1. A method of diagnosing breast cancer in the subject, comprising:
a) selecting protein makers, wherein the protein markers are the combination of cytokeratin 19, cathepsin D, ezrin, and slc9a3rl;
b) detecting a level of expression of the selected protein markers in a biological fluid sample isolated from the subject by contacting the biological fluid sample with a targeting agent specific for a protein marker in the combination of the selected protein markers;
c) detecting a level of expression of the selected protein markers in a control biological fluid sample by contacting the control sample with the targeting agent specific for a protein marker in the combination of the selected protein markers; and
d) comparing the levels of expression of the selected protein markers in the biological fluid sample to the levels of expression of the same protein markers in the control sample,
wherein the presence of breast cancer is indicated if the level of expression of the selected protein markers in the biological fluid sample is greater than the level of expression for the selected protein markers in the control sample.
2. The method of claim 1, further comprises detecting a level of expression of HER-2.
3. The method of claim 1, wherein the level of expression of protein markers is detected by protein capture probes attached to a solid support.
4. The method of claim 1, wherein the subject is a human.
5. The method of claim 1, wherein the biological fluid sample is selected from the group consisting of blood, bile, serum, sweat, urine, mucosal secretions, saliva, seminal fluid, cerebrospinal fluid, tears, and sebaceous secretions.
6. The method claim 5, wherein the biological fluid sample comprises blood or serum.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A torque generation device, comprising:
an armature winding configured to receive an input torque;
a shell comprising a magnetic cylinder and configured to deliver an output torque to an underactuated system disposed outside the torque generation device; and
a magnet set comprising a plurality of blocks of permanent magnets and disposed on an inner side of the shell,
wherein:
the plurality of blocks of permanent magnets are symmetrically fixed and distributed on the inner side of the shell and are in fixed connection so as to form an approximately constant magnetic field,
the armature winding is disposed coaxially in the shell with an air gap between the shell and the magnet set,
the armature winding is driven by the input torque to rotate in the approximately constant magnetic field in response to the armature winding receiving the input torque, and
the output torque is generated by an electromagnetic effect between the approximately constant magnetic field and the armature winding, the electromagnetic effect causing the shell to rotate and thereby deliver the output torque.
2. The torque generation device of claim 1, further comprising a motor configured to provide the input torque.
3. The torque generation device of claim 2, further comprising:
a front bearing;
a rear bearing;
a front end cap;
a rear end cap; and
a motor bracket,
wherein:
a lower part of the shell is connected with a rectangular parallelepiped that is configured to be fixedly connected with the underactuated system,
the front bearing is coaxially connected with the armature winding and is embedded in a bearing groove of the front end cap which is buckled in a front end part of the shell,
the rear bearing is coaxially connected with the armature winding and is embedded in a bearing groove of the rear end cap which is buckled in a rear end part of the shell,
the motor is in a coaxial rotary joint with a shaft of the armature winding with the armature winding protruding from the front end cap,
the motor bracket is formed by a ring located in an upper part of the motor bracket and a rectangular strip located at a lower part of the motor bracket,
the ring located in the upper part of the motor bracket and the motor are coaxially inserted and fixed, and
the rectangular strip located at the lower part of the motor bracket is in a fixed joint with the underactuated system.
4. The torque generation device of claim 2, further comprising:
a rear bearing; and
a rear end cap,
wherein:
a lower part of the shell is connected with a rectangular parallelepiped that is fixedly connected with the underactuated system,
the rear bearing is coaxially connected with the armature winding and is embedded in a bearing groove of the rear end cap which is buckled on a rear end part of the shell,
the motor is embedded in a front end part of the shell, and
a shaft of the motor is in a coaxial rotary joint with the armature winding.
5. The torque generation device of claim 2, further comprising:
a front end cap; and
a motor seat,
wherein:
the shell is formed through an integrated connection of a cylinder with one end open and a shaft of a variable cross-section at an external side of a bottom of the cylinder,
an internal bottom of the cylinder of the shell includes a bearing groove,
the shaft of the variable cross-section is in a coaxial fixed joint with the underactuated system,
the front end cap includes a bearing groove configured to receive a bearing which is in a rotary joint with a front end of the armature winding,
the front end cap is buckled in a front end part of the shell,
the motor is fixed on the motor seat that is in fixed connection with the underactuated system,
a shaft of the motor is in fixed connection with the armature winding, and
the armature winding protrudes from the front end cap.
6. The torque generation device of claim 2, further comprising:
a front end cap;
a rear end cap; and
a motor seat,
wherein:
a periphery of the magnetic cylinder of the shell is in integrated connection with an electromechanical transmission component and is cooperatively connected with the underactuated system,
the front end cap includes a bearing groove to receive a front bearing which is in a coaxial rotary joint with a front end of the armature winding,
the front end cap is buckled in a front end part of the shell,
the rear end cap includes a bearing groove configured to receive a rear bearing which is in a coaxial rotary joint with a rear end of the armature winding in a rotating manner,
the rear end cap is buckled in a rear end part of the shell,
the motor is fixed on the motor seat that is in fixed connection with the underactuated system,
a shaft of the motor is in fixed connection with the armature winding, and
the armature winding protrudes from the front end cap.
7. The torque generation device of claim 2, wherein the armature winding is in parallel connection with a load, and wherein the load comprises a power supply device that provides power to the motor.
8. The torque generation device of claim 1, wherein the input torque and the output torque are in a same direction.
9. The torque generation device of claim 1, wherein a periphery of the shell is coated with a layer of an electromagnetic shielding material.
10. The torque generation device of claim 1, wherein at least one permanent magnet of the magnet set is replaced by an exciting winding which coaxially winds around a main pole core to form a magnetic field.
11. The torque generation device of claim 1, wherein the armature winding is in parallel connection with a load.
12. The torque generation device of claim 1, wherein the plurality of blocks of permanent magnets comprises four or more blocks of permanent magnets.
13. A method for applying a torque to an underactuated system, comprising:
determining a magnitude of the torque to be applied to the underactuated system;
calculating a rotational speed of a motor based on a ratio between the magnitude of the torque and the rotating speed of the motor;
driving the motor at the rotational speed, the motor subsequently rotating an armature winding disposed coaxially in a cylindrical magnetic shell having an approximately constant magnetic field therein;
generating the torque in a form of a rotation of the cylindrical magnetic shell by an electromagnetic effect between the approximately constant magnetic field and the armature winding; and
applying the torque in the form of the rotation of the cylindrical magnetic shell to the underactuated system by a fixed connection between the cylindrical magnetic shell and the underactuated system.
14. The method of claim 13, wherein the determining of the magnitude of the torque to be applied to the underactuated system is based on a pre-programmed linear proportional-integral-derivative (PID) algorithm.
15. The method of claim 13, wherein the determining of the magnitude of the torque to be applied to the underactuated system is based on a pre-programmed nonlinear proportional-integral-derivative (PID) algorithm.
16. The method of claim 13, wherein the determining of the magnitude of the torque to be applied to the underactuated system is based on a fuzzy value algorithm.