1. A computer-implemented method comprising:
selecting, by a computer system, an image from a set of images, wherein the image is editable by a first user and a second user;
maintaining, by the computer system, attribute information about the first user and the second user;
providing, by the computer system, based on the attribute information, a first permission to allow the first user to edit a first content area of the image and a second permission to allow the second user to edit a second content area of the image; and
identifying a second image to be editable by the first user based on a time associated with the image and a time associated with the second image falling within a difference range.
2. The computer-implemented method of claim 1, wherein the attribute information includes a registered face image associated with the first user.
3. The computer-implemented method of claim 2, further comprising:
extracting a face from the image; and
identifying an individual in the image based on the extracted face.
4. The computer-implemented method of claim 3, further comprising comparing the registered face image and the extracted face to determine whether the first user and the individual are an identical person.
5. The computer-implemented method of claim 4, wherein the providing, based on the attribute information, the first permission to allow the first user to edit the first content area of the image is based on a determination that the first user and the individual are the identical person.
6. The computer-implemented method of claim 4, wherein the comparing the registered face image and the extracted face includes applying face recognition processing.
7. The computer-implemented method of claim 1, wherein the attribute information includes a key word selected by the first user.
8. The computer-implemented method of claim 7, wherein the providing, based on the attribute information, the first permission to allow the first user to edit the first content area of the image is based on a determination that the image includes a depiction of the key word.
9. The computer-implemented method of claim 1, wherein the providing, by the computer system, based on the attribute information, the first permission to allow the first user to edit the first content area of the image is based on a determination that the first user is a main subject of the image.
10. The computer-implemented method of claim 1, further comprising prohibiting the second user from applying editing processes to the second content area when the editing processes affect the first content area.
11. The computer-implemented method of claim 10, wherein the editing processes include at least one of enlargement, reduction, or clipping.
12. The computer-implemented method of claim 1, wherein the first content area is all of the image.
13. The computer-implemented method of claim 1, wherein the second content area is a portion of the image.
14. The computer-implemented method of claim 1, further comprising transferring the first permission to allow the first user to edit the first content area to another user.
15. The computer-implemented method of claim 1, wherein the attribute information includes ownership of the image.
16. The computer-implemented method of claim 1, further comprising allowing simultaneous editing of the image by the first user and the second user.
17. The computer-implemented method of claim 1, further comprising requiring sequential editing of the image by the first user and the second user.
18. A computer system comprising:
at least one processor; and
a memory storing instructions configured to instruct the at least one processor to perform:
selecting an image from a set of images, wherein the image is editable by a first user and a second user;
maintaining attribute information about the first user and the second user; and
providing based on the attribute information, a first permission to allow the first user to edit a first content area of the image and a second permission to allow the second user to edit a second content area of the image; and
identifying a second image to be editable by the first user based on a time associated with the image and a time associated with the second image falling within a difference range.
19. A non-transitory computer-storage medium storing computer-executable instructions that, when executed, cause a computer system to perform a computer-implemented method comprising:
selecting an image from a set of images, wherein the image is editable by a first user and a second user;
maintaining attribute information about the first user and the second user;
providing based on the attribute information, a first permission to allow the first user to edit a first content area of the image and a second permission to allow the second user to edit a second content area of the image; and
identifying a second image to be editable by the first user based on a time associated with the image and a time associated with the second image falling within a difference range.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An antigenically effective peptide comprising, from the amino to the carboxylic terminal, the amino acid sequence:
G Q S X1 G Q S X2 G X3 G X4 G X5 G X6 G X7 G K G (residues 19 to 39 of SEQ ID No. 1)
wherein
the amino acids X1-X7 are selected independently from the group consisting of an arginine residue and a citrulline residue, and
at least one of X1-X7 is a citrulline residue,
wherein said peptide is in linear form or in a form of a multimeric branched peptide.
2. The peptide of claim 1, comprising the amino acid sequence G Q S Cit G Q S Cit G X3 G Cit G X5 G X6 G X7 G K G (SEQ ID No. 27)
wherein
the amino acids X3, X5, X6 and X7 are selected independently from an arginine residue or a citrulline residue.
3. The peptide of claim 1, comprising the sequence selected from the group consisting of:
(SEQ\u2003ID\u2003No.\u20034)
GQSRGQSCitGRGRGRGRGRGKG,
(SEQ\u2003ID\u2003No.\u20036)
GQSRGQSRGRGCitGRGRGRGKG,
(SEQ\u2003ID\u2003No.\u200312)
GQSRGQSCitGRGCitGRGRGRGKG,
(SEQ\u2003ID\u2003No.\u200322)
GQSCitGQSCitGRGCitGRGRGRGKG
and
(SEQ\u2003ID\u2003No.\u20032)
G\u2003Q\u2003S\u2003Cit\u2003G\u2003Q\u2003S\u2003Cit\u2003G\u2003Cit\u2003G\u2003Cit\u2003G
Cit\u2003G\u2003Cit\u2003G\u2003Cit\u2003G\u2003K\u2003G
wherein
Cit is a citrulline residue.
4. The multimeric branched peptide of claim 1, comprising four identical copies of the peptide.
5. The multimeric branched peptide of claim 4 being (G Q S Cit G Q S Cit G Cit G Cit G Cit G Cit G Cit G K G)4 K2 K beta-Alanine:
wherein
Cit is a citrulline residue.
6. A method of diagnosing an autoimmune disease in a subject comprising detecting antibodies specific for the autoimmune disease in a biological sample obtained from the subject by
(a) reacting the biological sample under conditions suitable for the formation of immune complexes with the peptide of claim 1, to produce a complex,
(b) reacting the complex formed in (a) with a labeled antibody specific for human immunoglobulins and
(c) detecting the labeled complex of (b) to determine the presence of an autoimmune disease.
7. The method of claim 6, step (a), further comprising reacting the biological sample with a peptide consisting of the sequence (G G D N H G Cit G Cit G Cit G Cit G Cit G G G Cit P GAP G)4 K2 K beta-Alanine:
wherein Cit is citrulline,
to produce a complex.
8. The method of claim 6 comprising
(a) reacting the biological sample under conditions suitable for the formation of an immune complex with a peptide consisting of (G Q S Cit G Q S Cit G Cit G Cit G Cit G Cit G Cit G K G)4 K2 K beta-Alanine:
wherein Cit is citrulline, and also reacting the biological sample with a peptide consisting of (G G D N H G Cit G Cit G Cit G Cit G Cit G G G Cit P G A P G)4 K2 K betaAlanine:
wherein Cit is citrulline,
to produce a complex,
(b) reacting the complex formed in (a) with a labeled antibody specific for human immunoglobulins and
(c) detecting the labeled complex of (b) to determine the presence of an autoimmune disease.
9. The method of claim 6 being an immunological assay.
10. A kit for diagnosing an autoimmune disease comprising at least one antigenically effective peptide of claim 1, and at least one further reagent.
11. The kit of claim 10 further comprising a peptide consisting of the sequence (G G D N H G Cit G Cit G Cit G Cit G Cit G G G Cit P GAP G)4 K2 K beta-Alanine:
wherein Cit is citrulline.
12. The method of claim 6 wherein the autoimmune disease is rheumatoid arthritis.