1. A self-rotating deployed film solar batteries array, comprising:
film solar batteries, electrical cables, a center axle and connecting lines, wherein:
a. many long-strip-shaped film solar batteries radiate to form a circle or a polygon array; when linking two adjacent film solar batteries with a connecting line, each film solar battery links to a center axle in the middle of the array with the electrical cables;
b. the films deployed and maintained in an array shape by self-rotating centrifugal force in space;
c. the film batteries are coiling outside the surface of a center axle before deployment thereof; and
d. the film solar batteries array is used in spacecrafts.
2. The self-rotating deployed film solar batteries array in claim 1, wherein: a film battery (2) can be shaped into a matrix which length-to-width ratio is greater than 3, the thin film battery (2) has an outside reinforcing rod (3) at the end of the array’s rim and an outer ring connecting line (5) to link the end of adjacent outside reinforcing rods (3); one end of the film battery (2) near the center array has an inside reinforcing rod (4), and an inner ring connecting line (6) to link the junction of point M, N at the inside reinforcing rod (4), the junction is apart at where 25%-30% from the end of the rod, and the inner ring connecting line (6) has 50%-60% of the reinforcing rod length.
3. The self-rotating deployed film solar batteries array in claim 1, wherein: an inner ring connecting line (6) connects to the end of the inside reinforcing rod (4); inside the rod, a small line-reel and micromotor is provided near the end of each rod; after the film batteries array fully deployed, the micromotors pull the inner ring connecting line (6) into the reinforcing rod, driving the end of the adjacent inside reinforcing rods close together; changing the inner ring connecting line’s (6) length will control tilted angle of the film batteries array.
4. The self-rotating deployed film solar batteries array in claim 1, wherein: a center axle (1) of the film solar batteries array has an inner ring (39) and an outer ring (41); wheels (42), motor (11) and electrical cable reels (10) between the inner ring and outer ring are installed on the inner wall of the outer ring (41); grooves (12) paralleled to the center of the axle are defined in the wall of the outer ring (41) at the axis center, the angular distance between grooves is 2\u03c0n radian, wherein n is thin film strip number; many holes (9) are provided in the wall of the outer ring for the electrical cables to pass through; the center axis length is greater than the film battery’s width; when the film battery (2) is coiling on the center axis, the inside reinforcing rod (4) of the film battery is placed in the groove (12) on the surface of the center axis; the electrical cable (7) connecting to the inside reinforcing rod passes the hole on the center axis and coils on the electrical cable reel (10); the film batteries (2) are faceup overlapping and coiling in the same direction on the outside of the center axle (1); after the film batteries are self rotating in a full deployment, the motor (11) adjusts the electric cable’s length by driving the electrical cable reels (10), hence to control the inclining angle of the leaf blade and the center of gravity of the batteries array.
5. The self-rotating deployed film solar batteries array in claim 1, wherein: the center axle (43) of the film solar batteries array exterior is a cylindrical shell with an umbrella column (44) passing through the center of the center axle (43); two set of umbrella ribs are provided at both sides of the umbrella column, the electrical cable (7) runs through the hollow umbrella rib (19) to connect the inside reinforcing rod (4) of the film battery; both sides of the center axis’s wall have n slits (16) to open the umbrella ribs, wherein n is thin film strip number.
6. The self-rotating deployed film solar batteries array in claim 1, wherein: the long-strip-shaped thin film batteries (8) are fan-shaped, and are arranged into a circle of radiate form, the adjacent film batteries connect each other with an outer ring connecting line (5) and an inner ring connecting line (6); one side of the film battery near the center axis has an inside reinforcing rod (4), whereas both sides of the rod have electrical cable (7) connecting to the center axis (1) at the center of the array; thin film batteries (8) are counter-overlapped each other to coil on the center axle (1) when being folded.
7. The self-rotating deployed film solar batteries array in claim 1, wherein: the outside reinforcing rod (3) and the inside reinforcing rod (4) of the film battery (2) have a slide-block (23) respectively, an inner ring connecting line (6) and an outer ring line (5) connect to the slide-blocks of the inside and outside reinforcing rods respectively; under the driving force coming from the micromotor, the slide-blocks slide from one end to the other end on the reinforcing rod to turn over the film battery.
8. The self-rotating deployed film solar batteries array in claim 1, wherein: the center axle (1) harnesses on a cylindrical spacecraft, the thin film batteries array deploys around the spacecraft.
9. The self-rotating deployed film solar batteries array in claim 1, wherein: the center axle (43) of the array connects a satellite (26) with a pole support (13) and a universal holder (27), the universal holder (27) is a U shaped fork, two ends (28) of the U shaped fork connect with a rotating axle to the satellite.
10. The self-rotating deployed film solar batteries array in claim 1, wherein: the end of the center axle (43) of the array connects a satellite (26) with an electric driving-cable (30) and a universal holder (27), the film batteries array is drifting on the side where the satellite is back to the sunlight.
11. The self-rotating deployed film solar batteries array in claim 1, wherein: one end of a main-beam (32) of a spacestation connects one end of the center axle (43) of the film batteries array (36) with a pole support (13), and a capsule (34) is fixed on a cross-beam (37) which rotates around the main-beam (32).
12. The self-rotating deployed film solar batteries array in claim 1, wherein: a center axle (1) of the film batteries array (36) harnesses on the main-beam (32) of a spacestation; an inner ring (39) of the center axle is fixed on the main beam (32) and a capsule (34) is fixed on the cross-beam (37) which rotates around the main-beam (32).
13. The self-rotating deployed film solar batteries array in claim 1, wherein: one end of the film batteries array’s (36) center axle (43) connects an electrically-powered rocket (40) with a pole support, and the action line of the electrically-powered rocket’s thrust force runs through the center of entire spacecraft system.
14. The self-rotating deployed film solar batteries array in claim 1, wherein: using diffuse reflection film material of high reflection coefficient to replace the majority of thin film batteries in a thin film batteries array to make an extremely bright man-made moon.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for identifying putative therapeutic targets comprising:
Obtaining a paired brain tissue sample from a live human wherein each member of the pair has a different level of electrical brain activity from the other member;
Identifying long non-protein-coding RNA (IncRNA) molecules (IncRNAs) and protein-coding messenger RNA (mRNA) molecules (mRNAs) that are differentially expressed between the members of each individual sample pair;
Linking a first differentially expressed IncRNA with a differentially expressed mRNA andor a second differentially expressed IncRNA when the gene encoding the first differentially expressed IncRNA overlaps with, or is adjacent to, the gene encoding the differentially expressed mRNA andor the gene encoding the differentially expressed second IncRNA along the human genome, thereby identifying an IncRNAmRNA gene pair andor an IncRNAIncRNA gene pair as putative cis-encoded therapeutic targets; andor
Linking a first differentially expressed IncRNA with a differentially expressed mRNA andor with a second differentially expressed IncRNA when the differentially expressed first IncRNA and the differentially expressed mRNA andor second IncRNA are encoded at different genomic loci, thereby identifying an IncRNAmRNA gene pair andor an IncRNAIncRNA gene pair as putative trans-encoded therapeutic targets.
2. A method of claim 1 wherein linking of differentially expressed IncRNA with differentially expressed mRNA andor IncRNA further requires that the differential expression of the IncRNA and mRNA or IncRNA and IncRNA be observed in more than one brain sample pair, each pair having a low electrical brain activity member and a high electrical brain activity member.
3. A method of claim 1 or 2 wherein electrical brain activity is classified as high or low based on the frequency andor amplitude of interictal and ictal spiking.
4. A method of claim 1, 2 or 3 wherein differential expression is identified by quantifying IncRNA and mRNA expression.
5. A method of claim 4 wherein the expression quantification utilizes at least one microarray capable of quantifying IncRNA expression and mRNA expression.
6. A method of claim 4 or 5 wherein the quantifying utilizes at least one microarray capable of quantifying IncRNA expression and at least one microarray capable of quantifying mRNA expression wherein consistency of differential expression data between the at least one IncRNA microarray and the at least one mRNA microarray is evaluated by correlating the fold-change of protein-coding control genes common to both arrays.
7. A method of claim 4, 5 or 6 further comprising evaluating the putative therapeutic target as a molecular site of effective intervention.
8. A method of claim 7 wherein the therapeutic target of a pair is IncRNA, mRNA andor both.
9. A microarray for identifying putative therapeutic targets in the human brain comprising probes for IncRNA and probes for mRNA wherein at least a subset of the mRNA probes is included based on the representation of their corresponding genes by probes on a different genomewide expression analysis microarray.
10. A microarray of claim 8 or 9 wherein the IncRNA probes are 50-mer to 70-mer probes mapped to a single genomic location.
11. A microarray of claim 8, 9 or 10 wherein the IncRNA probes are free of interspersed and simple repeats and segmental duplications.
12. A microarray of claim 8, 9, 10 or 11 comprising 7 or 8 distinct probes per IncRNA.
13. A microarray of claim 8, 9, 10, 11 or 12 comprising probes for at least 1000 IncRNA genes.
14. A method of assessing putative therapeutic targets in the human brain comprising:
Exposing human neuroblastoma cells to either a single depolarization or repeated depolarizations;
Identifying time-dependent differential IncRNA and mRNA expression in the cells exposed to either single andor repeated depolarizations, relative to untreated control cells; and
(i) Linking a first differentially expressed IncRNA with differentially expressed mRNAs andor second differentially expressed IncRNAs when the gene encoding the first differentially expressed IncRNA overlaps with, or is adjacent to the gene encoding the differentially expressed mRNA or second differentially expressed IncRNA thereby identifying IncRNAmRNA andor IncRNAIncRNA gene pairs as putative cis-encoded therapeutic targets; andor
(ii) Linking a first differentially expressed IncRNA with a differentially expressed mRNA andor with a second differentially expressed IncRNA when the first IncRNA and mRNA andor second IncRNA are encoded at different genomic loci, thereby identifying IncRNAmRNA andor IncRNAIncRNA gene pairs as putative trans-encoded therapeutic targets.
15. A method comprising targeting the first IncRNA of an IncRNAmRNA or IncRNAIncRNA gene pair as a putative therapeutic target wherein the first IncRNA and mRNA or second IncRNA are differentially expressed in areas of the brain having a different characteristic demonstrated to be relevant in one or more of epileptic activity, inflammation, cellular proliferation multiple sclerosis, neurodegeneration or autism andor have been linked because the gene encoding the differentially expressed IncRNA overlaps with, or is adjacent to the gene encoding the differentially expressed mRNA or second differentially expressed IncRNA.
16. A method of claim 15 wherein the gene pair is BDNFOS (SEQ ID NO: 1)BDNF (SEQ ID NO: 2); AF086035 (SEQ ID NO: 3)MAPK1IP1L (SEQ ID NO: 4); AK093366 (SEQ ID NO: 5)AG2 (SEQ ID NO: 6); BC047792 (SEQ ID NO: 7)PURB (SEQ ID NO: 8); AK096235 (SEQ ID NO: 9)LCP1 (SEQ ID NO: 10); AL110130 (SEQ ID NO: 11)SMEK2 (SEQ ID NO: 12); BC013641 (SEQ ID NO: 13)ARC (SEQ ID NO: 14); hTF27297 (SEQ ID NO: 15)CYR61 (SEQ ID NO: 16); RPPH1 (SEQ ID NO: 17)NEAT1 (SEQ ID NO: 18); NEAT1 (SEQ ID NO: 18)EGR3 (SEQ ID NO: 19); NEAT1 (SEQ ID NO: 18)CR600638 (SEQ ID NO: 20); RPPH1 (SEQ ID NO: 17)NEAT2 (MALAT1) (SEQ ID NO: 21); CR600638 (SEQ ID NO: 20)FLT1 (SEQ ID NO: 22); BC012463 (SEQ ID NO: 23)LRRN1 (SEQ ID NO: 24); CR615000 (SEQ ID NO: 25)ERAP1 (SEQ ID NO: 26); BCO28229 (SEQ ID NO: 27)BTG3 (SEQ ID NO: 28); BC078172 (SEQ ID NO: 29)VIM (SEQ ID NO: 30); AF075087 (SEQ ID NO: 31)S1PR1 (SEQ ID NO: 32); AK123944 (SEQ ID NO: 33)TRIM47 (SEQ ID NO: 34); or AL110176 (SEQ ID NO: 35)PLOD2 (SEQ ID NO: 36).
17. A method comprising targeting an IncRNA gene as a site of putative therapeutic intervention wherein the IncRNA gene is differentially expressed in at least one area of the brain having a different characteristic then a second area and wherein the IncRNA gene is KCNQ1OT1; RPPH1; NEAT1; NEAT2 or MIAT.
18. A method comprising targeting a gene as a site of therapeutic intervention when the gene was identified by a method or microarray of any one of claims 1-17.
19. A method of claim 18 wherein the targeting includes gene silencing or gene activating.
20. A method of claim 18 or 19 wherein the targeting includes gene silencing through RNA interference.