1. A method of treating autoimmune polyarthritis but not treating psoriatic arthritis, comprising administering, to a patient in need of treatment for said polyarthritis but not for said psoriatic arthritis, an amount of a pharmaceutical preparation effective for treating said polyarthritis, the pharmaceutical preparation comprising
at least one excipient or at least one carrier or a combination thereof and
an active ingredient only consisting of dimethyl fumarate, methyl hydrogen fumarate, or a combination thereof.
2. The method of claim 1, wherein 10 mg to 300 mg of the active ingredient is administered.
3. The method of claim 1, wherein the active ingredient is provided in one or more capsules.
4. The method of claim 1, wherein the active ingredient consists of 50 mg of dimethyl fumarate.
5. The method of claim 1, wherein the active ingredient consists of 110 mg of dimethyl fumarate.
6. The method of claim 1, wherein the active ingredient consists of 120 mg of dimethyl fumarate.
7. The method of claim 1, wherein the active ingredient consists of methyl hydrogen fumarate.
8. The method of claim 7, wherein the active ingredient consists of 10 mg to 300 mg of methyl hydrogen fumarate.
9. The method of claim 1, wherein the active ingredient consists of dimethyl fumarate.
10. The method of claim 9, wherein the active ingredient consists of 10 mg to 300 mg of dimethyl fumarate.
11. The method of claim 9, wherein the active ingredient consists of 50 mg of dimethyl fumarate.
12. The method of claim 9, wherein the active ingredient consists of 110 mg of dimethyl fumarate.
13. The method of claim 9, wherein the active ingredient consists of 120 mg of dimethyl fumarate.
14. The method of claim 1, wherein the pharmaceutical preparation is formulated for oral administration.
15. The method of claim 1, wherein the pharmaceutical preparation is formulated as a solid dosage form.
16. The method of claim 1, wherein the pharmaceutical preparation is in the form of microtablets.
17. The method of claim 16, wherein the microtablets are provided in one or more capsules, each capsule containing at least 50 mg of dimethyl fumarate.
18. The method of claim 17, wherein each capsule contains at least 110 mg of dimethyl fumarate.
19. The method of claim 18, wherein each capsule contains at least 120 mg of dimethyl fumarate.
20. The method of claim 16, wherein the microtablets are enteric-coated.
21. The method of claim 16, wherein the microtablets have a mean diameter in the range of 0.3 mm to 2.0 mm, exclusive of any coating on the microtablets.
22. The method of claim 21, wherein the microtablets have a mean diameter of 2.0 mm, exclusive of any coating on the microtablets.
23. The method of claim 1, wherein the active ingredient consists of at least 50 mg of dimethyl fumarate.
24. The method of claim 1, wherein the active ingredient consists of at least 110 mg of dimethyl fumarate.
25. The method of claim 1, wherein the active ingredient consists of at least 120 mg of dimethyl fumarate.
26. The method of claim 1, wherein the pharmaceutical preparation comprises at least one carrier.
27. The method of claim 1, wherein the pharmaceutical preparation comprises at least one excipient.
28. The method of claim 1, wherein the active ingredient consists of only both dimethyl fumarate and methyl hydrogen fumarate.
29. The method of claim 1, wherein the pharmaceutical preparation comprises at least one excipient and at least one carrier.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A device for combating targets (10, 12) with or without using shaped charge effect wherein an ammunition unit (1), for example in the form of a round, shell, projectile, etc., is designed with an openable or removable and replaceable hull or outer casing (2) and whereby the ammunition unit charge comprises an explosive charge section (3) with shaped charge function such that the said charge section is arranged to be indexible between two freely selectable positions, in the first of which the shaped charge function is enabled and in the second of which the shaped charge function is disabled and the charge thus exerts a different function such as a pressure generating andor fragmentation effect function.
2. A device as claimed in claim 1 wherein the explosive charge section (3) is arranged to be indexible from the first modeposition to the second, or vice versa, by indexingreversing the main charge 180\xb0 in the ammunition unit, such indexing preferably being performed manually.
3. A device as claimed in claim 1 or 2 wherein the initial position of the explosive charge section in the ammunition unit is the position that enables the shaped charge function and the said explosive charge section can be indexed to the second position after opening or removing the hull or outer casing or parts thereof, or can be indexed from second position to initial position in a similar manner.
4. A device as claimed in claim 1, 2 or 3 wherein the explosive charge section (3), herein called the first charge section in the ammunition unit, is interactable with another charge section herein called the second charge section (4).
5. A device as claimed in claim 4 wherein in the first position the conical shaped charge liner (3a, 3b) faces forwards and the rear face (3c) of the first charge section (3) abuts on the front face (4a) of the second charge section (4).
6. A device as claimed in claim 5 wherein the first charge section (3) displays a flat rear face (3c) that in the first position interacts with the corresponding flat front face (4a) of the second charge section (4) while in the second position the first charge section rests against the periphery of the flat front face (4a) of the second charge section (4) to form an empty triangular space (11).
7. A device as claimed in any of the previous claims wherein the hull or casing is openable or removable via a screw joint (9, 9\u2032) arranged so that at least the front section (2a) of the hull or casing (2) is removable to enable the first charge section (3) to be indexed 180\xb0.
8. A device as claimed in any of the previous claims wherein the conical front and rear cavities of the first charge section are arranged so that the distance (a) between the innermost points of the said cavities is relatively small.
9. A device as claimed in any of the previous claims wherein the shaped charge liner (3a, 3b) extends to the lateral surface (3d) of the first charge section (3) thereby forming an extension of the said lateral surface.