1. A connecting device for mating and making up a connection on the seabed of a first and a second pipeline having first and second pipe ends at the connection site, comprising:
a first connecting part retaining the first pipe end of the first pipeline, which first connecting part and first pipeline are designed to be lowered and deployed on the seabed in advance, and the first connecting part comprises a guiding structure that is spaced apart from the pipe end, and
a second submersible connecting part retaining the second pipe end of the second pipeline, the second connecting part and second pipeline configured to be lowered from the surface of the water towards the first connecting part,
wherein the second connecting part comprises guiding means spaced apart from the pipe end, and
wherein the connecting parts comprise means that cooperate during relative motion between said connecting parts, and hingedly tilts the second connecting part by means of forced motion, and thus aligning the second pipe end in the direction toward the first pipe end such that the first and second pipelines are brought to be in line with each other on the seabed, and
a connector arranged between the first and second connecting parts for final connection between the pipeline ends.
2. The connecting device according to claim 1, wherein the guiding structure is a guide post optionally connected to a surface vessel via a guide line, said guide post being able to receive a corresponding guide means arranged on the second connecting part.
3. The connecting device according to claim 1, wherein the forced motion means on the second connecting part comprises a projecting bar which, in a slidable way, cooperates with a frame part on the first connecting part, said sliding cooperation tilts the second connecting part and thus the pipe end towards alignment of the pipelines.
4. The connecting device according to claim 2, wherein the forced motion means on the second connecting part comprises the said guiding means and the guiding means is fixedly connected to the projecting bar which, in a slidable way, cooperates with said frame part.
5. The connecting device according to claim 1, wherein the forced motion means on the second connecting part is fixedly connected to the second pipe end via a plate part that is secured substantially normally to the central axis of the pipe end.
6. The connecting device according to claim 1, wherein the guiding structure is an upwardly projecting frame structure that is able to receive a corresponding guide means arranged on the second connecting part.
7. The connecting device according to claim 6, wherein the forced motion means on the second connecting part comprises a projecting bail structure which, in an initial phase, in a slidable way cooperate with the upwardly projecting frame structure on the first connecting part, and when the bail structure is completely introduced into and bottoms against a part of the upwardly projecting frame structure, the second connecting part and thus the pipe end tilt in the direction towards alignment of the pipelines.
8. The connecting device according to claim 6, wherein the forced motion means on the second connecting part is fixedly connected to the second pipe end via a plate part that is secured substantially perpendicular to the central axis of the pipe end.
9. The connecting device according to claim 1, wherein the connector constitutes an integrated part of the connecting device, the connector being secured on the second connecting part and the second connecting part is displaceable in a direction towards and away from the first connecting part, said pipe ends thus are positioned before final connection of the pipe ends by said connector.
10. The connecting device according to claim 2, wherein the connector constitute an integrated part of the connecting device, the connector being secured on the first connecting part and the second connecting part is displaceable in a direction towards and away from the first connecting part, said pipe ends thus are positioned before final connection of the pipe ends by said connector.
11. The connecting device according to claim 3, wherein the connector constitute an integrated part of the connecting device, the connector being secured on the second connecting part and the first connecting part is displaceable in a direction towards and away from the second connecting part, said pipe ends thus are positioned before final connection of the pipe ends by said connector.
12. The connecting device according to claim 4, wherein the connector constitute an integrated part of the connecting device, the connector being secured on the first connecting part and the first connecting part is displaceable in a direction towards and away from the second connecting part, said pipe ends thus are positioned before final connection of the pipe ends.
13. The connecting device according to claim 1, wherein the connector constitute a separate unit that can be lowered down between the pipe ends after the pipe ends are coarsely positioned and aligned relative to each other.
14. The connecting device according to claim 1, wherein at least one of the connecting parts comprises orienting means that are able to turn the second connecting part in the horizontal plane to coarsely align the second connecting part in respect of the first connecting part such that the pipe ends thus are brought substantially in line before lowering of the second connecting part along said guide post.
15. The connecting device according to claim 1, wherein the second connecting part comprises a plate part, and
wherein the guiding means are hingedly connected to the plate part.
16. The connecting device according to claim 2, wherein the forced motion means on the second connecting part comprises a projecting bar which, in a slidable way, cooperates with a frame part on the first connecting part, said sliding cooperation tilts the second connecting part and thus the pipe end towards alignment of the pipelines.
17. The connecting device according to claim 3, wherein the forced motion means on the second connecting part comprises the said guiding means and the guiding means is fixedly connected to the projecting bar which, in a slidable way, cooperates with said frame part.
18. The connecting device according to claim 2, wherein the forced motion means on the second connecting part is fixedly connected to the second pipe end via a plate part that is secured substantially normally to the central axis of the pipe end.
19. The connecting device according to claim 3, wherein the forced motion means on the second connecting part is fixedly connected to the second pipe end via a plate part that is secured substantially normally to the central axis of the pipe end.
20. The connecting device according to claim 4, wherein the forced motion means on the second connecting part is fixedly connected to the second pipe end via a plate part that is secured substantially normally to the central axis of the pipe end.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of the formula:
CH3\u2014(CH2)4\u2014CO-Lys-Gly-His-Lys-NH2 (SEQ ID NO: 1)
wherein:
each Lys is independently of the other a L- or D-lysine residue;
His is a L- or D-histidine residue;
or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.
2. The compound of claim 1, wherein the lysine and histidine residues are in L-configuration.
3. A composition comprising the compound according to claim 1, and a topically, cosmetically or pharmaceutically acceptable excipient or carrier.
4. The composition of claim 3, wherein said composition comprises between about 10\u22128 M and about 10\u22122 M of said compound.
5. The composition of claim 4, wherein said composition comprises between about 10\u22126 M and about 10\u22125 M of said compound.
6. The composition of claim 3, wherein said composition is a topical composition.
7. The composition of claim 3, wherein said composition is an aqueous solution, a cream, a water-in-oil emulsion, a oil-in-water emulsion, a gel, a spray, an ointment, a lotion, or a paste.
8. The composition of claim 3, further comprising at least one additional active agent.
9. A method of preventing, reducing, delaying or treating the appearance or presence of (a) wrinkles, (b) fine lines or (c) both (a) and (b), on the skin in a subject, said method comprising administering an effective amount of the compound of claim 1, to said subject.
10. The method of claim 9, wherein the administration is topical.
11. The method of claim 9, wherein said effective amount is between about 10\u22128M and about 10\u22122M of said compound.
12. The method of claim 11, wherein said effective amount is between about 10\u22126M and about 10\u22125M of said compound.
13. A method for inducing or increasing the production of at least one dermo-epidermal junction (DEJ) molecule in a biological system, said method comprising contacting said biological system with the compound of claim 1, or the composition of claim 8.
14. The method of claim 13, wherein said at least one DEJ molecule is (a) laminin-5, (b) collagen VII, or (c) both (a) and (b).
15. The method of claim 13, wherein said biological system is a cell, a tissue or an organ.
16. The method of claim 15, wherein said cell is a skin cell.
17. The method of claim 15, wherein said organ is skin.
18. A kit or package comprising the compound of claim 1, together with (i) instructions for preventing, reducing, delaying or treating the appearance or presence of (a) wrinkles, (b) fine lines or (c) both (a) and (b), on the skin in a subject; andor together with (ii) a container.
19. A kit or package comprising the composition of claim 3, together with (i) instructions for preventing, reducing, delaying or treating the appearance or presence of (a) wrinkles, (b) fine lines or (c) both (a) and (b), on the skin in a subject; andor together with (ii) a container.