1. A method of killing breast cancer cells comprising administering to a breast cancer patient an effective amount of a combination of anti-cancer compounds, wherein the anticancer compounds comprise a glucocorticoid receptor antagonist and a chemotherapeutic.
2. The method of claim 1, wherein the breast cancer cells were previously administered a first chemotherapeutic more than two weeks prior to the combination of anti-cancer compounds.
3. The method of claim 2, wherein the breast cancer cells that were previously administered a first chemotherapeutic are chemo-resistant.
4. The method of claim 3, wherein the breast cancer cells are determined not to be chemo-sensitive or are determined to be chemo-resistant.
5. The method of claim 1, wherein the breast cancer cells are glucocorticoid receptor-positive (GR+).
6. (canceled)
7. The method of claim 1, wherein the breast cancer cells do not express detectable levels of estrogen receptor.
8. The method of claim 1, wherein the breast cancer cells express a detectable level of estrogen receptor.
9. (canceled)
10. (canceled)
11. The method of claim 1, wherein the glucocorticoid receptor antagonist is administered prior to the chemotherapeutic.
12. (canceled)
13. The method of claim 1, wherein the glucocorticoid receptor antagonist is administered after the chemotherapeutic is administered.
14. (canceled)
15. The method of claim 1, wherein the glucocorticoid receptor antagonist is administered prior to and after administration of the chemotherapeutic.
16. (canceled)
17. The method of claim 1, wherein the glucocorticoid receptor antagonist has undetectable or a lower level of activity as a progesterone receptor antagonist.
18. The method of claim 17, wherein the glucocorticoid receptor antagonist does not have detectable progesterone receptor antagonist activity.
19. The method of claim 1, wherein the breast cancer is an unresectable breast cancer.
20.-26. (canceled)
27. A method of treating chemotherapy-insensitive breast cancer cells comprising administering to a breast cancer patient an effective amount of a glucocorticoid receptor antagonist followed by chemotherapy.
28. The method of claim 27, wherein the glucocorticoid receptor antagonist is not specific for progesterone receptor.
29. (canceled)
30. The method of claim 27, wherein the patient was previously treated with chemotherapy.
31.-33. (canceled)
34. A method of treating breast cancer cells comprising administering to a breast cancer patient an effective amount of a glucocorticoid receptor antagonist followed by at least one apoptosis-inducing agent.
35. The method of claim 34, wherein at least one apoptosis inducing agent is radiation, a chemotherapeutic, or an immunotherapy.
36. (canceled)
37. (canceled)
38. The method of claim 34, wherein the breast cancer cells are determined to be resistant to apoptosis.
39.-50. (canceled)
51. A method for treating breast cancer in a patient comprising:
a) administering radiation or at least a first chemotherapeutic to the patient;
b) subsequently administering an effective amount of a glucocorticoid receptor antagonist to the patient;
c) administering radiation again or at least a second chemotherapeutic to the patient after the glucocorticoid receptor antagonist is administered to the patient.
52.-91. (canceled)
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for processing an alarm, comprising:
receiving an alarm related to a multicast service;
retrieving multicast data, wherein said multicast data comprises one or more of: a source Internet Protocol (IP) address for a source, a group IP address, or Protocol Independent Multicast (PIM) data;
retrieving interface information, wherein said interface information comprises one or more of: an interface IP address, a PIM mode, and a Designated Router (DR) IP address;
retrieving a status of a neighbor of said source in accordance with said source IP address; and
determining if a neighbor is established for said source IP address.
2. The method of claim 1, further comprising:
performing a Layer 1 test and a Layer 2 test if said neighbor is not established.
3. The method of claim 1, further comprising:
determining if said PIM mode is a Source Specific Mode (SSM), if said neighbor is established.
4. The method of claim 3, further comprising:
notifying a work center of a configuration problem, if said PIM mode is not SSM.
5. The method of claim 3, further comprising:
retrieving one or more of: a multicast routing table, a Reverse Path Forwarding (RPF) table, a status for said source, an incoming IP address, or an outgoing IP address, if said mode is SSM;
determining if an RPF configuration problem exists; and
reporting said RPF configuration problem to a work center, if said RPF configuration problem is detected.
6. The method of claim 5, further comprising:
retrieving one or more of: a group address, or a receiver IP address, if said RPF configuration problem is not detected.
7. The method of claim 6, further comprising:
determining if there is a connectivity problem between a local Provider Edge (PE) router and said source IP address; and
notifying a work center of a customer premise problem, if there is connectivity problem between said local PE router and said source IP address.
8. The method of claim 7, further comprising:
determining if there is a connectivity problem between said local PE router and said receiver IP address, if there is no connectivity problem between said local PE router and said source IP address.
9. The method of claim 8, further comprising:
closing a ticket associated with said alarm automatically if there is no connectivity problem between said local PE router and said receiver IP address.
10. The method of claim 8, further comprising:
determining if there is connectivity problem between a remote PE router and said receiver IP address, if there is a connectivity problem between said local PE router and said receiver IP address;
notifying a work center of a customer premise problem, if there is a connectivity problem between said remote PE router and said receiver IP address; and
notifying a work center of a network problem, if there is no connectivity problem between said remote PE router and said receiver IP address.
11. A computer-readable medium having stored thereon a plurality of instructions, the plurality of instructions including instructions which, when executed by a processor, cause the processor to perform steps of a method for processing an alarm, comprising:
receiving an alarm related to a multicast service;
retrieving multicast data, wherein said multicast data comprises one or more of: a source Internet Protocol (IP) address for a source, a group IP address, or Protocol Independent Multicast (PIM) data;
retrieving interface information, wherein said interface information comprises one or more of: an interface IP address, a PIM mode, and a Designated Router (DR) IP address;
retrieving a status of a neighbor of said source in accordance with said source IP address; and
determining if a neighbor is established for said source IP address.
12. The computer-readable medium of claim 11, further comprising:
performing a Layer 1 test and a Layer 2 test if said neighbor is not established.
13. The computer-readable medium of claim 11, further comprising:
determining if said PIM mode is a Source Specific Mode (SSM), if said neighbor is established.
14. The computer-readable medium of claim 13, further comprising:
notifying a work center of a configuration problem, if said PIM mode is not SSM.
15. The computer-readable medium of claim 13, further comprising:
retrieving one or more of: a multicast routing table, a Reverse Path Forwarding (RPF) table, a status for said source, an incoming IP address, or an outgoing IP address, if said mode is SSM;
determining if an RPF configuration problem exists; and
reporting said RPF configuration problem to a work center, if said RPF configuration problem is detected.
16. The computer-readable medium of claim 15, further comprising:
retrieving one or more of: a group address, or a receiver IP address, if said RPF configuration problem is not detected.
17. The computer-readable medium of claim 16, further comprising:
determining if there is a connectivity problem between a local Provider Edge (PE) router and said source IP address; and
notifying a work center of a customer premise problem, if there is connectivity problem between said local PE router and said source IP address.
18. The computer-readable medium of claim 17, further comprising:
determining if there is a connectivity problem between said local PE router and said receiver IP address, if there is no connectivity problem between said local PE router and said source IP address.
19. The computer-readable medium of claim 18, further comprising:
closing a ticket associated with said alarm automatically if there is no connectivity problem between said local PE router and said receiver IP address.
20. An apparatus for processing an alarm, comprising:
means for receiving an alarm related to a multicast service;
means for retrieving multicast data, wherein said multicast data comprises one or more of: a source Internet Protocol (IP) address for a source, a group IP address, or Protocol Independent Multicast (PIM) data;
means for retrieving interface information, wherein said interface information comprises one or more of: an interface IP address, a PIM mode, and a Designated Router (DR) IP address;
means for retrieving a status of a neighbor of said source in accordance with said source IP address; and
means for determining if a neighbor is established for said source IP address.