What is claimed is:
1. An indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof:
17
wherein R1 represents hydrogen atom, a halogen atom or cyano group;
R2 and R3 are the same as or different from each other and each represents a hydrogen atom, a C1-C4 lower alkyl group or a halogen atom;
R4 represents a hydrogen atom or a C1-C4 lower alkyl group; and
the ring A represents an aminopyrimidyl group wherein (i) all of R1, R2 and R3 are not hydrogen atoms or (ii) both R2 and R3 are not hydrogen atoms.
2. The indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof, wherein two of R1, R2 and R3 are not hydrogen atoms.
3. The indole compound as claimed in claim 1 or 2, its pharmacologically acceptable salt or hydrates thereof, wherein the ring A is 2-amino-5-pyrimidyl group.
4. The indole compound as claimed in claim 1, wherein said indole compound is 2-amino-N-(4-bromo-3-chloro-1H-indol-7-yl)-5-pyrimidinesulfonamide, its pharmacologically acceptable salts or hydrates thereof.
5. An antiangiogenic compound which comprises an effective amount of the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof.
6. An antitumor compound for pancreatic, colon, gastric, breast, prostate, lung, or ovarian cancer, said antitumor compound comprising an effective amount of the indole compound in claim 1, its pharmacologically acceptable salt or hydrates thereof.
7. A method for treating a disease against which an inhibitory effect of angiogenesis at the site of a tumor from pancreatic, colon, gastric, breast, prostate, lung, or ovarian cancer, rheumatic arthritis or diabetic retinopathy is effective for the treatment thereof, by administering an effective amount of the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof to a patient.
8. A therapeutic compound for pancreatic cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
9. A therapeutic compound for cancer of the colon which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
10. A therapeutic compound for gastric cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
11. A therapeutic compound for breast cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
12. A therapeutic compound for prostatic cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
13. A therapeutic compound for lung cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
14. A therapeutic compound for ovarian cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
15. A suppressor for metastasis of cancer which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
16. A therapeutic compound for diabetic retinopathy which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
17. A therapeutic compound for rheumatic arthritis which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
18. A therapeutic compound for hematoma which comprises the indole compound as claimed in claim 1, its pharmacologically acceptable salt or hydrates thereof as an effective ingredient.
19. The method as claimed in claim 7, wherein the disease is tumor, pancreatic cancer, cancer of the colon, gastric cancer, breast cancer, prostatic cancer, lung cancer, ovarian cancer, metastasis of cancer, diabetic retinopathy, rheumatic arthritis or hematoma.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A pig launching apparatus comprising:
a housing;
a plurality of pigs initially attached to each other for placement in said housing; and
a separator device to release one pig for launching.
2. The apparatus of claim 1, wherein:
said pigs are attached to each other at a predetermined distance.
3. The apparatus of claim 2, wherein:
said housing is configured to stop the advancement of lowermost pig at a location where said separation device can separate one pig from 4 another.
4. The apparatus of claim 3, wherein:
said configuration of said housing comprises a taper.
5. The apparatus of claim 4, wherein:
said pigs are separated from each other by a member which is exposed between each pair of pigs.
6. The apparatus of claim 5, wherein:
said separation device selectively severs said member.
7. The apparatus of claim 6, wherein:
said separation device is operable form a closed position where it supports all unlaunched pigs followed by an open position where it allows for one pig to drop onto said taper, followed by a closed position where said member is severed behind the pig resting on said taper.
8. The apparatus of claim 7, further comprising:
a weight on said pigs to assist them into dropping down toward said taper.
9. The apparatus of claim 8, further comprising:
at least one connection on said housing which can be made or released with an ROV.
10. The apparatus of claim 1, wherein:
said attachment of said pigs is accomplished by a member, a portion of which is exposed between said pigs.
11. The apparatus of claim 10, wherein:
said member is aligned with said separation device after said separation device is retracted which allows said pigs to advance in tandem by a predetermined amount.
12. The apparatus of claim 11, wherein:
said separation device shears said member above the lowermost pig to allow said lowermost pig to be launched.
13. The apparatus of claim 12, further comprising:
a taper on said housing to stop the lowermost pig with said member aligned with said separation device.
14. A pig launching apparatus, comprising:
a housing;
a plurality of undirectional pigs insertable in said housing for launching one at a time.
15. The apparatus of claim 14, further comprising:
a separating device to separate one pig from other pigs for launching.
16. The apparatus of claim 15, wherein:
said separating device functions as a pressure isolation valve.
17. The apparatus of claim 16 further comprising:
attaching a plurality of pigs to each other.
18. The apparatus of claim 17, wherein:
said separation device selectively breaks the attachment between two pigs.
19. The apparatus of claim 14, further comprising:
a cartridge to support said pigs which can be inserted by an ROV into said housing to load said pigs therein.