1. A temperature sensor with a housing, said temperature sensor comprising:
a first expansion element connected to said housing and being in a form of a tube and containing a second expansion element in a form of a rod, said first and said second expansion elements having different coefficients of thermal expansion;
a first switching spring being pre-stressed and comprising a switching contact, said rod acting on one side of said switching spring; and
a second switching spring provided in a direction of said rod or of an intermediate element as an extension of said rod, said second switching spring fastened to a second switching spring base,
wherein said second switching spring base is configured to be movable along a longitudinal direction of said rod thereby adjusting a switching point of said second switching spring, wherein locking means fixes a position of said second switching spring base,
wherein said second switching spring base is elongated and is connected to said second switching spring in an end region of said second switching spring, wherein said end region is remotely positioned from a switching contact of said second switching spring, said second switching spring base fixed in an unalterable manner to another end region to said temperature sensor housing, and
wherein an adjustable locking arm is provided in said end region between said second switching spring and said second switching spring base, wherein said locking arm is fixed to said temperature sensor housing or to a part fixed in said temperature sensor housing in a particular position.
2. The temperature sensor according to claim 1, wherein said rod rests against said first switching spring by means of said intermediate element in order to trigger said spring.
3. The temperature sensor according to claim 2, wherein an adjustable metal pin is provided at an end of said tube for adjusting a triggering point of said first switching spring, wherein said metal pin is configured to be movable in a longitudinal direction of said tube, and wherein said rod rests against said pin.
4. The temperature sensor according to claim 1, wherein said locking arm comprises a section protruding from said second switching spring base and said section is approximately at right angle to a longitudinal extent of said second switching spring base.
5. The temperature sensor according to claim 4, wherein said locking arm comprises a protruding locking arm being welded to a metal part fastened in said temperature sensor housing.
6. The temperature sensor according to claim 1, wherein a first switching spring base is fixed in its position in order to fasten said first switching spring or is designed such that it is unadjustable with respect to said temperature sensor housing.
7. A temperature sensor with a housing, said temperature sensor comprising:
a first expansion element being connected to said housing comprising a tube containing a second expansion element comprising a rod, said first and second expansion elements having different coefficients of thermal expansion;
a first switching spring being pre-stressed and comprising a switching contact, said rod acting on one side of said switching spring;
a second switching spring provided in a direction of said rod or of an intermediate element as an extension of said rod, said second switching spring fastened to a second switching spring base;
a mating contact being assigned to said switching contact; and
a counter-stop provided for stopping said switching contact when said switching spring is open, wherein said counter-stop is configured to be adjustable either in a direction towards the mating contact or away from said mating contact prior to being fixed in position,
wherein said counter-stop is configured to be adjustable approximately along a direction of movement of said switching contact during opening or closing of said switching spring prior to being fixed in position,
wherein said counter-stop is crimped so as to be fixed in position to the housing, and
wherein said counter-stop comprises a slide on a holder, and said slide and said holder being fixed to one another after setting said counter-stop.
8. The temperature sensor according to claim 7, wherein said counter-stop is configured to be bent for purposes of adjustment thereby setting a distance from said mating contact.
9. A method for adjusting a temperature sensor with a housing, said method comprising:
connecting a first expansion element to said housing and being in a form of a tube and containing a second expansion element in a form of a rod, said first and said second expansion elements having different coefficients of thermal expansion;
pre-stressing a first switching spring comprising a switching contact, said rod acting on one side of said switching spring;
providing a second switching spring in a direction of said rod or of an intermediate element as an extension of said rod, said second switching spring fastened to a second switching spring base,
wherein said second switching spring base is configured to be movable along a longitudinal direction of said rod thereby adjusting a switching point of said second switching spring, wherein locking means fixes a position of said second switching spring base;
setting a switching point of said second switching spring at a particular temperature at which said second switching spring triggers or is intended to switch; and
fixing a position of said second switching spring base by a locking means after setting said switching point.
10. The method according to claim 9, wherein said switching spring base is fixed in its position by welding a locking arm to a metal part in said temperature sensor housing.
11. The method for adjusting a temperature sensor according to claim 9, wherein, at said particular temperature at which said switching spring is intended to close again thereby contacting a counter-stop, said counter-stop is moved in a direction of a mating contact until said switching spring switches again or closes at said temperature.
12. The method according to claim 11, wherein, at said particular temperature, said counter-stop is fixed in position.
13. The method according to claim 12, wherein said counter-stop is fixed permanently by means of welding.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula I
where:
R1 is CO2R5 or CONR6R7;
R2 is
R3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, alkoxy, or haloalkoxy;
R4 is cycloalkyl;
R5 is hydrogen or alkyl;
R6 is hydrogen, alkyl, alkylSO2, alkenylSO2, cycloalkylSO2, haloalkylSO2, (R9)2NSO2, or (R10)SO2;
R7 is hydrogen or alkyl;
R8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, haloalkyl, alkoxyalkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO2, cycloalkylSO2, haloalkylSO2, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, (R11)CO, benzyl, benzyloxycarbonyl, or pyridinyl;
R9 is hydrogen, alkyl, or cycloalkyl;
R10 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 alkyl substituents;
R11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 alkyl substituents; and
X is absent, a bond, or methylene;
or a pharmaceutically acceptable salt thereof.
2. A compound of claim 1 where
R1 is CONR6R7;
R2 is
R3 is alkoxy;
R4 is cycloalkyl;
R6 is alkylSO2, alkenylSO2, cycloalkylSO2, or (R9)2NSO2;
R7 is hydrogen;
R8 is hydrogen, alkyl, cycloalkyl, haloalkyl, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl, alkylSO2, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, or (R11)CO;
R9 is alkyl; and
X is absent, a bond, or methylene;
or a pharmaceutically acceptable salt thereof.
3. A compound of claim 2 where
R1 is CONR6R7;
R2 is
R3 is methoxy;
R4 is cyclohexyl;
R6 is isopropylSO2, isobutylSO2, isopropenylSO2, cyclopropylSO2, or (Me)2NSO2;
R7 is hydrogen; and
R8 is hydrogen, methyl, ethyl, cyclopropyl, trifluoroethyl, ethoxyethyl, acetyl, methoxycarbonyl, isopropylSO2, (methylamino)carbonyl, (dimethylamino)carbonyl, (diisopropylamino)carbonyl, (pyrrolidinyl)CO, or (morpholinyl)CO; and
X is absent, a bond, or methylene;
or a pharmaceutically acceptable salt thereof.
4. A compound of claim 1 where R1 is CONR6R7.
5. A compound of claim 1 where R3 is hydrogen, halo, or alkoxy.
6. A compound of claim 1 where R6 is alkylSO2, alkenylSO2, cycloalkylSO2, haloalkylSO2, (R9)2NSO2, or(R10)SO2 and R7 is hydrogen or alkyl.
7. A compound of claim 1 where R8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, haloalkyl, alkoxyalkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO2, cycloalkylSO2, haloalkylSO2, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, (R11)CO, benzyl, benzyloxycarbonyl, or pyridinyl.
8. A compound of claim 1 where X is absent.
9. A compound of claim 1 where X is a bond.
10. A compound of claim 1 where X is methylene.
11. A compound of claim 1 selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
12. A composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
13. A method of treating hepatitis C infection comprising administering a therapeutically effective amount of a compound of claim 1 to a patient.