1. In a mobile communication system having a plurality of radio base stations and a mobile station, a radio base station selection method in which a radio base station to start communicating with a mobile station is selected from among adjacent radio base stations capable of communicating with the mobile station, the method comprising the steps of:
measuring, by a mobile station, a reception quality of each of a plurality of adjacent radio base stations;
receiving, by a radio base station in service, a signal including a connection request and the measured reception quality of each of the plurality of adjacent radio base stations from the mobile station;
transmitting, by the radio base station in service, to each adjacent radio base station, but not to the mobile station, a message requesting a radio channel available capacity report;
making the radio channel available capacity report by each adjacent radio base station, but not by the mobile station;
sending the radio channel available capacity report directly from said each adjacent radio base station, but not from the mobile station, to the radio base station in service, each radio channel available capacity report including an available bandwidth of the respective adjacent radio base station;
making, by the radio base station in service, a table including the reception qualities measured by the mobile station and the radio channel available capacity reports directly obtained from the adjacent radio base stations;
selecting, by the radio base station in service, but not by a radio base station control station or an adjacent radio base station, a radio base station to be connected to the mobile station, based on the table; and
notifying the mobile station of information necessary for communicating with the selected radio base station.
2. The radio base station selection method as claimed in claim 1, wherein the signal for requesting connection from the mobile station is a signal relating to sending a call to or from the mobile station.
3. The radio base station selection method as claimed in claim 1, wherein the signal for requesting connection from the mobile station is a signal relating to a handoff request.
4. The radio base station selection method as claimed in claim 1, wherein
the radio base station in service selects one radio base station satisfying a predetermined receiving quality, from among more than one adjacent radio base stations having radio channel available capacity necessary for accommodating the connection to the mobile station, based on the radio channel available capacity reports directly obtained from the adjacent radio base stations.
5. The radio base station selection method as claimed in claim 1, wherein
the radio base station in service notifies the mobile station of identification information about the selected radio base station; and
the mobile station establishes connection to the selected radio base station identified by the identification information provided by the radio base station in service.
6. The radio base station selection method as claimed in claim 1, wherein
the radio base station in service instructs the selected radio base station to assign a radio channel to the mobile station;
the selected radio base station reports information about the radio channel assigned according to the instruction, to the radio base station in service;
the radio base station in service notifies the mobile station of the reported information about the radio channel; and
the mobile station communicates with the selected radio base station using the assigned radio channel.
7. In a mobile communication system having a plurality of radio base stations and a mobile station, a radio base station selection system in which a radio base station to start communicating with a mobile station is selected from among adjacent radio base stations capable of communicating with the mobile station, the system comprising a radio base station in service,
the mobile station including means for measuring a reception quality of each of a plurality of adjacent radio base stations;
the radio base station in service including:
radio channel available capacity requiring means for requiring a radio channel available capacity report from each adjacent radio base station, but not from the mobile station, when receiving a signal for requesting connection and including the measured reception quality from the mobile station;
means for receiving the radio channel available capacity reports directly from said each adjacent radio base station, but not from the mobile station, each radio channel available capacity report including an available bandwidth of the respective adjacent radio base station;
means for making, by the radio base station in service, a table including the reception qualities measured by the mobile station and the radio channel available capacity reports directly obtained from the adjacent radio base stations;
radio base station selecting means for selecting by the radio base station in service, but not by a radio base station control station or an adjacent radio base station, a radio base station to be connected to the mobile station, based on the table; and
notifying means for notifying the mobile station of information necessary for communicating with the selected radio base station.
8. The radio base station selection system as claimed in claim 7, wherein the signal for requesting connection from the mobile station is a signal relating to sending a call to or from the mobile station.
9. The radio base station selection system as claimed in claim 7, wherein the signal for requesting connection from the mobile station is a signal relating to a handoff request.
10. The radio base station selection system as claimed in claim 7, wherein
the radio base station selecting means selects one radio base station satisfying a predetermined receiving quality, from among more than one adjacent radio base stations having radio channel available capacity necessary for accommodating the connection to the mobile station, based on the radio channel available capacity reports directly obtained from the adjacent radio base stations.
11. The radio base station selection system as claimed in claim 7, wherein
the notifying means notifies the mobile station of identification information about the selected radio base station; and
the mobile station establishes connection to the selected radio base station identified by the identification information provided by the notifying means.
12. The radio base station selection system as claimed in claim 7, further comprising:
radio channel assignment instruction means for instructing the selected radio base station to assign a radio channel to the mobile station;
wherein the selected radio base station includes radio channel information reporting means for reporting information about the radio channel assigned according to the instruction, to the radio base station in service;
the radio base station in service includes radio channel information notifying means for notifying the mobile station of the reported information about the radio channel; and
the mobile station communicates with the selected radio base station using the assigned radio channel.
13. A radio base station in service and communicating with a mobile station capable of measuring a reception quality of each of a plurality of adjacent radio base stations, comprising:
radio channel available capacity requiring means for receiving a signal including a connection request and the measured reception quality from the mobile station, and for requesting a radio channel available capacity report from each adjacent radio base station, but not from the mobile station;
means for receiving the radio channel available capacity reports directly from said each adjacent radio base station, but not from the mobile station, each radio channel available capacity report including an available bandwidth of the respective adjacent radio base station;
means for making, by the radio base station in service, a table including the reception qualities measured by the mobile station and the radio channel available capacity reports directly obtained from the adjacent radio base stations;
radio base station selecting means for selecting, by the radio base station in service, but not by a radio base station control station or an adjacent radio base station, a radio base station to be connected to the mobile station, based on the table; and
notifying means for notifying the mobile station of information necessary for communicating with the selected radio base station.
14. The radio base station as claimed in claim 13, wherein the signal for requesting connection from the mobile station is a signal relating to sending a call to or from the mobile station.
15. The radio base station as claimed in claim 13, wherein the signal for requesting connection from the mobile station is a signal relating to a handoff request.
16. The radio base station as claimed in claim 13, wherein
the radio base station selecting means selects one radio base station satisfying a predetermined receiving quality, from among more than one adjacent radio base stations having radio channel available capacity necessary for accommodating the connection to the mobile station, based on the radio channel available capacity reports directly obtained from the adjacent radio base stations.
17. The radio base station as claimed in claim 13, wherein
the notifying means notifies the mobile station of identification information about the selected radio base station; and
the mobile station establishes connection to the selected radio base station identified by the identification information provided by the notifying means.
18. The radio base station as claimed in claim 13, further comprising:
radio channel assignment instruction means for instructing the selected radio base station to assign a radio channel to the mobile station; and
radio channel information notifying means for notifying the mobile station of information about the radio channel assigned according to the instruction.
19. The radio base station as claimed in claim 18, wherein
the radio base station instructed to assign a radio channel by the radio channel assignment instruction means reports information about the assigned radio channel according to the instruction, to the in service radio base station.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I):
39
wherein
R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; R1 is bicyclyl or heterobicyclyl; R2 is aryl, heteroaryl, heterocyclyl, alkoxy, alkyl, aryloxy, hydroxy or optionally substituted amino and n is from 0 to 3; with the provisos that when n is 0 R2 is alkyl or when n is from 1 to 3 R2 is not alkyl.
2. A compound according to claim 1 wherein R is isobutyl, phenyl or cyclohexyl, andor R1 is 2-naphthyl, 5-benzothiophene, 2-tetrahydronaphthyl or 2-indanyl andor R2 is 2-methoxyethoxy, pyridin-3-yl, furan-2-yl, 5-dimethylaminofuran-2-yl, 2,5-dioxoimidazolidin-1-yl, 3-methyl-2,5-dioxoimidazolidin-1-yl, 3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl, N-morpholino, N,N-dimethylamino, N-succinimido, N-pyrrolidone or phenoxy and n is 1 or 2.
3. A compound selected from the group consisting of
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)2-(2-methoxyethoxy)-ethylamino-N-hydroxy-2-phenylacetamide;
(R,S)-2-(Benzobthiophen-5-ylmethanesulfonyl)(pyridin-3 -ylmethyl)-amino-N-hydroxy-2-phenylacetamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)(furan-2-ylmethyl)-amino-2-cyclohexyl-N-hydroxy-acetamide;
(R)-N-Hydroxy-4-methyl-2-(naphthalen-2-ylmethanesulfonyl)(pyridin-3-ylmethyl)aminopentanoic acid amide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)2-(2,5-dioxo-imidazolidin-1-yl)ethylamino-4-methyl-N-hydroxy-pentanamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)2-(3-methyl-2,5-dioxo-imidazolidin-1-yl)ethylamino-N-hydroxy-2-phenylacetamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)2-(2,5-dioxo-imidazolidin-1-yl)ethylamino-N-hydroxy-2-phenyl-acetamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)2-(3,4,4-trimethyl)-2,5-dioxo-imidazolidin-1-yl)ethylamino-N-hydroxy-2-phenyl-acetamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)-2-(2-methoxyethoxy)ethyl-amino4-methyl-N-hydroxy-pentanamide;
(R,S)-2-(Benzobthiophen-5-ylmethanesulfonyl)-2-(morpholin-4-yl)-ethyl)-amino-N-hydroxy-2-phenylacetamide;
(R,S)-2-(Benzobthiophen-5-ylmethaesulfonyl)-(2-dimethylaminoethyl)-amino-N-hydroxy-2-phenylacetamide;
(R,S)-2-(Benzobthiophen-5 -ylmethanesulfonyl)-2-(2,5-dioxopyrrolidin-1-yl)ethyl-amino-N-hydroxy-2-phenylacetamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)-2-(2,5-dioxopyrrolidin-1-yl)ethyl-amino-4-methyl-N-hydroxy-pentanamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)-(pyridin-3-ylmethyl)-amino-4-methyl-N-hydroxy-pentanamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)-2-(2-oxopyrrolidin-1-yl)-ethyl-amino-4-methyl-N-hydroxy-pentanamide;
(R)-2-(Benzobthiophen-5-ylmethanesulfonyl)-(5-dimethylaminomethylfuran-2-ylmethyl)-amino-4-methyl-N-hydroxy-pentanamide;
(R,S)-2-(Benzobthiophen-5-ylmethanesulfonyl)-(5 -dimethylaminomethylfuran-2-ylmethyl)-amino-N-hydroxy-2-phenylacetamide;
(R,S)-2-(Benzobthiophen-5-ylmethanesulfonyl)-2-(2-oxo-pyrrolidin-1-yl)-ethyl-amino-N-hydroxy-2-phenylacetamide; and
(R,S)-2-(Benzobthiophen-5 -ylmethanesulfonyl)-(2-phenoxyethyl)-amino-N-hydroxy-2-phenylacetamide
4. Use of a compound according to any preceding claim for the production of a medicament of the treatment or prophylaxis of disorders in which the overproduction of s-CD23 is implicated.
5. A method for the treatment or prophylaxis of disorders in which the overproduction of s-CD23 is implicated, which method comprises the administration of a compound according to any one of claims 1 to 3 to a human or non-human mammal in need thereof.
6. A pharmaceutical composition for the treatment or prophylaxis of disorders in which the overproduction of s-CD23 is implicated which comprises a compound according to any one of claims 1 to 3 and optionally a pharmaceutically acceptable carrier therefor.
7. Use of a compound according to any one of claims 1 to 3 for the production of a medicament for the treatment or prophylaxis of conditions mediated by TNF.
8. A method for the treatment or prophylaxis of conditions mediated by TNF, which method comprises the administration of a compound according to any one of claims 1 to 3 to a human or non-human mammal in need thereof.
9. A pharmaceutical composition for the treatment or prophylaxis of conditions mediated by TNF, which comprises a compound according to any one of claims 1 to 3 and optionally a pharmaceutical acceptable carrier therefor.
10. A process for preparing a compound according to any one of claims 1 to 3 which process comprises
(a) deprotecting a compound of formula (II):
40
wherein
R, R1, R2 and n are as defined hereinabove, and X is a protecting group such as benzyl, t-butyldimethylsilyl or trimethylsilyl, or
(b) reacting a compound of formula (III):
41
wherein
R, R1, R2 and n are as defined hereinabove, with hydroxylamine or a salt thereof, or
(c) converting a compound of formula (I) to a different compound of formula (I) as defined hereinabove.
11. A compound of formula (II):
42
wherein
R, R1, R2 and n are as defined hereinabove.
12. A compound of formula (III):
43
wherein
R, R1, R2 and n are as defined hereinabove.