1. A method of treating a patient having acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS), comprising administering an unconjugated humanized M195 antibody to the patient at a dose of 1.5 to about 12 mgkg body weight, whereby progression of the AML or MDS is inhibited.
2. The method of claim 1, wherein the antibody is administered at weekly intervals for a period of about one to three months.
3. The method of claim 2, further comprising administering the antibody at biweekly intervals for a period of one to six months.
4-10. (canceled)
11. The method of claim 1, whereby at least one symptom of AML associated cachexia is reduced.
12. (canceled)
13. The method of claim 1, wherein the humanized M195 antibody decreases the number of involved non-malignant effector cells, andor decreases the levels of one or more inflammatory cytokines, chemokines or growth factors, in the patient.
14-17. (canceled)
18. The method of claim 1, wherein the patient is at least 60 years of age.
19-27. (canceled)
28. A method of treating acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) in a patient, or of preventing or delaying recurrence of AML or MDS in a patient in remission, comprising administering an unconjugated humanized M195 antibody to the patient at a dose of 550-650 mg regardless of body weight.
29. The method of claim 28, wherein the antibody is administered at weekly intervals for a period of about one to three months.
30. The method of claim 28, whereby at least one symptom of AML associated cachexia is reduced.
31. The method of claim 28, wherein the patient is at least 60 years of age.
32. The method of claim 28, wherein the antibody is administered at a dose of about 600 mg.
33. The method of claim 32, wherein the antibody is administered at weekly intervals for a period of about one to three months.
34. The method of claim 32, wherein the patient is at least 60 years of age.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A regulator coupling comprising
a dissipation-type voltage regulator, which has an input for receiving input voltage (Vs) and an output for providing output voltage (Vout), and
means (Vbat) for providing the said input voltage to the voltage regulator, wherein the regulator coupling comprises
a first and second operating mode,
means for providing the said input voltage with the first voltage value in the said first operating mode, and
means for providing the said input voltage with the second voltage value in the said second operating mode, in which the second voltage value is smaller than the said first voltage value.
2. A regulator coupling according to claim 1, wherein the said voltage regulator is arranged to provide an equal voltage to the output as the said output voltage (Vout) in the said first and second operating mode.
3. A regulator coupling according to claim 1, wherein it comprises regulator means for forming the said second voltage value by regulating from the said first voltage value.
4. A regulator coupling according to claim 3, wherein the said regulator means comprise
a return coupling for monitoring the voltage level of the input voltage (Vs),
a control device, switches and the said control device further comprises an output for controlling the switches, an input for receiving the control signal and an input for receiving the return coupled voltage through the said return coupling, and switches are arranged to form a pulse-form voltage from the used voltage supply’s voltage (Vbat), and
a coil and capacitor for filtering the formed pulse-form voltage as the voltage regulator’s input voltage (Vs).
5. A regulator coupling according to claims 1-4, wherein it is used in a mobile communications device and that the said first operating mode is the idle mode of the mobile communications device and the said second operating mode is the call mode of the mobile communications device.
6. A method for using a dissipation-type voltage regulator, in which an input voltage (Vs) is formed to the voltage regulator and an output voltage (Vout) is gained from voltage regulator, wherein the method
uses the voltage regulator in a first and second operating mode,
a first voltage value is formed for the said input voltage (Vs) in the first operating mode, and
a second voltage value is formed for the said input voltage (Vs) in the second operating mode, in which the second voltage value is smaller than the said first voltage value.
7. A method according to claim 6, wherein the said first and second operating mode provide an equal output voltage as the said voltage regulator’s output voltage (Vout).
8. A method according to claim 6, wherein when the load current flowing through the said voltage regulator exceeds a predetermined limit value, the process moves from the first operating mode to the second operating mode.
9. A method according to claim 6, wherein when the load current flowing through the said voltage regulator decreases below a predetermined limit value, the process moves from the second operating mode to the first operating mode.
10. A method according to claim 6, wherein the said first voltage value in the said first operating mode is formed from the voltage of the voltage supply (Vbat) to form the said voltage regulator’s output voltage (Vout).
11. A method according to claim 6, wherein the said second voltage value in the said second operating mode is regulated from the said first voltage value to form the output voltage of the voltage regulator (Vout).
12. A method according to claim 11, wherein in the said second operating mode
a pulse voltage is formed from the voltage supply’s voltage (Vbat),
the said pulse voltage is filtered as the second voltage value of the said voltage regulator’s input voltage (Vs).
13. An electronic device comprising
at least one dissipation-type voltage regulator, which has an input for receiving input voltage (Vs) and an output for providing output voltage (Vout), and
means for providing the said input voltage to the voltage regulator, wherein the device comprises
a first and second operating mode,
means for providing the said input voltage with the first voltage value in the said first operating mode, and
means for providing the said input voltage with the second voltage value in the said second operating mode, in which the second voltage value is smaller than the said first voltage value.
14. A device according to claim 13, wherein the said device is a mobile communications device.
15. A device according to claim 13, wherein the said voltage regulator is a linear regulator.