What is claimed is:
1. A combination of (a) an inhibitor of platelet-derived growth factor activity and (b) a vector for vascular endothelial growth factor gene transfer, where the components (a) and (b) may be separate or in fixed combination.
2. A combination according to claim 1, wherein the component (a) is selected from N-5-4-(4-methyl-piperazino-methyl)-benzoylamido-2-methylphenyl-4-(3-pyridyl)-2-pyrimidine-amine andor 6,7-dimethoxy-2-thiophen-3-yl-quinoxaline, or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical preparation comprising components (a) and (b) as defined in claim 1 in combination together with a pharmaceutically acceptable carrier material.
4. A product comprising components (a) and (b) as defined in claim 1 and optionally a pharmaceutically acceptable carrier material, for simultaneous, chronologically staggered or separate use, especially in the treatment of endothelial damage.
5. A product according to claim 4, wherein components (a) and (b) are formulated separately, especially for use in the method of administration according to the invention, component (a) for parenteral or more preferably enteral use together with a pharmaceutically acceptable carrier material, especially as a capsule or tablet or drink, component (b) as a solution or suspension in a sterile aqueous solution that may comprise additional salts, polysaccharides, like dextrose, or buffers, especially in physiological saline (0.9% NaCl), or as dry form allowing completion prior to use by addition of water or an aqueous solution with buffers, salts or polysaccharides, or the like, e.g. physiological saline.
6. A product according to claim 4 or 5, where the endothelial damage is surgically or catheterendoscopically induced endothelial damage, preferably pathological neointima formation, restenosis andor vein graft thickening, more especially after balloon-catheter treatment, surgical carotid artery endarterectomy, stent implantation, angioplasty or bypass graft.
7. A method of treating a warm-blooded animal having an endothelial damage comprising administering to the animal a combination which comprises component (a) and component (b) according to claim 1 in a quantity which is jointly therapeutically effective against an endothelial damage and in which the components can also be present in the form of their pharmaceutically acceptable salts.
8. A method of administering or the use of a combination according to claim 1, where components (a) and (b) may be administered together or in chronologically staggered manner, or preferably of a product according to any one of claims 4 to 6 for the treatment of endothelial damage, especially surgically or catheterendoscopically induced endothelial damage, preferably pathological neointima formation, restenosis andor vein graft thickening, more especially after balloon-catheter treatment, surgical carotid artery endarterectomy, stent implantation, angioplasty or bypass graft.
9. The use of components (a) and (b) as defined in claim 1 for the manufacture of a pharmaceutical preparation according to claim 3 or a product according to any one of claims 4 to 6 for the treatment of endothelial damage.
10. The use according to claim 9 where the endothelial damage is surgically or catheterendoscopically induced endothelial damage, preferably pathological neointima formation, restenosis andor vein graft thickening, more especially after balloon-catheter treatment, surgical carotid artery endarterectomy, stent implantation, angioplasty or bypass graft.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A product of a process of integration of mixed format data, said product comprising at least one storage media device including a database of integrated data, said product produced by an integration process comprising the steps of:
accessing a database of structured data, the structured data comprising a set of data tuples;
accessing a source of unstructured data, the unstructured data including free text relatable to the data tuples of the structured data;
interpreting the free text to produce a set of construed data reflecting at least one relational fact conveyed in the free text, each construed datum relatable to a data tuple of the structured data;
integrating the produced data with the data tuples of the structured data; and
storing the integrated data produced by said integrating to the at least one storage media device in the form of a database.
2. A product of the process recited in claim 1, wherein said interpreting the free text includes the steps of:
identifying roles within the parsed text records, said identifying producing attribute extractions, each of said attribute extractions containing attribute information of the derived source text; and
applying caseframes to the attribute extractions, said applying caseframes producing a filtered set of attribute extractions.
3. A product of the process recited in claim 2 wherein said interpreting the free text further includes the step of identifying domains of the filtered set of attribute extractions.
4. A product of the process recited in claim 2, wherein said interpreting the free text further includes the step of assigning domain roles.
5. A product of the process recited in claim 4, wherein said interpreting the free text further includes the step of producing relation types.
6. A product of the process recited in claim 1, wherein:
said interpreting the free text further includes the step of creating a new database containing the structured data element produced in said producing; and
said product includes the created database.
7. A product of the process recited in claim 1, wherein:
said interpreting the free text further includes the step of producing a file containing the structured data element produced in said producing; and
said product includes the produced file.
8. A product of the process recited in claim 1, wherein the produced file has a format selected from the group of XML, character separated values, spreadsheet formats and file-based database structures.
9. A product of the process recited in claim 1, wherein said the stored integrated data includes reference information to the original free text for construed data.
10. A product of the process recited in claim 1, wherein:
the process further includes the step of constructing a library containing extracted attributes; and
said product includes the constructed library.
11. A product of the process recited in claim 1, wherein said interpreting the free text further includes the step of combining like relation types.
12. A product of the process recited in claim 1, wherein said interpreting the free text further includes the step of combining like attributes.
13. A product of the process recited in claim 1, wherein said interpreting the free text further includes the step of coalescing the identified attributes.
14. A product of the process recited in claim 1, wherein said interpreting the free text further includes the step of coalescing identified relation types.
15. A product of a process of integration of mixed format data, said product comprising a memory device having stored thereon integrated data, said product produced by an integration process comprising the steps of:
accessing a database of structured data, the structured data comprising a set of data tuples;
accessing a source of unstructured data, the unstructured data including free text relatable to the data tuples of the structured data;
interpreting the free text to produce a set of construed data reflecting at least one relational fact conveyed in the free text, each construed datum relatable to a data tuple of the structured data;
integrating the produced data with the data tuples of the structured data; and
storing the integrated data produced by said integrating to the memory device.
16. A product of the process recited in claim 15, wherein said interpreting the free text includes the steps of:
identifying attributes within the parsed text records, said identifying producing attribute extractions, each of said attribute extractions containing attribute information of the derived source text; and
applying caseframes to the attribute extractions, said applying caseframes producing a filtered set of attribute extractions.
17. A product of the process recited in claim 16, wherein said interpreting the free text further includes the step of identifying domains of the filtered set of attribute extractions.
18. A product of the process recited in claim 17, wherein said interpreting the free text further includes the step of assigning domain roles.
19. A product of the process recited in claim 18, wherein said interpreting the free text further includes the step of producing relational facts.
20. A product of the process recited in claim 15, wherein:
said interpreting the free text further includes the step of creating a new database containing the structured data element produced in said producing; and
said product includes the created database.
21. A product of the process recited in claim 15, wherein:
said interpreting the free text further includes the step of producing a file containing the structured data element produced in said producing; and
said product includes the produced file.
22. A product of the process recited in claim 15, wherein the produced file has a format selected from the group of XML, character separated values, spreadsheet formats and file-based database structures.
23. A product of the process recited in claim 15, wherein said the stored integrated data includes reference information to the original free text for construed data.
24. A product of the process recited in claim 15, wherein:
the process further includes the step of constructing a library containing extracted attributes; and
said product includes the constructed library.
25. A product of the process recited in claim 15, wherein said interpreting the free text further includes the step of combining like relation types.
26. A product of the process recited in claim 15, wherein said interpreting the free text further includes the step of combining like attributes.
27. A product of the process recited in claim 15, wherein said interpreting the free text further includes the step of coalescing the identified attributes.
28. A product of the process recited in claim 15, wherein said interpreting the free text further includes the step of coalescing identified relation types.