1. An oral formulation for gastrointestinal drug delivery which comprises an adhesion site-controlling layer for attaching the formulation to a selected site in the intestines, a drug-carrying layer containing a drug and an adhesive to attach the drug containing layer to the selected site in the intestines when the adhesion site-controlling layer dissolves at the selected site in the intestines, and a protecting layer structured and arranged for preventing digestive juice from permeating into the drug-carrying layer and the drug-carrying layer from releasing the drug through the protecting layer, the drug-carrying layer existing between the protecting layer and the adhesion site-controlling layer, the adhesion site-controlling layer is attached to the protecting layer and the adhesion site-controlling layer is a film made of an enteric polymer, and the adhesion site-controlling layer contains a plasticizer.
2. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein each of the adhesion site-controlling layer, the drug-carrying layer and the protecting layer is in the form of film, and said three layers are laminated.
3. The oral formulation for gastrointestinal drug delivery according to claim 2 wherein each of the adhesion site-controlling layer, the drug-carrying layer and the protecting layer has a thickness of from 20 to 100 \u03bcm.
4. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the protecting layer is in hemispherical form forming an inner space and an opening part, and the drug-carrying layer exists in the inner space of the protecting layer in said hemispherical form, and wherein the adhesion site-controlling layer covers the opening part of the protecting layer in said hemispherical form.
5. The oral formulation for gastrointestinal drug delivery according to claim 4 wherein the hemisphere has an inside depth from 50 to 500 \u03bcm, the opening part of the hemisphere has an inside diameter of from 20 to 800 \u03bcm, and each of the protecting layer and the adhesion site-controlling layer has a thickness of from 20 to 100 \u03bcm.
6. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the drug-carrying layer is a porous sheet substrate soaked with a drug, or a sheet or a film of a gel or a wax which contains a drug.
7. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the drug-carrying layer further contains one or more ingredients selected from the group consisting of absorption promoters, protease inhibitors and transporter inhibitors.
8. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the protecting layer is a film or a capsule, each of said film or capsule being composed of at least one of a water-insoluble polymer and a wax.
9. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the drug is a physiologically active protein or peptide.
10. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the drug is G-CSF, interferon or indinavir.
11. An oral capsule formulation which is prepared by filling the formulation according to claim 1 in a capsule.
12. The oral capsule formulation according to claim 11 which is an enteric capsule.
13. An oral capsule formulation which is prepared by filling the formulation according to claim 2 in a capsule.
14. An oral capsule formulation which is prepared by filling the formulation according to claim 4 in a capsule.
15. An oral capsule formulation which is prepared by filling the formulation according to claim 6 in a capsule.
16. An oral capsule formulation which is prepared by filling the formulation according to claim 7 in a capsule.
17. An oral capsule formulation which is prepared by filling the formulation according to claim 8 in a capsule.
18. An oral capsule formulation which is prepared by filling the formulation according to claim 9 in a capsule.
19. An oral capsule formulation which is prepared by filling the formulation according to claim 10 in a capsule.
20. The oral formulation for gastrointestinal drug delivery according to claim 1 wherein the drug-carrying layer is sealed between the adhesion site-controlling layer and the protecting layer to prevent leaking of the drug.
21. The oral capsule formulation according to claim 13 which is an enteric capsule.
22. The oral capsule formulation according to claim 14 which is an enteric capsule.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An actuator latch apparatus for a data storage device comprising:
a latch lever having a first latch portion at one end portion of the latch lever and having the other end portion fixed to a base plate of the data storage device, and made of a shape memory alloy capable of being deformed according to application of electric power; and
a second latch portion provided at an end portion of an actuator moving a readwrite head to a predetermined position of a disk,
wherein, when the rotation of the disk is stopped and the actuator is parked at a parking position, the first latch portion of the latch lever interferes with the second latch portion, thus locking the actuator not to rotate, and when the disk rotates, the latch lever is deformed so that the first latch portion is separated from the second latch portion, thus allowing the actuator to rotate.
2. The actuator latch apparatus as claimed in claim 1, wherein the shape memory alloy latch lever is made of a Ni\u2014Ti alloy.
3. The actuator latch apparatus as claimed in claim 1, wherein the shape memory alloy latch lever remembers a first shape in a room temperature and a second shape substantially at a temperature over 80\xb0 C.
4. The actuator latch apparatus as claimed in claim 1, wherein wires to apply the electric power are connected to both end portions of the shape memory alloy latch lever.
5. The actuator latch apparatus as claimed in claim 4, wherein the wires are flexible printed circuits.
6. The actuator latch apparatus as claimed in claim 1, wherein, when the electric power is not applied to the shape memory alloy latch lever, the shape memory alloy latch lever is straightened, and when the electric power is applied to the shape memory alloy latch lever, the temperature of the shape memory alloy latch lever rises so as to be bent.
7. The actuator latch apparatus as claimed in claim 1, wherein the first latch portion is a hook and the second latch portion is a protrusion.
8. The actuator latch apparatus as claimed in claim 7, wherein at least one of contact surfaces of the hook and the protrusion is formed inclined.