1. A method for generating an Environmental Genetic Composite Index (EGCI) score for a disease or condition for an individual comprising:
(a) generating a genomic profile from a genetic sample of said individual;
(b) obtaining at least one environmental factor from said individual, wherein said at least one environmental factor has a relative risk for said disease or condition of at least approximately 1;
(c) generating an EGCI score from said genomic profile and said at least one environmental factor using a computer; and,
(d) reporting said EGCI score obtained and outputted from said computer to said individual or a health care manager of said individual.
2. The method of claim 1, wherein said relative risk is at least approximately 1.1, 1.2, 1.3, 1.4, or 1.5.
3. The method of claim 1, wherein said relative risk is at least approximately 2, 3, 4, 5, 10, 12, 15, 20, 25, 30, 25, 40, 45, or 50.
4. The method of claim 1, wherein said at least one environmental factor has an odds ratio (OR) of at least approximately 1.
5. The method of claim 4, wherein said OR is at least approximately 1.1, 1.2, 1.3, 1.4, or 1.5
6. The method of claim 4, wherein said OR is at least approximately 2, 3, 4, 5, 10, 12, 15, 20, 25, 30, 25, 40, 45, or 50.
7. The method of claim 1, wherein said at least one environmental factor is selected from the group consisting of: said individual’s birthplace, location of residency, lifestyle conditions; diet, exercise habits, and personal relationships.
8. The method of claim 7, wherein said lifestyle condition is smoking or alcohol intake.
9. The method of claim 1, wherein said at least one environmental factor is a physical measurement of said individual.
10. The method of claim 9, wherein said physical measurement of said individual is selected from the group consisting of: body mass index, blood pressure, heart rate, glucose level, metabolite level, ion level, weight, height, cholesterol level, vitamin level, blood cell count, protein level, and transcript level.
11. The method of claim 1, wherein generating said EGCI score uses at least 2 environmental factors.
12. The method of claim 1, wherein generating said EGCI score assumes said at least one environmental factor is an independent risk factor for said disease or condition.
13. The method of claim 1, wherein said disease or condition has a heritability of less than approximately 95%.
14. The method of claim 1, wherein said disease or condition has a heritability of less than approximately 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, or 90%.
15. The method of claim 1, wherein a third party obtains said genetic sample.
16. The method of claim 1, wherein generating said genomic profile is by a third party.
17. The method of claim 1, wherein said reporting comprises transmission of said EGCI score over a network.
18. The method of claim 1, wherein said reporting is through an on-line portal.
19. The method of claim 1, wherein said reporting is by paper or by e-mail.
20. The method of claim 1, wherein said reporting comprises reporting in a secure manner.
21. The method of claim 1, wherein said reporting comprises reporting in a non-secure manner.
22. The method of claim 1, wherein said genetic sample is DNA.
23. The method of claim 1, wherein said genetic sample is RNA.
24. The method of claim 1, wherein said genetic sample is from a biological sample selected from the group consisting of: blood, hair, skin, saliva, semen, urine, fecal material, sweat, and buccal sample.
25. The method of claim 1, wherein said individual’s genomic profile is deposited into a secure database or vault.
26. The method of claim 1, wherein said genomic profile is a single nucleotide polymorphism profile.
27. The method of claim 1, wherein said genomic profile comprises truncations, insertions, deletions, or repeats.
28. The method of claim 1, wherein said genomic profile is generated using a high density DNA microarray.
29. The method of claim 1, wherein said genomic profile is generated using RT-PCR.
30. The method of claim 1, wherein said genomic profile is generated using DNA sequencing.
31. The method of claim 1, further comprising (e) updating said EGCI score with additional or modified environmental factors.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. Microcapsules having walls obtained by polyaddition of at least one polyisocyanate and at least one polyamine in an aqueous emulsion comprising a protein hydrolysate emulsifier.
2. Microcapsules according to claim 1 prepared using an at least bifunctional isocyanate containing on average at least one ester andor amide group per mole in the main chain.
3. Microcapsules according to claim 1 prepared using an isocyanate or an isocyanate mixture containing 100 to 1% by weight of isocyanates having on average at least one ester andor amide group per mole in the main chain and 0 to 99% by weight of at least one other bifunctional isocyanate.
4. Microcapsules according to claim 1 wherein the polyisocyanate has been partly reacted with a salt-forming andor hydrophilicizing compound.
5. Microcapsules according to claim 4 wherein the hydrophilicizing compound contains polyether chains.
6. Microcapsules according to claim 1 wherein the microcapsule walls encapsulate a leucodye, a perfume oil, a crop protection agent, a reactive adhesive, or a pharmaceutical.
7. Microcapsules according to claim 1 prepared in the presence of a hydrophobic solvent selected from the group consisting of cotton seed oil, peanut oil, palm oil, and castor oil.
8. Method for preparing carbonless paper comprising encapsulating a leucodye in a microcapsule according to claim 1 and applying the encapsulated leucodye to a substrate.
9. Process for preparing microcapsules comprising
(a) emulsifying an oil phase comprising an organic water-immiscible isocyanate-inert solvent, a material to be encapsulated, and at least one polyisocyanate in a water phase comprising a protein hydrolysate as emulsifier with or without additives, and
(b) adding to the emulsion an NH2-containing crosslinker (polyamine) capable of reaction with isocyanate groups.