What is claimed is:
1. A method for identifying and measuring geometric, spatial, and anatomical changes in real-time in airway structures in a mammal during inhalation comprising the steps of:
using a magnetic resonance imaging device (MRI) to produce real-time dynamic images from said magnetic resonance imaging at a rapid rate thereby depicting the mobility of the airway structures during inhalation;
applying geometric alignment, spatial configuration, and volumetric descriptors to the different type of images produced with said magnetic resonance imaging;
evaluating such imaging to determine the anatomical changes in the airway structures during inhalation; and
wherein inhalation takes place through a mouthpiece used to dispense a substance which comprises an aerosol medicament, placebo or air.
2. The method of claim 1 wherein said substance includes a contrasting agent.
3. The method of claim 2 wherein the contrasting agent is gadolinium.
4. The method of claim 2 wherein the contrasting agent is technetium.
5. The method of claim 1 which further includes the step of magnetic resonance imaging the upper regions of the oropharyngeal, lower trachea and lungs of the mammal to determine flow of the substance within the airway structures.
6. The method of claim 1, further including the step of determining the flow rate during inhalation and correlating the flow rate data with the real-time imaging.
7. The method of claim 5, further including the step of determining flow rate data of inhalation and correlating the flow rate data with the real-time imaging.
8. The method of claim 6, wherein the flow rate data is determined simultaneously with the production of said real-time images.
9. The method of claim 7, wherein the flow rate data is determined simultaneously with the production of said real-time images.
10. The method of claim 6, further including the step of using said imaging and said flow rate data in determining design criteria for aerosol delivery devices.
11. The method of claim 7, further including the step of using said imaging and said flow rate data in determining design criteria for aerosol delivery devices.
12. The method of claim 6, further including the step of using said imaging and said flow rate data to establish a database of information for a plurality of delivery devices.
13. The method of claim 7, further including the step of using said imaging and said flow rate data to establish a database of information for a plurality of delivery devices.
14. The method of claim 4, further including the step of determining an amount and location of the substance being dispensed into the airway.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
I claim:
1. A method of producing a security document, comprising:
providing multi-bit binary data;
forming a pattern of recesses in a metal member, said pattern having the multi-bit binary data encoded therein; and
pressing a substrate into said metal member to texture the substrate in accordance with said binary data.
2. The method of claim 1 further including inking the recesses prior to the pressing.
3. The method of claim 1 in which the pattern has the multi-bit binary data steganographically encoded therein, wherein a human viewer of the texture on the substrate is not alerted that it conveys multi-bit binary data.