1. A product containing the compound of formula (I) below
in free or a pharmaceutically acceptable salt form, in combination with paclitaxel, in free or a pharmaceutically acceptable salt form.
2. A method for the treatment of ovarian cancer, comprising administering, simultaneously, separately or over a period of time, to a patient in need thereof, a compound of formula (I):
in free or a pharmaceutically acceptable salt form, in combination with paclitaxel, in free or a pharmaceutically acceptable salt form.
3. The method according to claim 2, wherein the compound of formula (I) in free or a pharmaceutically acceptable salt form is administered by intravenous or intraperitoneal route.
4. The method according to claim 2, wherein the compound of formula (I) in free or a pharmaceutically acceptable salt form is administered by oral route.
5. The method according to claim 2, wherein paclitaxel in free or a pharmaceutically acceptable salt form is administered by intravenous or intraperitoneal route.
6. A pharmaceutical composition containing, as active principle, the product of claim 1, as well as at least one non-toxic excipient.
7. The pharmaceutical composition according to claim 6, which is in a liquid form suitable for intravenous or intraperitoneal administration.
8. The pharmaceutical composition according to claim 7, which contains the compound of formula (I), in free or a pharmaceutically acceptable salt form, and paclitaxel, in free or a pharmaceutically acceptable salt form, in solution in a mixture of polyoxyethylated castor oil and ethanol.
9. The pharmaceutical composition according to claim 8, wherein the mixture of polyoxyethylated castor oil and ethanol is such that it contains from 40 to 60% in volume of polyoxyethylated castor oil in ethanol.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of treating a hard surface comprising treating a hard surface with an antifouling detergent composition comprising an antifouling detergent and a cationic surfactant, wherein said antifouling detergent comprises a polymer which comprises
a monomer unit A
derived from a compound represented by the general formula (1) andor a compound represented by the general formula (2):
wherein R1, R2, R3, R7, R8 and R9 each represent a hydrogen atom, a hydroxyl group or a C1-3 alkyl group;
X and Y are independently selected from the group consisting of a C1-12 alkylene group, \u2014COOR12\u2014, \u2014CONHR12\u2014, \u2014OCOR12\u2014 and R13\u2014OCO\u2014R12 wherein R12 and R13 each represent a C1-5 alkylene group;
R4 represents a C1-3 alkyl group, a C1-3 hydroxyalkyl group or R1R2C\u2550C(R3)\u2014X\u2014;
R5 represents a C1-3 alkyl group, a C1-3 hydroxyalkyl group or a benzyl group;
R6 represents a C1-10 alkyl group optionally substituted with a hydroxy group, a carboxyl group, a sulfonate group, a sulfate group or a benzyl group, wherein when R6 comprises an alkyl group, a hydroxyalkyl group or a benzyl group, Z\u2212 represents an anion and when R6 comprises a carboxyl group, a sulfonate group and a sulfate group, Z\u2212 is absent, but R6 anions;
R10 represents a hydrogen atom, a C1-3 alkyl group, a C1-3 hydroxyalkyl group or R7R8C\u2550C(R9)\u2014Y\u2014; and
R11 represents a hydrogen atom, a C1-3 alkyl or a C1-3 hydroxyalkyl group and
a monomer unit B represented by \u2014SO2\u2014, and
a monomer unit C derived from at least one monomer selected from the group
consisting of acrylic acid or salts thereof, methacrylic acid or salts thereof, maleic acid or salts thereof, maleic anhydride, styrene sulfonate, 2-acrylamido-2-methylpropanesulfonate, allyl sulfonate, vinyl sulfonate, methallyl sulfonate, sulfopropyl methacrylate, and mono-\u03c9-methacryloyloxyalkyl(C1 to 12) phosphate
wherein the content of the monomer unit A in the whole monomer units is 30 to 90 mol-% wherein
the molar ratio of the monomer unit B to the monomer unit A is from 0.01 to 1,
the molar ratio of the monomer unit C to the monomer unit A is from 0.05 to 1 and
wherein the surface comprises the ceramic surface of a toilet bowl.
2. The method of claim 1, wherein a concentration of said polymer is 0.01 to 35 mass percent.
3. The method of claim 1, wherein said antifouling detergent composition is a liquid.
4. The method of claim 1, wherein monomer (C) further comprises at least one monomer selected from the group consisting of
(ii) an amide group-containing compound selected from acryl(or methacryl)amide, N,N-dimethylaminopropylacryl(or methacryl)amide, N,N-dimethylacryl(or methacryl)amide, N,N-dimethylaminoethylacryl(or methacryl)amide, N,N-dimethylaminomethylacryl(or methacryl)amide, N-vinyl-2-caprolactam, and N-vinyl-2-pyrrolidone,
(iii) an ester group-containing compound selected from alkyl(C1 to C5) acrylate(or methacrylate), 2-hydroxyethyl acrylate(or methacrylate), N,N-dimethylaminoalkyl(C1 to 5) acrylate(or methacrylate), and vinyl acetate, and
(iv) an olefinic compound selected from ethylene, propylene, n-butylene, isobutylene, n-pentene, isoprene, 2-methyl-1-butene, n-hexene, 2-methyl-1-pentene, 3-methyl-1-pentene, 4-methyl-1-pentene, 2-ethyl-1-butene, styrene, vinyl toluene and \u03b1-methylstyrene.