Form I of claim 1 comprising:
a) treating sunitinib with an ascorbic acid; and
b) isolating the crystalline Form I from the reaction mixture of step a).
7. The process according to claim 6, wherein the ascorbic acid used for the preparation of the salt of sunitinib is L-ascorbic acid, D-ascorbic acid, or mixtures thereof.
8. The process according to claim 7, wherein the ascorbic acid used for the preparation of the salt of sunitinib is L-ascorbic acid.
9. The process according to claim 6, wherein the treatment of sunitinib with an ascorbic acid is carried out in the presence of an organic solvent selected from the group consisting of water, ethers, alcohols, ketones, hydrocarbons, esters, halogenated hydrocarbons, and mixtures thereof.
10. The process according to claim 9, wherein the ether solvents are selected from the group consisting of methyl tertiary butyl ether, tetrahydrofuran, or diethyl ether.
11. The process according to claim 9, wherein the alcohol solvents are selected from the group consisting of methanol, ethanol, or n-butanol.
12. The process according to claim 9, wherein the ketone solvents are selected from the group consisting of acetone or methyl ethyl ketone.
13. The process according to claim 9, wherein the hydrocarbon solvents are selected from the group consisting of pentane, hexane, or heptane.
14. The process according to claim 9, wherein the ester solvents are selected from the group consisting of ethyl acetate, butyl acetate, or isopropyl acetate.
15. The process according to claim 9, wherein the halogenated hydrocarbon is dichloromethane.
16. The process according to claim 9, wherein the organic solvent is methanol or methyl tertiary butyl ether.
17. A pharmaceutical composition comprising the crystalline Form I of claim 1 and a pharmaceutically acceptable carrier.
18. A method of treating or preventing a protein kinase related disorder, comprising administering to a patient in need thereof a therapeutically effective amount of the crystalline Form I of claim 1.